• Title/Summary/Keyword: Rapid R&D

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Exploration of underground utilities using method predicting an anomaly (이상대 판정기법을 활용한 지하매설물 탐사)

  • Ryu, Hee-Hwan;Kim, Kyoung-Yul;Lee, Kang-Ryel;Lee, Dae-Soo;Cho, Gye-Chun
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.17 no.3
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    • pp.205-214
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    • 2015
  • Rapid urbanization and industrialization have caused increased demand for underground structures such as cable, and other utility tunnels. Recently, it has become very difficult to construct new underground structures in downtown areas because of civil complaints, and engineering problems related to insufficient information about existing underground structures, cable tunnels in particular. This lack of information about the location and direction-of-travel of cable tunnels is causing many problems. To solve these problems, this study was focused on the use of geophysical exploration of the ground in a way that is theoretically, different from previous electrical resistivity surveys. An electric field analysis was performed on the ground with cable tunnels using Gauss' law and the Laplace equation. The electrical resistivity equation, which is a function of the cable tunnel direction, the cable tunnel location, and the electrical conductivity of the cable tunnel, can be obtained through electrical field analysis. A field test was performed for the verification of this theoretical approach. A field test results provided meaningful data.

Real-Time PCR for Validation of Minute Virus of Mice Safety during the Manufacture of Mammalian Cell Culture-Derived Biopharmaceuticals (세포배양 유래 생물의약품 생산 공정에서 Minute Virus of Mice 안전성 검증을 위한 Real-Time PCR)

  • Lee, Dong-Hyuck;Cho, Hang-Mee;Kim, Hyun-Mi;Lee, Jung-Suk;Kim, In-Seop
    • Microbiology and Biotechnology Letters
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    • v.36 no.1
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    • pp.12-20
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    • 2008
  • Validation of viral safety is essential in ensuring the safety of mammalian cell culture-derived biopharmaceuticals, because numerous adventitious viruses have been contaminated during the manufacture of the products. Mammalian cells are highly susceptible to minute virus of mice(MVM), and there are several reports of MVM contamination during the manufacture of biopharmaceuticals. In order to establish the validation system for the MVM safety, a real-time PCR method was developed for quantitative detection of MVM in cell lines, raw materials, manufacturing processes, and final products as well as MVM clearance validation. Specific primers for amplification of MVM DNA was selected, and MVM DNA was quantified by use of SYBR Green I. The sensitivity of the assay was calculated to be $6{\times}10^{-2}TCID_{50}/mL$. The real-time PCR method was proven to be reproducible and very specific to MVM. The established real-time PCR assay was successfully applied to the validation of Chinese hamster ovary (CHO) cell artificially infected with MVM. MVM DNA could be Quantified in CHO cell as well as culture supernatant. When the real-time PCR assay was applied to the validation of virus removal during a virus filtration process, the result was similar to that of virus infectivity assay. Therefore, it was concluded that this rapid, specific, sensitive, and robust assay could replace infectivity assay for detection and clearance validation of MVM.

A Study on the compensation regime and response cost for oil pollution in Korea and advanced country (선진국과 우리나라의 유류오염 방제비용 및 피해보상제도에 관한 연구)

  • Kim, Du-Ho;Im, Taek-Soo;Na, Eun-Young;Kim, Han-Gyu
    • Proceedings of KOSOMES biannual meeting
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    • 2006.11a
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    • pp.175-179
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    • 2006
  • With the rapid development of oil and chemical industry in the late 20C, massive transportation of oil by oil tanker vessel has grown and it caused the big oil pollution accidents. When oil spill from the oil tanker, damages reach into the astronomical figures in economically and damages affect wide area and many people with break the balance of ecosystem. Recently in Korea, the oil pollution accidents has occurred frequently as growing of oil consumption and it caused large-scale damages to the victim. Oil pollution in Korean offshore takes not only korean fishermen from their life ground and break the ecosystem but it takes too much time and money to recover. To minimize oil pollution damages, it is necessary to make pre-caution effort as a ship owner and relevant government bodies should endeavor to prevent from more damages. But once oil pollution accidents occurs in territorial sea, compensation for victim fishermen is very important. But it is true that compensation is not paid to victim smoothly. So this study aims at the problems of oil pollution compensation to the Korean victim and find the best way to get reasonable compensation.

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A research framework for development of a LCCA based tunnel asset management system (LCCA기반 터널 자산관리 시스템 개발을 위한 연구개발 프레임웍 설계)

  • Lee, Seung Soo;Kim, Kwang Yeom;Kim, Dong-Gyou;Shin, Hyu-Soung;Seo, Jong Won
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.16 no.6
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    • pp.615-625
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    • 2014
  • As many parts of Korea are mountainous, many tunnels have been constructed to be in step with rapid economic development since 1970's. However, the interest on maintenance of tunnels is far less than the awareness of need for tunnels. As the tunnel maintenance system is the responsive maintenance system which responds to the problems found during the inspection, it will be very difficult to respond to each problem with the limited budget and manpower of the government agencies when the number of aged tunnels rapidly increase in the future. As such, this study presents the need for the LCCA (Life Cycle Cost Analysis) based tunnel asset management system to transform the tunnel maintenance to a preventive management system in a strategic and long-term viewpoint and proposes the framework for development direction. It observed the asset management implementation cases of social infrastructure in other countries and analyzed the need for asset management technique to manage the tunnels in Korea. Moreover, it applied the LCCA model, which is the economic and engineering quantitative decision making technique, for tunnel asset management to present the concrete direction for development of an asset management model and designed the R&D framework to systemize it.

