• Publications of The Korean Astronomical Society
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• v.25 no.4
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• pp.141-154
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• 2010

In the beginning of the Joseon dynasty, the Royal Astronomical Bureau (觀象監, shortly RAB) was established. After the double RAB had settled down by King Sejong (世宗), it continued to function until 1907. Before the Japanese invasion of Korea in 1592, the Joseon court had the Inner RAB in the Gyeongbok Palace (景福宮) and the Outer RAB in the Northen District Gwangwha-Bang (北部廣化坊) at the western side of the Changdeuk Palace (昌德宮). In the reign of King Sukjong (肅宗) the double system of the RAB was transformed into the Geumho-Gate (金虎門) Outer RAB and the Gaeyang-Gate (開陽門) Outer RAB. During the reconstruction of the Gyeongbok Palace in the early reign of King Gojong (高宗), the Gaeyang-Gate Outer RAB was replaced by the Yeongchu-Gate (迎秋門) Outer RAB in 1865. All RAB had the Royal Astronomical Observatory (觀天臺, RAO hereinafter), so called the Soganui-platform (小簡儀臺) on which the Soganui (小簡儀) has been put. The Soganui (小簡儀) is a small simplified armillary sphere. While the Gwangwha-Bang RAO handed down from the reign of King Sejong still exists, other RAOs, such as Gyeongbok Palace RAO, Gaeyang-Gate and Yeongchu-Gate RAOs, do not remain. According to our study, the Changgyeong Palace (昌慶宮) RAO was not indeed the RAO with the Soganui.

• Proceedings of the Korean Biophysical Society Conference
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• 1996.07a
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• pp.38-38
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• 1996

Rab3A is a synaptic vesicle-associated, GTP-binding protein that has been implicated in the regulation of neurotransmission. We show here that Ca2+/calmodulin can form a 1:1 complex with Rab3A and cause it to dissociate from synaptosomal membranes. Formation of the complex requires both the lipidated C-terminus of Rab3A and the presence of guanine nucleotide. (omitted)

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1821-1824
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• 2004

In order to investigate the effects of Radix Achyranthis Bidentatae (RAB) on the growth and differentiation of human osteoblast-like cells, we supplemented the culture medium of MG-63 cells with various concentrations of RAB water extracts. RAB extracts significantly stimulated cell growth, as confirmed by the colorimetric MTT (3-dimethylthiazol-2,5-diphenyltetrazolium bromide) assay. RAB extracts also increased the alkaline phosphatase (ALP) activity, which is a osteoblast differentiation marker. These results suggest that RAB can stimulate osteoblastic activity and may represent new pharmacological tools for the treatment of osteoporosis.

• Biomedical Science Letters
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• v.5 no.1
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• pp.17-26
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• 1999

To evaluate the spreading possibilities of the marRAB mutation of E. coli Mar mutant among gram-negative bacilli, chromosomal marRAB mutations of Mar mutants were transduced by $\lambda$placMu9 into pUC19 (Lac$^{+}$, Ap$^{r}$) cloning site in another strains of E. coli or onto the chrmosome of S. typhimurium and P. aeruginosa, selected for transduction by Mar phenotype, Lac$^{-}$, or Ap$^{r}$, and tested for their antimicrobial resistance with or without addition of salicylate (SAL). Compared with wild type strains of JM109, NM522, harboring pUC19 or not, respectively, all strains of JM109 or NM522 carrying pUC19::marRAB mutation showed higher levels of antimicrobial resistance and SAL induction of Mar phenotype than those of wild type. However, in contrast to the original Mar mutants, there were some tendencies of decreased antimicrobial resistance of JM109 or NM522 harboring pUC19::marRAB mutation with SAL induction against chlorarnphenicol (Cm) and tetracycline (Tc), or Tc and ciprofloxacin (Cp), respectively. Almost the same results, as shown as the cases of E. coli JM109 or NM522, were obtained from all transductants of S. typhimurium and P. aeruginosa, except Cp, against which increased antimicrobial resistance with SAL induction was shown. This study, employed the methods of transformation or transduction among intercellular gene transfer methods between gram-negative bacteria, shows the evidences that suggest indirectly the spreading possibilities of marRAB mutation among gram-negative bacilli.

