• The Korean Journal of Physiology and Pharmacology
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• v.23 no.2
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• pp.103-111
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• 2019

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ${\pm}dP/dt$ and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of $CD3^+$ and $CD14^+$ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.

• Journal of Agricultural Extension & Community Development
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• v.8 no.1
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• pp.133-142
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• 2001

The objectives of this study were 1) to review the current status of cooperative extension services in Japan, and 2) to draw implications for improving Korean agricultural extension system. Faced with various problems since its localization of extension services in 1997, Korean agricultural extension needs to be improved and strengthened in order to continually achieve the national goals of food production, balanced national development and preservation of environment, at the same time to meet increasing needs of farmers. The results of the study revealed the major characteristics of agricultural extension services in Japan as follows; 1) Each agricultural extension centers were administratively and technically coordinated by the prefectural (provincial) government, 2) There were 11 public corporations with agricultural extension functions under the MAFF(Ministry of Agricultural Forestry and Fisheries) financed by government subsidies 3) Agricultural experiment stations at provincial level were responsible for developing agricultural innovations for farmers' adoption, 4) The functions and operation of the agricultural extension centers were independent from the local agricultural administration. Some of the implications drawn from the study were as follows; 1) In order to accomplish major objectives of agricultural extension services in Korea legal status of agricultural extension centers should be changed from city/county to provincial government, 2) It would be desirable to establish public corporations concerned with agricultural extension under the Rural Development Administration, 3) Provincial Rural Development Administration should be reinforced in terms of applied farming research and diffusion of new technology, 4) Agricultural extension centers should be independent from administrative function and be separated from administration at the city/county level.

• Journal of Korean Library and Information Science Society
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• v.34 no.4
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• pp.291-312
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• 2003

The purpose of this paper is to review the school library movement of provincial level. For the purpose current school library movement of Gyeonggy-Do and Gyeongsangbuk-Do are analyzed. The writer looks into motivations, strategies, accomplishments, and characteristics of the movements at the viewpoint of comparison.

• Korean Chemical Engineering Research
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• v.53 no.4
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• pp.503-508
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• 2015

The adsorption characteristics of ammonia on MSWI bottom ash were investigated. The effect of the variation of the landfill environmental parameters including pH, anions and organic matter on the adsorption process was discussed. Results showed that the adsorption could be well described by pseudo-second-order kinetics and Langmuir model, with a maximum adsorption capacity of 156.2 mg/g. The optimum adsorption of ammonia was observed when the pH was 6.0. High level of ion and organic matter could restrict the adsorption to a low level. The above results suggested that MSWI bottom ash could affect the migration of ammonia in the landfill, which is related to the variation of the landfill circumstance.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.4
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• pp.181-191
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• 2021

The aim of the study is to empirically investigate and analyze the influence of public welfare, audit findings, and follow-up of audit recommendations on audit opinion with the disclosure level of financial reports as an intervening variable using agency theory and signaling theory. To achieve this purpose, a quantitative research method was employed. Population of this study is Provincial Government Financial Reports in Indonesia for fiscal years 2016 to 2018. There were 84 financial reports that met the criteria of purposive sampling. The data were gathered from the websites of the Audit Board of the Republic of Indonesia and the Indonesian Central Bureau of Statistics. In this study, the hypothesis-testing tool is path analysis using the Statistical Package for Social Sciences version 15. Based on the multiple regression analysis, the results show that audit findings, public income, and the disclosure level of financial reports significantly influenced audit opinion. Besides, the follow-up of audit recommendations and public health significantly influenced audit opinion through the disclosure level of financial reports. This study suggests that, in order to have better audit opinion, local governments need to improve public welfare, follow-up audit finding, and disclose more details in financial report.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.5
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• pp.621-628
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• 2012

The FAT-1 protein is an n-3 fatty acid desaturase, which can recognize a range of 18- and 20-carbon n-6 substrates and transform n-6 polyunsaturated fatty acids (PUFAs) into n-3 PUFAs while n-3 PUFAs have beneficial effect on human health. Fat1 gene is the coding sequence from Caenorhabditis elegans which might play an important role on lipometabolism. To reveal the function of fat1 gene in bovine fetal fibroblast cells and gain the best cell nuclear donor for transgenic bovines, the codon of fat1 sequence was optimized based on the codon usage frequency preference of bovine muscle protein, and directionally cloned into the eukaryotic expression vector pEF-GFP. After identifying by restrictive enzyme digests with AatII/XbaI and sequencing, the fusion plasmid pEF-GFP-fat1 was identified successfully. The pEF-GFP-fat1 vector was transfected into bovine fetal fibroblast cells mediated by Lipofectamine2000$^{TM}$. The positive bovine fetal fibroblast cells were selected by G418 and detected by RT-PCR. The results showed that a 1,234 bp transcription was amplified by reverse transcription PCR and the positive transgenic fat1 cell line was successfully established. Then the expression level of fat1 gene in positive cells was detected using quantitative PCR, and the catalysis efficiency was detected by gas chromatography. The results demonstrated that the catalysis efficiency of fat1 was significantly high, which can improve the total PUFAs rich in EPA, DHA and DPA. Construction and expression of pEF-GFP-fat1 vector should be helpful for further understanding the mechanism of regulation of fat1 in vitro. It could also be the first step in the production of fat1 transgenic cattle.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.387-396
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• 2020

