• Title/Summary/Keyword: RAM model

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Refractive Index and Excess Volume for Diisopropylamine + Isomeric Butanol Mixtures in terms of Nakata and Sakurai model

  • Kumari, Kavitha;Maken, Sanjeev
    • Korean Chemical Engineering Research
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    • v.59 no.4
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    • pp.644-651
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    • 2021
  • Alkyl amines are widely used in various industries. Nowadays these are also used in CO2 capture technology because amines react with CO2 and remove it from the flue gas. To make the amines more compatible towards this technology, physico chemical properties may be altered by mixing with other solvents. In the present report, we measured the refractive properties of pure diisopropylamine (DIPA) (1) + isomeric butanol (2) at 298.15 K to 308.15 K. The 𝚫n values were positive for DIPA + n-butanol or sec-butanol or isobutanol or tert-butanol mixtures. The measured data was correlated with Redlich-Kister equation. The excess molar volume data were predicted from refractive index data using Nakata and Sakurai model. The experimental data were also predicted by various correlations, and the prediction capability of these correlations was reported through standard deviation. Further, the deviation in refractive index (𝚫n) data was interpreted by the consideration of specific molecular interactions between DIPA and isomeric butanol.

Exploratory Analysis of Patients With Gastric/Gastroesophageal Junction Adenocarcinoma With or Without Liver Metastasis From the Phase 3 RAINBOW Study

  • Takatsugu Ogata;Yukiya Narita;Zev A. Wainberg;Eric Van Cutsem;Kensei Yamaguchi;Yongzhe Piao;Yumin Zhao;Patrick M. Peterson;Sameera R. Wijayawardana;Paolo Abada;Anindya Chatterjee;Kei Muro
    • Journal of Gastric Cancer
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    • v.23 no.2
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    • pp.289-302
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    • 2023
  • Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM-) LM at baseline. Materials and Methods: Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM-: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM-: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan-Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM- subgroups was analyzed using the Cox regression model with reported interaction P-values. Results: The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM- (OS HR, 0.71 [LM+] vs. 0.88 [LM-]; PFS HR, 0.47 [LM+] vs. 0.76 [LM-]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions: RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.

Application of Flory-Treszczanowicz-Benson model and Prigogine-Flory-Patterson theory to Excess Molar Volume of Binary Mixtures of Ethanol with Diisopropyl Ether, Cyclohexane and Alkanes (C6-C9)

  • Kashyap, Pinki;Rani, Manju;Tiwari, Dinesh Pratap;Park, So-Jin
    • Korean Chemical Engineering Research
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    • v.58 no.2
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    • pp.257-265
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    • 2020
  • Densities (ρ) for binary mixtures of ethanol (1) + diisopropyl ether (DIPE) or cyclohexane or alkane (C6-C9) (2) were measured at 298.15 K, 308.15 K and 318.15 K. The excess molar volume (VEm) of binary mixtures was calculated using ρ data and correlated with Redlich-Kister polynomial equation. The VEm values for binary mixtures of ethanol (1) + cyclohexane or n-alkane (C6-C9) (2) were positive, whereas for ethanol (1) + DIPE (2) these were negative. The magnitude of VEm values follows the order: cyclohexane > n-nonane > n-octane > n-heptane > n-hexane > DIPE. The VEm values have been interpreted qualitatively and also quantitatively in terms of Flory-Treszczanowicz-Benson (FTB) model and Prigogine-Flory-Patterson (PFP) theory. The values VEm predicted using FTB model agree well with experimental VEm values at all mole fractions. But the PFP theory describes well VEm data in ethanol-rich region (x1 > 0.5) for all binary mixtures and is able to predict the sign of VEm vs x1 curve for ethanol-lean region (x1 < 0.5) except for ethanol (1) + nonane (2) mixtures.

Analysis of the Availability of Risk Assessment Model for Typhoon Path which Affected Korean Peninsula (한반도에 영향을 미친 태풍 경로별 재해평가모형의 활용도 분석)

  • Park, Jong-Kil;Lee, Bo-Ram;Jung, Woo-Sik
    • Journal of Environmental Science International
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    • v.25 no.11
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    • pp.1521-1530
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    • 2016
  • As a result of dividing typhoon that affected Korean Peninsular between 1999 and 2012 into 7 types of path and entering forecast field and analysis field of RDAPS, until 36 hours from the time of forecast, it is reliable to use the forecast field of RDAPS to predict typhoon and for each typhoon path, the difference between the forecast and the analysis shows normal distribution, which is usable for weather forecast until the $36^{th}$ hour. In the $48^{th}$ hour from the time of forecast, the difference of result depending on each typhoon path increased, which was analyzed to be due to errors in the forecast. It was expected that relatively reasonable results should be shown if the $36^{th}$ hour forecast is used to predict the strength and distribution of strong wind. As a result of using Korean RAM and observing the difference of the maximum damage, reliability was secured up to 36 hours and after 48hours, it was expected that the fluctuation of results may become more severe.

