• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.828-837
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• 2024

Vancomycin (VAN) and metronidazole (MTR) remain the current drugs of choice for the treatment of non-severe Clostridioides difficile infection (CDI); however, while their co-administration has appeared in clinical treatment, the efficacy varies greatly and the mechanism is unknown. In this study, a CDI mouse model was constructed to evaluate the therapeutic effects of VAN and MTR alone or in combination. For a perspective on the intestinal ecology, 16S rRNA amplicon sequencing and non-targeted metabolomics techniques were used to investigate changes in the fecal microbiota and metabolome of mice under the co-administration treatment. As a result, the survival rate of mice under co-administration was not dramatically different compared to that of single antibiotics, and the former caused intestinal tissue hyperplasia and edema. Co-administration also significantly enhanced the activity of amino acid metabolic pathways represented by phenylalanine, arginine, proline, and histidine, decreased the level of deoxycholic acid (DCA), and downregulated the abundance of beneficial microbes, such as Bifidobacterium and Akkermansia. VAN plays a dominant role in microbiota regulation in co-administration. In addition, co-administration reduced or increased the relative abundance of antibiotic-sensitive bacteria, including beneficial and harmful microbes, without a difference. Taken together, there are some risks associated with the co-administration of VAN and MTR, and this combination mode should be used with caution in CDI treatment.

• Journal of Communications and Networks
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• 제14권4호
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• pp.374-384
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• 2012

Utilizing artificial noise (AN) is a good means to guarantee security against eavesdropping in a multi-inputmulti-output system, where the AN is designed to lie in the null space of the legitimate receiver's channel direction information (CDI). However, imperfect CDI will lead to noise leakage at the legitimate receiver and cause significant loss in the achievable secrecy rate. In this paper, we consider a delayed feedback system, and investigate the impact of delayed CDI on security by using a transmit beamforming and AN scheme. By exploiting the Gauss-Markov fading spectrum to model the feedback delay, we derive a closed-form expression of the upper bound on the secrecy rate loss, where $N_t$ = 2. For a moderate number of antennas where $N_t$ > 2, two special cases, based on the first-order statistics of the noise leakage and large number theory, are explored to approximate the respective upper bounds. In addition, to maintain a constant signal-to-interferenceplus-noise ratio degradation, we analyze the corresponding delay constraint. Furthermore, based on the obtained closed-form expression of the lower bound on the achievable secrecy rate, we investigate an optimal power allocation strategy between the information signal and the AN. The analytical and numerical results obtained based on first-order statistics can be regarded as a good approximation of the capacity that can be achieved at the legitimate receiver with a certain number of antennas, $N_t$. In addition, for a given delay, we show that optimal power allocation is not sensitive to the number of antennas in a high signal-to-noise ratio regime. The simulation results further indicate that the achievable secrecy rate with optimal power allocation can be improved significantly as compared to that with fixed power allocation. In addition, as the delay increases, the ratio of power allocated to the AN should be decreased to reduce the secrecy rate degradation.

• Journal of the Optical Society of Korea
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• 제18권4호
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• pp.317-329
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• 2014

In vision measurement systems based on structured light, the key point of detection precision is to determine accurately the central position of the projected laser line in the image. The purpose of this research is to extract laser line centers based on a decision function generated to distinguish the real centers from candidate points with a high recognition rate. First, preprocessing of an image adopting a difference image method is conducted to realize image segmentation of the laser line. Second, the feature points in an integral pixel level are selected as the initiating light line centers by the eigenvalues of the Hessian matrix. Third, according to the light intensity distribution of a laser line obeying a Gaussian distribution in transverse section and a constant distribution in longitudinal section, a normalized model of Hessian matrix eigenvalues for the candidate centers of the laser line is presented to balance reasonably the two eigenvalues that indicate the variation tendencies of the second-order partial derivatives of the Gaussian function and constant function, respectively. The proposed model integrates a Gaussian recognition function and a sinusoidal recognition function. The Gaussian recognition function estimates the characteristic that one eigenvalue approaches zero, and enhances the sensitivity of the decision function to that characteristic, which corresponds to the longitudinal direction of the laser line. The sinusoidal recognition function evaluates the feature that the other eigenvalue is negative with a large absolute value, making the decision function more sensitive to that feature, which is related to the transverse direction of the laser line. In the proposed model the decision function is weighted for higher values to the real centers synthetically, considering the properties in the longitudinal and transverse directions of the laser line. Moreover, this method provides a decision value from 0 to 1 for arbitrary candidate centers, which yields a normalized measure for different laser lines in different images. The normalized results of pixels close to 1 are determined to be the real centers by progressive scanning of the image columns. Finally, the zero point of a second-order Taylor expansion in the eigenvector's direction is employed to refine further the extraction results of the central points at the subpixel level. The experimental results show that the method based on this normalization model accurately extracts the coordinates of laser line centers and obtains a higher recognition rate in two group experiments.

