• Proceedings of the PSK Conference
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• 2003.10b
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• pp.213.1-213.1
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• 2003

Sphingolipids and their metabolites are highly bioactive molecules that affect various cellular functions including differentiation, cellular senescence, apoptosis, and proliferation when added exogenously, or elevated intracellularly by turnover of complex sphingolipids or synthesis from de novo pathway. We are investigating the relationship of sphingolipids cycle in apoptosis early events. A new column liquid chromatography- tandem mass spectrometry (LC/MS/MS) in combination with multiple reaction monitoring (MRM) method was developed for the rapid, simultaneous and quantitative determination of unambiguous detecting sphingolipids in cells. (omitted)

• Nonlinear Functional Analysis and Applications
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• v.26 no.4
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• pp.811-837
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• 2021

In this paper, we propose a new conjugate gradient method for solving unconstrained optimization models. By using exact and strong Wolfe line searches, the proposed method possesses the sufficient descent condition and global convergence properties. Numerical results show that the proposed method is efficient at small, medium, and large dimensions for the given test functions. In addition, the proposed method was applied to solve practical application problems in portfolio selection.

• Microbiology and Biotechnology Letters
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• v.50 no.2
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• pp.240-244
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• 2022

Precisely reliable and quantitative reporters can provide phenotypes that are consistent with research goals in protein expression. Here, we developed an improved reporter mATglu III 5 by directed evolution using a versatile β-glucosidase ATglu derived from Agrobacterium tumefaciens. When expressed in hosts, a vector containing this mutant distinctly showed a colored or fluorescent phenotype, according to the supplemented substrate, without any inducer. Analysis of mATglu III 5 showed it to be fully functional in fusion state with oligomeric proteins, especially under non-induction conditions, thereby offering an alternative to conventional reporters.

• Journal of Applied and Pure Mathematics
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• v.4 no.3_4
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• pp.185-209
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• 2022

Here we exhibit multivariate quantitative approximations of Banach space valued continuous multivariate functions on a box or ℝ^N, N ∈ ℕ, by the multivariate normalized, quasi-interpolation, Kantorovich type and quadrature type neural network operators. We treat also the case of approximation by iterated operators of the last four types. These approximations are achieved by establishing multidimensional Jackson type inequalities involving the multivariate modulus of continuity of the engaged function or its high order Fréchet derivatives. Our multivariate operators are defined by using a multidimensional density function induced by the generalized symmetrical sigmoid function. The approximations are point-wise and uniform. The related feed-forward neural network is with one hidden layer.

• Journal of Applied and Pure Mathematics
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• v.5 no.1_2
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• pp.69-93
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• 2023

Here we give multivariate quantitative approximations of Banach space valued continuous multivariate functions on a box or ℝ^N, N ∈ ℕ, by the multivariate normalized, quasi-interpolation, Kantorovich type and quadrature type neural network operators. We treat also the case of approximation by iterated operators of the last four types. These approximations are derived by establishing multidimensional Jackson type inequalities involving the multivariate modulus of continuity of the engaged function or its high order Fréchet derivatives. Our multivariate operators are defined by using a multidimensional density function induced by a parametrized Gudermannian sigmoid function. The approximations are pointwise and uniform. The related feed-forward neural network is with one hidden layer.

• Parasites, Hosts and Diseases
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• v.30 no.2
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• pp.141-146
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• 1992

A total of 197 fecal specimens was prepared for quantitative examination of helminth eggs by modified Kato's cellophane thick smear (M.C.T.S.) and Stoll's dilution egg counting technique (D.E,C.T.). The comparative effectiveness of two techniques was evaluated and conversion function was deduced. The average time required for the microscopic examination on one slide by M.C.T.S. was 12.6 minutes and that of D.E.C.T. was 14.6 minutes. M.C.T.S. showed lower false negative rate than D.E.C.T in light worm burden cases. Functions to convert the counts obtained by M.C.T.S. to E.P.G. by Stoll's dilution egg counting technique were $47.86{\times}10^{0.87{\;}logM.C.T.S.},{\;}$ in A. lumbricoides, $41.69{\times}10^{0.82{\;}logM.C.T.S.}$ in T. trichiura and $63.10{\times}10^{0.85{\;}logM.C.T.S.}$ in C. sinensis. It was suggested M.C.T.S. be better than D.E.C.T. for the quantitative examination of intestinal helminthiases such as A. lumbricoides, T. trichiura, and C. sinensis infections even in the cases with low worm burden.

• Journal of the Korea Institute of Building Construction
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• v.20 no.1
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• pp.83-91
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• 2020

The recent bridge construction projects is demanded more sophisticated risk management measures and loss forecasts to brace for risk losses from an increase in the trend of bridge construction. This study aims to analyze the risk factors that caused the loss of material in actual bridge construction and to develop a quantified predictive loss model, based on the past record of insurance payment by major domestic insurance companies for bridge construction projects. For the development of quantitative bridge construction loss model, the dependent variable was selected as the loss ratio, i.e., the ratio of insurance payout divided by the total project cost, while the independent variable adopted 1) Technical factors: superstructure type, foundation type, construction method, and bridge length 2) Natural hazards: typhoon and flood 3) Project information: construction period and total project cost. Among the selected independent variables, superstructure type, construction method, and project period were shown to affect the ratio of bridge construction losses. The results of this study can provide government agencies, bridge construction design and construction and insurance companies with the quantitative damage prediction and risk assessment services, using risk indicators and loss prediction functions derived from the findings of this study and can be used as a guideline for future basic bridge risk assessment development research.