A Study on I/O Buffer Modeling to Supply PCB Simulation (PCB시뮬레이션을 지원하기 위한 입출력 버퍼 모델링에 관한 연구)

  • 김현호;이용희;이천희
    • Proceedings of the IEEK Conference
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    • 2000.11b
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    • pp.345-348
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    • 2000
  • In this paper, We described the procedures to generate an input-output buffer information specification (IBIS) model in digital IC circuits. We gives the method to describe IBIS standard I/O for the characteristics of I/O buffer and to represent its electrical characteristics. The parameters of I/O structure for I/O buffer modelling are also referred, and an IBIS model for CMOS, TTL IC, ROM and RAM constructed amounts about 216. This IBIS model can be used to the simulation of signal integrity of high speed circuits in a PCB level.

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A Stochastic Simulation Model for Integrated Weapon System Design and Performance Evaluation (복합 무기체계 비용${\cdot}$효과 분석 방법론 연구)

  • Hwang Heung-Seok
    • Journal of the military operations research society of Korea
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    • v.18 no.2
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    • pp.23-43
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    • 1992
  • A Stochastic simulation model for optimal design and evaluation of the integrated weapon systems under the consideration of the RAM (reliability, availability and maintainability) and life cycle cost (LCC) was developped. This model is supposed to satisfy a need regarding the methodology of optimaldesign and performance evaluation for both developpers and users of weapon systems.

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Analysis of the Aluminum Extrusion Process Equipped with the Continuous Heat Treatment System

  • Lee, Bong-Sang;Cho, Young-Hee;Lee, Jeong-Min;Lim, Hak-Jin;Koo, Jar-Myung;Yoon, Bo-Hee;Lee, Tae-Hyuk;Lee, Jong-Hyeon
    • Korean Journal of Materials Research
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    • v.21 no.1
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    • pp.39-45
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    • 2011
  • In this study, the heat flow of the plant scale aluminum extrusion process was investigated to establish optimum continuous heat treatment conditions. During the extrusion of 6061 aluminum alloy, processing parameters such as the extrusion pressure, speed and temperature histories of billets were logged as a function of time. The surface temperature of the billets increased at constant ram speed, while it decreased with decreases of the ram speed. In order to maintain the billet temperature within a solutionizing temperature range prior to the succeeding water quenching step, the ram speed or the temperature of the blower should be controlled. The temperature histories of the billets during the extrusion and hot air blowing processes were successfully simulated by using the velocity boundary model in ANSYS CFX. The methodology to design an optimum process by using a commercial simulation program is described in this study on the basis of the metallurgical validation results of the microstructural observation of the extrudates. The developed model allowed the advantages of taking into account the motion of the extrudate coupled with the temperature change based on empirical data. Calculations were made for the extrudate passing through the isothermal chamber maintained at appropriate temperature. It was confirmed that the continuous heat treatment system is beneficial to the productivity enhancement of the commercial aluminum extrusion industry.

Particle Behavior and Deformation During Compaction of Al Powder Using MPFEM (다입자유한요소법을 이용한 Al분말 압축공정에서 입자의 거동과 변형에 관한 연구)

  • Lee, Kyung-Hun;Lee, Jung-Min;Kim, Byung-Min
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.34 no.4
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    • pp.383-390
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    • 2010
  • This paper describes multiparticle finite element model (MPFEM)-based powder compaction simulations performed to demonstrate the densification of compacted aluminum powders. A 2D MPFEM was used to explore the densification of a collection of aluminum particles with different average particle sizes under various ram speeds. Individual particles are discretized using a finite element mesh for a detailed description of contact mechanics. Porous aluminum powders with average particle sizes of $20\;{\mu}m$ and $3\;{\mu}m$ were compressed uniaxially at ram speeds of 5, 15, 30, and 60 mm/min by using an MTS servo-hydraulic tester. The slow ram speed was of great advantage to powder densification in low compaction force due to sufficient particle rearrangement. Owing to a decrease in the average particle size of aluminum, the compaction force increased.

Development of Simulator using RAM Disk for FTL Performance Analysis (RAM 디스크를 이용한 FTL 성능 분석 시뮬레이터 개발)

  • Ihm, Dong-Hyuk;Park, Seong-Mo
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.47 no.5
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    • pp.35-40
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    • 2010
  • NAND flash memory has been widely used than traditional HDD in PDA and other mobile devices, embedded systems, PC because of faster access speed, low power consumption, vibration resistance and other benefits. DiskSim and other HDD simulators has been developed that for find improvements for the software or hardware. But there is a few Linux-based simulators for NAND flash memory and SSD. There is necessary for Windows-based NAND flash simulator because storage devices and PC using Windows. This paper describe for development of simulator-NFSim for FTL performance analysis in NAND flash. NFSim is used to measure performance of various FTL algorithms and FTL wear-level. NAND flash memory model and FTL algorithm developed using Windows Driver Model and class for scalability. There is no need for another tools because NFSim using graph tool for data measure of FTL performance.