Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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A single-center, randomized, double-blind, placebo-controlled study on the efficacy and safety of "enzyme-treated red ginseng powder complex (BG11001)" for antiwrinkle and proelasticity in individuals with healthy skin

  • Park, Sang-Yong (Graduate School of Biotechnology, Kyung Hee University) ;
  • Shin, Yu-Kyong (Graduate School of Biotechnology, Kyung Hee University) ;
  • Kim, Hee-Taek (College of Oriental Medicine, Semyung University) ;
  • Kim, Yong Min (College of Oriental Medicine, Semyung University) ;
  • Lee, Don-Gil (Graduate School of Biotechnology, Kyung Hee University) ;
  • Hwang, Eunson (Graduate School of Biotechnology, Kyung Hee University) ;
  • Cho, Byung-Goo (Korea Ginseng Research Institute, Korea Ginseng Corporation) ;
  • Yin, Chang Shik (Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Ki-Young (Graduate School of Biotechnology, Kyung Hee University) ;
  • Yi, Tae Hoo (Graduate School of Biotechnology, Kyung Hee University)
  • Received : 2015.02.11
  • Accepted : 2015.08.23
  • Published : 2016.07.15
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Abstract

Background: During the aging process, skin shows visible changes, characterized by a loss of elasticity and the appearance of wrinkles due to reduced collagen production and decreased elasticity of elastin fibers. Panax ginseng Meyer has been used as a traditional medicine for various diseases due to its wide range of biological activities including skin protective effects. Ginsenosides are the main components responsible for the biological activities of ginseng. However, the protective activities of an enzymatic preparation of red ginseng against human skin aging have not been investigated. Methods: The efficacy of an enzyme-treated powder complex of red ginseng (BG11001) in preventing human skin aging was evaluated by oral administration to 78 randomized individuals. All patients were requested to take three daily capsules containing either 750 mg of BG11001 or a placebo vehicle for 24 wk; at the end of the testing period, skin roughness, elasticity, and skin water content were measured. Results: BG11001 significantly reduced the average roughness of eye wrinkles and the Global Photo Damage Score compared with the placebo, although there were no significant differences in arithmetic roughness average between the groups. In addition, gross elasticity and net elasticity values increased, and transepidermal water loss level decreased, indicating improved skin elasticity and moisture content. Conclusion: In conclusion, enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content. Moreover, enzyme-treated red ginseng extract would be useful substance as a bio-health skin care product.

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References

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