• Journal of Pharmaceutical Investigation
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• 제29권3호
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• pp.205-210
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• 1999

To formulate the parenteral delivery of a new cephalosporin derivative, 7-${\beta}$-[(2)-2-(2-arninothiazol-4-yl)-2methoxyiminoacetamido]- 3- [(2,3-cyclopenteno-4-carbamoyl-l-pyridinium)methyl]- 3-cephem-4-carboxylate sulfate( CKD604), the stability and solubility of CKD-604 in various aqueous media were investigated. The degradation kinetics of CKD-604 in aqueous solutions (ionic strength 0.1, pH 1-8) were studied at $37^{\circ}C$. The observed degradation rates followed pseudo first order kinetics. The pH-rate profile exhibited a minimum degradation rate at pH 5. The Arrhenius activation energy was 14.2 kcal/mol in pH 5 buffer solution. Excellent agreement between the cephalosporins' theoretical pH-rate profile and the experimental data indicated that the degradation pathway of CKD-604 could be predicted according to the general pathway of cephalosporins. The solubility of CKD-604 was 8.16 mg/ml at $25^{\circ}C$. To enhance the solubility and adjust the suitable pH, CKD-604 was solubilized by using sodium ascorbate, ascorbic acid and urea. The compositions were obtained to satisfy optimum pH and concentration, and the total amount of additives was several times of the active ingredient, CKD-604.

• 한국컴퓨터정보학회논문지
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• 제29권1호
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• pp.131-138
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• 2024

해군 함정의 위협에 대한 전투체계의 신속하고 정확한 대응능력은 함정의 생존력 및 전투력과 직결된다. 하지만 현재 해군 함정전투체계의 적 잠수함 잠망경 탐지 방법은 센서로부터 수신한 정보를 운용자가 직접 확인하고 분석하는 수동적이고 주관적인 방법에 의존하고 있다. 이는 위협에 대한 대응 시간을 지연시켜 함정의 생존력을 저해하는 요인이 된다. 본 논문에서는 표적의 고해상도 거리 측면도(High Resolution Range Profile, 이하 HRRP)를 통해 생성된 Plot 정보를 확률에 따른 의심 등급으로 구분하고, 등급별 알림을 통해 위협 대응 시간을 비약적으로 단축시키는 잠망경 탐지 알고리즘을 소개한다. 알고리즘 테스트 결과 운용자 대비 133.3791 × 10⁶배 빠른 탐지판단시간과 12.78%p 높은 탐지 성공률을 도출하여 해군 함정 생존력을 높일 수 있는 위협 대응시간 단축 가능성을 확인하였다.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2007년도 공동학술대회 논문집
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• pp.251-256
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• 2007

The aim of this paper is development of resistivity seismic dilatometer (RSDMT) system. The resistivity module for obtaining apparent resistivity depth plot and seismic module for obtaining shear wave velocity (Vs) depth plot are attached to the conventional flat dilatometer testing equipment. From shear wave velocity profile, the stiffness at low strains of a site can be evaluated in undisturbed condition. And the resistivity value contains some information about water content and mineral characteristics of clayey soil. Specially manufactured resistivity and seismic modules were connected between commercialized DMT blade and drilling rod. To enhance reliability and repeatability of RSDMT test, automatic testing system including notebook based data acquisition system and automatic surface source system were developed. RSDMT system can be performed rapidly and can obtaine more reliable data at the same point compared with the separated testing system. The verification studies for the developed RSDMT system are going to be performed. From these studies, the effectiveness of integrated hybrid testing system will be checked in light of proper evaluation of geotechnical design parameters of clayey soils.

• Bulletin of the Korean Chemical Society
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• 제24권11호
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• pp.1613-1617
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• 2003

In the phosphoric acid based etchant, the dissolution rates of Mo films were measured by microgravimetry and the corrosion potentials of Mo and Al were estimated by Tafel plot method with various concentrations of nitric acid. Dissolution rate of Mo increased with the nitric acid concentration and reached a limiting value at high concentration of nitric acid in ambient condition. Corrosion potentials of Mo and Al shifted to positive direction and the difference between potentials of both metals was about 1,100 mV and 1,200 mV with 1% and above 4% of $HNO_3$, respectively. For a Mo/Al bilayers, the dissolution rate inversion is the main reason for good taper angle in shower etching process. Taper angles are observed by scanning electron microscope (SEM) after wet etching process for Mo/Al layered films with different concentrations of $HNO_3$. In the etch side profile, it was found that Al corroded faster than Mo below 4% of $HNO_3$ in dip etching process, however, Mo corroded faster above 4%. Trend for variation of taper angle of etched side of Mo/Al layered film can be explained by considering the effect corrosion rates of both metals with various concentrations of $HNO_3$.

• 분석과학
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• 제10권5호
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• pp.362-369
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• 1997

HPLC를 이용하여 생산지와 밀원꽃이 알려진 5종의 꿀 중 당성분을 분석한 다음 화학계량학적 고찰을 수행하였다. 꿀의 주된 당성분은 fructose, glucose였으며, 1종의 꿀에서는 sucrose가 소량 검출되었다. 산지별, 밀원꽃별로 당 함량을 비교하였다. Fructose/glucose 함량비는 0.99~1.55 범위로서 문헌값과 잘 일치하였다. Principal components analysis(PCA) plot은 산지별, 밀원꽃별로 확연히 구분되었다. 주성분점수가 커질수록 당 함량이 증가되었고 fructose/glucose 함량비는 감소되었다. 화학계량학적 접근방법은 꿀시료의 당조성 패턴을 비교하고 품질평가 및 부정화 적발에 유용하였다.

