• 제목/요약/키워드: RFT1

검색결과 25건 처리시간 0.019초

스피닝 운동 후 발생한 횡문근융해증 치험 1례 (One Case of Rhabdomyolysis After Spinning Exercise)

  • 정호영;남승규;조충식
    • 대한한방내과학회지
    • /
    • 제37권5호
    • /
    • pp.711-716
    • /
    • 2016
  • Objective: To report a case of rhabdomyolysis that occurred after spinning exercise. Methods: A patient diagnosed with rhabdomyolysis received Korean medical treatment and Western medical treatment for 6 days. We observed the patient for 13 days. Clinical symptoms were evaluated with a Numerical Rating Scale (NRS) and laboratory tests, which included Liver Functional Test (LFT), Renal Functional Test (RFT), creatinine phosphokinase (CPK), myoglobin, and urine tests. Results: After treatment, the clinical symptoms were improved. In this case, acute renal failure did not occur. Laboratory results, including AST, ALT, CPK, and LDH, were also improved. Conclusions: Rhabdomyolysis can be treated cooperatively with Korean and western medical cooperative treatment.

Research Infrastructure Foundation for Core-technology Incubation of Radiation Detection System

  • Kim, Han Soo;Ha, Jang Ho;Kim, Young Soo;Cha, Hyung Ki
    • 방사선산업학회지
    • /
    • 제6권1호
    • /
    • pp.67-73
    • /
    • 2012
  • The development of radiation detection systems mainly consist of two parts-radiation detector fabrication including material development, and its appropriate electronics development. For the core-technology incubation of a radiation detection system, radiation fabrication and an evaluation facility are scheduled to be founded at the RFT (Radiation Fusion Technology) Center at KAERI (Korea Atomic Energy Research Institute) by 2015. This facility is utilized for the development and incubation of bottleneck-technologies to accelerate the industrialization of a radiation detection system in the industrial, medical, and radiation security fields. This facility is also utilized for researchers to develop next-generation radiation detection instruments. In this paper, the establishment of core-technology development is introduced and its technological mission is addressed.

홍게 자숙액으로부터 게향 제조를 위한 반응향의 최적화 (Optimal Conditions of Reaction Flavor for Synthesis of Crab-like Flavorant from Snow Crab Cooker Effluent)

  • 안준석;정은정;조우진;차용준
    • 한국식품영양과학회지
    • /
    • 제43권1호
    • /
    • pp.128-134
    • /
    • 2014
  • 천연 게향을 제조하기 위하여 홍게 농축가공 자숙액($20^{\circ}Brix$)을 원료로 여기에 4종류의 아미노산(proline, glycine, arginine, methionine)과 단당류(fructose)를 선정하여 반응향을 유도하고자 하였다. 4종류의 아미노산과 fructose를 각각 독립변수로 두고 종속변수로는 odor, taste 및 overall acceptance를 두고 중심합성계획법에 따라 반응표면분석법으로 최적 가공조건을 선정하였다. 모델식의 결정계수(R-square)는 odor가 0.88, taste는 0.90, overall acceptance는 0.95였고, 적합결여검증(lack of fit)(P<0.05)에서는 odor(0.01)를 제외하고는 2차식으로의 설계가 유의함을 알 수 있었다(P<0.05). 그러나 odor에서도 결정계수 값이 0.88로서 전체적인 식은 만족할 만하였다. Odor score는 $7.17-0.24[Pro]^2-0.21[Gly]^2-0.21[Arg]^2-0.23[Met]^2-0.27[Fru]^2$의 식으로 나타났으며, 각각 독립변수의 2차항 만이 모두가 유의성(P<0.05)을 나타내었다. 정상점에서의 odor 값은 7.21로 정상점이 최고점이었다. 얻어진 모델식에서의 최적농도는 홍게 농축자숙액($20^{\circ}Brix$)에 proline 0.29 g/100 mL(w/v), glycine 0.63 g/100 mL(w/v), arginine 0.61 g/100 mL(w/v), methionine 0.02 g/100 mL(w/v) 및 fructose 1.07 g/100 mL(w/v)이었으며, 이 조건에서의 실제 관능검사(odor) 값은 7.56이었다.

