• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3829-3833
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• 2016

Inhibition of cancer-associated fibroblasts (CAFs) may improve the efficacy of cancer therapy. Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (p<0.001) without inhibiting the growth of normal fibroblasts (NAFs). Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs. 3-methyl-adenine(3-MA) is an autophagy inhibitor. 3-MA was added to prostate-CAFs with polysaccharide from polygonatum to determine whether autophagy plays an important role in the restrained effect. Finally, polysaccharide from polygonatum treatment significantly increased the activation of Beclin-1 and LC3, key autophagy proteins. Polysaccharide from polygonatum stimulates autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate-CAFs.

• BMB Reports
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• 제36권4호
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• pp.379-386
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• 2003

A mutant herpes simplex virus 1, mtHSV, was constructed by inserting the E. coli beta-galactosidase gene into the loci of icp34.5, the apoptosis-inhibiting gene of HSV. The mtHSV replicated in and lysed U251 (human glioma cells), EJ (human bladder cells), and S-180 (mice sarcoma cells), but not Wish (human amnion cells) cells. With its intact tk (thymidine kinase) gene, mtHSV exhibited susceptibility to acyclovir (ACV), which provided an approach to control viral replication. An in vivo test with mtHSV was conducted in immune-competent mice bearing sarcoma S-180 tumors, which were treated with a single intratumoral injection of mtHSV or PBS. Tumor dimensions then were measured at serial time points, and the tumor volumes were calculated. Sarcoma growth was significantly inhibited with prolonged time and reduced tumor volume. There was microscopic evidence of necrosis of tumors in treated mice, whereas no damage was found in other organs. Immunohistochemical staining revealed that virus replication was exclusively confined to the treated tumor cells. HSV-1 DNA was detected in tumors, but not in the other organs by a polymerase chain reaction analysis. From these experiments, we concluded that mtHSV should be a safe and promising oncolytic agent for cancer treatment.

• 동의신경정신과학회지
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• 제20권2호
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• pp.217-227
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• 2009

Objectives : Multiple sclerosis (MS) is a demyelination disease of central nervous system, presenting a various neurological disorders depending on the lesion. In the view of oriental medicine, MS is similar to Flaccidity-syndrome(痿證). Also, since MS is a chronic disease which repeats the recurrences with periods of remission of the symptoms in between, it may usually be accompanied by depression. However, the etiology, treatment, and cause of recurrence of MS remain unknown, and also, as the recurrences of MS have been repeated, disease burden has been accumulated, which aggravates disorder. This case of MS experienced depression after the patient had been diagnosed as bad consequence based on the past 5 times recurrences of multiple sclerosis. Methods : We saw the causes as vicera and bowels functional disorder which might have come from a poor diet. Thus, we diagnosed this case as dual deficiency of spleen and kidney(脾腎兩虛), stagnant qi transforming into fire(氣鬱化火) and liver-kidney deficiency(肝腎不足) and treated it with Herb medication, acupuncture therapy, and supportive therapy, making the patient better. Results : We have improved the patient's condition to the time before 5th recurrence. Conclusions : This result suggests that our oriental medical treatments was effective on multiple sclerosis with depression.

• 동의신경정신과학회지
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• 제21권3호
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• pp.151-161
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• 2010

Objectives : Postpartum depression is a kind of serious problem which influences on the parturients, her family. In this case we tried psychotherapy to postpartum depression patient. Methods : We treated the patient with Oriental psychotherapy. And then we compared postpartum depression before treatment with on after treatment by Korean version of Edinburgh Postnatal Depression Scale(K-EPDS). Results : After treatments, the clinical symptoms were improved and K-EPDS was reduced 16 to 6. Conclusions : Oriental psychotherapy is effective on postpartum depression.

• 대한한의학회지
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• 제17권1호
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• pp.84-110
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• 1996

Meridian collateral and meridian points have been the base of acupuncture and moxibustion therapy. Also the theory have composed the main portion of Oriental Medicine. But the mechanism and scientific background has not been completely eatablished, and the research on the objectification of diagnosis of meridian collateral and meridian points, and acupuncture & moxibustion therapy has been necessary nowadays. A new understanding of value of Oriental Medicine has been increasing, the scientific understanding of meridian collateral and meridian points should have been examined. The system of meridian collateral and meridian points was very interesting topics between the scientists in the world. Especially, the elucidation of function and mechanism of Qi(氣) was very important in the scientific theme of 21th century. But there has been many difficulties in the study of meridian collateral and meridian points, since the system of meridian collateral and meridian points has the complexed function and vague structure in the organism. As the one of index of meridian points, the electric current has been used. In this report, the volume of electric current on the skin around the meridian points was investigated. The results of investigation showed the meridian points have higher electric current volume than non-meridian points.

