• 전자공학회논문지
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• 제52권7호
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• pp.169-177
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• 2015

본 논문에서는 다층 의사결정을 위한 퍼지 포괄 평가 빙식을 제안하고 평가 시스템을 구축하였다. 제안한 방법은 퍼지 포괄평가 방법과 엔트로피 가중치를 이용하여 주요 평가 항목에 대해서 입찰 전에 평가하는 방식이다. 주요 평가 항목은 중요 스포츠 이벤트 조직위원들의 광범위한 조사에 의해 구성되었다. 본 논문에서는 낮은 단계에서 높은 단계로 순차적으로 단일 인자에 대한 평가와 퍼지 포괄 평가가 수행되었다. 제안한 방식의 유용성을 확인하기 위해서 후보도시의 평가를 위한 스포츠 이벤트 관리 서비스 플랫폼을 구축하였다. 이 방법은 정량적 결과와 전문가의 판단에 근거한 정성적 결과를 통합하여 출력한다.

• 한국노년학
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• 제36권3호
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• pp.827-846
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• 2016

본 연구는 개인적 생애 과정의 다기화에 따른 연령분절적 사유의 한계와 임금피크제에 대한 경영효율성 중심의 계량화 된 성과평가의 문제의식에 기초한다. 임금피크제의 적용을 받고 있는 노동자의 경험을 통해 임금피크제가 노동시장의 진출입이 연령에 의해 제한되지 않고 다양한 연령대의 노동자간 상호작용이 활발한 조직차원의 연령통합에 미치는 영향을 밝히고자 했다. 본 연구는 연구 주제에 대해 심층적으로 이야기해줄 수 있는 연구참여자 사례들을 선정하여 연구하는 질적사례 연구방법을 사용하였다. 본 연구는 특정한 이슈를 중심으로 복합적 사례들(stake 1995)을 해석학적으로 분석하는 본질적 사례 접근을 사용하였다. 연구결과, 이슈를 중심으로 찾은 의미들은 크게 3개의 하위 범주; '중고령 근로자의 고용연장과 직책해제로 인한 젊은 근로자들의 불편한 시선', '젊은 세대와 중고령 세대가 공생하기 힘든 고용현황으로 인한 중고령 근로자의 동전의 앞뒷면과 같은 처지', '의사소통과 공감대형성으로 세대 간 갈등을 해소하며 서로의 이점과 상생점 찾기'로 집합되었고 '임금피크제 시행으로 인한 중고령 근로자들의 고용변화가 빚은 세대 간의 갈등 은 서로의 의사소통과 공감노력을 통해 조직이 연령통합사회로 향하게 함.'라는 상위주제가 도출되었다.

• 동굴
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• 제34권35호
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• pp.32-42
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• 1993

The Paektu-san mountains are geographically situated in the Korea strait to the north of the main peninsula, coordinated between the longitudes of W(127$^{\circ}$15'~128$^{\circ}$00')and E(128$^{\circ}$15'~129$^{\circ}$00'), and between the latitudes of S(41$^{\circ}$15'~42$^{\circ}$00') and N(42$^{\circ}$10'~42$^{\circ}$40'). The volcanic group of the Paektu-san mountains can be devided into 2 main kinds of volcanos by the method investigation, The ashes are mainly made of tremolite, trachte, basalt and pumice, or, a little quartz, labradorite and volcanic glass. These sorts, ratios and forms of the rocks are respectively similar. The Haeven lake is surrounded by 19 peaks. The central volcanic cone is a secant cone in shape, with an altitude of the 1800m to 2749,2m (Chang-kun-bong), an average diameter of 10km, and a shape of an ellipse seen high from the plane. They say there were several eruptions in 1668, 1700 and 1702 A. D. The crystal structure of the rock sample collected at the cave of Mt. Paektu-san is monoclinic. The quantitative analysis of the rock samples in the cave is done by using XRF this time. The chemical compositions by XRF fundamamental parameter analysis is : SiO$_2$: 50.72Wt%, TiO = 2.422Wt%, $Al_2$O$_3$= 17.65Wt%, Fe$_2$O$_3$= 9.371Wt%, CaO = 8.711Wt%, MgO = 4.l19Wt%, MnO = 0.l15Wt%, $K_2$O = 1.369Wt%, Na$_2$O : 3.028Wt% and P$_2$O$_{5}$ = 0.365Wt%. The K-Ar age of the rock sample is also determined to be 0.16Ma. This paper describes some problems experienced in dating young volcanic rocks, and then discusses chemical compositions, X-ray fluorescence analyses and the age of the formation of a lava tunnel such as in Mt. Paektu-san.n.

