Journal of Korean Clinical Health Science (한국임상보건과학회지)

The Korean Society of Clinical Health Science (한국임상보건과학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-cancer and Anti-inflammatory Properties of Korean Citrus Fruits (Citrus aurantium L.)

  • Nagappan, Arulkumar (Research Institute of Life Science and College of Veterinary Medicine (BK21 plus project), Gyeongsang National University) ;
  • Park, Hyeon-Soo (Research Institute of Life Science and College of Veterinary Medicine (BK21 plus project), Gyeongsang National University) ;
  • Hong, Gyeong-Eun (Research Institute of Life Science and College of Veterinary Medicine (BK21 plus project), Gyeongsang National University) ;
  • Yumnam, Silvia (Research Institute of Life Science and College of Veterinary Medicine (BK21 plus project), Gyeongsang National University) ;
  • Lee, Ho-Jeong (Research Institute of Life Science and College of Veterinary Medicine (BK21 plus project), Gyeongsang National University) ;
  • Kim, Douk-Hoon (Department of Optometry, Masan University) ;
  • Kim, Eun-Hee (Department of Nursing Science, International University of Korea) ;
  • Kim, Gon-Sup (Research Institute of Life Science and College of Veterinary Medicine (BK21 plus project), Gyeongsang National University)
  • Received : 2014.01.21
  • Accepted : 2014.02.04
  • Published : 2014.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose. Citrus aurantium L.(familyRutaceae), alsoknownasbitter orange, have been used as traditional herbal medicine in many Asian countries since ancient times. Hence, the purpose of the study was to briefly discuss the new findings about anti-inflammatory and anti-cancer activities of Citrus aurantium L in-vitro. Methods. The articles for this study were collected from pubmed and scopus electronic resources. Results. Citrus aurantium L contains an abundant Flavonoids, including hesperidin, naringin and nobiletin. These Flavonoids has reported to have various medicinal benefits that include antioxidant, antimicrobial, anti-inflammatory, anticancer, anti-diabetic activities, and also used to treat cardiovascular diseases. Conclusion. Based on the above evidence, we propose that Flavonoids from Korea Citrus aurantium L would be a therapeutic potential for cancer treatment and pharmacological benefit for inhibiting the inflammatory effect.

