• Title/Summary/Keyword: Provoked

Search Result 274, Processing Time 0.028 seconds

An Experimental study on the effects of Insambakhab-tang on the Anti-allergic effect and Pulmonary Function of $O_3$ intoxicated Mice (인삼백합탕이 알레르기와 폐손상에 미치는 영향)

  • Oh Chang Sun;Kam Cheal Woo;Park Dong Il
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.16 no.3
    • /
    • pp.577-583
    • /
    • 2002
  • Experimental studies were done to research the Clinical effects of Insambakhab-tang on the Anti-allergic effect and pulmonary function of O₃ intoxicated Mice. Anti-allergic effect experiment consisted of vascular permeability responses to intradermal histamine and serotonin, 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, and delayed type hypersensitivity responses to Picryl Chloride and SRBC. Pulmonary function of O₃ intoxicated Mice experimental consisted of pulmonary thromboembolism (Sodium Arachidonate-induced and ADP-induced), lung TBA value, and serum Na/sup +/, K/sup +/, Cl/sup +/ level. The results obtained as follows; 1. In the effects of Insambakhab-tang on the pulmonary thromboembolism by Sodium Arachidonic acid and ADP, Insambakhab-tang group revealed significant effect. 2. In the effects of Insambakhab-tang on the vascular permeability responses to intradermal histamine, Insambakhab-tang group revealed significant effect. 3. In the effects of Insambakhab-tang on the vascular permeability responses to intradermal serotonine, Insambakhab-tang group revealed significant effect. 4. In the 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, Insambakhab-tang group revealed significant effect. 5. In the delayed type hypersensitivity responses to Picryl Chloride, Insambakhab-tang group revealed significant effect. 6. Insambakhab-tang group revealed significant effect on decrease of the lung TBA value of lung. 7. In the effects of Insambakhab-tang on Serum Na/sup +/, K/sup +/ Level in O₃-intoxicated Mice. Insambakhab-tang group revealed none significant effect, but In the effects of Insambakhab-tang on Serum Cl/sup +/ Level in O₃-intoxicated Mice, Insambakhab-tang group revealed significant effect.

Isolation of Hepatic Drug Metabolism Inhibitors from the Seeds of Myristica fragrans

  • Shin, Kuk-Hyun;Kim, Ok-Nam;Woo, Won-Sick
    • Archives of Pharmacal Research
    • /
    • v.11 no.3
    • /
    • pp.240-243
    • /
    • 1988
  • The hexane extract from Nutmeg, the seed of Myristica fragrans significantly inhibited hepatic drug-metabolizing enzyme activity. Through systematic fractionation by $SiO_2$ column and vacuum liquid chromatography monitoring by bioassay, three components, myristicin, (I), licarin-B (II) and dehydrodiisoeugenol (III) were isolated as active principles. Compounds II and III, with a single treatment (200mg/kg, i.p.) showed not only a significant prolongation of hexobarbital-induced sleeping time but also a significant inhibition of aminopyrine N-demethylase and hexobarbital hydroxylase activities in mice. Compounds I and II provoked a sleep episode at a subhypnotic dose of HB, suggesting that they possess CNS-depressant properties.

  • PDF

A Basic Study on the Uniformity of Apartment Dwelling and Handling Measure (주거 획일화와 극복방안에 대한 기초적 연구)

  • Choi Jung-Min
    • Journal of the Korean housing association
    • /
    • v.17 no.4
    • /
    • pp.25-36
    • /
    • 2006
  • The aim of this paper is to study on the background and the reasons of the uniformity of housing type and planning, and to find ways of coping with the related problems, focusing on the uniformity of apartment housing and it's excessive typical planning. In this process, I try to take suggestive hints from the case of Japan which already made an issue of uniformity of housing type and promoted the handling measure for the problem in a national level. The result includes that supplied apartment housing in Korea occupies about 80% of total housing supply each year, and the reasons for the increased apartment housing supply are attributed to many interactive influence factors. One of the influence factors is ascribed to mass housing system where many academic theories have supported the system under the interdisciplinary cooperation. In the case of Japan too many supplied condominium housing provoked the uniformity problem, however, the establishment of HOPE plan and a special association board oriented to the study of regional housing planning under Architectural Institute of Japan have considerably relaxed the uniformity problem.

Effect of Juglandis Semen Aqua-acupuncture and Acupuncture on the Allergic Response (호도약침이 알레르기에 미치는 영향)

  • Lee Zoo Eun;Lee Tae Yong
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.17 no.1
    • /
    • pp.123-129
    • /
    • 2003
  • Experimental studies were done to research the dinical effects of Juglandis Semen aqua-acupuncture and acupuncture(BL 13) on the anti-allergic response. anaphylaxis provoked by the compound 48/80, delayed type hypersensitivity response to picryl chloride and SASC and inflammation response to egg albumin. The following results have been obtained: Juglandis Semen aqua-acupuncture and acupuncture(BL13) group were increased the survival rate in compound48/80 induced systemic anaphylactic reaction. Picryl chloride induced contact dermatitis and delayed type hypersensitivity in SRBC challenged mouse were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture (BL13) group. Inflammation response - WBC, CRP and Nitric Oxide in egg albumin induced allergic rat were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture(BL13) group. According to the above results, Semen aqua-acupuncture and acupuncture(BL13) both depress the allergy reaction.