A Delphi Study of Standardization Strategies for Disruptive Technologies (파괴적 기술 분야에 대한 표준화 전략 연구: 전문가 델파이 조사를 중심으로)

  • Eom, Doyoung;Kim, Dong-hyu;Lee, Heejin
    • Journal of Korea Technology Innovation Society
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    • v.19 no.3
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    • pp.483-510
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    • 2016
  • Disruptive technology is increasingly gaining attention by industries, standards development organizations (SDOs), academia, government and regulatory bodies due to its massive scope of impact on the incumbents and consumers. Companies that take a lead in new technologies intend to dominate the global market by making their technologies into an international standard. However, they tend to seek ways of by-passing the slow procedures of formal SDOs that often hinder prompt action in response to rapid changes in technology and market situations. In the area of disruptive technologies, there is a need to harmonize standardization efforts in formal SDOs for various companies and stakeholders to reap the benefits of technological development and diffusion of innovation. This paper examines the reasons why standardization is more active using market-based mechanisms than through formal SDOs for disruptive technologies. We conducted a Delphi study to investigate standardization strategies in the area of disruptive technologies. This research found that experts understood the core element of disruptive technologies as creating new markets and changing the competition basis in existing industries through the transformation of consumers' behavior. Based on these core characteristics, experts agreed that flexibility and speed are the most important factors for standardization. Results also show that the perception that standardization activities are not directly connected to companies' profit-making is the key barrier to links between research and companies' participation in standardization. This research provides implications for formal SDOs and policymakers.

A Study on the Threats of Wiretapping and Effective Security Management Strategies (도청보안의 취약성 및 개선방안에 관한 연구)

  • Lee, Young Ho;Choi, Kyung Cheol;Woo, Sang Yeob
    • Korean Security Journal
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    • no.62
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    • pp.347-367
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    • 2020
  • Rapid advancement of technology in today's society has allowed for easy access and use of data, promoting the process of informationization. Along with the merits of such development, unintended consequences of security risks involving wiretapping have been increasing as well. The security threats posed by wiretapping technology must be addressed by every organization and individual, as it could be used to leak confidential information about the nation's security, military and diplomatic strategies, industrial technologies, and personal information. Despite increasing threats stemming from the surrounding nations using advanced wiretapping technology, there is a lack of awareness at the government level, and the existing security measures for detecting and counteracting the wiretapping equipment are ineffective. In this research, the authors offered technical suggestions for improving the security strategies against the threats of wiretapping and information leakage by conducting a content analysis. The authors suggested the units of an agency be assigned a security grade based on its importance, and that adequate security equipment should be operated according to the grade. For instance, around-the-clock surveillance is recommended for grade-1 facilities, and portable wiretapping equipment detectors should be used to protect conference rooms and other key sites.

Quality of Tteokbokki tteok prepared by adding various concentration of brown rice (흑미 첨가량을 달리한 떡볶이 떡의 품질에 관한 연구)

  • Shin, Dong-Sun;Yoo, Seon-Mi;Han, Gwi-Jung;Oh, Se-Gwan
    • Food Science and Preservation
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    • v.23 no.2
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    • pp.194-203
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    • 2016
  • The purpose of this study was to investigate the properties of tteok prepared from white (Samkwang) and brown rice (Heugseol, Heugjinju). The moisture and crude protein contents of rice were 14.89~17.15% and 4.79~6.81%, respectively. The crude lipid and crude ash contents of rice were 0.48~2.66% and 0.39~1.60%, respectively. The water binding capacity of Heugjinju (141.97%) was higher than those of other rice flours. As the soaking time increased, water absorption ability was in the order of Samkwang > Heugseol > Heugjinju. Using a rapid visco analyser (RVA), the initial pasting temperature of Heugseol was the highest, and the peak viscosities of Heugseol were higher than those of other rice flours. The quality characteristics of Tteokbokki tteok were assessed after its preparation by adding different amounts of Heugseol and Heugjinju (0, 5, 10, and 20%, w/w) content. The textural properties (hardness), of Heugseol and Heugseol measured using a texture analyzer, were greater than those of the control. Sensory preference tests revealed that 10% Heugseol and, 10% Heugjinju had the highest scores in appearance, color, and overall acceptability. The sensory test results revealed that Tteokbokki tteok prepared by addition of 10% added brown rice was the best.

