• Journal of Physiology & Pathology in Korean Medicine
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• v.37 no.1
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• pp.1-8
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• 2023

The aim of this study is to evaluate the antidiabetic effect of the water extract of Aurantii fructus immaturus (WAF), in diabetic models using enzyme, cells and mice, and to suggest a putative mechanism explaining its antidiabetic effect. In an enzyme model using the enzyme α-glucosidase, WAF had no significant effect on α-glucosidase, as compared with acarbose, an antidiabetic drug. Nonetheless, WAF was capable of reducing the blood glucose levels during oral sucrose tolerance test and oral glucose tolerance test, implying that there would be other antidiabetic pathways in no relation to inhibition of α-glucosidase. In cell models using RIN-m5f β-cells and L6 myotubes, WAF, at its non-cytotoxic doses, augmented the secretion of insulin in RIN-m5f β-cells stimulated with 5 mM glucose. In addition, it enhanced the cellular uptake of glucose in L6 myotubes stimulated with deprivation of glucose for 12 h. Therefore, it is most likely that WAF may exert its antidiabetic effects, at least in part, by enhancing insulin secretion and glucose uptake. Meanwhile, in diabetic mice induced with peritoneal injection of streptozotocin (STZ), WAF significantly improved fast blood glucose levels, glycosylated hemoglobin levels, body weight loose, blood pressure, and diabetic adverse effects on functions of the kidney and the liver. Taken together, the water extract of Aurantii fructus immaturus may ameliorate diabetes in mice injected with STZ, at least in part, by enhancing insulin secretion and glucose uptake.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.3
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• pp.230-239
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• 2021

There is a growing interest in project management knowledge, project management information systems, and process improvement to systematically project execution in public sectors, achieve high performance and value, and increase the effectiveness of the overall industry. In particular, the software industry is a knowledge-intensive industry centered on professional manpower. This study examines the effect of the project managers' competences of regional SW promotion agencies on and project performance and the moderating effect of the level of project management maturity. We collected data using a questionnaire to the project managers of regional SW promotion agencies. In this study, a structural equation model was used to analyze the relationship between project managers' competences and performance. In addition, a multi-group structural equation model was used to analyze the moderating effect according to the high and low project maturity. As a result of the analysis, it was found that only contextual competence among the competences of the project manager had a positive effect on project performance. It was found that technical and behavioral competence did not have a positive effect on management and completion performance. It was found that the moderating effect according to the maturity of business management of local institutions was not significant.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.363-372
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• 2017

This study was conducted to investigate the effects of nursing professional attitude and employment strategy on graduate nursing students core fundamental nursing education program, after applied the core fundamental nursing education program for one semester. There were 165 subjects who were surveyed from June 23 to 24, 2016. The mean score of the core fundamental nursing education program satisfaction was $3.99({\pm}0.48)$. The mean score of nursing professional attitude was $3.77({\pm}0.49)$ and that of employment strategy was $3.28({\pm}0.49)$. The nursing professional attitude related to campus life satisfaction n(p=0.004), employment preparation(p=0.002), factors affecting employment(p=0.005), and employment strategy related with motivation for entering(p=0.018), average credits(p<0.001), employment preparation(p<0.001), information route of employment(p=0.048) showed statistical significance. A significant and positive correlation was found between nursing professional attitude and employment strategy(r=0.472, p<0.001). Nursing professional attitude(${\beta}=0.462$, p<0.001) was found to be an influential variable in core fundamental nursing education programs. The regression model explained 29% of the core fundamental nursing education program(F=17.79, p<0.001). In conclusion, nursing students' nursing professional attitude was related to employment strategy. To increase the core fundamental nursing skills, it is necessary to develop a practical education program and institutional strategies to establish a nursing professional attitude and strengthen employment strategy.

• Journal of the Korean Data and Information Science Society
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• v.27 no.1
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• pp.191-201
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• 2016

The purpose of this study was to explore the correlation among professional self-concept, self-efficacy and job satisfaction and to identify the effect of professional self-concept and self-efficacy on job satisfaction in general hospital nurses. Questionnaires were completed by 156 nurses who were working for one general hospital in Busan. The mean score of professional self-concept and self-efficacy were $3.02{\pm}0.23$ and $2.92{\pm}0.21$ respectively. The mean score of job satisfaction was $2.76{\pm}0.26$. With respect to job satisfaction, the correlations were .325 (p<.001) for professional self-concept and .212 (p=.008) for self-efficacy. As integrate of the study result showed job satisfaction had correlation to professional self- concept and self-efficacy. The regression model explained 12.6% of job satisfaction. Professional self-concept was factor influencing job satisfaction. So professional self-concept enhancement strategies and self-efficacy improvement programs should be developed to improve job satisfaction.

