• Korean Journal of Oriental Medicine
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• v.16 no.1
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• pp.173-178
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• 2010

The purpose of this study was investigation of quantitative analysis of marker substances in solid fermented Angelicae Gigantis Radix by High performance liquid chromatography(HPLC). HPLC was performed for determination of nodakenin and decursin in solid fermented Angelicae Gigantis Radix extract, the separation method was performed on C18 column ($250\;mm\;{\times}\;4.6\;mm$, $5\;{\mu}m$, RS tech) using gradient solvent mixtures of water-acetonitrile with photodiode array detector (330 nm). The flow rate was 1.0 ml/min. Retention time of nodakenin and decursin was about 11.47, 46.79 min and linearity of calibration was showed good result(r2=0.9999, 0.9999), respectively. Content of nodakenin was $0.76\;{\pm}\;0.02%$ in control, $0.31\;{\pm}\;0.00%$ in Angelicae Gigantis Radix extract fermented with Paecilomyces japonica(SDT)(p<0.01), $0.51\;{\pm}\;0.02%$ in Angelicae Gigantis Radix extract fermented with Ganoderma lucidum(SYT)(p<0.01), $0.82\;{\pm}\;0.03%$ in Angelicae Gigantis Radix extract fermented with honey(SST)(p<0.05) and $0.88\;{\pm}\;0.01%$ in Angelicae Gigantis Radix extract fermented with Nuruk(SNT)(p<0.01). Content of decursin was $4.50\;{\pm}\;0.08%$ in control, $2.90\;{\pm}\;0.05%$ in Angelicae Gigantis Radix extract fermented with Paecilomyces japonica(SDT)(p<0.01), $2.65\;{\pm}\;0.08%$ in Angelicae Gigantis Radix extract fermented with Ganoderma lucidum(SYT)(p<0.01), $4.46\;{\pm}\;0.11%$ in Angelicae Gigantis Radix extract fermented with honey(SST) and $4.73\;{\pm}\;0.04%$ in Angelicae Gigantis Radix extract fermented with Nuruk(SNT)(p<0.05), respectively.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2003.02a
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• pp.140-142
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• 2003

We have designed a SFQ (Single Flux Quantum) D2 Cell and Inverter(NOT) for a superconducting ALU (Arithmetic Logic Unit). To optimize the circuit, we have used Julia, XIC and Lmeter for simulations and layouts. We obtained the circuit margin of larger than $\pm$25%. After layout, we drew chip for fabrication of SFQ D2 Cell and Inverter. We connected D2 Cell and Inverter to jtl, DC/SFQ, SFQ/DC and RS flip-flop for measurement.

• Journal of Chest Surgery
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• v.26 no.2
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• pp.122-128
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• 1993

This series compromised 31 patients with pulmonary hypertension of 282 patients of ventricular septal defect(VSD) who underwent operation at the department of Thoracic and Cardiovascular Surgery in Chonnam University Hospital, from January, 1986 to December, 1991. Pulmonary hypertension was noted in 59 of 280 cases of VSD. Of them, 31 cases underwent cardiac catheterization on postoperative 8th to 77th month. Age at operation was ranged from 10 months to 29 years (mean 9.13 years). 17 patients were male and 14 patients were female. Results of follow-up studies were as follows: Cardiothoracic ratio was decreased from 0.59${\pm}$0.04 to 0.54${\pm}$0.03 (p=NS). Postoperative systolic pulmonary arterial pressure (PAPs), mean pulmonary arterial pressure (PAPm), and systolic right ventricular pressure (RVPs) were decreased significantly (p<0.001). And also Rp/Rs was decreased from 0.37${\pm}$0.21 to 0.14${\pm}$0.06 (p<0.02). However, systemic arterial pressure (SAP), right atrial pressure (RAP), and pulmonary capillary wedge pressure (PCWP) were changed insignificantly. There were significant relations of follow-up period with the decrement of PAP(p<0.005). In contrary, ther were no relations between the decrement of PAP and the age at operation. These data suggested that the long-term hemodynamic changes remained to be determined in some of the patients, even though they Were asymptomatic, with pulmonary hypertension.

• Proceedings of the KIEE Conference
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• 2007.11c
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• pp.131-133
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• 2007

본 연구에서는 현재 주로 사용하고 있는 광파장인 980nm, 1310nm, 1480nm, 1550nm 에 대한 안정화된 광파워를 갖는 광원개발이다. 내부에 온도안정화와, 자체 광파워 피드백에 의한 안정화 회로를 내장하고 있으며, 독립적 혹은 동시적으로 4 개의 광파장을 출력할 수 있도록 구성하였다. 또한 $0{\sim}-7dBm$ 사이의 광파워를 0.5dB 단위로 가변시킬 수 있으며, ${\mp}0.05dB$ 이내의 안정성을 갖는다. 또한 RS-232 시리얼 통신으로 PC와 인터페이스가 가능하며, 광출력 상태를 모니터링하거나 원격으로 광파워를 제어할 수 있도록 구성하였다. 온도범위는 ${\pm}0.5$도 이내에서 제어가 가능하며, 이러한 부분으로 구성된 4파장 광원은 ${\pm}0.05dB$ 이내에서 안정화된 광을 출력할 수 있게 되었다. 현재 확산되고 있는 광통신 시장에서 광통신 부품, 광케이블, 통신망 등에서 각종 소자 및 선로의 광학적 특성을 측정하는데 필수적으로 이용될 것으로 기대된다.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.202-205
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• 2008

