• Bulletin of the Korean Chemical Society
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• 제33권7호
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• pp.2365-2368
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• 2012

The $11{\beta}$-hydroxysteroid dehydrogenase type 1 ($11{\beta}$-HSD1) enzyme is involved in modulation of glucocorticoid activity within target tissues. This enzyme may contribute to obesity and/or metabolic disease through its action in adipose or liver tissue. Inhibition of $11{\beta}$-HSD1 has major therapeutic potential for glucocorticoid-associated diseases, including obesity, diabetes (wound healing), and muscle atrophy. To develop such therapeutics, we performed a pharmacophore-based virtual screening (VS) for identification of novel $11{\beta}$-HSD1 inhibitors and found that the VS hit compounds show potent inhibition of $11{\beta}$-HSD1 enzyme activity. Further, we present a binding model for active compounds. The proposed pharmacophore may serve as a useful guideline for future design of new chemical entities as $11{\beta}$-HSD1-targeted antidiabetic agents.

• Bulletin of the Korean Chemical Society
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• 제19권12호
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• pp.1314-1319
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• 1998

Electronic structures and properties of the organometallic precursors [Me2AlNHR]2 (R =Me, iPr, and tBu) have been calculated by the semiempirical (ASED-MO, MNDO, AM1 and PM3) methods. Optimized structures obtained from the MNDO, AM1, and PM3 calculations indicate that the N-C bond lengths are considerably affected by the change of the R groups bonded to nitrogen, but the bond lengths of the Al-N and Al-C bonds are little affected. This result is useful in explaining the experimental results for the elimination of the R groups bonded to nitrogen, and could serve as a guide in designing an optimum precursor for the AlN thin film formation.

• 한국응급구조학회지
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• 제5권1호
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• pp.23-35
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• 2001

This study was done to examine the relationship between stress and coping methods of 86 emergency medical technicians with the 1st or 2nd grade qualifications who serve at 36 fire stations in Gwangju and Jeonnam region from Aug. 1 to Aug. 31, 2001. Data collection was done by questionnaire. The research instruments used the stress measure tool developed by Cho Hee et al.(1999) and revised and complemented by the researcher to measure firemen's stress, and health instrument revised by Suh Mi Hye et al(1993). Data were analyzed by t-test, ANOVA, and Pearson's correlation using SPSS. The results of this study were as follows : 1. The mean score of perceived stress was 3.4. The mean score of coping methods was 2.11. 2. The levels of stress according to the general characteristics of subjects were significantly different at marital status(t=7.054, p=.009) and in relation with organization(t=3.989, p=.049). 3. The relationship between levels of stress and health status was significantly correlated(r=.325, p=.000), and so the hypothesis of this research, "the less levels of stress, the better health status is." was supported. 4. The relationship between stress and health status was significantly different at crisis status(r=.393, p=.000), relation with organization(r=.348, p=.001), the characteristics of subjects(r=.387, p=.000), special knowledge and technology(r=.337, p=.001), and the roll complication as a professional(r=.343, p=.001).

• 한국재난정보학회 논문집
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• 제19권4호
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• pp.924-935
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• 2023

Purpose: The central aim of this study is to leverage machine learning techniques for the classification of Intrusion Detection System (IDS) data, with a specific focus on identifying the variables responsible for enhancing overall performance. Method: First, we classified 'R2L(Remote to Local)' and 'U2R (User to Root)' attacks in the NSL-KDD dataset, which are difficult to detect due to class imbalance, using seven machine learning models, including Logistic Regression (LR) and K-Nearest Neighbor (KNN). Next, we use the SHapley Additive exPlanation (SHAP) for two classification models that showed high performance, Random Forest (RF) and Light Gradient-Boosting Machine (LGBM), to check the importance of variables that affect classification for each model. Result: In the case of RF, the 'service' variable and in the case of LGBM, the 'dst_host_srv_count' variable were confirmed to be the most important variables. These pivotal variables serve as key factors capable of enhancing performance in the context of classification for each respective model. Conclusion: In conclusion, this paper successfully identifies the optimal models, RF and LGBM, for classifying 'R2L' and 'U2R' attacks, while elucidating the crucial variables associated with each selected model.

• 한국산학기술학회논문지
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• 제10권12호
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• pp.3797-3803
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• 2009

우리나라 IT산업성장에서 혁신잠재력과 혁신수행능력이 중요한 역할을 했다. 글로벌 R&D센터는 IT산업의 혁신의 중요한 요소이다. IT산업에서 혁신환경에 대한 글로벌 R&D센터구조를 파악하기 위하여 R&D센터구성원과 정책입안자 각 50명씩 현장설문을 실시하였다. 본 실증분석결과를 보면 단기적으로 R&D정책은 연구영역과 시장역역의 인식차이를 해소하는 촉진자로서 역할이 중요하며, 중기적으로 R&D정책은 개발과 시장의 영격의 인식차이를 좁히는 조정자로 그리고 장기적으로는 기술능력과 시장의 확산 자로서 역할이 중요함을 보여준다. IT 정책입안자는 R&D정책에서 글로벌 R&D센터를 혁신체계의 요소로 활용하는 것이 요구된다.