• Genes and Genomics
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• 제40권12호
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• pp.1383-1388
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• 2018

The development of therapeutic bacteriophages will provide several benefits based on an understanding the basic physiological dynamics of phage and bacteria interactions for therapeutic use in light of the results of antibiotic abuse. However, studies on bacteriophage therapeutics against microbes are very limited, because of lack of phage stability and an incomplete understanding of the physiological intracellular mechanisms of phage. The major objective of this investigation was to provide opportunity for development of a novel therapeutic treatment to control respiratory diseases in swine. The cytokine array system was used to identify the secreted cytokines/chemokines after Bordetella bronchiseptica infection into swine nasal turbinate cells (PT-K75). We also performed the real-time quantitative PCR method to investigate the gene expression regulated by B. bronchiseptica infection or bacteriophage treatment. We found that B. bronchiseptica infection of PT-K75 induces secretion of many cytokines/chemokines to regulate airway inflammation. Of them, secretion and expression of IL-$1{\beta}$ and IL-6 are increased in a dose-dependent manner. Interestingly, membrane-bound mucin production via expression of the Muc1 gene is increased in B. bronchiseptica-infected PT-K75 cells. However, cytokine production and Muc1 gene expression are dramatically inhibited by treatment with a specific B. bronchiseptica bacteriophage (Bor-BRP-1). The regulation of cytokine profiles in B. bronchiseptica-induced inflammation by B. bronchiseptica bacteriophage is essential for avoiding inappropriate inflammatory responses. The ability of bacteriophages to downregulate the immune response by inhibiting bacterial infection emphasizes the possibility of bacteriophage-based therapies as a novel anti-inflammatory therapeutic strategy in swine respiratory tracts.

• Annals of Clinical Neurophysiology
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• 제21권2호
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• pp.87-93
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• 2019

Background: The standardized autonomic function test has become widely available. However, there are no reference data for this test for the Korean population. This study explored reference data for sudomotor and cardiovagal function tests for the Korean population. Methods: The sweat volume by quantitative sudomotor axon reflex test, heart-rate response to deep breathing (HRdb), expiration:inspiration (E:I) ratio, and Valsalva ratio (VR) were measured in 297 healthy Korean volunteers aged from 20 to 69 years. Multivariate regression analysis was performed to evaluate the effects of age, sex, and body mass index on these variables. The 2.5th, 5th, 10th, 90th, 95th, and 97.5th percentile values were obtained for each investigation. Results: The sweat volume was higher in males than in females. The HRdb and E:I ratio were negatively correlated with age, and were higher in males than in females. The VR was negatively correlated with age, but it was not correlated with sex. Conclusions: This study has provided data on the reference ranges for sudomotor and cardiovagal function tests in healthy Korean adults.

• 대한본초학회지
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• 제36권5호
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• pp.59-67
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• 2021

Objectives : Hibiscus (Hibiscus sabdariffa L.) is rich in antioxidants such as flavonoids and anthocyanins and is known to have anti-inflammatory activity and anti-aging function of the skin, but there is no study on its effect on the skin barrier. This study aim to investigate the positive effect on the skin barrier by confirming the effect of water extracts of Hibiscus sabdariffa L. (WEHS) on the tight junction-related gene expression. Methods : The antioxidant efficacy of WEHS was investigated through ABTS and DPPH assays, and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium was performed to examine the effect on cell viability. quantitative Reverse transcription polymerase chain reaction and immunoblot analysis were performed to confirm the effect of WEHS on the expression of tight junction-related genes, and immunofluorescence microscopy was used to confirm the movement of Claudin 1 protein into tight junctions. Results : WEHS showed strong antioxidant activity and induced an increase in both mRNA and protein expression levels of Claudin 1 among tight junction-related genes. The strong localization of Claudine 1 protein increased by WEHS to the tight junction was confirmed by immunofluorescence microscopy. Conclusions : Hibiscus was confirmed through this study to show antioxidant activity and the function of promoting the expression of the tight junction Claudin 1 gene, suggesting that Hibiscus can be used as a material for the prevention and treatment of skin moisturizing and atopy, which have an important influence on tight junction.