Effect of magnesium and calcium phosphate coatings on osteoblastic responses to the titanium surface

  • Park, Ki-Deog;Lee, Bo-Ah;Piao, Xing-Hui;Lee, Kyung-Ku;Park, Sang-Won;Oh, Hee-Kyun;Kim, Young-Joon;Park, Hong-Ju
    • The Journal of Advanced Prosthodontics
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    • v.5 no.4
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    • pp.402-408
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    • 2013
  • PURPOSE. The aim of this study was to evaluate the surface properties and in vitro bioactivity to osteoblasts of magnesium and magnesium-hydroxyapatite coated titanium. MATERIALS AND METHODS. Themagnesium (Mg) and magnesium-hydroxyapatite (Mg-HA) coatings on titanium (Ti) substrates were prepared by radio frequency (RF) and direct current (DC) magnetron sputtering.The samples were divided into non-coated smooth Ti (Ti-S group), Mg coatinggroup (Ti-Mg group), and Mg-HA coating group (Ti-MgHA group).The surface properties were evaluated using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The surface roughness was evaluated by atomic force microscopy (AFM). Cell adhesion, cell proliferation and alkaline phosphatase (ALP) activity were evaluated using MC3T3-E1 cells. Reverse transcription polymerase chain reaction (RT-PCR) analysis was performed. RESULTS. Cross-sectional SEM images showed that Mg and Mg-HA depositionson titanium substrates were performed successfully. The surface roughness appeared to be similaramong the three groups. Ti-MgHA and Ti-Mg group had improved cellular responses with regard to the proliferation, alkaline phosphatase (ALP) activity, and bone-associated markers, such as bone sialoprotein (BSP) and osteocalcin (OCN) mRNA compared to those of Ti-S group. However, the differences between Ti-Mg group and Ti-MgHA group were not significant, in spite of the tendency of higher proliferation, ALP activity and BSP expression in Ti-MgHA group. CONCLUSION. Mg and Mg-HAcoatings could stimulate the differentiation into osteoblastic MC3T3-E1 cells, potentially contributing to rapid osseointegration.

Experimental Investigation into the Combustion Characteristics on the Co-firing of Biomass with Coal as a Function of Particle Size and Blending Ratio (바이오매스(우드펠릿) 혼소율 및 입자크기에 따른 연소 특성에 관한 연구)

  • Sh, Lkhagvadorj;Kim, Sang-In;Lim, Ho;Lee, Byoung-Hwa;Kim, Seung-Mo;Jeon, Chung-Hwan
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.40 no.1
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    • pp.31-37
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    • 2016
  • Co-firing of biomass with coal is a promising combustion technology in a coal-fired power plant. However, it still requires verifications to apply co-firing in an actual boiler. In this study, data from the Thermogravimetric analyzer(TGA) and Drop tube furnace(DTF) were used to obtain the combustion characteristics of biomass when co-firing with coal. The combustion characteristics were verified using experimental results including reactivity from the TGA and Unburned carbon(UBC) data from the DTF. The experiment also analyzed with the variation of the biomass blending ratio and biomass particle size. It was determined that increasing the biomass blending ratio resulted in incomplete chemical reactions due to insufficient oxygen levels because of the rapid initial combustion characteristics of the biomass. Thus, the optimum blending condition of the biomass based on the results of this study was found to be 5 while oxygen enrichment reduced the increase of UBC that occurred during combustion of blended biomass and coal.

Policy Measures for Improving Health Care Services in Rural Areas (농촌보건의료서비스 향상을 위한 제도 개선방안)

  • Moon, O.R.;Lee, L.S.;Park, J.Y.;Ko, D.H.;Lee, K.H.
    • Journal of agricultural medicine and community health
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    • v.16 no.2
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    • pp.97-119
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    • 1991
  • Korea has made a rapid economic development since the last three decades. This has helped Korea narrow the gap in health service differences in resource availability and in quality of care. However urban and rural differentials are still remarkable. This study has maintained that health status of rural residents is inferior to that of urban dwellers. Therefore, this study was carried out to develop policy measures for improving health services in rural areas. In order to achieve the objective of this study the authors collaborated closely and made field visits, interviews and conducted an extensive literature review regarding rural health services. The following policy options are recommended as a summary ; First, the quality of rural health personnel is a single most important factor influencing the level of rural health services. An innovative program for public health doctors to the internship and/or residency training program such as specialty board program of family medicine. Second, dissatisfaction regarding employment of public health doctors is problematic. More rational employment and deployment programs are needed to meet their personal desire. One way to do this is to make it wide open and competitive. Third this study shows how to increase physician productivity in the rural public health sector. Incentive system needs to be elaborated for the career development of rural health workers. University linked job opportunity as clinical professor is an example. Fourth, without straightening the function of health centers and subcenters, the future of rural health services is doomed to failure. Straightening primary health care is one way to enrich the program of public health facilities and reactivating the operation of health center/hospital is another. A close linkage of public facilities with private hospitals is a minimum requirement for the operation of health delivery system within a health district. Fifth, some measures are urgently required to enhance hospital services in medically underserved areas. Financial subsidy, tax exemption, long-term public loans and higher priority of health manpower deployment are some of them. Sixth, new health programs should be in tiated to meet changing needs of peoples in rural areas. Home health care program, hospice program, nursing home, residential program for the elderly are recommended.

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