• 자원ㆍ환경경제연구
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• 제25권1호
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• pp.27-60
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• 2016

기후경제통합평가모형(Integrated assessment model of climate and the economy)은 기후변화에 관한 경제 분석과 정책제안을 위한 필수적인 도구가 되어왔다. 최근에는 기후변화에 대응하기 위한 정책적 노력들이 대부분 국가 또는 지역 수준에서 일어난다는 인식 하에 국가 또는 지역에서의 기후변화 영향과 정책수단의 효과를 평가할 수 있는 기후경제통합-지역평가모형(Regional integrated assessment model of climate and the economy)의 중요성이 더욱 커지고 있다. 이 논문에서는 국내에서 기후경제통합-지역평가모형을 개발하기 위한 첫 번째 단계로서 사회후생함수를 중심으로 기후경제통합-지역평가모형을 이론적으로 유형화했으며, RICE(Regional integrated climate-economy model) 모형을 통해 기후변화 대응전략에 따른 국가별 기후변화정책의 변화를 수치적으로 살펴보았다. 변화하는 국제 상황, 새롭게 드러나는 과학적 증거, 국내 여건 등을 모두 반영한 기후변화정책을 수립하기 위해서는 이를 분석할 수 있는 효과적인 도구를 갖추고 있어야 한다. 이 논문에서 살펴본 기후경제통합-지역평가모형은 이를 위한 유용한 도구가 될 수 있다.

• 한국전산구조공학회논문집
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• 제27권3호
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• pp.147-154
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• 2014

충격 및 폭발하중으로 인한 위험으로부터 구조물의 안정성을 확보하기 위한 필요성의 증대에 따라 고율변형을 받는 콘크리트의 거동은 중요한 연구주제가 되었다. 콘크리트의 고율변형 거동은 정적인 상태와는 다른 독특한 거동을 보이기 때문에 다양한 고율변형모델들이 제안되어 고율변형 상태를 수치해석하는데 사용되고 있다. 이러한 수치해석 과정에서 발생하는 문제가 요소의 크기에 따라 수치해석결과가 크게 변하는 요소의존성 문제이다. 본 논문에서는 파괴에너지이론에 기초하여 요소의존성을 최소화할 수 있는 기준식을 제안하고 HJC(Holmquist Johnson Cook)모델을 이용한 관통수치해석을 통해 기준식을 검증하였다. 그 결과 기준식을 통해 산정된 파괴변형률을 수치해석상에 적용해줌으로써 해석결과의 요소의존성이 감소하였고 해의 정확성 또한 향상되는 것을 파악할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4747-4753
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• 2016

Background: The prevalence of Helicobacter pylori (H. pylori) infection in Indonesia has been reported to be exceedingly low. The purpose of our study was to confirm whether this is the case in Northern Jakarta using a sensitive 13C-urea breath test (UBT), and to examine any associations with lifestyle/environment factors and potential routes of transmission. Methods: We recruited a total of 196 subjects from a low-income community in Northern Jakarta, Indonesia, data from 193 who completed a questionnaire about their lifestyle/environment and had UBT being included as the final. Odds ratios (ORs) adjusted for sex and age with 95% confidence intervals (CIs) were calculated using a logistic regression model. Results: The overall H. pylori infection rate was 15.0% (95%CI, 10.3-20.9), with variation among Javanese (9.1%, total=77), Buginese (40.0%, 35), Betawi (9.1%, 33), Sundanese (3.7%, 27), and Batak (40.0%, 5). On multivariate analysis, the ORs for intake of soybean milk, cucumber more than once a week, infrequent hand washing practice before meals, and alcohol consumption were 0.10 (95%CI: 0.01-0.97), 6.61 (95%CI: 1.87-23.3), 4.10 (95%CI: 1.15-14.6), and 61.9 (95%CI: 1.67-2300.8), respectively. Rates for Buginese (OR=7.84; 95%CI: 1.82-33.8) and Batak (OR=20.1; 95%CI: 1.90-213.2) were significantly higher than for Javanese. Conclusions: The H. pylori infection rate in this study was relatively low, in line with previous studies. Regarding ethnicity factors, Buginese and Batak reported eating food using fingers more frequently than Javanese, Betawi, and Sundanese. Our study indicated that person-person transmission is possible in this low prevalence area. The low infection rates for H. pylori among Javanese, Betawi, and Sundanese ethnics could be partly due to their sanitary practices.

