• ETRI Journal
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• v.36 no.2
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• pp.293-300
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• 2014

As the system-on-chip (SoC) design becomes more complex, the test costs are increasing. One of the main obstacles of a test cost reduction is the limited number of test channels of the ATE while the number of pins in the design increases. To overcome this problem, a new test architecture using a channel sharing compliant with IEEE Standard 1149.1 and 1500 is proposed. It can significantly reduce the pin count for testing a SoC design. The test input data is transmitted using a test access mechanism composed of only input pins. A single test data output pin is used to measure the sink values. The experimental results show that the proposed architecture not only increases the number of sites to be tested simultaneously, but also reduces the test time. In addition, the yield loss owing to the proven contact problems can be reduced. Using the new architecture, it is possible to achieve a large test time and cost reduction for complex SoC designs with negligible design and test overheads.

• BMB Reports
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• v.45 no.8
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• pp.458-463
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• 2012

We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known functions, SIRT4 ribosylated GDH and reduced its activity, and SIRT3 deacetylated GDH, increasing its activity. However, KHG26377 did not affect SIRT4-mediated ADP-ribosylation/inhibition or SIRT3-mediated deacetylation/activation of GDH. KHG26377 had no effect on SIRT4 protein levels, and did not alter total GDH, acetylated GDH, or SIRT3 protein levels in pancreatic mitochondrial lysates. These results suggest that the mechanism by which KHG26377 inhibits GDH activity and insulin secretion does not involve ADP-ribosylation of GDH by SIRT4 or deacetylation of GDH by SIRT3.

• BMB Reports
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• v.50 no.8
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• pp.411-416
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• 2017

The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.

• Advanced Composite Materials
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• v.18 no.1
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• pp.77-93
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• 2009

This paper investigated the damage transition mechanism between the fiber-breaking mode and the fiber-avoiding crack mode when the fiber-length is reduced in the unidirectional discontinuous carbon fiber-reinforced-plastics (CFRP) composites. The critical fiber-length for the transition is a key parameter for the manufacturing of flexible and high-strength CFRP composites with thermoset resin, because below this limit, we cannot take full advantage of the superior strength properties of fibers. For this discussion, we presented a numerical model for the microscopic damage and fracture of unidirectional discontinuous fiber-reinforced plastics. The model addressed the microscopic damage generated in these composites; the matrix crack with continuum damage mechanics model and the fiber breakage with the Weibull model for fiber strengths. With this numerical model, the damage transition behavior was discussed when the fiber length was varied. The comparison revealed that the length of discontinuous fibers in composites influences the formation and growth of the cluster of fiber-end damage, which causes the damage mode transition. Since the composite strength is significantly reduced below the critical fiber-length for the transition to fiber-avoiding crack mode, we should understand the damage mode transition appropriately with the analysis on the cluster growth of fiber-end damage.

• Journal of the Korean Society of Safety
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• v.30 no.3
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• pp.7-12
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• 2015

CFRP composites are used as primary structural members in various industrial fields because their specific strength and specific stiffness are excellent in comparison to conventional metals. Their usage is expanding to high added-value industrial fields because they are more than 50% lighter than metals, and have excellent heat resistance and wear resistance. However, when CFRP composites suffer impact damage, destruction of fiber and interface delamination occur. This causes an unexpected deterioration of strength, and for this reason it is very difficult to ensure the reliability of the excellent mechanical properties. Therefore, for the destruction mechanism in bending with impact damage, this study investigated the reinforcement data regarding various external loads by identifying the consequential strength deterioration. Specimens were damaged by impact with a steel ball propelled by air pressure. Decrease in bending strength caused by the tension and compression of the impact side, and depending on the lamination direction of fiber and interface inside the specimen. From the bending test it was found that the bending strength reduced when the impact energy increased. Especially in the case of compression on the impact side, as tensile stress occurred at the damage starting point, causing rapid failure and a substantially reduced failure strength.