• Journal of radiological science and technology
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• v.44 no.6
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• pp.645-653
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• 2021

With the recent development of precision medicine(Theranostics), interest and utilization of the quantitative function of SPECT/CT are increasing. This study aims to investigate the effect on the radioactivity concentration estimate by the increase or decrease in the total time of SPECT/CT imaging conditions. A standard image was obtained by the conditions of a total acquisition time of 600 sec(10 sec/f × 120 frames) by diluting ^99mTc 91.76 MBq in a cylindrical phantom filled with sterile water, and a comparative image was obtained by increasing the total acquisition time by -90%, -75%, -50%, -25%, +50%, +100%. The CNR, radioactive concentration estimate(cps/ml), and the variation rate(%) of the recovery coefficient(RC) were analyzed by measuring the overall coefficient of interest in each image. The results[CNR, Radiation Concentration, RC] by the change in the number of projections for each increase or decrease rate(-90%, -75%, -50%, -25%, +50%, +100%) of total acquisition time are as follows. [-89.5%, +3.90%, 1.04] at -90%, [-77.9%, +2.71%, 1.03] at -75%, [-55.6%, +1.85%, 1.02] at -50%, [-33.6%, +1.37%, 1.01] at -25%, [-33.7%, +0.71%, 1.01] at +50%, [+93.2%, +0.32%, 1.00] at +100%. and also The results[CNR, Radiation Concentration, RC] by the acquisition time change for each increase or decrease rate(-90%, -75%, -50%, -25%, +50%, +100%) of total acquisition time are as follows. [-89.3%, -3.55%, 0.96] at -90%, [-73.4%, -0.17%, 1.00] at -75%, [-49.6%, -0.34%, 1.00] at -50%, [-24.9%, 0.03%, 1.00] at -25%, [+49.3%, -0.04%, 1.00] at +50%, [+99.0%, +0.11%, 1.00] at +100%. Image quality(CNR) showed a pattern of change in proportion to the increase or decrease in the total acquisition time of SPECT/CT, but the result at quantitative evaluation showed a change of less than 5% in all experimental conditions, maintaining quantitative accuracy(RC less than 0.05) without much influence.

• Journal of the Korean Society for information Management
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• v.24 no.3
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• pp.219-244
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• 2007

Reference resources management tools can be divided into three types: Desktop-based, Web-based, and Web 2.0-based. This study is intended to compare and analyze the functions provided by the three types of tools and also to compare and evaluate their usability. Each Tools were chosen to represent each type. For comparison and analysis of the functions provided by the three types of tools, we divided the process of using reference resources management tools into four steps and then compared and analyzed sub items in each step. Satisfaction, understandability, conformance and efficiency that items for comparison and evaluation of the usability were compared using both quantitative and qualitative approaches. We surveyed the participants to collect data for quantitative research; and interviewed them and analyzed the results for qualitative research. Here are the results from evaluating the usability of Tool A(Desktop-based), B(Web-based), C(Web 2.0 based). First, Tool B had the highest mean user satisfaction, followed by Tool A and Tool C. Secondly, Tool B had the lead in understandability, followed by Tool A and Tool C. Thirdly, Tool A had the highest mean conformance, followed by Tool B and Tool C. Fourth, Tool B had the highest mean efficiency, followed by Tool A and Tool C.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.41
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• pp.6.1-6.10
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• 2019

Background: Osteomyelitis is an intraosseous inflammatory disease characterized by progressive inflammatory osteoclasia and ossification. The use of quantitative analysis to assist interpretation of osteomyelitis is increasingly being considered. The objective of this study was to perform early diagnosis of osteomyelitis on digital panoramic radiographs using basic functions provided by picture archiving and communication system (PACS), a program used to show radiographic images. Methods: This study targeted a total of 95 patients whose symptoms were confirmed as osteomyelitis under clinical, radiologic, pathological diagnosis over 11 years from 2008 to 2017. Five categorized patients were osteoradionecrosis, bisphosphonate-related osteonecrosis of jaw (BRONJ, suppurative and sclerosing type), and bacterial osteomyelitis (suppurative and sclerosing type), and the control group was 117 randomly sampled. The photographic density in a certain area of the digital panoramic radiograph was determined and compared using the "measure area rectangle," one of the basic PACS functions in INFINITT PACS^® (INFINITT Healthcare, Seoul, South Korea). A conditional inference tree, one type of decision making tree, was generated with the program R for statistical analysis with SPSS^®. Results: In the conditional inference tree generated from the obtained data, cases where the difference in average value exceeded 54.49 and the difference in minimum value was less than 54.49 and greater than 12.81 and the difference in minimum value exceeded 39 were considered suspicious of osteomyelitis. From these results, the disease could be correctly classified with a probability of 88.1%. There was no difference in photographic density value of BRONJ and bacterial osteomyelitis; therefore, it was not possible to classify BRONJ and bacterial osteomyelitis by quantitative analysis of panoramic radiographs based on existing research. Conclusions: This study demonstrates that it is feasible to measure photographic density using a basic function in PACS and apply the data to assist in the diagnosis of osteomyelitis.