Keywords

References

  1. Ghobrial IM, Witzig TE, Adjei AA. Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin, 2005;55:178-194. https://doi.org/10.3322/canjclin.55.3.178
  2. Deyhim F, Lopez E, Gonzalez J, Garcia M, Patil BS. Citrus juice modulates antioxidant enzymes and lipid profiles in orchidectomized rats. J Med Food, 2006;9:422-426. https://doi.org/10.1089/jmf.2006.9.422
  3. Kim DI, Lee SJ, Lee SB, Park K, Kim WJ, Moon SK. Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis, 2008;29: 1701-1709. https://doi.org/10.1093/carcin/bgn055
  4. Kang SR, Han DY, Park KI, Park HS, Cho YB, Lee HJ, Lee WS, Ryu CH, Ha YL, Lee do H, Kim JA, Kim GS. Suppressive Effect on Lipopolysaccharide-Induced Proinflammatory Mediators by Citrus aurantium L. in Macrophage RAW 264.7 Cells via NF-kappaB Signal Pathway. Evid Based Complement Alternat Med, 2011; 2011: 10.1155/2011/248592. Epub 2010 Sep 21.
  5. Jung KH, Ha E, Kim MJ, Won HJ, Zheng LT, Kim HK, Hong SJ, Chung JH, Yim SV. Suppressive effects of nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by Citrus reticulata extract in RAW 264.7 macrophage cells. Food Chem, Toxicol, 2007;45: 1545-1550. https://doi.org/10.1016/j.fct.2007.02.017
  6. Li Y, Fang H, Xu W . Recent advance in the research of flavonoids as anticancer agents. Mini Rev Med Chem, 2007;7:663-678. https://doi.org/10.2174/138955707781024463
  7. Quilez A, Berenguer B, Gilardoni G, Souccar C, de Mendonca S, Oliveira LF, Martin-Calero MJ, Vidari G. Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav, J Ethnopharmacol 2010;128:583-589. https://doi.org/10.1016/j.jep.2010.01.060
  8. Gange CA, Madias C, Felix-Getzik EM, Weintraub AR, Estes NA,3rd . Variant angina associated with bitter orange in a dietary supplement. Mayo Clin Proc, 2006;81:545-548. https://doi.org/10.4065/81.4.545
  9. Sultan S, Spector J, Mitchell RM . Ischemic colitis associated with use of a bitter orange-containing dietary weightloss supplement. Mayo Clin Proc, 2006;81:1630-1631. https://doi.org/10.4065/81.12.1630
  10. Liu L, Shan S, Zhang K, Ning ZQ, Lu XP, Cheng YY. Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin. Phytother Res, 2008; 22: 1400-1403 [PMID: 18690615 DOI:10.1002/ptr.2504; 10.1002/ptr.2504].
  11. Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem, 2001; 8: 135-153. https://doi.org/10.2174/0929867013373723
  12. Harapu CD, Miron A, Cuciureanu M, Cuciureanu R. Flavonoids--bioactive compounds in fruits juice. Rev Med Chir Soc Med Nat Iasi, 2010; 114: 1209-1214.
  13. Park KI, Park HS, Nagappan A, Hong GE, Lee do H, Kang SR, Kim JA, Zhang J, Kim EH, Lee WS, Shin SC, Hah YS, Kim GS . Induction of the cell cycle arrest and apoptosis by flavonoids isolated from Korean Citrus aurantium L. in non-small-cell lung cancer cells. Food Chem, 2012;135:2728-2735. https://doi.org/10.1016/j.foodchem.2012.06.097
  14. Lee DH, Park KI, Park HS, Kang SR, Nagappan A, Kim JA, Kim EH, Lee WS, Hah YS, Chung HJ, An SJ, Kim GS. Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. Evid Based Complement Alternat Med, 2012; 2012: 515901.
  15. Ghorbani A, Nazari M, Jeddi-Tehrani M, Zand H . The citrus flavonoid hesperidin induces p53 and inhibits NF-kappaB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARgamma-dependent mechanism. Eur J Nutr, 2012; 51: 39-46.
  16. Natarajan N, Thamaraiselvan R, Lingaiah H, Srinivasan P, Periyasamy BM. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomedicine & Preventive Nutrition, 2011; 1: 1207-215.
  17. Lee KA, Lee SH, Lee YJ, Baeg SM, Shim JH . Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells. Biomol Ther (Seoul), 2012; 20: 273-279. https://doi.org/10.4062/biomolther.2012.20.3.273
  18. Lee EJ, Moon GS, Choi WS, Kim WJ, Moon SK. Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. Food Chem Toxicol, 2008; 46: 3800-3807 https://doi.org/10.1016/j.fct.2008.10.002
  19. Ramesh E, Alshatwi AA. Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. Food Chem Toxicol, 2013; 51: 97-105. https://doi.org/10.1016/j.fct.2012.07.033
  20. Arul D, Subramanian P . Naringenin (citrus flavonone) induces growth inhibition, cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Pathol Oncol Res, 2013; 19: 763-770. https://doi.org/10.1007/s12253-013-9641-1
  21. Reshef N, Hayari Y, Goren C, Boaz M, Madar Z, Knobler H . Antihypertensive effect of sweetie fruit in patients with stage I hypertension. Am J Hypertens, 2005; 18: 1360-1363. https://doi.org/10.1016/j.amjhyper.2005.05.021
  22. Bodet C, La VD, Epifano F, Grenier D. Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models. J Periodontal Res, 2008; 43: 400-407. https://doi.org/10.1111/j.1600-0765.2007.01055.x
  23. Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJ. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab, 2011; 96: E782-92. https://doi.org/10.1210/jc.2010-2879
  24. Kim JA, Park HS, Kang SR, Park KI, Lee DH, Nagappan A, Shin SC, Lee WS, Kim EH, Kim GS . Suppressive effect of flavonoids from Korean Citrus aurantium L. on the expression of inflammatory mediators in L6 skeletal muscle cells. Phytother Res, 2012; 26: 1904-1912. https://doi.org/10.1002/ptr.4666
  25. Kim JA, Park HS, Park KI, Hong GE, Nagappan A, Zhang J, Han DY, Shin SC, Won CG, Kim EH, Kim GS . Proteome analysis of the antiinflammatory response of flavonoids isolated from Korean Citrus aurantium L. in lipopolysaccharide- induced L6 rat skeletal muscle cells. Am J Chin Med, 2013; 41: 901-912. https://doi.org/10.1142/S0192415X13500602
  26. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell, 2004; 6: 203-208. https://doi.org/10.1016/j.ccr.2004.09.003