• Bulletin of the Korean Chemical Society
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• 제34권3호
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• pp.810-814
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• 2013

The thermodynamic parameters for the intercalative interaction of structurally related well known intercalators, 9-aminoacridine (9AA) and proflavine (PF) were determined by means of fluorescence quenching study. The fluorescence intensity of 9AA decreased upon intercalation to DNA, poly[$d(A-T)_2$] and poly[$d(G-C)_2$]. A van't Hoff plot was constructed from the temperature-dependence of slope of the ratio of the fluorophore in the absence and presence of a quencher molecule with respect to the quencher concentration, which is known as a Stern-Volmer plot. Consequently, the thermodynamic parameters, enthalpy and entropy change, for complex formation was calculated from the slope and y-intercept of the van't Hoff plot. The detailed thermodynamic profile has been elucidated the exothermic nature of complex formation. The complex formation of 9AA with DNA, poly[$d(A-T)_2$] and poly[$d(G-C)_2$] was energetically favorable with a similar negative Gibb's free energy. On the other hand, the entropy change appeared to be unfavorable for 9AA-poly[$d(G-C)_2$] complex formation, which was in contrast to that observed with native DNA and poly[$d(A-T)_2$] cases. The equilibrium constant for the intercalation of PF to poly[$d(G-C)_2$] was larger than that to DNA, and was the largest among sets tested despite the most unfavorable entropy change, which was compensated for by the largest favorable enthalpy. The favorable hydrogen bond contribution to the formation of the complexes was revealed from the analyzed thermodynamic data.

• Animal Bioscience
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• 제35권1호
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• pp.39-46
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• 2022

Objective: The fermentation profile and silage quality of 3 Italian ryegrass (Lolium multiflorum Lam.) cultivars (cvs. Devis, Hellen, and Trinova) treated with 5 nitrogen doses (0, 50, 100, 150, and 200 kg/ha) were evaluated. Methods: The experiment was laid out in split plot in randomized complete block design with three replications. Annual ryegrass cultivars used in this study have been commonly grown in Turkey. Nitrogen doses were set in main plot and cultivars in split plot in the field. Plants were harvested at full-flowering stage with dry matter content about 220 g/kg for first cutting and 260 g/kg for second cutting. Harvested plants were chopped theoretically into 2 to 3 cm lengths for ensiling. Chopped fresh materials were ensilaged by compressing in 2 L plastic jars about 3±0.1 kg. Results: Effects of N doses on dry matter, neutral detergent fiber, acid detergent fiber, dry matter digestibility, relative feed value, crude protein, pH, ammonia nitrogen, lactic acid, acetic acid, and lactic acid/acetic acid were statistically significant while water soluble carbohydrate, ash and organic matter were not statistically different. Ammonia nitrogen, crude protein, ash, organic matter, lactic acid, and lactic acid/acetic acid were affected by cultivars, but the other parameters were not. Increasing nitrogen applications positively affected the chemical composition of annual ryegrass silage. The significant increase in protein content was remarkable, however, silage fermentation properties were adversely affected by the increasing nitrogen dose. Conclusion: It can be recommended 150 kg/ha nitrogen dose for annual ryegrass harvested at full blooming stage. Even though the silage fermentation properties of the used cultivars were similar, cv. Devis gave better results than the others in terms of silage pH and relative feed value.

• 대한기계학회논문집
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• 제12권2호
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• pp.262-270
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• 1988

본 연구에서는 필자들의 수치해석방법을 발전시켜 프로파일링을 한 로울러의 프로파일 시작점부근에서의 압력과 유막의 거동을 보다 상세하게 해석하고자 한다.이를 위하여, 수치해석시 로울러 길이방향의 분할을 불균일하게 하여 프로파일 시작점부근에서의 절점의 간격을 조밀하게 하였으며 윤활유의 압축성효과도 고려하였다.

• 제어로봇시스템학회논문지
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• 제20권8호
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• pp.828-834
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• 2014

This paper presents a comparison among three types of approaches to an ARC (Active Roll Control) with an AARB(Active Anti-Roll Bar) for a vehicle system. Lateral acceleration and road profile are considered as disturbance. The ARC is designed with an LQ SOF (Linear Quadratic Static Output Feedback) control, $H_{\infty}$ control and SMC (Sliding Mode Control). These approaches are compared in terms of rollover prevention and ride comfort. For comparison, Bode plot analysis based on linear model and frequency response analysis based on CarSim simulation are performed.

• 전기화학회지
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• 제12권3호
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• pp.258-262
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• 2009

The composition and semiconducting properties of the passive films formed on Ni- (15, 30)Cr-5Mo alloys in pH 8.5 buffer solution were examined. The depth concentration profile of passive films formed on Ni-(15, 30)Cr-5Mo in pH 8.5 buffer solution showed that Mo enhances the enrichment of Cr. The Mott-Schottky plot for the passive film on Ni-(15, 30)Cr- 5Mo closely resembled that for the film on Cr, whereas those for the less Cr-enriched film on Mo-free alloys showed similar behavior to that for the film on Ni. The acceptor density was reduced by increasing Cr content in Ni-(15, 30)Cr-(0, 5)Mo alloys, but addition of Mo considerably increased the acceptor density.