Histone Deacetylase 701 (HDT701) Induces Flowering in Rice by Modulating Expression of OsIDS1

  • Cho, Lae-Hyeon;Yoon, Jinmi;Wai, Antt Htet;An, Gynheung
    • Molecules and Cells
    • /
    • 제41권7호
    • /
    • pp.665-675
    • /
    • 2018
  • Rice is a facultative short-day (SD) plant in which flowering is induced under SD conditions or by other environmental factors and internal genetic programs. Overexpression of Histone Deacetylase 701 (HDT701) accelerates flowering in hybrid rice. In this study, mutants defective in HDT701 flowered late under both SD and long-day conditions. Expression levels of florigens Heading date 3a (Hd3a) and Rice Flowering Locus T1 (RFT1), and their immediate upstream floral activator Early heading date 1 (Ehd1), were significantly decreased in the hdt701 mutants, indicating that HDT701 functions upstream of Ehd1 in controlling flowering time. Transcript levels of OsINDETERMINATE SPIKELET 1 (OsIDS1), an upstream repressor of Ehd1, were significantly increased in the mutants while those of OsGI and Hd1 were reduced. Chromatin-immunoprecipitation assays revealed that HDT701 directly binds to the promoter region of OsIDS1. These results suggest that HDT701 induces flowering by suppressing OsIDS1.

간, 신장수치 이상 환자에 부자(附子) 배합 처방 투여가 미치는 영향 (The Study of Safety of Herbal Medicine Including Fuzi(附子) on High Range of LFT, RFT Patients)

  • 이영준;황원덕;이재욱;정희진;배수현;김규곤
    • 대한한의학방제학회지
    • /
    • 제19권2호
    • /
    • pp.179-189
    • /
    • 2011
  • Objectives : Aconiti Lateralis Preparata Radix(fuzi, 附子) and its class herbs(chaunwu, caowu etc.) are necessary for some clinical conditions, such as cold pain, chilling etc,. But, they has some poison component. And, they have been known to cause liver and kidney injury, and dangerous in the patients who has abnormal range of LFT and RFT. This study shows the consequences for aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrate(BUN), and Creatinine were analyzed using samples from patients who took the decoction containing fuzi. Methods : Blood samples for Experiment Group(E) were collected from 63 patients, who took the decoction containing fuzi, admitted into the 6th internal medicine department of Dong Eui Oriental Medical Hospital between from January 2007 to March 2011. In compared to those of experiment group, blood samples as Control Group(C) were collected from 64 patients, who took the decoction not containing fuzi, admitted into the same hospital from January 2009 to April 2011. Results and Conclusions : 1. AST No changed : E 4.17%, C 2.63%, Increased : E 12.5%, C 28.95%, Decreased : E 80.33%, C 68.42% 2. ALT No changed : E2.94%, C5.13%, Increased : E 8.82%, C 20.51%, Decreased : E 88.24%, C 74.36% 3. BUN No changed : E 0%, CG 7.14%, Increased : E 32.25%, CG 14.29% Decreased : EG 67.65%, CG 78.57% 4. Creatinine No changed : EG 5.00%, CG 0%, Increased : EG 35.00%, CG 54.55% Decreased : EG 60.00%, CG 45.45% 5. The results suggest that the decoction containing fuzi isn't harmful AST, ALT, BUN, Cr of the patients who has high range of them.

차량 로드 휠의 복합축 평가 프로세스 구축을 통한 내구신뢰성 강건화 및 주행안정성 향상 (Improvement of Durability and Reliability by Developing a Bi-axial Test Process of Road Wheel)

  • 정수식;유연상;김대성
    • 자동차안전학회지
    • /
    • 제8권1호
    • /
    • pp.26-30
    • /
    • 2016
  • The steel road wheel on ventilation holes was cracked in the vehicle durability test. But the component durability test by uni-axial, CFT(Cornering Fatigue Test) and RFT(Radial Fatigue Test) had been satisfied. That is, the uni-axial component test could not forecast the crack of vehicle. Therefore this study developed the bi-axial test mode to reflect a vehicle condition(to reflect both vertical and lateral force simultaneously) based on real load data which was measured in Europe and China and developed CAE simulation too. It reproduced the cracks same as vehicle's and verified by bi-axial test machine in the LBF(Fraunhofer Institute for Structural Durability and System Reliability) durability research center in Germany. Finally this the durability CAE simulation by using HMC(Hyundai Motor Company)'s the bi-axial test mode predicts feasibly the steel wheel's durability performance before vehicle durability test.