This paper presents an optimization of permanent magnet (PM) in a brushless dc (BLDC) motor using the response surface methodology (RSM). Size and angle of the PM are optimized to minimize the cogging torque, while reducing the magnitude of harmonic at a dominant frequency and maintaining the operating torque. A fitted RS model is constructed by verifying the high reliability of the total variation and the variation of estimated error. The optimized design is validated by carrying out the reanalysis and comparing to the initial model using the nonlinear transient finite element analysis.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.59 no.3
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• pp.319-324
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• 2014

Soybean (Glycine max (L.) Merr.) is an important crop for protein, oil, carbohydrates, isoflavones, and many other nutrients to humans and animals. But, antinutritional factors in the raw mature soybean are exist. Raffinose and stachyose are main antinutritional factors in soybean seed. Both raffinose and stachyose are carbohydrates, belonging to the raffinose family of oligosaccharides (RFOs). RFOs are not readily digested in humans and cause flatulence or diarrhea. The objective of this research is to obtain the information on raffinose and stachyose content according to genotype and environment. A total of twenty two soybean genotypes (11 cultivars, 3 germplasms and 8 breeding lines) were selected. Each genotype was grown in the field for two years with two replications and harvested in bulk at natural maturity for two years. Content of raffinose and stachyose was detected by HPLC. The raffinose content (g/kg) of 22 genotypes was $2.68{\pm}0.21-5.87{\pm}2.43$ in year 1 and was $3.24{\pm}0.37-9.05{\pm}0.16$ in year 2. The stachyose content (g/kg) was $4.23{\pm}0.98-27.68{\pm}9.90$ at year 1 and was $5.11{\pm}1.09-25.32{\pm}0.35$ in year 2. Genotype and environment have highly significant effects on raffinose and stachyose content. Three genotypes (Da-7, 116-13, and RS-78) have low stachyose content at 5% significant level in two years. A positive correlation ($R^2=0.1985^*$) between raffinose and stachyose was observed in year 2. These informations are valuable in soybean genetics and breeding program related with raffinose and stachyose content.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.11
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• pp.63-70
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• 2008

In this paper, a smart sensor system for the MEMS pressure sensor was developed. A compensation algorithm and programmable calibration circuits were presented to eliminate errors caused by temperature drift of piezoresistive pressure sensors in itself. This system consisted of signal conditioning, calibration, temperature detection, microprocessor, and communication parts and these were integrated into a SOC. A RS-232 interface was employed for monitoring and control of a smart sensor system. The area of fabricated IC is $4.38{\times}3.78\;mm^2$ and a $0.35{\mu}m$ high voltage CMOS process was used. Compensation error for temperature drift of 50 KPa pressure sensors was measured into ${\pm}0.48%$ in the range of $-40^{\circ}C{\sim}150^{\circ}C$. Total power consumption was 30.5 mW.

• Journal of Korean Neurosurgical Society
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• v.54 no.4
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• pp.296-301
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• 2013

Objective : We conducted a retrospective study examining the outcomes of intracerebral hemorrhage (ICH) in patients with chronic kidney disease (CKD) to identify parameters associated with prognosis. Methods : From January 2001 to June 2008, we treated 32 ICH patients (21 men, 11 women; mean age, 62 years) with CKD. We surveyed patients age, sex, underlying disease, neurological status using Glasgow Coma Scale (GCS), ICH volume, hematoma location, accompanying intraventricular hemorrhage, anti-platelet agents, initial and 3rd day systolic blood pressure (SBP), clinical outcome using the modified Rankin Scale (mRS) and complications. The severity of renal functions was categorized using a modified glomerular filtration rate (mGFR). Multifactorial effects were identified by regression analysis. Results : The mean GCS score on admission was $9.4{\pm}4.4$ and the mean mRS was $4.3{\pm}1.8$. The overall clinical outcomes showed a significant relationship on initial neurological status, hematoma volume, and mGFR. Also, the outcomes of patients with a severe renal dysfunction were significantly different from those with mild/moderate renal dysfunction (p<0.05). Particularly, initial hematoma volume and sBP on the 3rd day after ICH onset were related with mortality (p<0.05). However, the other factors showed no correlation with clinical outcome. Conclusion : Neurological outcome was based on initial neurological status, renal function and the volume of the hematoma. In addition, hematoma volume and uncontrolled blood pressure were significantly related to mortality. Hence, the severity of renal function, initial neurological status, hematoma volume, and uncontrolled blood pressure emerged as significant prognostic factors in ICH patients with CKD.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.6-6
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• 2016

