• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.13-24
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• 2024

Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing in the tumor microenvironment (TME). Therefore, cytokines have been considered potential anti-cancer immunotherapy, and cytokine-based anti-cancer therapies continue to be an active area of research and development in the field of cancer immunotherapy, with ongoing clinical trials exploring new strategies to improve efficacy and safety. In this review, we examine past and present clinical developments for major anticancer cytokines, including interleukins (IL-2, IL-15, IL-12, IL-21), interferons, TGF-beta, and GM-CSF. We identify the current status and changes in the technology platform being applied to cytokine-based immune anti-cancer therapeutics. Through this, we discuss the opportunities and challenges of cytokine-based immune anti-cancer treatments in the current immunotherapy market and suggest development directions to enhance the clinical use of cytokines as immuno-anticancer drugs in the future.

• Fisheries and Aquatic Sciences
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• v.12 no.2
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• pp.138-151
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• 2009

We quantitatively investigated compositions of fish and invertebrate bycatch in Korean shrimp fisheries. We sampled shrimp trawl bycatch from 48 commercial trawls over 1 year. These samples contained 108 taxa from 50 families, with 60 fish taxa contributing 51.2% of the total biomass and 48 invertebrate taxa 48.8%. However, 86.32% of the total individual organism density comprised invertebrates, while individual fishes made up the remainder. Within the bycatch, two fish species varied in population size structure by season, suggesting recruitment is seasonal in these taxa. Overall general catch characteristics (total bycatch biomass and organism density) varied significantly by season and tide, and a significant interaction effect was observed (season$\times$tide) on total density, but not on total biomass. The data collected will be used in designing a program of long-term bycatch monitoring.

• Journal of the Korea Society of Computer and Information
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• v.21 no.4
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• pp.89-96
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• 2016

In this paper, we study the relationship between vacancy duration and information items of a job posting by using generalized linear models and a decision tree analysis w.r.t. the three factors such as company characteristics, employment conditions, and constraints. The results indicate that the employment conditions rather than company characteristics are more influential to the vacancy duration. These effects are presumed to be based on the complex relations between the decisions of the employers and the job seekers. And in this paper we suggest the need to provide personalized and profiled labor market information tailored for a quick decision to job seekers and employers. Policy implication is that since employer's decision affects the vacation duration, employers may had better to provide a comprehensive labour market information including supply and demand of the required skills in order to reduce the time for judgment on the cost-effectiveness.

• Animal cells and systems
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• v.16 no.1
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• pp.1-10
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• 2012

Most living organisms synchronize their physiological and behavioral activities with the daily changes in the environment using intrinsic time-keeping systems called circadian clocks. In mammals, the key molecular features of the internal clock are transcription- and translational-based negative feedback loops, in which clock-specific transcription factors activate the periodic expression of their own repressors, thereby generating the circadian rhythms. CLOCK and BMAL1, the basic helix-loop-helix (bHLH)/PAS transcription factors, constitute the positive limb of the molecular clock oscillator. Recent investigations have shown that various levels of posttranslational regulation work in concert with CLOCK/BMAL1 in mediating circadian and cellular stimuli to control and reset the circadian rhythmicity. Here we review how the CLOCK and BMAL1 activities are regulated by intracellular distribution, posttranslational modification, and the recruitment of various epigenetic regulators in response to circadian and cellular signaling pathways.

• International Journal of Quality Innovation
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• v.7 no.2
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• pp.125-140
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• 2006

One of the most important service industries that emerged in the last decade is "Higher Education". The most of the higher education institutes involve in marketing efforts to build up a good image, to improve the level of satisfaction of students and the stakeholders, to gain competitive advantage with respect to competitors and as well as to increase their market share. Within this intense competition universities should identify and meet the expectations of students to attract more and to retain the existing students. This study is to gain more insights into the dimensions of satisfaction of the university students and factors that affecting their judgments. SSI educational experience questionnaire is used to identify the importance and performance perceptions of students' in Eastern Mediterranean University among different dimensions and also study find out the difference between importance and performance scores of eleven educational experience dimensions. Results show that "Academic Advising", "Instruction Effectiveness", "Recruitment and Financial Aid" and "Student Centeredness" was very important to students. Study also provides managerial implications as well.