• BMB Reports
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• v.34 no.1
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• pp.28-32
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• 2001

The Fos-Jun heterodimers are part of the regulatory network of gene expression and nuclear proteins encoded by proto-oncogenes. The activation of Fos-Jun is important in the transmission of the tumor-promoting signal from the extracellular environment to the nuclear transcription mechanism. To search for the inhibitors of the Fos-Jun DNA complex formation, several natural products were screened and water-soluble paeoniflorin reduced the binding activity of the Fos-Jun heterodimer. This active compound was purified by silica gel column chromatography and HPLC. The electrophoresis mobility shift assay and reverse-phase HPLC test showed that paeoniflorin reduced the AP-l function. The cytotoxic effect of paeoniflorin was observed in HL-60. These results indicate that paeoniflorin blocks the Fos-Jun heterodimer-binding site of the AP-l DNA and it also has cytotoxic effects on human leukemia cell lines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.6
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• pp.809-817
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• 2013

The aim of this study was to evaluate the mechanism of vasodilation of Lespedezea cuneata(LC) in rabbit common carotid artery and cavernosal smooth muscle. LC relaxed arterial strips precontracted with norepinephrine and cavernosal strips precontracted with phenylephrine. The arterial relaxation effects of LC was endothelium-dependent. $N{\omega}$-nitro-L-arginine(L-NNA), NOS inhibitor, methylene blue(MB), cGMP inhibitor, indomethacin(IM), cyclo-oxygenase inhibitor and tetraethylammonium chloride(TEA), KCa-channel blocker attenuate the relaxation responses of LC in arterial strips. In $Ca^{2+}$-free krebs-ringer solution, pretreatment of LC extract significantly reduced the contraction induced by addition $Ca^{2+}$. L-NNA reduced LC extract-induced relaxation in cavernosal strips, but IM, TEA and MB didn't affect LC extract-induced relaxation. When LC extract was applicated on human umbilical vein endothelial cell, the nitric oxide concentration was increased. We conclude that in rabbit common carotid artery, LC may suppress influx of extra-cellular $Ca^{2+}$ through the release of endothelium derived relaxing factor including nitric oxide, prostacyclin, endothelium derived hyperpolarizing factor. And LC exerts a relaxing effect on corpus cavernosum through activating the NO.

• KIEAE Journal
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• v.13 no.6
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• pp.83-91
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• 2013

Cool roofs are currently being emerged as one of important mechanism to save energy in relation to the building. It is specifically proposed that the changing trends of rooftop surface temperature in the flat roof building model could be used effectively as an indicator to reduced cooling load reduced by cool roof since it can present stable temperature record, that is not influenced according to the nearby physical as well as human variables. The temperature of cool roof in summer was lower around $20^{\circ}C$, compared to the general roofs. Such a seasonal or daily comparative study for rooftop temperature in the building model will highlight that the cool roof efficiency could be calculated in much area-wide context according to rooftop color distribution in urban residential area. It is anticipated that this research output could be used as a valuable reference in identifying energy saving by cool roof since an objective monitoring has been proposed based on the rooftop temperature in the building model, fully quantitative performance of thermal infrared image.

• International Journal of Control, Automation, and Systems
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• v.4 no.4
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• pp.438-447
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• 2006

Fuzzy controller's design depends mainly on the rule base and membership functions over the controller's input and output ranges. This paper presents two different approaches to deal with these design issues. A simple and efficient approach; namely, Fuzzy Subtractive Clustering is used to identify the rule base needed to realize Fuzzy PI and PD type controllers. This technique provides a mechanism to obtain the reduced rule set covering the whole input/output space as well as membership functions for each input variable. But it is found that some membership functions projected from different clusters have high degree of similarity. The number of membership functions of each input variable is then reduced using a similarity measure. In this paper, the fuzzy subtractive clustering approach is shown to reduce 49 rules to 8 rules and number of membership functions to 4 and 6 for input variables (error and change in error) maintaining almost the same level of performance. Simulation on a wide range of linear and nonlinear processes is carried out and results are compared with fuzzy PI and PD type controllers without clustering in terms of several performance measures such as peak overshoot, settling time, rise time, integral absolute error (IAE) and integral-of-time multiplied absolute error (ITAE) and in each case the proposed schemes shows an identical performance.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2003.10a
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• pp.78-82
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• 2003

The cooling mechanism for a regenerative cooling liquid rocket engine of 10tf-thrust using kerosene as a fuel was studied from the viewpoint of curtain cooling. Based on the concept of a highly-stratified gas flow in the combustion chamber, the cross section of the combustion chamber was spilt into 2 independent parts, core and exterior part. Additional fuel is injected into the exterior section and gas temperature can be reduced in the exterior section. Consequently, the heat flux into the coolant and wall temperature are reduced and the thermal stability of a liquid rocket engine could be improved.