• Toxicological Research
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• 제26권1호
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• pp.9-14
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• 2010

The evaluation of eye and skin irritation potential is essential to ensuring the safety of human in contact with a wide variety of substances. Despite this importance of irritation test, little is known with respect to the irritation potency of lomefloxacin, a fluoroquinolone antibiotic, which has been known to cause phototoxicity with an abnormal reaction of the skin. Thus, to investigate the tendency of lomefloxacin to cause eye and skin irritation, we carried out in vitro eye irritation test using Balb/c 3T3, and in vitro skin irritation test using $KeraSkin^{TM}$ human skin model system. 3T3 neutral red uptake assay has been proposed as a potential replacement alternative for the Draize Eye irritation test. In this study, the $IC_{50}$ value obtained for lomefloxacin was 375 ${\mu}g$. According to the classification model used for determining in vitro categories, lomefloxacin was classified as moderately irritant. For evaluation of skin irritation, engineered epidermal equivalents ($KeraSkin^{TM}$) were subjected to 10 and 25 mg of lomefloxacin for 15 minutes. Tissue damage was assessed by tissue viability evaluation, and by the release of a pro-inflammatory mediator, interleukin- 1${\alpha}$. Lomefloxacin increased the interleukin-1${\alpha}$ release after 15 minutes of exposure and 42 hours of post incubation, although no decrease in viability was observed. Therefore, lomefloxacin is considered to be moderately irritant to skin and eye.

• 한국환경생태학회지
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• 제28권5호
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• pp.542-549
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• 2014

이 연구는 2006년 5월부터 2009년 6월까지 제주도와 작은 부속섬인 가파도 두 지역에 서식하는 쇠살모사 개체군간 몸의 크기와 성적크기이형 및 이에 따른 환경요인을 밝히고, 종 다양성 유지에 필요한 자료를 제공하기 위하여 이루어졌다. 연구결과, 제주도 개체군의 몸길이는 암컷 242-532mm ($422.0{\pm}46.7mm$, n = 100), 수컷 296-580mm ($434.5{\pm}51.7mm$, n = 63)이었고, 가파도 개체군의 몸길이는 암컷 205-395mm ($335{\pm}43.6mm$, n = 55), 수컷 215-430mm ($328{\pm}39.4mm$, n = 73)으로 암수 모두 제주도 개체군이 가파도 개체군에 비해 큰 것으로 나타났다(암컷 t = 17.343, df = 115, P<0.001; 수컷 t = 19.128, df = 101, P<0.001). 성적크기이형 지수(SSD)는 제주도 개체군이 -0.03으로 수컷이 다소 크고, 가파도 개체군은 0.02로 암컷이 다소 컸다. 이처럼 제주도 개체군과 가파도 개체군이 몸의 크기에 있어 차이가 나타나는 것은 서로 다른 환경에 적응된 결과라 판단된다. 또한 두 지역 개체군 및 새끼의 성적크기이형은 제주도 개체군의 몸길이는 수컷이 암컷보다 다소 컸으나(t = -2.011, df = 117, P<0.05), 가파도 개체군과 새끼에서는 유의한 차이가 없었다. 제주도 개체군에서 머리 길이(F = 6.318, $df_{1,2}$ = 1,117, P<0.05), 머리 폭(F = 8.090, $df_{1,2}$ = 1,117, P<0.01), 눈 사이 거리(F = 15.898, $df_{1,2}$ = 1,117, P<0.001) 및 꼬리 길이(F = 238.488, $df_{1,2}$ = 1,111, P<0.001)에서 수컷이 암컷보다 컸으며, 체중은 암컷이 수컷보다 무거운 것으로 나타났다(F = 64.111, $df_{1,2}$ = 1,114, P<0.001). 가파도 개체군에서는 머리 길이, 머리 폭, 눈 사이 거리에서는 암컷과 수컷 간에 유의한 차이는 없었고, 꼬리 길이에서 수컷이 암컷보다 길었으며(F = 168.555, $df_{1,2}$ = 1,74, P<0.001), 체중은 암컷이 수컷보다 무거운 것으로 나타났다(F = 17.812, $df_{1,2}$ = 1,76, P<0.001). 새끼에서는 머리길이, 머리 폭, 눈 사이 거리에서 유의한 차이가 없었으나, 꼬리 길이(F = 67.793, $df_{1,2}$ = 1,72, P<0.001)와 체중(F = 4.558, $df_{1,2}$ = 1,72, P<0.05)에서 수컷이 암컷보다 크게 나타났다. 새끼에서 성적크기이형 현상이 나타나지 않았던 몸길이, 머리길이, 머리 폭 및 눈 사이 거리가 제주도 개체군에서는 모두 수컷이 암컷보다 큰 것으로 나타나 제주도 개체군에서의 성적크기이형 현상은 성장과정에서 생기는 것이라 판단된다.

