• Journal of Microbiology and Biotechnology
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• 제31권5호
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• pp.659-666
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• 2021

After Candida albicans, Candida glabrata is one of the most common fungal species associated with candidemia in nosocomial infections. Rapid acquisition of nutrients from the host is important for the survival of pathogens which possess the metabolic flexibility to assimilate different carbon and nitrogen compounds. In Saccharomyces cerevisiae, nitrogen assimilation is controlled through a mechanism known as Nitrogen Catabolite Repression (NCR). NCR is coordinated by the action of four GATA factors; two positive regulators, Gat1 and Gln3, and two negative regulators, Gzf3 and Dal80. A mechanism in C. glabrata similar to NCR in S. cerevisiae has not been broadly studied. We previously showed that in C. glabrata, Gln3, and not Gat1, has a major role in nitrogen assimilation as opposed to what has been observed in S. cerevisiae in which both factors regulate NCR-sensitive genes. Here, we expand the knowledge about the role of Gln3 from C. glabrata through the transcriptional analysis of BG14 and gln3Δ strains. Approximately, 53.5% of the detected genes were differentially expressed (DEG). From these DEG, amino acid metabolism and ABC transporters were two of the most enriched KEGG categories in our analysis (Up-DEG and Down-DEG, respectively). Furthermore, a positive role of Gln3 in AAA assimilation was described, as was its role in the transcriptional regulation of ARO8. Finally, an unexpected negative role of Gln3 in the gene regulation of ABC transporters CDR1 and CDR2 and its associated transcriptional regulator PDR1 was found. This observation was confirmed by a decreased susceptibility of the gln3Δ strain to fluconazole.

• 대한가정학회지
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• 제35권2호
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• pp.345-358
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• 1997

This study investigated the pattern of division of household labor between married couples and the determining variables of the division of household work. In addition, this study examined the effect of the pattern of the division of household work and the sense of fairness on marital satisfaction. Two hundreds forty two married couples living near seoul were selected. Both wives and husbands reported their daily time-use pattern. According to the results, flexibility of husbands' work schedules hours of market work of husbands, husbands' sex role attitudes, and the presence of household assistant affected significantly on the extent of household work time. In addition, husbands' household work time had direct effects on marital satisfaction of couples. In wives' hours of household labor, the significant variables were wives' employment status, presence of younger children, total income, wives' sex role attitudes, and hours of household labor performed by housework assistant. In addition, wives' sense of fairness had impact significantly on marital satisfaction.

• Journal of Chest Surgery
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• 제47권3호
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• pp.201-210
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• 2014

During the last decade the role of minimally invasive surgery has been increased, especially with the introduction of the robotic system in the surgical field. The most important advantages of robotic system are represented by the wristed instrumentation and the depth perception, which can overcome the limitation of traditional thoracoscopy. However, some data still exist in literature with regard to robotic lobectomy. The majority of papers are focused on its safety and feasibility, but further studies with long follow-ups are necessary in order to assess the oncologic outcomes. We reviewed the literature on robotic lobectomy, with the main aim to better define the role of robotic system in the clinical practice.

• E2M - 전기 전자와 첨단 소재
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• 제16권9호
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• pp.62.3-63
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• 2003

• E2M - 전기 전자와 첨단 소재
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• 제16권9호
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• pp.62.3-63
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• 2003

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.162.1-162.1
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• 2003

The purpose of this study was to determine the possibility of sphingolipid as a diagnostic marker for Myocardiac Infarction(MI), atherosclerosis-related cardiovascular disease. Sphingolipids are known to playa role in the occurrence of atherosclerosis in human blood vessels. Platelet-poor plasma(PPP) and washed platelets were prepared from healthy volunteers and MI patients, and sphingolipids analyzed. (omitted)

• Archives of Plastic Surgery
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• 제49권2호
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• pp.221-226
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• 2022

With the growing complexity of the U.S. health care system, highly motivated medical directors with strong leadership skills are vital to the success of health care facilities. Presently, there are no articles assessing a plastic surgeon's qualifications for the role of medical director. In addition, there is a paucity of literature comparing the responsibilities of medical directors across various types of health care institutions. Herein, we outline why plastic surgeons have the unique skillset to succeed in this role and highlight the differences between medical director positions across the vast landscape of health care. While the intricacies of this position vary greatly across different landscapes of the health care industry, successful medical directors lead by following a set of universal principles predisposing them for success. Plastic surgeons innately exhibit a subset of particular traits deeming them suitable candidates for the medical director position. While transitioning from the role of a surgeon to that of a medical director does require some show of adaptation, plastic surgeons are ultimately highly likely to find intrinsic benefit from serving as a medical director.

• 대한가정학회지
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• 제50권4호
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• pp.73-87
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• 2012

The purpose of this study was to analyze the difference in school adjustment and future time perspectives, according to the characteristics in regards to the role models of the children in institutional facilities. Data for this study were obtained from a survey conducted on 310 children aged 11-13. Data were analyzed using various statistical methods such as frequency analysis, chi-square test, t-test, one-way ANOVA, and one-way ANCOVA. The main findings of this study were as follows. First, overall, the majority of children selected entertainers and celebrities as their role models. Also, we found differences in children's school adjustment according to their background variables (gender, staying with their siblings, and having parents alive). Second, having role models was significantly related to the levels of school adjustment as well as the positive future time perspectives of the children. Based on the results, practical implications for children in institutional care were discussed.

• Journal of Microbiology and Biotechnology
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• 제14권5호
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• pp.1047-1051
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• 2004

The phytopathogenic bacterium Pectobacterium chrysanthemi secretes multiple isozymes of plant cell wall disrupting enzyme such as pectate lyase and cellulase. The cel gene, existing in tandem with the pel gene, was isolated previously [10]. The role of Cel5Z and PelL1 in P. chrysanthemi PY35 pathogenicity on potato tissues was assessed by mutagenizing cloned cel gene and pel gene in tandem and recombining them with the chromosomal alleles. Strains with the Km cassette interposon in pelL1 or a double mutant showed a delay in the appearance of symptoms, suggesting that P. chrysanthemi PY35 pectate lyase PelL1 may playa minor role in soft-rot pathogenesis.

• 공학교육연구
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• 제7권2호
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• pp.22-39
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• 2004

이 연구는 국가기술자격제도 관리 운영체제에 대한 국가와 민간의 적절한 역할분담 체계가 무엇인지를 알아보고 이를 구축하기 위한 방안을 마련하고자 하는 데 목적이 있다. 이 연구의 목적을 달성하기 위해 국가기술자격제도 관리의 국가와 민간의 역할분담에 대한 방향을 탐색하였다. 또한 국가기술자격제도의 관리 운영 현황을 분석하여 국가중심의 자격제도 운영의 한계를 살펴보았으며, 자격제도 관리 운영에 대한 국가 및 민간의 역할 분담 방안을 제시하였다. 연구방법으로 관련자료의 수집 및 분석, 기업체(사내자격관리자), 업종별 협회(사업주 단체)를 대상으로 한 설문조사, 국가와 민간의 역할 분담 방향을 설정하기 위한 전문가 협의회 개최, 기업체 및 업종별 협회에 대한 의견수렴을 위한 면담조사 등이 실시되었으며, 자격제도 전문가를 중심으로 연구 협력진 구성하여 운영하였다.