• The monthly packaging world
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• s.337
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• pp.78-83
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• 2021

• BMB Reports
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• v.45 no.6
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• pp.360-364
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• 2012

Uptake of circulating glucose into the cells happens via the insulin-mediated signalling pathway, which translocates the glucose transporter 4 (GLUT4) vesicles from the intracellular compartment to the plasma membrane. Rab GTPases are involved in this vesicle trafficking, where Rab GTPases-activating proteins (RabGAP) enhance the GTP to GDP hydrolysis. TBC1D4 (AS160) and TBC1D1 are functional RabGAPs in the adipocytes and the skeletonal myocytes, respectively. These proteins contain two phosphotyrosine-binding domains (PTBs) at the amino-terminus of the catalytic RabGAP domain. The second PTB has been shown to interact with the cytoplasmic region of the insulin-regulated aminopeptidase (IRAP) of the GLUT4 vesicle. In this study, we quantitatively measured the ${\sim}{\mu}M$ affinity ($K_D$) between TBC1D4 PTB and IRAP using isothermal titration calorimetry, and further showed that IRAP residues 1-49 are the major region mediating this interaction. We also demonstrated that the IRAP residues 1-15 are necessary but not sufficient for the PTB interaction.

• Bulletin of the Korean Chemical Society
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• v.32 no.6
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• pp.2125-2128
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• 2011

• Herbal Formula Science
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• v.28 no.1
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• pp.81-90
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• 2020

Objectives : This study was conducted to investigate the effects of major constituents of Epimedium koreanum Nakai (Icariin, epimedium A, epimedium B, and epimedium C) on melanin synthesis. Methods : We measured melanin contents, tyrosinase activity, and expression of Rab27a in B16F10 cells cultured with Epimedium koreanum Nakai ethanol extract (EKN) and their major constituents. After treatment with H89 and dibutyryl cAMP, which inhibit or promote the activation of PKA, we observed changes in melanin synthesis and tyrosinase activity stimulated by EKN. Results : Among them, EKN and icariin enhanced tyrosinase activity and melanin contents. We confirmed that EKN augmented melanin synthesis via cAMP/PKA pathway. Icariin-induced tyrosinase activity and melanin content were attenuated by PKA inhibitor H89, while melanogenic effect of icariin was further augmented by cAMP analog, dbc AMP. However, icariin did not affect the expression of small GTPase Rab27a involved in melanosome transport. Conclusions : These results suggest that icariin promotes melanogenesis through cAMP/PKA pathway but does not affect small GTPase Rab27a.

• The Korean Journal of Physiology
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• v.28 no.1
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• pp.61-70
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• 1994

A new method is used to record the actual shortening produced during the auxotonic activity of the sartorius (SAR), gastrocnemius (CAS) and rectus abdominis (RAB) muscles of a lizard Uromastix. The auxotonic twitch and tetanus records thus obtained were used for the first time to calculate the coefficient of linear shortening (COLS). This coefficient represent the relative Index between change in length $(\Delta\;L=L_0-L_1)$ and tension $({\Delta}P\;P_0-P_1)$ due to shortening at the steepest rising phase of the twitch and tetanus, recorded at resting length. In addition to this, maximum shortening $(S_{max})$ and auxotonic tensions were also determined at resting lengths of these muscles. The COLS was found to express the speed of shortening and auxotonic tensions are suggested to be of value to express the internal architecture of SAR, GAS & RAB muscles. The results are discussed in terms of contractile and elastic elements of the muscles alongwith the importance of shortening at resting lengths in skeletal muscles.

• Journal of the Korea Convergence Society
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• v.12 no.11
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• pp.19-26
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• 2021

A purpose of this study is to suggest distribution tariff regulation that encourages private investment on the energy efficiency industry of Ukraine. As the electricity market reform and the regulation introduction to encourage energy efficiency are ongoing in Ukraine, it is best time for Korean companies to enter to the market. Therefore, studies on the regulation and the market of Ukraine are required in advance. A simulation of private investment feasibility on AMI business is conducted on one of 32 DSOs in Ukraine. Through the simulation, the directions of RAB tariff regulation, which is the core of the distribution service tariff regulation, were derived. It is essential for DSOs to permit AMI lease assets, introduced by private investors, as regulated assets while other regulations are maintained as it is for investment. This study provides a practical basis by presenting objective data through simulation. It is expected to be helpful for overseas expansion of companies if the study is expanded to the various energy efficiency industries.