• Parasites, Hosts and Diseases
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• v.54 no.1
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• pp.39-46
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• 2016

Theileria annulata is a tick-borne intracellular protozoan parasite that causes tropical theileriosis, a fatal bovine lymphoproliferative disease. The parasite predominantly invades bovine B lymphocytes and macrophages and induces host cell transformation by a mechanism that is not fully comprehended. Analysis of signaling pathways by quantitative real-time PCR (qPCR) could be a highly efficient means to understand this transformation mechanism. However, accurate analysis of qPCR data relies on selection of appropriate reference genes for normalization, yet few papers on T. annulata contain evidence of reference gene validation. We therefore used the geNorm and NormFinder programs to evaluate the stability of 5 candidate reference genes; 18S rRNA, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), ACTB (${\beta}-actin$), PRKG1 (protein kinase cGMP-dependent, type I) and TATA box binding protein (TBP). The results showed that 18S rRNA was the reference gene most stably expressed in bovine PBMCs transformed and non-transformed with T. annulata, followed by GAPDH and TBP. While 18S rRNA and GAPDH were the best combination, these 2 genes were chosen as references to study signaling pathways involved in the transformation mechanism of T. annulata.

• Journal of KIISE:Computer Systems and Theory
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• v.29 no.7
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• pp.369-376
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• 2002

Although LRU is not adequate for database that has non-uniform reference pattern, it has been adopted in most database systems due to the absence of the proper alternative. We analyze database block reference pattern with the realistic database trace. Based on this analysis, we propose a new cache replacement policy. Trace analysis shows that extremely non-popular blocks take up about 70 % of the entire blocks. The influence of recency on blocks' re-reference likelihood is at first strong due to temporal locality, however, it rapidly decreases and eventually becomes negligible as stack distance increases. Based on this observation, RCB(Reference Characteristic Based) cache replacement policy, which we propose in this paper, classifies the entire blocks into four block groups by blocks' recency and re-reference likelihood, and operates different priority evaluation methods for each block group. RCB policy evicts non-popular blocks more quickly than the others and evaluates the priority of the block by frequency that has not been referenced for a long time. In a trace-driven simulation, RCB delivers a better performance than the existing polices(LRU, 2Q, LRU-K, LRFU). Especially compared to LRU. It reduces miss count by 5~l2.7%. Time complexity of RCB is O(1), which is the same with LRU and 2Q and superior to LRU-K(O(log$_2$N)) and LRFU(O(l) ~ O(log$_2$N)).

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.5
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• pp.437-450
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• 2014

In this study, we developed a methodology to determine the reference parameter for an aircraft impact induced risk assessment of nuclear power plant (NPP) using finite element impact analysis of containment building. The target structure used to develop the method of reference parameter selection is one of the typical Korean PWR type containment buildings. We composed a three-dimensional finite element model of the containment building. The concrete damaged plasticity model was used for the concrete material model. The steels in the tendon, rebar, and liner were modeled using the piecewise-linear stress-strain curves. To evaluate the correlations between structural response and each candidate parameter, we developed Riera's aircraft impact force-time history function with respect to the variation of the loading parameters, i.e., impact velocity and mass of the remaining fuel. For each force-time history, the type of aircraft is assumed to be a Boeing 767 model. The variation ranges of the impact velocity and remaining fuel percentage are 50 to 200m/s, and 30 to 90%, respectively. Four parameters, i.e., kinetic energy, total impulse, maximum impulse, and maximum force are proposed for candidates of the reference parameter. The wellness of the correlation between the reference parameter and structural responses was formulated using the coefficient of determination ($R^2$). From the results, we found that the maximum force showed the highest $R^2$ value in most responses in the materials. The simplicity and intuitiveness of the maximum force parameter are also remarkable compared to the other candidate parameters. Therefore, it can be concluded that the maximum force is the most proper candidate for the reference parameter to assess the aircraft impact induced risk of NPPs.

• The KIPS Transactions:PartA
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• v.13A no.4 s.101
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• pp.335-342
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• 2006

As PRC linear interpolation algorithm is applied after analysed and verified in this paper, the unknown location of a user can be identified by using PRC information of multi-DGPS reference station. The PRC information of each GPS satellite is not varying rapidly, which makes it possible to assume that PRC information of each GPS satellite varies linearly. So, the PRC regeneration algorithm with linear interpolation can be applied to improve the accuracy of finding a user's location by using the various PRC information obtained from multi-DGPS reference station. The desirable PRC is made by the linear combination with the known position of multi-DGPS reference station and PRC values of a satellite using signals from multi-DGPS reference station. The RTK-GPS result was used as the reference. To test the performance of the linearly interpolated PRC regeneration algorithm, multi-channel DGPS beacon receiver was built to get a user's position more exactly by using PRC data of maritime DGPS reference station in RTCM format. At the end of this paper, the result of the quantitative analysis of the developed navigation algorithm performance is presented.

