• Title/Summary/Keyword: Quantitative methods

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Identification of ginseng root using quantitative X-ray microtomography

  • Ye, Linlin;Xue, Yanling;Wang, Yudan;Qi, Juncheng;Xiao, Tiqiao
    • Journal of Ginseng Research
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    • v.41 no.3
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    • pp.290-297
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    • 2017
  • Background: The use of X-ray phase-contrast microtomography for the investigation of Chinese medicinal materials is advantageous for its nondestructive, in situ, and three-dimensional quantitative imaging properties. Methods: The X-ray phase-contrast microtomography quantitative imaging method was used to investigate the microstructure of ginseng, and the phase-retrieval method is also employed to process the experimental data. Four different ginseng samples were collected and investigated; these were classified according to their species, production area, and sample growth pattern. Results: The quantitative internal characteristic microstructures of ginseng were extracted successfully. The size and position distributions of the calcium oxalate cluster crystals (COCCs), important secondary metabolites that accumulate in ginseng, are revealed by the three-dimensional quantitative imaging method. The volume and amount of the COCCs in different species of the ginseng are obtained by a quantitative analysis of the three-dimensional microstructures, which shows obvious difference among the four species of ginseng. Conclusion: This study is the first to provide evidence of the distribution characteristics of COCCs to identify four types of ginseng, with regard to species authentication and age identification, by X-ray phase-contrast microtomography quantitative imaging. This method is also expected to reveal important relationships between COCCs and the occurrence of the effective medicinal components of ginseng.

Analysis of software quantitative evaluation index using ISO/IEC 25023 (ISO/IEC 25023을 활용한 소프트웨어 정량적 평가지표 분석)

  • Kim, Suwook;Park, Yoohyun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.1
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    • pp.7-12
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    • 2019
  • Variety of companies which carry out R&D projects supported by government are proposing quantitative evaluation index business plans. However, Many companies have difficulties in aspects of selecting quantitative evaluation index and in some cases they have troubles to get results from selecting unsuitable evaluation index. First of all, both methods of gathering the data to be analyzed and the products which are tested by the accredited testing institutes classifying by industrial sectors are classified as the quantitative evaluation index selected by the company according to the eight quality characteristics of ISO/IEC 25023 Standard. Secondly, based on the results of the quantitative evaluation indexes classified into eight quality characteristics of the ISO/IEC 25023 standard, the tendency of the quality characteristics of the quantitative evaluation indexes selected mainly by the companies will be understandable. It is hopefully expected that this research will be helpful to select a quantitative evaluation index to evaluate the quality of software products.

A Case Study on the Correlation between the Quantitative and the Qualitative Evaluation of IT Investment Performance (IT 투자성과의 정량적 평가와 정성적 평가의 상관관계에 관한 연구)

  • Lee, Jae-B.;Hong, Yu-Jin;Chang, Yun-Hi
    • Information Systems Review
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    • v.9 no.2
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    • pp.149-168
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    • 2007
  • As the need for quantitative qualities of IT investment performance heightens, numerous research organizations are developing various measurement methods for the quantitative evaluation and its currency value conversion. Corporations utilizing these methods to evaluate IT investment performance are gradually increasing. However, working-level staff in the corporations that have introduced the quantitative evaluation can not assure if the evaluation sufficiently reflects the actual effect provided by IT since the results arising from the conversion of currency value can't be visibly confirmed. This study tries to identify whether the quantitative evaluation of IT investment performance can be explained in terms of the level of consumer satisfaction proven by the qualitative evaluation by analyzing the level of consumer satisfaction and quantitative evaluation of a case company and identifying the correlation between them. As the result of the case study, the following points have been concluded. Firstly, the currency value of IT effect correlates with the level of consumer satisfaction. Secondly, in order to come up with a rational currency value of IT effect, developing an indicator as well as managing data on currency conversion that will enable the internal system's efficiency to become more quantitative is essential. Thirdly, IT ROI is not appropriate to compare the performance between systems and is utilized as a measurement standard for each system's performance and efficiency. Lastly, quantitative evaluation is still inadequate in the evaluation of the system's strategic side, and consumer satisfaction can be utilized as a supplementary method.