• 한국환경농학회지
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• 제29권1호
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• pp.86-91
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• 2010

This study was carried out to assess the antifungal potential of R. oligosporus and its ethyl acetate (EtOAc) extract against the fungal pathogens causing anthracnose disease in apple fruits using disc diffusion, antagonistic effect and morphological abnormalities in fungal mycelia. The percentage of inhibition of antifungal effect of the ethyl acetate extract (5 ${\mu}l$ $disc^{-1}$) of the R. oligosporus against C. acutatum KACC 40848, C. gloeosporioides KACC 40897, C. higginsianum KACC 40806, C. orbiculare KACC 40808, C. coccodes KACC 40008, C. musae KACC 40947, C. boninense KACC 40893, C. liliacearum KACC 40981, C. caudatum KACC 41028 and Colletotrichum sp. KACC 40811 was found to be 44.4, 35.5, 40, 31.1, 33.3, 37.7, 40, 51.1, 28.8 and 28.8%, respectively. Also the fungus R. oligosporus showed potential antagonistic effect of antifungal activity against the tested pathogens of Colletotrichum spp. Further, R. oligosporus had a potential detrimental effect on the morphology of the tested fungi of Colletotrichum spp. such as wrinkle abnormalities, abnormal cell formation, lysis of mycelium, empty cell formation, distorted cell formation and breakage of the mycelium. These findings strongly support the role of R. oligosporus to serve as a potential antifungal agent to control plant pathogenic fungi causing anthracnose disease in apple fruits.

• 통합자연과학논문집
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• 제9권2호
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• pp.128-135
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• 2016

5-hydroxytryptamine (serotonin) receptor ($5-HT_7R$) 7 is one of G-Protein coupled receptors, which is activated by the neurotransmitter Serotonin. After activation by serotonin, $5-HT_7$ activates the production of the intracellular signaling molecule cyclic AMP. $5-HT_7$ receptor has been found to be involved in the pathophysiology of various disorders. It is reported that $5-HT_7$ receptor antagonists can be used as antidepressant agents. In this study, we report the important structural and chemical parameters for 2-methoxyphenylpiperazinylakanamides as $5-HT_7R$ inhibitors. A 3D QSAR study based on comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with $q^2$ of 0.594 with 6 components, $r^2$ of 0.986, Fisher value as 60.607, and an estimated standard error of 0.043. The predictive ability of the test set was 0.602. Results obtained the CoMFA models suggest that the data are well fitted and have high predictive ability. The contour maps are generated and studied. The contour analyses may serve as tool in the future for designing of novel and more potent $5-HT_7R$ derivatives.

• 대한화장품학회지
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• 제40권1호
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• pp.89-94
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• 2014

물푸레나무 수피 추출물은 주요 생활성 물질로서 esculetin과 esculin을 포함하고 있다. 이 가운데, Esculetin은 B16F10 melanoma cells에서 $IC_{50}$ value $2.8{\mu}M$의 아주 좋은 melanogenesis 억제 활성을 나타내며, 이를 통해 Melan-A cell에서 melanin 합성을 감소시킨다. 더욱이, esculetin은 mushroom tyrosinase에서도 $IC_{50}$ value $40{\mu}M$의 억제 활성을 나타내어 melanin biosynthesis를 저해한다. 위의 결과들로서, 우리는 melanogenic enzyme 활성 조절에 의해 melanin 생성을 저해하는 효과적인 피부미백 물질로서 esculetin을 제안하고자 한다.

• 한국경영과학회지
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• 제16권2호
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• pp.36-48
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• 1991

In this study, an efficient algorithm is developed to compute steady state probabilities for the following M$_{x}$G/1 server vacation system under control-operating poligy: At the end of a busy period, the server takes a sequence of vacations, each for a random amount of time. At the end of each vacation, he inspects the length of the queue. If the queue length at this time is equal to or greater than a prespecified threshold value r, he begins to serve the queue until it is empty.y.

• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.95.1-95.17
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• 2018

Objective: Cervical cancer is one of the most common malignant tumors. Our previous results showed that long non-coding RNA (lncRNA) XLOC_006390 plays an important role in cervical cancer. In this study, we have explored the mechanism of action of lncRNA XLOC_006390. Methods: LncRNA XLOC_006390 was proposed to exercise its function as a competing endogenous RNA (ceRNA), and its potential targeted miRNAs was predicted through the database LncBase Predicted v.2. Two miRNAs, miR-331-3p, and miR-338-3p, were chosen for the study. Expression of miRNAs and lncRNA in cervical cancer cells and tissues was detected by reverse transcription polymerase chain reaction. To determine the correlation, silencing of XLOC_006390, over-expression of miR-331-3p, and miR-338-3p was performed in SiHa and Caski cell lines, respectively. Results: Based on the interactive effect between miRNA and lncRNA, miR-331-3p and miR-338-3p were significantly downregulated in cervical cancer cells and tissues, and their expression levels were negatively related to that of lncRNA. Our results also showed that the expression of miR-331-3p target gene NRP2, miR-338-3p target genes PKM2, EYA2 was significantly downregulated when the XLOC_006390 was knocked down. Further, XLOC_006390 was found to facilitate cervical cancer tumorigenesis and metastasis by downregulating miR-331-3p and miR-338-3p expression. Conclusion: Taken together, our study demonstrated that XLOC_006390 may serve as a ceRNA and reversely regulates the expression of miR-331-3p and miR-338-3p, thus facilitating cervical cancer tumorigenesis and metastasis.