• Molecules and Cells
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• v.41 no.12
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• pp.1016-1023
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• 2018

Regenerative orthopedics needs significant devices to transplant human stem cells into damaged tissue and encourage automatic growth into replacements suitable for the human skeleton. Soft biomaterials have similarities in mechanical, structural and architectural properties to natural extracellular matrix (ECM), but often lack essential ECM molecules and signals. Here we engineer mineralized polysaccharide beads to transform MSCs into osteogenic cells and osteoid tissue for transplantation. Bone morphogenic proteins (BMP-2) and indispensable ECM proteins both directed differentiation inside alginate beads. Laminin and collagen IV basement membrane matrix proteins fixed and organized MSCs onto the alginate matrix, and BMP-2 drove differentiation, osteoid tissue self-assembly, and small-scale mineralization. Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to up-regulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules. More significantly, nested BMP-2 and BM beads added to a non-union skull defect, self-generated osteoid expressing osteopontin (OPN) and osteocalcin (OCN) in a chain along the defect, at only four weeks, establishing a framework for complete regeneration expected in 6 and 12 weeks. Alginate beads are beneficial surgical devices for transplanting therapeutic cells in programmed (by the ECM components and alginate-chitosan properties) reaction environments ideal for promoting bone tissue.

• Journal of Korean Clinical Health Science
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• v.2 no.1
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• pp.73-78
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• 2014

Purpose. Citrus aurantium L.(familyRutaceae), alsoknownasbitter orange, have been used as traditional herbal medicine in many Asian countries since ancient times. Hence, the purpose of the study was to briefly discuss the new findings about anti-inflammatory and anti-cancer activities of Citrus aurantium L in-vitro. Methods. The articles for this study were collected from pubmed and scopus electronic resources. Results. Citrus aurantium L contains an abundant Flavonoids, including hesperidin, naringin and nobiletin. These Flavonoids has reported to have various medicinal benefits that include antioxidant, antimicrobial, anti-inflammatory, anticancer, anti-diabetic activities, and also used to treat cardiovascular diseases. Conclusion. Based on the above evidence, we propose that Flavonoids from Korea Citrus aurantium L would be a therapeutic potential for cancer treatment and pharmacological benefit for inhibiting the inflammatory effect.

• Journal of Magnetics
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• v.18 no.3
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• pp.339-341
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• 2013

The magnetic field standards, facilities and capabilities available at NPL for the calibration of magnetometers and gradiometers and the measurement of the magnetic properties of materials will be introduced. The details of the low magnetic field facility will be explained and the capabilities this facility enables for the characterisation and calibration of ultra-sensitive room temperature magnetic sensors will be presented. Building on core material capabilities that are compliant with the IEC 60404 series of written standards, the example of a standard permeameter that has been modified for the measurement of strips for real world conditions is discussed. This was incorporated into a stress machine to measure the DC properties of the soft magnetic materials used by the partners of a collaborative industry led R&D project at stress levels of up to 700 MPa. The results for three materials are presented and the changes in the properties with applied stress compared to establish which material exhibits favourable properties.

• Steel and Composite Structures
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• v.34 no.4
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• pp.581-597
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• 2020

Light-Weight Concrete containing Expanded Poly-Styrene Beads (EPS-LWC) is an approved structural and non-structural material characterized by a considerably lower density and higher structural efficiency, compared to concrete containing ordinary aggregates. The experimental campaign carried out in this project provides new information on the mechanical properties of structural EPS-LWC, with reference to the strength and tension (by splitting and in bending), the modulus of elasticity, the stress-strain curve in unconfined compression, the absorbed energy under compression and reinforcement-concrete bond. The properties measured at seven ages since casting, from 3 days to 91 days, in order to investigate their in-time evolution. Mathematical relationships are formulated as well, between the previous properties and time, since casting. The dependence of the compressive strength on the other mechanical properties of EPS-LWC is also described through an empirical relationship, which is shown to fit satisfactorily the experimental results.

• Korean Journal of Metals and Materials
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• v.47 no.10
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• pp.605-612
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• 2009

The suitability of twin roll strip casting for Ag-27.5%Cu-20.5%Zn-2.5%Mn-0.5%Ni brazing alloy (known as HS-49D) was examined in the present work and the mechanical properties and microstructure of the strip were also investigated. The effect of annealing heat treatment on the properties was also studied. The new manufacturing process has applications in the production of the brazing alloy. XRD and microstructural analyses of the Ag-27.5%Cu-20.5%Zn-2.5%Mn-0.5%Ni strip revealed a eutectic microstructure of an Ag-rich matrix (FCC) and a Cu-rich phase (FCC) regardless of heat treatment. The results of mechanical tests showed tensile strength of 434 MPa and 80% elongation for the twin roll casted strip. Tensile results showed decreasing strengths and increasing elongation with annealing heat treatment. Microstructural evolution and fractography were also investigated and related to the mechanical properties.