A Comparative Analysis of Field and Slide Survey on Subjective Image of the Nightscape (야경의 주관적 이미지에 관한 현지평가와 슬라이드평가의 비교분석)

  • Ahn, Hyun Tae;Moon, Ki Hoon;Kim, Jeong Tai
    • KIEAE Journal
    • /
    • v.7 no.2
    • /
    • pp.31-37
    • /
    • 2007
  • Despite of many supportive research to the usefulness of slide evaluation on environment of outdoor lighting, study method of using slides have provoked many discussions of its manifestation of reality of field conditions. This study aims to compare the results of slide survey with that of field survey. Distant view and short range view of nightscape of Seoul were selected. Field measurement of luminance and chromaticity were conducted and questionnaire survey were conducted. Frequency analysis, T-test, factor analysis were conducted. Results shows that distant view and short range view of field survey have better visual atmosphere than slide survey. In addition, slide survey on distant view shows lowest values. Difference between field survey and slide survey on distant view is much bigger than the results of short range view.

Safety factor calibration for bridge concrete girders

  • Silva, Rita C.;Cremona, Christian
    • Structural Engineering and Mechanics
    • /
    • v.49 no.2
    • /
    • pp.163-182
    • /
    • 2014
  • Safety factors proposed in codes CEB, B.A.E.L 91 and EUROCODE 1 cover a great number of uncertainties; making them inadequate for the assessment of existing structures. Suitable safety factors are established using a probabilistic assessment, once real dimensions, materials strength and existing structures deterioration mechanisms are taken into account. This paper presents a calibration method for safety factors using a typical set of RC bridges in France. It considers the principal stages of corrosion provoked by $CO_2$ and $Cl^-$ penetration and threshold indexes (${\beta}_0$) for existing structures. Reliability indexes are determined by the FORM method in the calibration method.

Business Issues in Enterprise Resource Planning (ERP) Implementation

  • Raj, John Rudolph;Seetharaman, A.
    • East Asian Journal of Business Economics (EAJBE)
    • /
    • v.2 no.4
    • /
    • pp.9-25
    • /
    • 2014
  • The successful implementation of various Enterprise Resource Planning (ERP) systems has provoked considerable interest in this subject over the last few years. The senior management, especially in large corporations have been attracted to look at new information technology and how to leverage it for corporate survival and to gain competitive advantage in volatile business environment. Although there is no shortage of positive reports on the success of ERP installations, many companies have invested millions of dollars in this direction with little to show for its success. Since many of the ERP failures today can be attributed to inadequate planning and poor execution in the implementation and closure of projects. The aim of this article is to offer some solutions to avert potential pitfalls in ERP implementation.

Exploring Quality Issues of Dairy Supply Chain and Proposing IOT-enabled Tracking Systems in Developing Country

  • Lee, Chul Ho
    • Agribusiness and Information Management
    • /
    • v.9 no.1
    • /
    • pp.1-6
    • /
    • 2017
  • Recent scandals of milk additives in several developing countries provoked controversy about quality issue of dairy products, grapping academic attention to the dairy supply chain. In this paper, we first focus on moral hazard problem of self-interested entities about the quality across the dairy supply chain, due to unobservable and unverifiable quality management efforts of all entities - including dairy producers, stations, and a final producer - and high inspection cost for the quality. Based on the identified moral hazard problem, we understand why the adoption of IoT-based tracking systems about quality produced from each entity is a must, different from RFID-based tracking systems.

Studies on Diuretic Action of Bumetanide (Bumetanide의 이뇨작용에 관한 연구)

  • 고석태;김일용
    • YAKHAK HOEJI
    • /
    • v.29 no.3
    • /
    • pp.130-143
    • /
    • 1985
  • Bumetanide, when given intravenously in dogs, induced a potent diuresis with an increased amounts of sodium and potassium excreted in urine due to inhibition of reabsorbing them in renal tubule. Furthermore, clearances of osmolar substance and para-aminohippuric acid were increased, but clearace of free water diminished without any change of creatinine clearance. Bumetanide, administered directly into a renal artery, elicited diuresis only in the infused(experimental) kidney by the same mode of action as in the intravenous cases in renal function of the dog. Renal effects of intravenous bumetanide after pretreatment with the small dose of indomethacin (5.0mg/kg) revealed reduction only in clearance of paraaminohippuric acid. However the much dose of indomethacin (5.0mg/kg+5.0mg/kg/hr) or arachidonic acid showed a significant inhibition in the change rates of all renal function by bumetanide. Morover, pretreatment of probenecid also made a marked reduction in renal effects induced by bumetanide. From the above results, it is thought that bumetanide causes diuretic action due to dual mechanism inhibiting reabsorption of electrolytes in loop of Henle and increasing blood flow in kindney, that are provoked through the mediation of prostaglandins.

  • PDF

EVALUATION FOR THE CONVULSIVE LIABILITY OF VARIOUS QUINOLONE DERIVATIVES IN MICE

  • Park, Kyung-Eob;Lim, Dong-Moon;Huh, Min-Do
    • Toxicological Research
    • /
    • v.8 no.1
    • /
    • pp.63-70
    • /
    • 1992
  • The present study was performed to evaluate whether the application of Fenbufen is reasonable for predicting the convulsive liability of the quinolone derivatives and to examine whether pentylenetetrazole (PTZ) can be used as a screening tool for their Central Nervous System (CNS) toxic pontential. The convulsive activity of the quinolones was markedly potentiated by the pretreatment of Fenbufen. In combination with Fenbufen, enoxacin (ENX), norfloxacin (XFLX), and ciprofloxacin (CPFX) provoked convlusions and subsequent death at the intravenous doses of 0.5mg/kg, 10mg/kg, and 40mg/kg, respectively, whereas ofloxacin (OFLX) and pefloxacin (PFLX) did not induce convulsions and death even at a relatively high dose of 100mg/kg iv.

  • PDF