최근 전 지구적인 기후 변화에 따라 수문 순환을 이루고 있는 다양한 수문 기상 인자들의 변동성에 영향을 미치고 있다. 특히, 증발산은 수문순환을 구성하는 중요한 인자로서 대기와 지표간의 상호 작용을 파악하기 위해서는 이에 대한 정확한 이해 및 산정이 필수적이다. 일반적으로 증발산량을 산정하기 위해서 증발 접시 및 에디 공분산 기반 플럭스 타워에서 관측된 지점 자료만을 이용하여 증발산량의 변동성을 파악하는 연구들이 수행되어왔다. 그러나 지점 자료만을 이용하여 증발산량을 산출하게 되면 공간적인 변동성을 파악하는데 있어서 한계점이 발생하게 된다. 이러한 제약 사항을 해결하기 위해서, 인공위성 기반의 수문 기상인자를 물리식 기반 증발산량 산정식의 입력 자료로 구축하여 증발산량을 산정하고 이에 대한 시 간적인 변동성을 파악하는 연구들이 활발히 이루어지고 있다. 인공위성 기반 증발산량 산정 알고리즘의 대표적인 예로 공기동역학적 항과 에너지 수지 항들을 동시에 고려할 수 있는 Penman-Monteith 방법을 근간으로 수정하여 만들어낸 Remote Sensing based Penman-Monteith (RS-PM) 알고리즘이 있다. 그러나 RS-PM 기반의 증발산량 경우 태양복사열, 풍속, 온도, 습도와 같은 많은 수문기상인자들이 입력 자료를 요구한다. 이에 따라, 본 연구에서는 기존의 방법에 비해 상대적으로 적은 입력 자료를 사용하는 Modified Satellite-Based Priestley-Taylor (MS-PT) algorithm의 적용성을 평가하기 위해 MODerate-Resolution Imaging Spectroradiometer (MODIS) 자료를 이용하여 한반도에서 순복사에너지 (Net radiation) 및 실제 증발산량 (Actual evapotranspiration)을 산정하였다. 또한, 이에 대한 검증을 위해 청미천 유역에 설치되어있는 에디 공분산 기반 플럭스 타워에서 관측된 순복사 에너지 및 실제 증발산량에 대한 통계적 검증을 실시하였다.

• Korean Journal of Biological Psychiatry
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• v.25 no.4
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• pp.101-109
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• 2018

Objectives According to previous studies, the Chromogranin B (CHGB) gene could be an important candidate gene for schizophrenia which is located on chromosome 20p12.3. Some studies have linked the polymorphism in CHGB gene with the risk of schizophrenia. Meanwhile, smooth pursuit eye movement (SPEM) abnormality has been regarded as one of the most consistent endophenotype of schizophrenia. In this study, we investigated the association between the polymorphisms in CHGB gene and SPEM abnormality in Korean patients with schizophrenia. Methods We measured SPEM function in 24 Korean patients with schizophrenia (16 male, 8 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated genotypes of polymorphisms in CHGB gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of polymorphism. Results The natural logarithm value of signal/noise ratio (Ln S/N ratio) of good SPEM function group was $4.19{\pm}0.19$ and that of poor SPEM function group was $3.17{\pm}0.65$. In total, 15 single nucleotide polymorphisms of CHGB were identified and the genotypes were divided into C/C, C/R, and R/R. Statistical analysis revealed that two genetic variants (rs16991480, rs76791154) were associated with SPEM abnormality in schizophrenia (p = 0.004). Conclusions Despite the limitations including a small number of samples and lack of functional study, our results suggest that genetic variants of CHGB may be associated with SPEM abnormality and provide useful preliminary information for further study.nwhile, smooth pursuit eye movement (SPEM) abnormality has been regarded as one of the most consistent endophenotype of schizophrenia. In this study, we investigated the association between the polymorphisms in CHGB gene and SPEM abnormality in Korean patients with schizophrenia. MethodsZZWe measured SPEM function in 24 Korean patients with schizophrenia (16 male, 8 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated genotypes of polymorphisms in CHGB gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of polymorphism. ResultsZZThe natural logarithm value of signal/noise ratio (Ln S/N ratio) of good SPEM function group was $4.19{\pm}0.19$ and that of poor SPEM function group was $3.17{\pm}0.65$. In total, 15 single nucleotide polymorphisms of CHGB were identified and the genotypes were divided into C/C, C/R, and R/R. Statistical analysis revealed that two genetic variants (rs16991480, rs76791154) were associated with SPEM abnormality in schizophrenia (p = 0.004). ConclusionsZZDespite the limitations including a small number of samples and lack of functional study, our results suggest that genetic variants of CHGB may be associated with SPEM abnormality and provide useful preliminary information for further study.