• Journal of Applied Biological Chemistry
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• 제63권4호
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• pp.407-412
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• 2020

Ulmus parvifolia 잎의 약리학적 지표 성분을 제시하기 위해 간단하고 신뢰할 수 있는 HPLC 분석방법을 개발하였다. 지표 성분들은 NMR 및 UPLC-QTof-MS 분석에 의해 neochlorogenic acid (trans-5-O-caffeoylquinic acid, 5-CQA)과 chlorogenic acid (trans-3-O-caffeoylquinic acid, 3-CQA)로 구조 동정 되었다. HPLC를 이용하여 두개 화합물을 포함한 잎 추출물의 정성/정량 분석 방법을 평가하였다. 잎 30% 에탄올 추출물과 지표 성분의 안정성 테스트는 6개월 동안 평가되었다. 그러나 안정성 조사 기간 동안 추출물과 지표 성분들 각각의 함량에 대한 유의한 변화는 관찰되지 않았다.

• 수산해양기술연구
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• 제57권2호
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• pp.149-161
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• 2021

The concern on the greenhouse gas emission is strongly increasing globally. In fishery industry section, the greenhouse gas emissions are an important issue according to The Paris Climate Change Accord in 2015. The Korean government has a plan to reduce the GHG emissions as 4.8% compared to the BAU in fisheries until 2020. Furthermore, the Korean government has also declared to achieve the carbon neutrality in 2050 at the Climate Adaptation Summit 2021. However, the investigation on the GHG emissions from Korean fisheries did not carry out extensively. Most studies on GHG emissions from Korean fishery have dealt with the GHG emissions by fishery classification so far. However, follow-up studies related to GHG emissions from fisheries need to evaluate the GHG emission level by species to prepare the adoption of environmental labels and declarations (ISO 14020). The purpose of this research is to investigate which degree of GHG emitted to produce the species (hairtail and small yellow croaker) from various fisheries. Here, we calculated the GHG emission to produce the species from the fisheries using the Life Cycle Assessment method. The system boundary and input parameters for each process level are defined for the LCA analysis. The fuel use coefficients of the fisheries for the species are also calculated according to the fuel type. The GHG emissions from sea activities by the fisheries will be dealt with. Furthermore, the GHG emissions for producing the unit weight species and annual production are calculated by fishery classification. The results will be helpful to understand the circumstances of GHG emissions from Korean fisheries.

• 동의생리병리학회지
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• 제34권4호
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• pp.191-200
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• 2020

The purpose of this pilot study was to examine the effect of tongue color change due to food ingestion on tongue diagnosis by both Korean Medicine doctors and digital tongue diagnosis system. In order to obtain objective and quantitative data, we used digital camera to collect the data. Prior to our investigation, we conducted a brief survey of 26 Korean Medicine doctors and found out that tongue diagnosis is frequently used and food-stained tongue could be commonly observed in clinics. Depending on their color, viscosity, and amount of intake, various foods caused stains with different colors and thicknesses. Also, duration and amount of food stain on tongue were different from person to person. Since coffee-stained tongue was the most frequently observed one in clinics according to the survey, we used coffee to evaluate the effect of food-stained tongue on tongue diagnosis. Korean Medicine doctors tended to interpret coffee-stained tongue as having yellow tongue coat but their judgement on tongue body color did not differ in spite of the coffee stains. Meanwhile, tongue diagnosis system algorithm tended to judge coffee-stained tongue as having normal but yellowish tongue coat and reddish tongue body. Altogether, food color on tongue can influence tongue diagnosis outcomes. Further research is needed in order to develop more efficient tongue diagnosis algorithm and digital medical service system.

• 산업경영시스템학회지
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• 제44권1호
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• pp.60-70
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• 2021

Recently, with the development of technologies for the fourth industrial revolution, convergence and complex technology are being applied to aircraft, electronic home appliances and mobile devices, and the number of parts used is increasing. Increasing the number of parts and the application of convergence technologies such as HW (hardware) and SW (software) are increasing the No Defect Found (NDF) phenomenon in which the defect is not reproduced or the cause of the defect cannot be identified in the subsequent investigation systems after the discovery of the defect in the product. The NDF phenomenon is a major problem when dealing with complex technical systems, and its consequences may be manifested in decreased safety and dependability and increased life cycle costs. Until now, NDF-related prior studies have been mainly focused on the NDF cost estimation, the cause and impact analysis of NDF in qualitative terms. And there have been no specific methodologies or examples of a working-level perspective to reduce NDF. The purpose of this study is to present a practical methodology for reducing NDF phenomena through data mining methods using quantitative data accumulated in the enterprise. In this study, we performed a cluster analysis using market defects and design-related variables of mobile devices. And then, by analyzing the characteristics of groups with high NDF ratios, we presented improvement directions in terms of design and after service policies. This is significant in solving NDF problems from a practical perspective in the company.