Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Polysaccharide from Polygonatum Inhibits the Proliferation of Prostate Cancer-Associated Fibroblasts Cells

  • Han, Shu-Yu (Institute of Biophysics, Chinese Academy of Sciences) ;
  • Hu, Ming-Hua (Infinitus Chinese Herbal Immunity Research Centre) ;
  • Qi, Guan-Yun (Institute of Biophysics, Chinese Academy of Sciences) ;
  • Ma, Chao-Xiong (Institute of Biophysics, Chinese Academy of Sciences) ;
  • Wang, Yuan-Yuan (Infinitus Chinese Herbal Immunity Research Centre) ;
  • Ma, Fang-Li (Infinitus Chinese Herbal Immunity Research Centre) ;
  • Tao, Ning (Institute of Biophysics, Chinese Academy of Sciences) ;
  • Qin, Zhi-Hai (Institute of Biophysics, Chinese Academy of Sciences)
  • Published : 2016.08.01
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Abstract

Inhibition of cancer-associated fibroblasts (CAFs) may improve the efficacy of cancer therapy. Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (p<0.001) without inhibiting the growth of normal fibroblasts (NAFs). Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs. 3-methyl-adenine(3-MA) is an autophagy inhibitor. 3-MA was added to prostate-CAFs with polysaccharide from polygonatum to determine whether autophagy plays an important role in the restrained effect. Finally, polysaccharide from polygonatum treatment significantly increased the activation of Beclin-1 and LC3, key autophagy proteins. Polysaccharide from polygonatum stimulates autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate-CAFs.

Keywords

Acknowledgement

Supported by : Nankai University

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