• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2000년도 추계학술대회 논문집
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• pp.91-97
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• 2000

The conventional model did not take momentum conservation into consideration when the electron absorbs and emits the photons. II-ray provides momentum conservations on any directions of the entering photons, and also the electrons have radial momentum conservations and fully elastic bouncing between two atoms, in the new atom model. Conventional atom model must be criticized on the following four points. (1) Natural motions between positive and negative entities are not circular motions but linear going and returning ones, for examples sexual motion, tidal motion, day and night etc. Because the radius of hydrogen atom's electron orbit is the order of 10$^{-11}$ m and the radia of the nucleons in the nucleus are the order of 10$^{-l4}$m and then the converging n-gamma rays to the nucleus have so great circular momentum, the electron can not have a circular motion. We can say without doubt that any elementary mass particle can have only linear motion because of the n-rays' hindrances, near the nucleus. (2) Potential energy generation was neglected when electron changes its orbit from outer one to inner one. The h v is the kinetic energy of the photo-electron. The total energy difference between orbits comprises kinetic and potential energies. (3) The structure of the space must be taken into consideration because the properties of the electron do not change during the transition from outer orbit to inner one even though it produces photon. (4) Total energy conservation law applies to the energy flow between mind and matter because we daily experiences a interconnection between mind and body. An understanding of the mechanisms responsible for the control of normal proliferation and differentiation of the various cell types which make up the human body will undoubtedly allow a greater insight into the abnormal growth of cells, A large body of biochemical evidence was eventually used to generate a receptor model with an external ligand binding domain linked through a single trans-membrane domain to the cytoplasmic tyrosine kinase and autophosphory-lation domains. The ligand induced conformational change in the external domain generates either a push-pull or rotational signal which is transduced from the outside to the inside of cell.l.ell.

• 수산해양기술연구
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• 제39권2호
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• pp.158-163
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• 2003

Thermosetting matrix composites have disadvantages in terms of moulding time, repairability and manufacturing cost. Thus the high-performance thermoplastic composites to eliminate such disadvantages have been developed so far. As a result of environmental and economical concerns, there is a growing interest in the use of thermoplastic composites. However, since their mechanical properties are very sensitive to the environment such as moisture, temperature etc., those behaviors need to be studied. Particularly the temperature is a very important factor influencing the mechanical behavior of thermoplastic composites. The effect of temperature have not yet been fully quantified. Since engineering applications of reinforced composites necessitate their fracture mechanic characterization, work is in progress to investigate the fracture and related failure behavior. An approach which predicts the tensile strength was perpormed in the tensile test. The main goal of this work is to study the effect of temperature on the result of tensile test with respect to GF/PE composite. The tensile strength and failure mechanisms of GF/PE composites were investigated in the temperature range 6$0^{\circ}C$ to -5$0^{\circ}C$. The tensile strength increased as the fiber volume fraction ratio increased. The tensile strength showed the maximum at -5$0^{\circ}C$, and it tended to decrease as the temperature increased from -5$0^{\circ}C$. The major failure mechanism was classified into the fiber matrix debonding, the fiber pull-out, the delamination and the matrix deformation.

• 한국지반공학회논문집
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• 제27권12호
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• pp.39-52
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• 2011

본 연구에서는 유한요소해석 및 전단강도 감소기법을 적용하여 가압식 그라우팅 쏘일네일로 보강된 사면의 시공 단계를 고려한 사면안정 해석을 수행하였으며 무보강 자연사면 및 중력식 그라우팅 쏘일네일로 보강된 사면의 안전율과 비교함으로써 가압식 그라우팅 쏘일네일의 사면 보강효과를 분석하였다. 그 결과, 가압식 그라우팅 쏘일네일로 보강된 사면의 안전율이 중력식 그라우팅 쏘일네일로 보강된 사면에 비해 50% 이상 크게 나타났으며, 쏘일네일의 길이가 증가할수록 가압에 따른 보강효과가 우수한 것으로 나타났다. 또한 가압에 의해 사면 활동파괴영역이 확대됨에 따라 사면 전단저항 능력이 증가하는 것을 확인하였으며, 쏘일네일의 인발저항력이 사면보강에 가장 큰 영형을 미치는 것을 알 수 있었다.

