• 한국산학기술학회논문지
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• 제20권9호
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• pp.323-332
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• 2019

본 연구의 목적은 제주국제관악제에 대한 지역경제파급효과를 측정하는 데 있다. 이를 위하여 '2013년 제주지역 투입산출표'에 기반 한 두 지역(제주-전국) 산업연관모형을 활용하여 제주국제관악제 개최로 인한 지역경제에 파급되는 효과를 알아보았다. 또한 지역에 미치는 효과를 알아보기 위하여 2017년과 2018년 비교를 통하여 제주국제관악제가 얼마나 성장하고 지역경제에 어떠한 효과를 주는지 비교해보았다. 제주국제관악제 개최에 투입된 투자 지출액을 분석한 지역 내 유발된 산업의 생산, 부가가치 효과분석 결과를 비교해보면 생산유발효과는 2017년 9,056,430천원이고 2018년 18,709,179천원으로 2.1배가 증가하였다. 부가가치유발효과는 2017년 4,229,480천원이고 2018년 9,199,030천원으로 2.2배 증가하였다. 분석결과를 살펴보면 제주국제관악제는 지역주민의 소득증대에 많은 기여를 하고 있음을 알 수 있다. 이를 활용하여 관악제의 효과를 높이기 위해서는 제주지역 문화와 관광지를 연결하는 정책들이 필요할 것이다.

• 동의생리병리학회지
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• 제21권1호
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• pp.54-61
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• 2007

The study was designed to investigate the effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen (YTBCL) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats, and further to determine the mechanism of action of YTBCL. The results in rats were as follows ; YTBCL 25 ${\mu}l$ significantly decreased rCBF and MABP compared with basal condition. YTBCL 100 ${\mu}l$ significantly increased rCBF compared with basal condition, but decreased MABP compared with basal condition. YTBCL 50 ${\mu}l$ significantly increased rCBF compared with basal condition, but MABP was somewhat decreased compared with basal condition. The VTBCL 50 ${\mu}l$-induced increase in rCBF was significantly inhibited by pretreatment with methylene blue (10 ${\mu}g$/kg, i.p.), an inhibitor of guanylate cyclase and indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. The YTBCL 50 ${\mu}l$-induced decreased MABP significantly increased by pretreatment with methylene blue but was inhibited by indomethacin. This results were suggested that the mechanism of YTBCL was mediated Dy guanylate cyclase.

• 대한한방내과학회지
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• 제30권2호
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• pp.298-305
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• 2009

Objectives: The present study was carried out to investigate the effects of Yupoongyangyeong-tang(YYT) on changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. In addition, the author also investigated action mechanisms of YYT on changes in rCBF and MABP. Methods and Results : In this study, treatment with YYT elevated rCBF in a dose-dependent manner, but MABP levels were elevated only in the 10 mg/ml treatment group. Pre-treatment with indomethacin. an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. Pre-treatment with methylene blue, an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by YYT, too. In addition. pre-treatment with indomethacin also inhibited increase of MABP. However, pre-treatment with methylene blue did not affect MABP levels. Conclusion : These results suggest that YYT is useful to treat patients with diseases related to cerebral ischemia, because YYT can increase rCBF. In addition, the mechanisms are thought to be related to both cyclooxygenase and guanylate cyclase.

• 대한한의학방제학회지
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• 제10권1호
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• pp.93-103
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• 2002

This experimental studies were done to investigate the effects of Sambutang(SBT) and consitituent herbs on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(BP) in rats. The results are as follows: SBT and consitituent herbs(SBT omitting Zingiberis Rhizoma Recens, Zingiberis Rhizoma Recens. Ginseng Radix and Aconiti iateralis preparata Radix) was increased rCBF significantly in a dose-dependent manner. SBT omitting Zingiberis Rhizoma Recens and Ginseng Radix were decreased significantly BP in rats. But, SBT, Aconiti iateralis preparata Radix and Zingiberis Rhizoma Recens were not affected BP in rats. According to the above findings. it is suggested that SBT causes a diverse response of rCBF, and specially the rCBF by increasing SBT is mediated action of Zingiberis Rhizoma Recens.