Assessment of the Severity of Coronavirus Disease: Quantitative Computed Tomography Parameters versus Semiquantitative Visual Score

  • Xi Yin;Xiangde Min;Yan Nan;Zhaoyan Feng;Basen Li;Wei Cai;Xiaoqing Xi;Liang Wang
    • Korean Journal of Radiology
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    • v.21 no.8
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    • pp.998-1006
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    • 2020
  • Objective: To compare the accuracies of quantitative computed tomography (CT) parameters and semiquantitative visual score in evaluating clinical classification of severity of coronavirus disease (COVID-19). Materials and Methods: We retrospectively enrolled 187 patients with COVID-19 treated at Tongji Hospital of Tongji Medical College from February 15, 2020, to February 29, 2020. Demographic data, imaging characteristics, and clinical data were collected, and based on the clinical classification of severity, patients were divided into groups 1 (mild) and 2 (severe/critical). A semiquantitative visual score was used to estimate the lesion extent. A three-dimensional slicer was used to precisely quantify the volume and CT value of the lung and lesions. Correlation coefficients of the quantitative CT parameters, semiquantitative visual score, and clinical classification were calculated using Spearman's correlation. A receiver operating characteristic curve was used to compare the accuracies of quantitative and semi-quantitative methods. Results: There were 59 patients in group 1 and 128 patients in group 2. The mean age and sex distribution of the two groups were not significantly different. The lesions were primarily located in the subpleural area. Compared to group 1, group 2 had larger values for all volume-dependent parameters (p < 0.001). The percentage of lesions had the strongest correlation with disease severity with a correlation coefficient of 0.495. In comparison, the correlation coefficient of semiquantitative score was 0.349. To classify the severity of COVID-19, area under the curve of the percentage of lesions was the highest (0.807; 95% confidence interval, 0.744-0.861: p < 0.001) and that of the quantitative CT parameters was significantly higher than that of the semiquantitative visual score (p = 0.001). Conclusion: The classification accuracy of quantitative CT parameters was significantly superior to that of semiquantitative visual score in terms of evaluating the severity of COVID-19.

The Assessment on the Characteristics of Quantitative Image in Digora$\textregistered$ (Digora$\textregistered$에서 정량영상의 특성에 대한 평가)

  • Kim Jae-Duk
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.29 no.2
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    • pp.397-405
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    • 1999
  • Purpose: To clarify the usefulness and the limitation of Digora system/sup (R)/ by evaluating the physical characteristics as the quantitative image on Image Plate(Ip). Materials and Methods: Radiograms were taken by Heliodent MD(Siemens Co.. Germany) with the image plate for adult. Cu-step wedge as reference material. and three pieces of dry mandibular bone. Image analysis was performed by single color enhancement. density measurement with histogram. The relationship between the exposure conditions and the distribution of the pixel values of the image. the variation of pixel values of each step of Cu-step wedge at two different area and Cu-equivalent value of three pieces of dry mandibular bone measure by the conversion equation. Results: There was no linear relationship between the exposure condition and the average pixel value of the image. of which the distribution was not even. The pixel value differences between the center portion and the periphery were ranged from 60 to 70 in vertical plane and from 15 to 26 in horizontal plane. Two plot profile formed at two different areas of the Cu-step wedge were different. The measured Cu-equivalent values showed the discrepancy among the times of measurement. Conclusion: As above results. Image Plate(Ip) of Digora system/sup (R)/ showed the limitation as the quantitative image. The physical property of IP was expected to need to be compensated for the quantitative evaluation of the bone or others

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Benchmark Dose Modeling of In Vitro Genotoxicity Data: a Reanalysis

  • Guo, Xiaoqing;Mei, Nan
    • Toxicological Research
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    • v.34 no.4
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    • pp.303-310
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    • 2018
  • The methods of applied genetic toxicology are changing from qualitative hazard identification to quantitative risk assessment. Recently, quantitative analysis with point of departure (PoD) metrics and benchmark dose (BMD) modeling have been applied to in vitro genotoxicity data. Two software packages are commonly used for BMD analysis. In previous studies, we performed quantitative dose-response analysis by using the PROAST software to quantitatively evaluate the mutagenicity of four piperidine nitroxides with various substituent groups on the 4-position of the piperidine ring and six cigarette whole smoke solutions (WSSs) prepared by bubbling machine-generated whole smoke. In the present study, we reanalyzed the obtained genotoxicity data by using the EPA's BMD software (BMDS) to evaluate the inter-platform quantitative agreement of the estimates of genotoxic potency. We calculated the BMDs for 10%, 50%, and 100% (i.e., a two-fold increase), and 200% increases over the concurrent vehicle controls to achieve better discrimination of the dose-responses, along with their BMDLs (the lower 95% confidence interval of the BMD) and BMDUs (the upper 95% confidence interval of the BMD). The BMD values and rankings estimated in this study by using the EPA's BMDS were reasonably similar to those calculated in our previous studies by using PROAST. These results indicated that both software packages were suitable for dose-response analysis using the mouse lymphoma assay and that the BMD modeling results from these software packages produced comparable rank orders of the mutagenic potency.

