• Mass Spectrometry Letters
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• v.2 no.3
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• pp.69-72
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• 2011

Defective synthesis of the steroid hormones by the adrenal cortex has profound effects on human development and homeostasis. Due to the time-consuming chromatography procedure combined with mass spectrometry, the matrix-assisted laser desorption ionization method coupled to the linear ion-trap tandem mass spectrometry (MALDI-LTQ-MS/MS) was developed for quantitative analysis of 10 adrenal steroids in human serum. Although MALDI-MS can be introduced for its applicability as a high-throughput screening method, it has a limitation on reproducibility within and between samples, which renders poor reproducibility for quantification. For quantitative MALDI-MS/MS analysis, the stable-isotope labeled internal standards were used and the conditions of crystallization were tested. The precision and accuracy were 3.1~35.5% and 83.8~138.5%, respectively, when a mixture of 10 mg/mL ${\alpha}$-cyano-4-hydroxycinnamic acid in 0.2% TFA of 70% acetonitrile was used as the MALDI matrix. The limit of quantification ranged from 5 to 340 ng/mL, and the linearity as a correlation coefficient was higher than 0.988 for all analytes in the calibration range. Clinical applications include quantitative analyses of patients with congenital adrenal hyperplasia. The devised MALDI-MS/MS technique could be successfully applied to diagnosis of clinical samples.

• Journal of Sensor Science and Technology
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• v.21 no.5
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• pp.319-323
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• 2012

In this paper, we present the possibility of quantification analysis for $A{\beta}$ captured by micro beads using Near-filed detection. In order to evaluate detection efficiency, detected signals were compared with different sizes of micro beads and a varied number of micro beads. Also, $A{\beta}$ deposits and $A{\beta}$ binding to micro beads were measured, therefore, we observed the $A{\beta}$ deposit and light scattering around the surface of micro beads induced by attached $A{\beta}$. This method can be used for quantitative analysis for not only the number of $A{\beta}$, but also the binding ratio of $A{\beta}$ to micro beads.

• Journal of Korean Institute of Industrial Engineers
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• v.39 no.3
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• pp.212-221
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• 2013

As the convergence among technologies is reorganizing industry sectors, it is quite important to evaluate the probability of technological convergence, and to analyze how the technologies in a certain industry sector affect the same or other industry sectors. As a result, the large number of studies have been focused on the industry convergence. However, most of them have dealt mainly with case studies or strategy and policies and few efforts have been made to study it using quantitative data. The investigation of industry convergence using quantitative data will help understand the characteristics of industry and forecast the future of the industry from an objective point of view. Therefore, this research proposes a methodology to evaluate the possibilities of industry convergence using patent data. In particular, we emphasize the possibilities of technology convergence and suggest a technology relationship matrix to evaluate the technology convergence, as an antecedent of industry convergence. The feasibility and utility of the suggested methodology was verified with a case study on the convergence of IT and BT. The research results are expected to provide a useful guideline for developing a measure of convergence.

• Convergence Security Journal
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• v.18 no.1
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• pp.103-110
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• 2018

Modern society is increasingly demanding in many areas of big data processing technology to collect, aggregate, and analyze large amounts of data over the Internet and SNS. A typical application is to evaluate the reputation of a company or college. To measure and quantify a reputation, fair and precise data and efficient data processing are very important. For this purpose, a quantitative quotient was obtained using public data, a qualitative quotient was obtained through sentiment analysis using news articles, and a complex college reputation quotient was calculated. In this paper, a complex college reputation quotient was calculated based on the quantitative index, reflecting the sentimental reputation, and based on the proposed mixed university system. In this paper, the Complex College Reputation System(CCRS) was proposed, which produced the Complex College Reputation Quotient with an objective quantitative quotient and qualitative quotient reflecting the sentimental reputation to measure the college reputation.

• Proceedings of the Korean Vacuum Society Conference
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• 2009.02a
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• pp.226.2-226.2
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• 2009

• Journal of the Korean Society of Safety
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• v.32 no.5
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• pp.88-95
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• 2017

As the safety fields are expanding to a variety of industrial fields, safety technology has been developed by convergence between industrial safety fields such as mechanics, ergonomics, electronics, chemistry, construction, and information science. As the technology convergence is facilitating recently advanced safety technology, it is important to explore the trends of safety technology for understanding which industrial technologies have been integrated thus far. For studying the trends of technology, the patent is considered one of the useful sources that has provided the ample information of new technology. The patent has been also used to identify the patterns of technology convergence through various quantitative methods. In this respect, this study aims to identify the convergence patterns and fields of safety technology using association rule mining(ARM)-based patent co-classification(co-class) analysis. The patent co-class data is especially useful for constructing convergence network between technological fields. Through linkages between technological fields, the core and hub classes of convergence network are explored to provide insight into the fields of safety technology. As the representative method for analyzing patent co-class network, the ARM is used to find the likelihood of co-occurrence of patent classes and the ARM network is presented to visualize the convergence network of safety technology. As a result, we find three major convergence fields of safety technology: working safety, medical safety, and vehicle safety.