• 동의신경정신과학회지
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• 제34권4호
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• pp.421-431
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• 2023

Objectives: The purpose of this study was to report the effect of complex Korean medicine treatments on Essential Tremor Plus (ET plus) patient aggravated by a traffic accident. Methods: We treated an ET plus patient with complex Korean medicine. The patient's resting tremor and kinetic tremor in both hands intensified after experiencing a traffic accident, with tremor in the left hand being worse than that in the right hand. Effect of complex Korean medicine treatment was evaluated using Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS), Numerical Rating Scale (NRS), and Beck Anxiety Inventory (BAI). Results: After 26 weeks of treatments (acupuncture, pharmacupuncture, cupping, Iigyeungbyunqi-therapy, and herbal medicine), the FTMTRS decreased from 38 to 15. NRS of Lt. upper limb pain decreased from NRS 9 to 0. BAI score also decreased from 31 to 17. Conclusions: Complex Korean medicine could be used to treat patients with ET plus aggravated by a traffic accident.

• 동의신경정신과학회지
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• 제34권4호
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• pp.453-461
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• 2023

Objectives: Major depressive disorder is a severe disease that is associated with suicidal ideation and behavior. In this case, Korean medicine psychotherapy and Korean medicine treatment were used to treat an adolescent patient with major depressive disorder. Methods: The Beck Depression Inventory, Reynolds Suicidal Ideation Questionnaire, and Crisis Triage Rating Scale were used as psychological evaluation scales. Korean medicine psychotherapy focuses on Giungoroen-therapy and IiGyeungByunQi-therapy and Korean medicine treatment combined with acupuncture, moxa, and herbal medicine. Results: Comparison before and after treatment showed improvement in clinical symptoms, Beck Depression Inventory, Reynolds Suicidal Ideation Questionnaire, and Crisis Triage Rating Scale. Conclusions: As a result of applying Korean medicine, psychotherapy and Korean medicine treatment reduces to an adolescent patient with major depressive disorder, depression, suicidal thoughts, and suicidal behavior.

• 대한한의학회지
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• 제29권3호
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• pp.161-168
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• 2008

We report the case of an 18-year-old woman with a 6-year history of widespread facial plane warts that had proved resistant to repeated treatments with laser therapy and imiquimod cream. The patient had recurrent lesions, which subsequently resolved with treatment. We diagnosed the case as heat and blood stasis and qi deficiency damp stagnation. Treatment with herb medication and herbal external wet dressing was initiated. During the 4-month treatment period, the warts resolved gradually. At 4 months follow up, there were no recurrent lesions and no other adverse effects.

• 동의생리병리학회지
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• 제24권6호
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• pp.1105-1110
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• 2010

The purpose of this case study is to report the effect of oriental medical treatment on chronic tension-type headache. Despite the patient was treated by cervical nerve block for headache, headache was not improved. We diagnosed chronic tension-type headache according to ICHD-II(The International Classification of Headache Disorders) and Qi deficiency, dampness and phlegm by oriental differential diagnosis of symptom and signs. We applied herbal medicine, acupuncture, moxibustion and cupping therapy for hospitalization(7 days). Oriental medical treatment may have effective results in treating chronic tension-type headache that was not improved by cervical nerve block treatment. But this is a single case study, so further case-series research should be compiled.

• 대한중풍순환신경학회지
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• 제10권1호
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• pp.74-80
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• 2009

Myocardial bridging, a congenital coronary anomaly, is present when a segment of a major epicardial coronary artery, runs intramurally through the myocardium. So with each systole, the coronary artery is compressed. It has been associated with angina, arrhythmia, myocardial infarction and sudden cardiac death. This is a case of a 39-year-old woman who was diagnosed myocardial bridge. She complained of recurrent chest pain, palpitation. We diagnosed her as Gyesimtong(JiXiTong, 悸心痛), and prescribed Jeongkicheonhyang-tang(正氣天香湯). After treatment, all of the symptoms had improved and have not recurred for 18 months. This case suggests that oriental medicine therapy can be applicable to improve in symptoms of myocardial bridge.