Quantitative Analysis for the Quality Evaluation of Scutellariae Radix by HPLC/UVD

  • Jeong, Su-Yang;Moon, Dong-Cheul;Son, Kun-Ho;Son, Jong-Keun;Min, Byung-Sun;Woo, Mi-Hee
    • Natural Product Sciences
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    • v.17 no.4
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    • pp.321-327
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    • 2011
  • In this study, quantitative analysis was developed using HPLC/UVD for the quality evaluation of Scutellariae Radix. For quantitative analysis, six major bioactive compounds were assessed. The separation conditions employed for HPLC/UVD were optimized using Phenomenex $C_{18}$ column ($250{\times}4.6$ mm, 5 ${\mu}m$) with a gradient of solvent A (1% acetic acid of $H_2O$) and solvent B (acetonitrile : methanol : acetic acid = 70 : 30 : 1) as the mobile phase at a flow rate of 1.0 mL/min and a detection wavelength of 275 nm. These methods were fully validated with respect to linearity, accuracy, precision and recovery. The HPLC/UVD method was applied successfully to the quantification of six major compounds in the extract of Scutellariae Radix. The results indicate that the established HPLC/UVD method is suitable for the quantitative analysis and quality control of multicomponents in Scutellariae Radix.

Relationship between Clock-Drawing Performance and Neuropsychological Functions in Patients with Chronic Schizophrenia (만성 조현병 환자의 시계 그리기 검사 수행과 신경심리 기능 간의 관련성)

  • Kwon, Mee-Yun;Park, Min-Seok;Kim, Myung-Sun
    • Korean Journal of Schizophrenia Research
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    • v.23 no.1
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    • pp.15-28
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    • 2020
  • Objectives: This study investigated the relationship between clock-drawing test (CDT) performance and neuropsychological functions in patients with chronic schizophrenia. Methods: Thirty-one patients with schizophrenia and 30 healthy controls participated in this study. The CDT was administered in three conditions and analyzed using both quantitative and qualitative scoring systems. Comprehensive neuropsychological tests were administered. Results: The results of the quantitative analysis showed that the schizophrenia group performed significantly worse in all three conditions of the CDT compared with the control group. However, no significant differences were observed between the two groups, when the IQ and educational level were controlled. The qualitative analysis showed that the schizophrenia group exhibited significantly more errors in "graphic difficulty" compared with the control group. In addition, CDT quantitative scores were significantly correlated with visuospatial function, memory, attention and executive functions in patients with schizophrenia. Conversely, each qualitative error type was correlated with specific cognitive domains. Furthermore, "graphic difficulty" and "spatial/planning deficit" were identified as predictors of depression symptoms in patients with schizophrenia. Conclusion: The present study demonstrated that the CDT is useful for assessing cognitive dysfunctions in patients with schizophrenia, while qualitative analyses provide more specific information about cognitive deficits compared with quantitative analyses.

Estimating Information Security Risk-Using Fuzzy Number Compromising Quantitative and Qualitative Methods (정보 자산 보안 위험 추정-정량적, 정성적 방법을 절충한 퍼지 숫자의 활용)

  • Pak, Ro-Jin;Lee, Dong-Hoon
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.19 no.6
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    • pp.175-184
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    • 2009
  • There have been two methods of estimating computer related security risk such as qualitative and quantitative methods which have distinctive advantages or disadvantages. The former is too narrative and somehow abstract to implement and the latter produces concrete result but needs lots of data, so that it is needed to develop a method overcoming such difficulties. It is advised to mix such two methods in a proper way depending on the conditions of a computer system. In this article, a concept of fuzzy number is employed on the way of mixing the two methods and provide a simple example using fuzzy numbers. Simulation was conducted for an assumed model system and it is demonstrated how to calculated expected and unexpected risk.