• BMB Reports
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• v.52 no.2
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• pp.113-118
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• 2019

The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.

• Fisheries and Aquatic Sciences
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• v.24 no.1
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• pp.41-52
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• 2021

Data for fish species composition and the catch of fish species were obtained from the daily trading records for the period between April and December 2016 to 2018 at the set net fishing grounds in Yeosu Bay, Korea. The annual mean total catch was 195.8 tons, and the dominant species was the Spanish mackerel (Scomberomorus niphonius), which accounts for about 55 percent of the total catch. The catch increased in spring and autumn. Increase in spring is caused by not Spanish mackerel but other fish while the increase in autumn by Spanish mackerel. The distinct increase of the catch in summer, 2017 was due to the new recruitment of small-sized Spanish mackerel, which was probably to be from the fish population hatched in spring in the East China Sea. Our results showed a strong correlation between water temperature and catch fluctuation. The catch increases with the increase in water temperatures, and the periodic pattern of the water temperature and catch fluctuation is more consistent in the offshore waters, in which warm current flows, than in the coast waters.

• BMB Reports
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• v.55 no.4
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• pp.166-174
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• 2022

Hepatic macrophages are key immune cells associated with the broad ranges of liver diseases including steatosis, inflammation and fibrosis. Hepatic macrophages interact with other immune cells and orchestrate hepatic immune circumstances. Recently, the heterogenous populations of hepatic macrophages have been discovered termed residential Kupffer cells and monocyte-derived macrophages, and identified their distinct population dynamics during the progression of various liver diseases. Liver injury lead to Kupffer cells activation with induction of inflammatory cytokines and chemokines, which triggers recruitment of inflammatory monocyte-derived macrophages. To understand liver pathology, the functions of different subtypes of liver macrophages should be regarded with different perspectives. In this review, we summarize recent advances in the roles of hepatic macrophages under liver damages and suggest hepatic macrophages as promising therapeutic targets for treating liver diseases.

• Environmental Analysis Health and Toxicology
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• v.17 no.4
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• pp.357-362
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• 2002

Tests for the toxicity of tributyltin (TBT) were conducted on mysid collected from Dadepo beach, Pusan, Korea. The toxic effects of tributyltin on the survival, growth and oxygen consumption of the mysid, Neomysis awatschensis have been evaluated. Mysids were exposed to several concentrations of TBT (0, 0.56, 1.15, 3.07 and 6.12 $\mu\textrm{g}$/L) for 6 weeks. Survival rate was decreased with increases in concentration and exposure time and the reduction of more than 40％ occurred at TBT concentration greater than 1.15 $\mu\textrm{g}$/L after 6 weeks. Growth rate was significantly decreased at concentrations greater than 1.15 $\mu\textrm{g}$/L. Oxygen consumption rate was also decreased in a concentration-dependent way and significantly decreased to 39,47 and 69％ of the control at 1.15, 3.07 and 6.12 $\mu\textrm{g}$/L, respectively. These results indicate that the contamination of aquatic environment by TBT has the potential to significantly reduce coastal and estuaries recruitment of mysids.

• Korean Management Science Review
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• v.10 no.2
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• pp.145-161
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• 1993

Human Resource Management (HRM) performs numerous activities in organizations including employee recruitment, selection, placement, job analysis, training and development, and labor relations. POSCO (Pohang Steel Company) has concerned with employee management related to job placement and analysis among these activities because of the problems of over-complexity of placement precedures for the variety of recruits, the frequency of selection, a large amount of job descriptions / specifications, and their changes. This study, as a phase of developing the entire HRM systems in the organization, briefly summarizes the preliminary information related and describes an implementation of expert system as a means for effective job placement based on the principle of right-person-in-right-place with identifying aptitudes and personalities of employees. Thus, a new approach for developing a job description/specification using a formal specification language like Z is also proposed. The result of this study will cultivate the performance of personnel, prevent conflicts between labor and management, promote overall productivity of organization, as well as helpfully verify job analysis.