약침치료를 이용한 각종 암환자의 임상사례 (Case Study of Cancer Patients Treated with Herbal Acupuncture Therapy)

  • 유화승;조정효;이연월;손창규;조종관
    • 대한약침학회지
    • /
    • 제7권1호
    • /
    • pp.27-36
    • /
    • 2004
  • Objective : This study was aimed to validate the Herbal Acupuncture Therapies(HAT) for cancer patients. Patients and methods : This retrospective study was performed on 8 patients who were diagnosed as cancer in Korea and treated with HAT in the oriental hospital of Daejeon University, from January 2003 to January 2004. We retrospectively analyzed the medical records of 8 patients for improvement of symptoms, toxic effects of liver and kidney, myelosupression and changes of Quality of Life(QOL). Results : Analysis of change of chief complaints showed that 75% patients replied moderate relief and 25% replied complete relief in Likert scale. Analysis of Liver Function Test(LFT), Renal Function Test(RFT) level showed that HAT does not have toxic effects on liver and kidney. Analysis of Complete Blood Count(CBC) level showed that HAT does not have myelosuppression effects on bone marrow. Analysis of QOL showed that 100% patients replied improvement in Eastern Cooperative Oncology Group status(ECOG) status. Conclusion : Our findings suggest that HAT offer potential benefits for cancer patients.

급성 파라콰드중독후 생존한 15예환자의 임상적 고찰 (Clinical study of the 15 patients survived after acute paraquat intoxication)

  • 김동웅
    • 대한예방한의학회지
    • /
    • 제3권1호
    • /
    • pp.55-65
    • /
    • 1999
  • From January 1994 to April 1997, there was 15 survivals who was admitted to the department of internal medicine, Wonkwang Oriental Medicine Hospital in Cheun-ju, after ingestion of paraquat, and treated with Oriental and western medicine therapy. For the patients, I investigated clinical symptoms, gastroduodenoscopy, intake by oral and parenteral route, and output by urine and stool, serum ALP, AST. ALT, Bilirubin, BUN, Creatinine level and urine analysis. On admission day, the LFT level was as follows. The serum mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin was $10.05{\pm}2.75\;KAU$, $66.67{\pm}9.88\;IU/L$, $43.80{\pm}7.74\;IU/L$, $1.89{\pm}1.22\;mg/dl$ and $1.10{\pm}1.14\;mg/dl$ respectively. After that day, administered Gamdutang and checked the mean LFT level regullary. Until the 3rd day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was $11.01{\pm}3.16\;KAU$, $56.47{\pm}7.19\;IU/L$, $59.00{\pm}7.57\;IU/L$, $2.54{\pm}1.78\;mg/dl$, $1.64{\pm}1.59\;mg/dl$ respectively. From 4th day to 7th day, the mean ALP; AST, ALT, Total Bilirubin and Direct Bilirubin level was $12.51{\pm}3.49\;KAU$, $77.85{\pm}7.17\;IU/L$, $58.00{\pm}9.09\;IU/L$, $2.54{\pm}1.97\;mg/dl$, and $1.80{\pm}1.81\;mg/dl$ respectively. From 8th day to 10th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was $12.43{\pm}3.14\;KAU$, $41.13{\pm}6.49\;IU/L$, $50.40{\pm}7.17\;IU/L$, $1.66{\pm}1.90\;mg/dl$ and $1.14{\pm}1.50\;mg/dl$ respectively. From 11th day to 14th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was $12.30{\pm}3.25\;KAU$, $31.07{\pm}3.85\;IU/L$, $43.33{\pm}5.49\;IU/L$, $1.62{\pm}1.95\;mg/dl$, $1.17{\pm}1.71\;mg/dl$ respectvely. On admission day, the mean RFT level as follows. Serum BUN and Creatinine level was $28.73{\pm}5.19\;mg/dl$ and $1.82{\pm}1.27\;mg/dl$ respectively. After that day, administered Gamdutang and checked the mean RFT level regullary. Until the 3rd day, the mean BUN and Creatinine level was $32.12{\pm}5.65\;mg/dl$ and $2.31{\pm}0.45\;mg/dl$ respectively. From 4th day to 7th day, the mean BUN and Creatinine level was $31.07{\pm}5.47\;mg/dl$ and $1.92{\pm}0.79\;mg/dl$ respectively. From 7th day to 10th day, the mean BUN and Creatinine level was $17.47{\pm}3.57\;mg/dl$ and $1.33{\pm}0.59\;mg/dl$ respectively. From 11th day to 14th day, the mean BUN and Creatinine level was $11.93{\pm}3.16\;mg/dl$, $1.27{\pm}0.38\;mg/dl$ respectively.