• Korean Journal of Soil Science and Fertilizer
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• v.48 no.5
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• pp.522-527
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• 2015

Decision of available soil depth based on soil physical and hydraulic properties for the $3^{rd}$ Landscape Vegetation Project in the Incheon International Airport was attempted. The soil samples were collected from the 8 sites at different depths, 0-20 and 20-60cm, for the three project fields, A, B, and C area. Physical and chemical properties including particle size distribution, organic matter content and electrical conductivity were analyzed. Hydrological properties including bulk density and water holding capacity at different water potential, -6 kPa, -10 kPa, -33 kPa, and -1500 kPa were calculated by SPAW model of Saxton and Rawls (2006), and air entry value was calculated by Campbell model (1985). Based on physical and hydrological limitation, feasibility and design criteria of soil depth for vegetation and landfill were recommended. Since the soil salinity of the soil in area A area was $19.18dS\;m^{-1}$ in top soil and $22.27dS\;m^{-1}$ in deep soil, respectively, landscape vegetation without amendment would not be possible on this area. Available soil depth required for vegetation was 2.51 m that would secure root zone water holding capacity, capillary fringe, and porosity. Available soil depth required for landscape vegetation of the B area soil was 1.51 m including capillary fringe 0.14 m and available depth for 10% porosity 1.35 m. The soils in this area were feasible for landscape vegetation. The soil in area C was feasible for bottom fill purpose only due to low water holding capacity.

• Bulletin of the Korean Chemical Society
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• v.26 no.3
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• pp.428-432
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• 2005

Squarylium or squaraine dyes are derived from 1,2-dihydroxycyclobuten-3,4-dione, otherwise known as squaric acids. They are two principal types: the 1,2-bisdonorsubstituted derivatives, and the 1,3-bisdonorsubstituted derivatives. The former are essentially merocyanines and have no distinctive properties, whereas the latter represent a unique type of chromophore, which is neither a merocyanines nor cyanine and has exceptional light absorption characteristics. They also have many functional applications based on their special properties. Thus it was the objective of this research project to synthesize a range of 1,3-squarylium dyes of widely differing structural types, and to investigate their light absorption and fluorescence properties in general, and the color change properties of appropriate examples in particular. Also in this study, the various pHinduced colour change processes were examined.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.05b
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• pp.341-344
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• 1997

A vitrification process is under development in KEPRI for the treatment of low-and medium-level radioactive waste. Although the project is for developing and building Vitrification Pilot Plant in Korea, one of KEPRI's concerns is the quality control of the vitrified glass. This paper discusses a methodology for the estimation of glass composition by on-line measurement of molten glass properties, which could be applied to the plant for real-time quality control of the glass product. By remotely measuring viscosity and density of the molten glass, the glass characteristics such as composition can be estimated and eventually controlled. For this purpose, using the database of glass composition vs. physical properties in isothermal three-component system of SiO$_2$-Na$_2$O-B$_2$O$_3$, a software TERNARY has been developed which determines the glass composition by using two known physical properties(e.g. density and viscosity).

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.453-455
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• 2015

In this paper we introduce the Plasma Physics of Active Galactic Nuclei project, which is an ongoing experiment with Korean VLBI Network (KVN) and KVN and VERA Array (KaVA) to study multi-frequency polarimetric properties on parsec scales of active galaxies. The goal of the project is to improve our understanding of fundamental jet physics, especially evolution of the relativistic outflow coupled with the large-scale magnetic field. We selected six radio-loud AGN as our targets. So far we (i) detected resolved emissions regions at 86 and 129 GHz on VLBI scales, (ii) constructed 2D spectral index maps of the outflows, and (iii) found polarizations at 22 and 43 GHz for a few targets. Here we present spectral index distributions of 3C 120 between 22 and 43 GHz and a linear polarization map of BL Lac at 43 GHz obtained with KVN.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.53.1-53.1
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• 2014

The M81 group is a nearby galaxy group hosted by M81, a twin galaxy of Milky Way. This galaxy group is considered as an ideal laboratory for near-field cosmology to understand mass assembly and evolution of galaxies in the group environment. We designed a project to investigate spectroscopic properties of globular cluster candidates in this group. We obtained spectra of globular cluster candidates using the MMT/Hectospec as a part of the K-GMT Science Program. Our main targets include globular cluster candidates of the M81 group member galaxies and those wandering in the intragroup region. We also observed supernova remnants and some background galaxies. Observing fields covered about 2 square degrees including three main galaxies of the M81 group. Using these spectra, we will identify globular clusters in the M81 group, and investigate their properties including age and metallicity. We will discuss the MMT/Hectospec data reduction processes, and future plan for this project.