• The Journal of Korean Physical Therapy
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• v.25 no.5
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• pp.260-265
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• 2013

Purpose: This study was conducted in order to evaluate the quantitative effectiveness of region of interest (ROI) setting in MR-DTI analysis with and without fMRI activation results. Methods: Ten right-handed normal volunteers participated in this study. DTI and fMRI datasets for each subject were obtained using a 1.5T MRI system. For neural fiber tracking, ROIs were drawn using two methods: The drawing points were located in the fMRI activation areas or areas randomly selected by users. In this study, the neural fiber tract targeted the corticospinal tract (CST) Quantitative analyses were performed and compared. The pixel numbers passing through the fiber tract in the individual brain volume were counted. The ratios between the ROI pixel numbers and the extracted fiber pixel numbers, and the ratios between the fiber pixel numbers and the whole-brain pixel numbers were also calculated. Results: According to our results, extracted CST fiber tract in which the ROI was drawn with fMRI activation areas showed higher distribution than drawing the ROI by users' hands. In addition, the quantitatively measured values represented higher pixel distribution: The counted average pixel numbers were 4553.8 and 1943.3. The average ratios of the ROI areas were 33.87 and 22.52. The average percentages of the individual whole-brain volume numbers were 2.06 and 0.87. Conclusion: Results of this study appear to indicate that use of this method can allow for more objectives and significant for study of the recovery of neural fiber mechanisms and brain rehabilitation.

• Korean Journal of Social Welfare
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• v.59 no.4
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• pp.5-34
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• 2007

This study explores the effects of philanthropy education for elementary school students by using a mixed method. To examine the effects of philanthropy education, two different approaches in research methods are conducted with different data collected from different target groups on the same phenomenon: a) experimental designs to analyze students' change(prosocial behaviors) by philanthropy education program performed in a summer camp(43 participants) and elementary schools(162 students); and b) qualitative analysis on students' changes in perceptual, attitudinal, and behavioral aspects by students' diary and memorandum(66 participants) and intensive interviews with teachers(5 teachers) and parents(4 mothers). The analysis of both quantitative and qualitative results shows that philanthropy education has effects on students' changes in diverse aspects including prosocial behavior. First, the results of quantitative analysis show that in every component of the prosocial behavior such as helping, being kind, empathizing, sharing, protecting, and cooperating, students have positive changes after philanthropy education. Such changes are statistically significant as well. Second, the results of qualitative analysis show that students after having philanthropy education display positive changes in diverse aspects. Particularly, the quantitative results are converged with the qualitative results from students, parents, and teachers. On the other hand, unique finding from qualitative analysis is that students after having philanthropy education can have fundamental changes in their personality. Such a change is commonly confirmed by students, parents, and teachers. This study makes it possible to compare results or to validate, confirm, or corroborate quantitative results with qualitative findings on the effects of philanthropy education for students.

• Genomics & Informatics
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• v.21 no.2
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• pp.24.1-24.7
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• 2023

Assays of clinical diagnosis and species identification using molecular markers are performed according to a quantitative method in consideration of sensitivity, cost, speed, convenience, and specificity. However, typical polymerase chain reaction (PCR) assay is difficult to quantify and have various limitations. In addition, to perform quantitative analysis with the quantitative real-time PCR (qRT-PCR) equipment, a standard curve or normalization using reference genes is essential. Within the last a decade, previous studies have reported that the digital PCR (dPCR) assay, a third-generation PCR, can be applied in various fields by overcoming the shortcomings of typical PCR and qRT-PCR assays. We selected Stilla Naica System (Stilla Technologies), Droplet Digital PCR Technology (Bio-Rad), and Lab on an Array Digital Real-Time PCR analyzer system (OPTOLANE) for comparative analysis among the various droplet digital PCR platforms currently in use commercially. Our previous study discovered a molecular marker that can distinguish Hanwoo species (Korean native cattle) using Hanwoo-specific genomic structural variation. Here, we report the pros and cons of the operation of each dPCR platform from various perspectives using this species identification marker. In conclusion, we hope that this study will help researchers to select suitable dPCR platforms according to their purpose and resources.

• Journal of the Korean Institute of Gas
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• v.21 no.1
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• pp.43-51
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• 2017

Recently, ammonia leak occurred frequently in the domestic refrigeration manufacturing facilities. Ammonia caused great damage to the environment and human health in the event of an accident as combustible gases and toxic gases. After considering the types of ammonia accidents of domestic refrigeration manufacturing facilities and selected accident scenarios and to analyze the risk analysis through Impact range estimates and frequency analysis and there was a need to establish measures to minimize accident damage. In this study, depending on the method of analysis quantitative risk assessment we analyzed the risk of the receiver tank of ammonia system. Scenario analysis conditions were set according to the 'Technical guidelines for the selection of accident scenario' under the chemicals control act and 'Guidelines for chemical process quantitative risk analysis' of center for chemical process safety. The risk estimates were utilized for consequence analysis and frequency analysis by SAFETI program of DNV, event tree analysis methodology and part count methodology. The individual risk of ammonia system was derived as 7.71E-04 / yr, social risk were derived as 1.17E-03 / yr. The derived risk was confirmed to apply as low as reasonably practicable of the national fire protection association and through risk calculation, it can be used as a way to minimize accidents ammonia leakage accident damage.