  • PDF

Identification of the Regulatory Region Responsible for Vascular Tissue-Specific Expression in the Rice Hd3a Promoter

  • Pasriga, Richa;Cho, Lae-Hyeon;Yoon, Jinmi;An, Gynheung
    • Molecules and Cells
    • /
    • 제41권4호
    • /
    • pp.342-350
    • /
    • 2018
  • Flowering time is determined by florigens. These genes include, Heading date 3a (Hd3a) and Rice FT 1 (RFT1) in rice, which are specifically expressed in the vascular tissues of leaves at the floral transition stage. To study the cis-regulatory elements present in the promoter region of Hd3a, we generated transgenic plants carrying the 1.75-kb promoter fragment of Hd3a that was fused to the ${\beta}$-glucuronidase (GUS) reporter gene. Plants expressing this construct conferred a vascular cell-specific expression pattern for the reporter gene. However, GUS was expressed in leaves at all developmental stages, including the early seedling stage when Hd3a was not detected. Furthermore, the reporter was expressed in roots at all stages. This suggests that the 1.75-kb region lackings cis-elements that regulate leaf-specific expression at the appropriate developmental stages. Deletion analyses of the promoter region indicated that regulatory elements determining vascular cell-specific expression are present in the 200-bp region between -245 bp and -45 bp from the transcription initiation site. By transforming the Hd3a-GUS construct to rice cultivar 'Taichung 65' which is defective in Ehd1, we observed that Ehd1 is the major regulatory element that controls Hd3a promoter activity.

장기간 한약복용이 부인과 환자의 간 및 신장기능에 미치는 영향: panel연구 - 복용 전과 후 3, 6개월 비교를 중심으로 - (Effects of Long-Term Intake of Korean Medicine on Gynecology Patients' Livers and Kidneys; Panel Study - Focus on Before Intake, After 3, 6 Months -)

  • 양준모;성동민;김유진;이선동
    • 대한한의학회지
    • /
    • 제41권1호
    • /
    • pp.84-92
    • /
    • 2020
  • Objectives: To observe the effects on liver and kidney of gynecology patients' during long term Korean Medicine. Methods: This research was conducted as a panel study on 29 female gynecology patients at Korean medicine clinic and compares their conditions before, 3 months after, and 6 months after Intake of Korean medicine. This analysis was conducted to frequency(%), repeated measure ANOVA and significantly statistics was p<0.05, confidence interval. Results: The most common conditions among the subjects were polycystic ovary syndrome, endometriosis, adenomyosis, and uterine myoma. Except in a few instances, liver functions (AST, ALT, γ-GTP) were within the normal range before and after the intake of Korean medicine. Further, while there was a slight change in liver functions when three months and six months after the intake, but there was no statistical significance (p>0.05). As for the kidney functions (BUN, Creatinine, BUN/Creatinine), they were within the normal range before and after the intake of Korean medicine. Further, while there was a slight change in kidney functions three months and six months after the intake, there was no statistical significance(p>0.05) either. Conclusions: Based on these results, it can be concluded that Korean medicine does not have a negative impact on the gynecology patients' liver and kidney.