The purpose of this study is to identify the variables of metropolitan and provincial offices of education that affect the academic achievement of unit schools, and to predict how academic achievements dynamically change with the support of offices of education. The results of academic achievement of 606 general high schools in 16 metropolitan and provincial offices of education(rates of attaining more than normal education in Korean, English, and mathematics subjects) were analyzed using a multi-level model and system dynamics. As a result of the analysis, it was confirmed that the provincial and provincial offices of education's efforts to increase the efficiency of local education finance, the efforts to reduce teacher administration, and the facilitation of faculty training were the variables of the provincial and provincial offices of education. In addition, through policy experiments, efforts to revitalize teacher training were the most influential factors in academic achievement of unit schools, followed by efforts to streamline local education finances and to reduce the administrative work of teachers. In order to improve the academic achievement of unit schools, the functions of the metropolitan and provincial offices of education should be strengthened based on the education accountability, and policies need to be established in the mid- to long-term perspective.

• Journal of Ginseng Research
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• v.39 no.2
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• pp.116-124
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• 2015

Background: Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. Panax ginseng has pharmacological effects on neurodegenerative diseases such as Alzheimer's disease (AD). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced AD in a rat model. Methods: Advanced glycation end products were injected bilaterally into the CA3 region of the rats' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell (NF-${\kappa}B$). Results: Behavioral results showed that PG (1 g/kg, 0.5 g/kg, and 0.25 g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in rats with AGE-induced AD. Panax ginseng also significantly reduced the malondialdehyde level, increased the glutathione content, and increased superoxide dismutase activity in the hippocampus. Panax ginseng significantly decreased the expression of RAGE and NF-${\kappa}B$. The blockade of anti-RAGE antibody could significantly reduce AGE-induced impairments and regulate these expressions. Conclusion: Our results demonstrated that PG significantly inhibits AGE-induced memory impairment and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the RAGE/NF-${\kappa}B$ pathway. Our results provided the experimental basis for applying PG in preventing and treating AD.

• The Korean Journal of Archival Studies
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• no.72
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• pp.33-89
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• 2022

Recently, following the opening of the Gyeongsangnam-do Archives and the Seoul Archives, work to establish local archives management institutions in cities and provinces is being actively carried out. In this process, there is an institution directly or indirectly affected by the records management work following the emergence of metropolitan·provincial office of education records management institutions. Article 11 of the current Public Archives Act is centered on cities and provinces, such as giving only the mayor and provincial governor the duty to establish a local record management institution. When a management agency is established, only the obligation to transfer the records with a retention period of 30 years or more among the records under its jurisdiction is specified. This is not appropriate when considering that each metropolitan·provincial office of education and each metropolitan·provincial perform their own duties and roles at the metropolitan·provincial level in accordance with the Constitution and laws. Therefore, in this study, legally, institutionally and historically, the fact that metropolitan·provincial offices of education and metropolitan ·provincial are the core institutions that realize local educational autonomy and local autonomy, and are equivalent administrative agencies independently in charge of their own affairs in their respective jurisdictions. We compared and examined the need to revise Article 11 of the current Public Archives Act, which is overly composed of cities and provinces, and presented the expected effects of the establishment of local records management institutions by cities and provinces of education.

• Korean Journal of Medicinal Crop Science
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• v.8 no.2
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• pp.89-93
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• 2000

This experiment was conducted to investigate the effects of soil texture on agronomic characteristics and tuber yield in chinese yam (Dioscorea opposita Thunb). Tuber length and weight was greater and tuber shape was much better in sandy loam and loam soil than in sandy or clay loam soil. In loam and sandy loam soil, fresh tuber yield was increased by $21{\sim}27%$ in short-tuber type and 6% in long-tuber type, and large tubers yield (above 260g) was increased by $45{\sim}55%$ in short-tuber type and $20{\sim}22%$ in long-tuber type compared to those in sandy soil. There was no differences in large tuber yield at the 5% level of significance between loam and sandy loam soil. Malformation of tuber with bifurcation was extremely increased in sandy soil, and tuber diameter of long-tuber type was decreased in clay loam soil compared to those of the other soil texture.