• Journal of Veterinary Science
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• 제22권5호
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• pp.65.1-65.12
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• 2021

Background: To assess the normal retina of the pigeon eye using spectral domain optical coherence tomography (SD-OCT) and establish a normative reference. Methods: Twelve eyes of six ophthalmologically normal pigeons (Columba livia) were included. SD-OCT images were taken with dilated pupils under sedation. Four meridians, including the fovea, optic disc, red field, and yellow field, were obtained in each eye. The layers, including full thickness (FT), ganglion cell complex (GCC), thickness from the retinal pigmented epithelium to the outer nuclear layer (RPE-ONL), and from the retinal pigmented epithelium to the inner nuclear layer (RPE-INL), were manually measured. Results: The average FT values were significantly different among the four meridians (p < 0.05), with the optic disc meridian being the thickest (294.0 ± 13.9 ㎛). The average GCC was thickest in the optic disc (105.3 ± 27.1 ㎛) and thinnest in the fovea meridian (42.8 ± 15.3 ㎛). The average RPE-INL of the fovea meridian (165.5 ± 18.3 ㎛) was significantly thicker than that of the other meridians (p < 0.05). The average RPE-ONL of the fovea, optic disc, yellow field, and red field were 91.2 ± 5.2 ㎛, 87.7 ± 5.3 ㎛, 87.6 ± 6.5 ㎛, and 91.4 ± 3.9 ㎛, respectively. RPE-INL and RPE-ONL thickness of the red field meridian did not change significantly with measurement location (p > 0.05). Conclusions: Measured data could be used as normative references for diagnosing pigeon retinopathies and further research on avian fundus structure.

• 복식문화연구
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• 제17권4호
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• pp.561-574
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• 2009

Black has been the most important color of all since the ancient times when the recognition of black roused, as well as during most of the eras; and can especially be said as the main color which controlled the chronicles of fashion. The purpose of the study was to broaden the application of black color image make-up by inquiring into make-up design elemental characteristics of lines and textures, after classifying magazine illustrations and advertisement make-up images using black. The photos which made effective use of black among fashion illustrations, magazine advertisements after 2001 were classified in to each type, and make-up expression method and characteristics according to design element of each image type was analyzed. The conclusion of such study was the following. 'Erotic image' showed contrast effect between eye make-up and lip color by using pale tone or red color. 'Mannish image' emphasized form and texture of eyebrow by restraining the colors of eyelids with natural brown tone eye make-up; 'Modern image' expressed vague eyebrow to bring the sensation of the direction of eye shadow on eyelids and eye line as well as slant line to relief. 'Kitsch image' showed free and light imagery by creating unique hair style with various colors; expressing lips mostly with colors similar to skin tone or by restraining colors on lips. 'Decadence image' showed messy and foul sensation with unstandardized eye make-up and matt skin of shimmer, glossy and pale tone, also with black colored lips; 'Retro image' expressed reinterpretation of images from 1920${\sim}$1960 to contemporary styles.

• 대한가정학회지
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• 제43권11호
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• pp.59-71
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• 2005

The purpose of this study was to observe the makeup behavior and cosmetics preference based on the segmented age group and fashion appearance interested group. The target consumers were women aged in their 20's. We distributed 443 questionnaires and conducted statistical analysis using SPSS program for the 400 reliable questionnaires. Statistical analyses included frequency, Chi-square test, t-test, ANOVA and cluster analysis(K-means). The results of this study were as follows: 1. There was a significant association between specific cosmetic items currently used and segmented age group. The age 24-29 had more basic makeup than color makeup, compared to the age 20-23 group. There was a statistical difference between the highly interested group and the lowly interested group in fashion and beauty. The group of highly interested in fashion and beauty considered trendy colors, while the group of lowly interested in fashion and beauty used their favorite color as an important factor in purchasing makeup products. 2. There was a significant difference in the preference of lip colors and textures, eye shadows textures, types of eye liner and types of foundation according to segmented age groups. 3. Those who sought 'sexy' images preferred red/wine/purple lipstick colors, and green/blue/violet eye shadow colors. They significantly preferred jell/liquid type eye liner and liquid type foundation. Those who sought 'pure' images preferred orange colors and glossy textures of lipsticks. Those who sought 'elegant' and 'intellectual' images preferred pearl type eye shadow.

• Journal of Ginseng Research
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• 제40권3호
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• pp.260-268
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• 2016

Background: During the aging process, skin shows visible changes, characterized by a loss of elasticity and the appearance of wrinkles due to reduced collagen production and decreased elasticity of elastin fibers. Panax ginseng Meyer has been used as a traditional medicine for various diseases due to its wide range of biological activities including skin protective effects. Ginsenosides are the main components responsible for the biological activities of ginseng. However, the protective activities of an enzymatic preparation of red ginseng against human skin aging have not been investigated. Methods: The efficacy of an enzyme-treated powder complex of red ginseng (BG11001) in preventing human skin aging was evaluated by oral administration to 78 randomized individuals. All patients were requested to take three daily capsules containing either 750 mg of BG11001 or a placebo vehicle for 24 wk; at the end of the testing period, skin roughness, elasticity, and skin water content were measured. Results: BG11001 significantly reduced the average roughness of eye wrinkles and the Global Photo Damage Score compared with the placebo, although there were no significant differences in arithmetic roughness average between the groups. In addition, gross elasticity and net elasticity values increased, and transepidermal water loss level decreased, indicating improved skin elasticity and moisture content. Conclusion: In conclusion, enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content. Moreover, enzyme-treated red ginseng extract would be useful substance as a bio-health skin care product.