• 에너지공학
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• 제19권3호
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• pp.156-162
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• 2010

국내 미분탄 보일러의 로내 공기량 공급에 따른 연소특성 분석을 위한 3차원 전산해석 연구를 수행하였다. 보일러 연소해석 해석 결과의 건전성 검증을 위하여 보일러 출구, 즉 절탄기 후단에서의 가스 온도,$O_2$, NO, SOx 농도를 발전소의 실제 운전데이터와 비교하였다. 검증된 해석 결과를 기준조건으로 SOFA(Separated Over Fire Air)와 CCOFA(Closed Coupled Over Fire Air)에서의 연소 공기량을 변화시킨 경우 보일러내 NOx와 가스 온도 분포를 중심으로 각각의 경우를 비교하였다. 본 연구를 통하여 CCOFA보다는 SOFA 공기량의 변화에 따라 NOx 농도의 민감도가 더 큰 것을 알 수 있었으며 대류 전열부의 전열관군에서의 온도 분포가 다르게 나타나고 있어 가스온도 편차 방지를 위한 연소조정이 필요함을 알 수 있었다.

• 한국통신학회논문지
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• 제34권7C호
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• pp.654-662
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• 2009

모바일 비디오 스트리밍을 위해 비디오 스트림들을 사용가능한 대역폭에 맞추면서 인코딩을 하기 위해서 시간 적 해상도, 공간적 해상도, 화면 화질의 세 가지 요소를 가지고 조절할 수 있는데, 그 중에서도 양자화 파라미터 (quantization parameter)를 가지고 화변 화질을 조절하는 것이 가장 널리 사용되고 있는 방법이다. 그러나 본 논 문에서는 낮은 대역폭 환경에서는 적응적으로 공간적 해상도를 변경하는 것이 화면 화질이나 에너지 소모량 면에서 더 효율적이라는 것을 보이고, 사용 가능한 대역폭에 대해서 최척의 공간적 해상도를 찾기 위한 모델을 제시 한다. 적응적 공간 해상도 제어 기법은 비디오 서버와 모바일 기기 간의 대역폭이 심하게 변화거나, 모바일 기기가 에너지 소모에 민감한 상황에서 특히 효과적이다. 본 기법은 낮은 비트율 상황에서 기존의 방법에 비해 화질을 약 0.5dB 만큼 개선하고, 에너지 소모를 50% 이상 줄일 수 있다.

• 대한의용생체공학회:의공학회지
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• 제32권1호
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• pp.7-14
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• 2011

This study suggested an optimized algorithm for detecting the loss of balance(LOB) in the seated position. And the sensitivity analysis was performed in order to identify the role of each design variable in the algorithm. The LOB algorithm consisted of data processing of measured signals, an internal model of the central nervous system and a control error anomaly(CEA) detector. This study optimized design variables of a CEA detector to obtain improved values of the success rate(SR) of detecting the LOB and the margin time(MT) provided for preventing the falling. Nine healthy adult volunteers were involved in the experiments. All the subjects were asked to balance their body in a predescribed seated posture with the rear legs of a four-legged wooden chair. The ground reaction force from the right leg was measured from the force plate while the accelerations of the chair and the head were measured from a couple of piezoelectric accelerometers. The measured data were processed to predict the LOB using a detection algorithm. Variables S2, h2 and hd are related to the detector: S2 represents a data selecting window, h2 a time shift and hd an operating period of the LOB detection algorithm. S2 was varied from 0.1 to 10 sec with an increment of 0.1 sec, and both h2 and hd were varied from 0.01 to 1.0 sec with an increment of 0.01 sec. It was found that the SR and MT were increased by up to 9.7% and 0.497 sec comparing with the previously published case when the values of S2, h2 and hd were set to 4.5, 0.3 and 0.2 sec, respectively. Also the results of sensitivity analysis showed that S2 and h2 had considerable influence on the SR while these variables were not so sensitive to the MT.

• 한국해양학회지
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• 제26권2호
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• pp.108-116
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• 1991

동해안 오호리에 서식하는 Sargassum confusum을 대상으로 광합성율과 생물량의 시간에 따른 변화를 조사하여 해조류의 년생산성을 예측하는 모델을 구성하였다. 즉 년생산량 P/SUB yr/를 P/SUB yr/ = .int.P/SUB t/·B/SUB t/dt (이때 P/SUB t/와 B/SUB t/는 주어진 시간에서의 광합성율과 생물량을 나타낸다)의 식을 설정하여 구하 였다. P/SUB t/는 수온과 광량의 함수로 보아 서로 다른 수온과 광도의 조건에서 광합 성을 측정하여 P/SUB t/에 대입하였다. 수온과 Sargassum confusum이 서식하는 수심 3 m를 기준으로 하였다. 모델에 의한 모의 결과는 수온이 일차생산량을 결정하는 가장 중요한 요인임을 보여주었다. 구름을 가정하여 30%의 광량을 무작위로 감소시켰을 때 해조류의 년생산량은 5%감소하였다.