• Journal of Acupuncture Research
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• 제37권1호
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• pp.42-48
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• 2020

Background: Atopic dermatitis (AD) is a chronic inflammatory condition which can be studied using phthalic anhydride (PA) to induce AD. Anti-inflammatory properties of bee venom (BV) wereinvestigated to determine whether it may be a useful treatment for AD. Methods: AD was induced by applying to pical PA to 8-week-old HR-1 mice (N = 50), then treating with (0.1, 0.25, and 0.5 ㎍) or without topical BV. Body weight, ear thickness histology, enzyme-linked immune sorbent assay (serum IgE concentrations), Western blot analysis [inducible nitric oxide synthase, cyclooxygenase-2, IκB-α, phospho-IκB-α, c-Jun N-terminal kinase (JNK), phospho-JNK, p38, phospho-p38, extra cellular signal-regulated kinase (ERK), and phospho-ERK], and the pull down assay for immunoblotting (p50), were used to measure inflammatory mediators. Results: PA + BV (0.1, 0.25, and 0.5 ㎍) significantly decreased ear thickness without altering body weight. IgE concentrations decreased in the PA + BV (0.5 ㎍)-treated groups compared with PAtreatment. Tumor necrosis factor-α, interleukin-1β, inducible nitric oxide synthase, cyclooxygenase-2, phospho-IκB-α, phospho-JNK, p38, phospho-p38, and phospho-ERK, all decreased following treatment with PA + BV compared with the PA-treatment alone. p50 was upregulated in the PA + BV-treated groups compared with the PA-treated group. Furthermore, the number of mast cells decreased in the PA + BV-treated groups compared with the PA-treated group. Epidermal thickness was significantly lower in the PA + BV-treated group compared with PA treatment alone. Conclusion: BV maybe a useful anti-inflammatory treatment for AD.

• 전기전자학회논문지
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• 제24권1호
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• pp.260-268
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• 2020

본 논문에서는 스위칭 시 발생하는 턴-온 및 턴-오프 손실을 줄일 수 있는 LS-ZVS-LSTC를 이용한 D급 SEPP형 고주파 공진 인버터에 대해서 나타내고 있다. 본 논문에서 제안한 LS-ZVS-LSTC를 이용한 고주파 공진 회로의 해석은 무차원화 파라메타를 도입하여 범용성 있게 기술하였다. 또한 제안 인버터의 운전 특성은 무파원화 제어 주파수(μ), 무차원화 부하시정수(τ), 결합계수(κ) 등의 제어 파라메타를 이용하여 특성 평가를 수행하였다. 특성 평가를 통한 특성치를 토대로 1.8[kW] D급 SEPP형 LS-ZVS-LSTC 고주파 인버터 설계 기법의 일예를 제시하였으며, 이론 해석의 정당성은 실험을 통해 입증하였다.

• 서비스연구
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• 제9권1호
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• pp.73-86
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• 2019

본 연구는 제4차 산업혁명과 기술 상용화에 대해 논의하고, 기술 상용화에 영향을 미치는 성공 요인을 문헌 연구를 통하여 도출하여, 제4차 산업혁명을 주도하는 산업계 경영진에게 설문을 통하여 이들 요인을 실증적으로 검증하였다. 문헌연구 결과 기술 상용화에 영향을 미치는 11가지 성공 요인은'대화와 소통','경영층 지원','경영에 대한 이해','기술 상용화의 이해','관련자간의 협력','기술 상용화 장려책','공동목표 인식','정부 지원','기술 상용화 경험', '기술의 구체성','수요자 요청 기술'이었다. 404부의 설문지를 제4차 산업혁명 업계에 속하는 기업의 CEO와 CIO에게 발송하였고, 최종 응답률은 64.4%(260부)로서 상당히 높은 참여율을 보였다. 응답자들은 제4차 산업혁명의 기술 상용화에 가장 중요한 요인으로'관련자간의 협력'을 꼽았고, 뒤이어'경영층 지원','대화와 소통','공동 목표 인식','기술 상용화에 대한 이해'순으로 평가하였다. 기업이 제4차 산업혁명의 기술 상용화 프로젝트의 성공 가능성을 제고하기 위해서는, 본 연구에서 높은 평가를 받은 성공 요인들에 높은 관심을 가지고 사업을 추진하여야 할 것이다.