• 대한화학회지
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• 제6권1호
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• pp.32-35
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• 1962

Six frogs (Rana nigromaculata 25∼40 gm) were adapted to light for 2 hours. Then 0.02 ml of 3% nicotinamide and 0.02 ml of 0.6% folic acid were injected into the vitreous body of the right eye-ball, and 0.02 ml normal saline solution into the vitreous body of the left eye-ball respectively. After dark adaptation for an hour-their heads were cut off under a dim red light (650 $m{\mu}$). The retinae were removed from the left eye-ball for the control group and from the right for the test group respectively. Then rhodopsin was extracted from the retinae with 3 ml of 2% digitonin solution(pH = 7.0) for 17 hours at 0$^{\circ}C$ in the dark. The optical densities before and after the illumination of the extract were measured and compared with those of the control group. The results are as follows: 1) The group which had been injected with 0.02 ml of 3% nicotinamide solution had the promotive action on tile regeneration of rhodopsin in comparison with the control group. 2) The group which had been injected with 0.02 ml of 0.6% folic acid solution had the controlling action on the regeneration of rhodopsin in comparison with the control group.

• 복식
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• 제57권6호
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• pp.62-70
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• 2007

The purpose of this study was to examine a unique characteristic of the colors of the costumes in Korean basic culture in the aim of seeking Five-elements color found in Korean civilian's costume culture. The scope of Korean basic culture was 32 items specified as an import intangible cultural asset in the side of religion and art for the majority of the Korean people. Within these limits, the colors of the dress, accessories, instruments were extracted by comparing with the naked eye in NCS Color System. The result of this investigation was that Red was yellowish red and high chromatic and deep tone within 4area. Blue was purplish blue and high chromatic and deep tone within 4area, similarly Red. Yellow was pure yellow and high chromatic and bright tone within 3area. Red and Blue in Korean basic culture were more primary color and more high brightness than Korean traditional colors. Religion and art fer Korean civilian revealing the Korean basic culture reflected impending real-life of Korean civilian who intend to overcome their desperate reality at using Five-elements color in their costume.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 추계종합학술대회 논문집(4)
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• pp.25-28
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• 2000

Gaze detection is to find out the position on a monitor screen where a user is looking at, using the computer vision processing. This System can help the handicapped to use a computer, substitute a touch screen which is expensive, and navigate the virtual reality. There are basically two main types of the study of gaze detection. The first is to find out the location by face movement, and the second is by eye movement. In the gaze detection by eye movement, we find out the position with special devices, or the methode of image processing. In this paper, we detect not the iris but the pupil from the image captured by Head-Mounted Camera with infra-red light, and accurately locate the position where a user looking at by A(fine Transform.

• Journal of Preventive Medicine and Public Health
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• 제31권4호
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• pp.666-679
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• 1998

This study aims at providing the fundamental data on the field of cosmetics by comparing heavy metal concentration in terms of domestic/foreign products, items, companies and colors. This study has determined the concentration of chromium, lead, mangagnese, nickel, copper and vanadium in cosmetics such as moisturizer, concealer, foundation (Ivory-yellow), compact powder (Ivory-yellow), lip colo. (Red, brown), eye shadow (Red, brwon and dark green) and eye liner (Black) manufactured by five domestic cosmetic companies and five foreign cosmetic companies on the market. The samples have been collected in cosmetic stores in Pusan from Dec. lst 1996 to Jan. 3lst 1997. The results are as follows : 1. The heavy metal concentration in cosmetics was $2.420{\mu}g/g$ for chromium, $0.82{\mu}g/g$ for lead, $4.49{\mu}g/g$ for manganese, $1.69{\mu}g/g$for nickel, $0.53{\mu}g/g$ for copper, and $51{\mu}g/g$ for vanadium, respectively. 2. Lead and vanadium concentration were significantly higher in domestic cosmetics than foreign cosmetics(p<0.05). 3. The mean(GM) concentrations of heavy metal were different significantly (p<0.01) when classified with cosmetic items. The highest means shown at eye shadow in $Cr(14.96{\mu}g/g),\;Cu(1.32{\mu}g/g),\;V(1.28{\mu}g/g),\;and\;Ni(8.30{\mu}g/g)$, compact powder in $Pb(2.50{\mu}g/g)$, eye liner in $Mn(90.62{\mu}g/g)$. 4. The mean(GM) concentrations of heavy metal were different significantly (p<0.01) among colored cosmetics. The highest mean concentration of Cr, Ni, Cu and V were dark green-colored cosmetics, that of Mn was black-colored cosmetics, and that of Pb was ivory yellow- colored cosmetics.