• 한국지역지리학회지
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• 제10권1호
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• pp.151-157
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• 2004

1월의 clo 값은 대체로 삼지연 지역이 가장 높게 나타나고, 장전 일대의 동해안 지역이 가장 낮게 나타난다. 또한 해안 지역보다 내륙 지역이, 동해안보다 서해안이 clo 값이 높게 나타난다. 이는 지형적 영향과 기온과 풍속의 지역적 차이에 기인한다. 8월에도 삼지연, 해산 일대, 개마고원 등이 높게 나타나는데, 이는 지형적 영향으로 기온 저하와 풍속의 증가로 나타나는 현상이다. 특히 8월에는 삼지연을 중심으로 북동-남서 내륙지역으로 등치선이 만곡하고, 이 축을 중심으로 한 이외의 지역이 비교적 낮은 분포를 보인다. 이러한 원인으로는 위도, 지형 및 장마 이후의 고온 다습한 북태평양 기단의 영향과 강한 일사에 의한 지면 복사열의 방출에 있다고 사료된다.

• 동의생리병리학회지
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• 제19권6호
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• pp.1599-1603
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• 2005

The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LHE. The results in normal rats were as follows, LHE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that LHE significantly increased rCBF by dilating pial arterial diameter. The LHE-induced increase in rCBF was significantly inhibited by Pretreatment with indomethacin(1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and was significantly inhibited by methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. The LHE-induced MABP did not change by pretreatment with indomethacin but was significantly inhibited by methylene blue. This results were suggested that the mechanism of LHE was mediated by cyclooxygenase.

• 생명과학회지
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• 제11권1호
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• pp.62-69
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• 2001

This study was aimed to investigate the effect Chukdamtanggamibang on the vascular systems including changes in blood pressure and regional cerebral blood flow(rCBF) of male Sprague-Dawely rats, contractile force of guinea pig`s tracheal smooth muscle and abdominal aorta and femoral artery in rabbits. Blood pressure was not affected by Chukdamtanggamibang in rats. rCBF was significantly increased by Chukdamtanggamibang in a dose-dependent manner. Contractile force of isolated guinea pig`s tracheal smooth muscle evoked by His ({TEX}$ED_{50}${/TEX}) were inhibited significantly by Chukdamtanggamibang. Propranolol, indomethacin and methylene blue did not significantly alter the inhibitory effect of Chukdamtanggamibang. Contractile force of isolated rabbit`s abdominal aorta and femoral artery evoked by NE ({TEX}$ED_{50}${/TEX}) were inhibited significantly by Chukdamtanggamibang. ODQ and L-NNA significantly attenuated the inhibitory effects of Chukdamtanggamibang in abdominal aorta, whereas propranolol did not significantly alter the inhibitory effect of Chukdamtanggamibang. These results indicate that Chukdamtanggamibang can relax hitamine-induced contraction of guinea pig`s tracheal smooth muscle and that this inhibition involves, in part, the relation to the soluble guanylyl cyclase synthesis and nitric oxide (NO) synthesis.

• 한국산학기술학회논문지
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• 제10권11호
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• pp.3506-3513
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• 2009

본 연구는 2008년에 개최된 제주국제관악제에 따른 관광산업이 제주지역 경제에 미치는 파급효과를 분석하고, 제주지역 사회 문화에 미치는 영향을 살펴보았다. 제주지역 산업연관표를 활용하여, 축제 개최에 따른 관광산업의 경제적 파급효과를 분석하였고, 선행연구를 정리하여 사회통합적 측면, 정치선전적 측면, 문화발전적 측면, 산업적 측면 4부문으로 나누어 제주국제관악제가 제주지역 사회에 미치는 영향을 분석하였다.

• 동아시아식생활학회지
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• 제15권5
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• pp.606-612
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• 2005

This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit and measured the changes of regional cerebral hood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic $\beta-receptor$. Also mechanism in artery contraction decrease is also mediated by prostaglandis and cyclic GMP. These results indicate that SMS can be nsed as a safe and clinically applicable as a supplementation of diet therapy for cerebral cardiovascular disease patients.

• Journal of Acupuncture Research
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• 제18권5호
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• pp.147-154
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• 2001

Amun(GV15), Habkook(LI4) and Shinsu(B23) have been used as a meridian point for apoplexy, hypertention, vertigo etc. The effects of GV 15, LI4 and B23 on the vascular system is not known. The purpose of this Study was to investigate the effect of several meridian points on the regional cerebral bloof flow(rCBF), mean arterial blood pressure(BP) in rats. The changes of BP and rCBF were tested Laser-Doppler Flowmetry(LDF). Results : The results of this Study were obtained as follows ; 1. GV15 and LI4 were increased significantly rCBF. 2. GV15, LI4 and B23 were increased BP, but have not significance. Conclusion : This results suggest that GV15 was increased rCBF by increasing pial arterial diameter, and LI4 was increased rCBF by increasing BP.