• Journal of Navigation and Port Research
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• v.45 no.1
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• pp.26-32
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• 2021

In ocean field, the spread of the Fourth Industrial Revolution based on information and communication technology requires high precision and stable PNT&D (Position, Navigation, Timing and Data). As the IMO (International Maritime Organization) and IALA (The International Association of Marine Aids to Navigation and Lighthouse Authorities) are requiring backup systems due to mitigate vulnerabilities and the increase of dependency on GNSS (Global Navigation Satellite System), Korea is conducting a research & development of R-Mode. An DGPS (Differentiate Global Positioning System) reference station that uses MF, an existing maritime infrastructure, and AIS (Automatic Identification System) base stations that use 34 integrity station and VHF will be utilized in this study to avoid redundant investment. Because there are radio shadow areas that display low signal levels in the west sea, the establishment of new R-Mode reference and integrity station will be intended to resolve problems regrading the radio shadow area. Because the frequency has a characteristic in that radio wave transmits well along the ground (water surface) in low frequency band, simulation and measurement were conducted therefore this paper to propose candidate sites for R-Mode reference and integrity station resulted through p wave's propagation characteristics analysis. Using this paper, R-Mode reference and integrity station can be established at appropriate locations to resolve radio shadow areas in other regions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.985-988
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• 2008

This paper introduces a new TR-UWB system, using frequency-domain components of UWB pulses. This is achieved by separating converted frequency-components into real and imaginary parts, and both parts are correlated and effectively combined. We make an analysis that the new scheme improves performance compared with a conventional by complex correlation computing. The simulation results confirmed that the proposed scheme has better performance than existing system.

• Journal of the Korean Data and Information Science Society
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• v.19 no.2
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• pp.621-634
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• 2008

This paper addresses the problem of testing whether the means in several inverse Gaussian populations with heterogeneity are equal. The analysis of reciprocals for the equality of inverse Gaussian means needs the assumption of equal scale parameters. We propose Bayesian model selection procedures for testing equality of the inverse Gaussian means under the noninformative prior without the assumption of equal scale parameters. The noninformative prior is usually improper which yields a calibration problem that makes the Bayes factor to be defined up to a multiplicative constant. So we propose the objective Bayesian model selection procedures based on the fractional Bayes factor and the intrinsic Bayes factor under the reference prior. Simulation study and real data analysis are provided.

• Toxicological Research
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• v.23 no.2
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• pp.173-177
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• 2007

The GLP contains specific language concerning characterization of the test, control and reference substances used in toxicity studies. This paper will describe and discuss what types of documents are required to support test/reference substance characterization under GLP system. The purpose of this article is to present an overview of data needed in the characterization package that will adequately define the substance. Most sponsors use a certificate of analysis (COA) to communicate the test sub-stance characterization status information to the contracting research organizations. The COA should provide the test $material^{\circ}{\phi}s$ characterization results, substance storage requirements, expiration dates, verification of the collection of the retention sample, archival location of the data to support the characterization and GLP compliance status of the characterization.

• Asian-Australasian Journal of Animal Sciences
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• v.7 no.4
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• pp.509-512
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• 1994

High performance liquid chromatography (HPLC) analysis was applied for determination of guanine plus cytosine (G + C) contents of DNA of Butyrivibrio fibrisolvens. By values of G + C contents, a reference strain and 20 wild strains of B. fibrisolvens were classified into at least two distinct subgroups, i.e. G + C contents of 18 strains were 38-40 mol% and those of 3 strains including the reference strain were 43-45 mol%. Clear relationships were not observed between G + C contents and biological properties of 21 strains of B. Fibrisolvens.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.54 no.1
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• pp.8-14
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• 2005

This paper is proposed hybrid artificial intelligent(HAI) controller for speed control of surface permanent magnet synchronous motor(SPMSM) drive. The design of this algorithm based on HAI controller that is implemented using fuzzy control and neural network. This controller uses fuzzy rule as training patterns of a neural network. Also, this controller uses the back-propagation method to adjust the weights between the neurons of neural network in order to minimize the error between the command output and actual output. A model reference adaptive scheme is proposed in which the adaptation mechanism is executed by fuzzy logic based on the error and change of error measured between the motor speed and output of a reference model. The control performance of the HAI controller is evaluated by analysis for various operating conditions. The results of analysis prove that the proposed control system has strong high performance and robustness to parameter variation, and steady-state accuracy and transient response.