• Journal of Gastric Cancer
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• 제19권4호
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• pp.460-472
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• 2019

Purpose: Long noncoding RNA 00703 (LINC00703) was found originating from a region downstream of Kruppel-like factor 6 (KLF6) gene, having 2 binding sites for miR-181a. Since KLF6 has been reported as a target of miR-181a in gastric cancer (GC), this study aims to investigate whether LINC00703 regulates the miR-181a/KLF6 axis and plays a functional role in GC pathogenesis. Materials and Methods: GC tissues, cell lines, and nude mice were included in this study. RNA binding protein immunoprecipitation (RIP) and pull-down assays were used to evaluate interaction between LINC00703 and miR-181a. Quantitative real-time polymerase chain reaction and western blot were applied for analysis of gene expression at the transcriptional and protein levels. A nude xenograft mouse model was used to determine LINC00703 function in vivo. Results: We revealed that LINC00703 competitively interacts with miR-181a to regulate KLF6. Overexpression of LINC00703 inhibited cell proliferation, migration/invasion, but promoted apoptosis in vitro, and arrested tumor growth in vivo. LINC00703 expression was found to be decreased in GC tissues, which was positively correlated with KLF6, but negatively with the miR-181a levels. Conclusions: LINC00703 may have an anti-cancer function via modulation of the miR-181a/KLF6 axis. This study also provides a new potential diagnostic marker and therapeutic target for GC treatment.

• 농촌계획
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• 제26권2호
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• pp.39-49
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• 2020

This study was attempted to grasp the push-pull factors of urban to rural migrants in relation to services and infrastructure of rural welfare and culture. Online and offline survey were conducted for urban residents who were willing to return to the rural area and those who were already returning to the rural area. In the fields of health care, social welfare, and education, it was found that the satisfaction level of urban-to-rural migrants was relatively higher than those of latent urban-to-rural migrants. In the field of culture, leisure and sports, the level of satisfaction and concern were similar, so it was found that the expectations for the field were relatively high before returning rural area. As for the agreement degree to expand support, the demand for emergency medical facilities and dementia care program was the highest, and the demand for health care was found to be relatively high. The results of the survey on the top priority items indicate that latent urban-to-rural migrants require support of facility and space item and expansion of program item, and urban-to-rural migrants have high demand for expansion of program item in all field except healthcare field. The results of this study are expected to provide useful information for establishing the direction of the rural area development project in connection with the revitalization of policy of people return to rural area.

• 생약학회지
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• 제50권3호
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• pp.185-190
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• 2019

Periodontitis is a chronic inflammatory disease and gums pull away from the teeth and form spaces. The main goal of treatment is to control the infection and anti-inflammation. Eucommia ulmoides Oliv. Bark (EU) is a traditional Korean herbal used for the treatment of arthritis and hypertension. In the present study, we investigated the anti-inflammatory properties of EU in Porphyromonas gingivalis-LPS (LPS-PG) induced YD-38 epithelial cells. We observed significant inhibition of nitric oxide (NO) production and the expression of interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor alpha ($TNF-{\alpha}$), cyclooxygenase-2 (COX-2) in LPS-PG-induced YD-38 cells. These results support that EU has an anti-inflammatory effects for the treatment of periodontitis.

• Mycobiology
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• 제51권5호
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• pp.372-378
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• 2023

Lkh1, a LAMMER kinase homolog in the fission yeast Schizosaccharomyces pombe, acts as a negative regulator of filamentous growth and flocculation. It is also involved in the response to oxidative stress. The lkh1-deletion mutant displays slower cell growth, shorter cell size, and abnormal DNA content compared to the wild type. These phenotypes suggest that Lkh1 controls cell size and cell cycle progression. When we performed microarray analysis using the lkh1-deletion mutant, we found that only four of the up-regulated genes in the lkh1-deletion were associated with the cell cycle. Interestingly, all of these genes are regulated by the Mlu1 cell cycle box binding factor (MBF), which is a transcription complex responsible for regulating the expression of cell cycle genes during the G1/S phase. Transcription analyses of the MBF-dependent cell-cycle genes, including negative feedback regulators, confirmed the up-regulation of these genes by the deletion of lkh1. Pull-down assay confirmed the interaction between Lkh1 and Yox1, which is a negative feedback regulator of MBF. This result supports the involvement of LAMMER kinase in cell cycle regulation by modulating MBF activity. In vitro kinase assay and NetPhosK 2.0 analysis with the Yox1T40,41A mutant allele revealed that T40 and T41 residues are the phosphorylation sites mediated by Lkh1. These sites affect the G1/S cell cycle progression of fission yeast by modulating the activity of the MBF complex.