• Journal of Industrial Convergence
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• v.21 no.6
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• pp.61-71
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• 2023

The objective of this research is to examine the mediating roles of nursing professional values and occupational stress in the relationship between self-leadership and patient-centered nursing among nurses employed at COVID-19 designated hospitals. This study were 160 nurses at a COVID-19 designated hospitals, and the data were collected from January 10 to February 30, 2022. The collected data were analyzed by independent t-test, one-way ANOVA, correlation analysis, multiple linear regression analysis, and SPSS PROCESS Macro model No 4 bootstrapping method. The average score for self-leadership was 61.3±8.55, nursing professional values was 95.5±11.66, occupational stress was 51.3±4.76, and patient-centered nursing was 59.3±7.63. The mediating effect of nursing professional values and occupational stress was confirmed in the influence relationship between self-leadership and patient-centered nursing of nurses at COVID-19 designated hospitals. This result suggests that the content related to improve nursing professional values and reduce occupational stress should be considered when applying the patient-centered nursing enhancement program.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.137.2-137.2
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• 2003

Dendritic cells (DCs) are known to professional antigen presenting cell (APC). Due to the role as an effective activator of cytotoxic T Lymphocytes by expressing MHC, adhesion and co-stimulatory molecules, DCs are now widely recognized to play an important role in the immune responses to tumors.We investigated the effect of cultured DCs in murine melanoma pulmonary metastasis model. To follow the metastasis protocol, syngenic melanoma cells were inoculated intra-venously into the mouse (B16F10 into the C57BL/6)8 days prior to the first DC injection (1$\times$106 DCs/ mouse, i.p.) and the autologous tumor cell lysate pulsed-DCs were injected as a therapeutic module twice in two weeks. (omitted)

• Korean Journal of Social Welfare
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• v.67 no.2
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• pp.85-112
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• 2015

This study examined the relationship structure among personal and social cognitive factors contributing to professional help-seeking decisions to relieve distress of those in low-income, then suggested an appropriate model to inform knowledge for better social work practice. Using data of a purposive sampling from 331 low-income people, covariance structural analyses were conducted in two stages of model exploration, one for TPB model and another for its extended model including the level of distress, family support, and willingness. As results, in the path analyses with the observed variables of the basic components of the TPB, subjective norm showed the strongest effect on the intention, following by attitudes towards help-seeking, then behavioral control the least; in turn both the intention, positively, and behavioral control, negatively, contributed to help-seeking decisions. In the second stage of the path analyses with the extended model of the TPB, each of distress and family support demonstrated direct positive effect on each of attitudes, subjective norm, and behavioral control; each of the attitudes, subjective norm, and behavioral control showed positive effect on both intention and willingness; in turn, while intention showed strong positive effect on help-seeking decisions, willingness had no significant effect and behavioral control had negative effect on decisions. There were significant indirect effects of behavioral control on intention through willingness and of willingness on decisions through intention. These results suggested that the TPB model is useful for modeling help-seeking decisions through personal and social cognitions, especially the significance of subjective norm implied the importance of social cognition for the people in low-income with distress. Further, it was implied that the extended model needs to address particularity of those people in low-income and the mechanism shown by behavioral control and willingness implied the importance of practicing respect for the client's autonomy and will for self-support in social work practice.

• The Journal of Korean Association of Computer Education
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• v.12 no.4
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• pp.13-21
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• 2009

Educational robots have various potentialities to support programming learners because it is interesting enough to improve the learners' participation and motivation. Nonetheless, some researches assert that the use of educational robot does not necessarily lead to effective and successful learning. With respect to these serious problems, the researchers are emphasizing that it is needed to overcome the probable 'Novelty Effect' by means of considering specific features of the robot programming environment and the participants. We analyzed and found some features of robot programming teaching and learning environment and professional high school students through reviewing of the literatures, and then conducted delphi research to abstract motivational strategies and to develop their applying methods with the specific features. We developed a robot programming teaching and learning model for stimulating and maintaining professional high school student's motivation, which includes 5 factors and 21 strategies.

• Journal of Environmental Health Sciences
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• v.27 no.1
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• pp.20-26
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• 2001

personal nitrogen dioxide(NO$_2$) exposures for 31 professional drivers were measured using passive sampler and time activity diary in Asan and Chunan area, and were estimated using time-weighted average model. Mean concentrations of driver’s indoor and outdoor were 24.7$\pm$10.7 ppb and 23.3$\pm$8.3 ppb, respectively with indoor/outdoor of 1.1. Mean personal NO$_2$ exposure was 30.3$\pm$9.7 ppb. Personal NO$_2$ exposures were strongly correlated with indoor car NO$_2$ levels ($R^2$=0.80) rather than residential indoor NO$_2$ level ($R^2$=0.55). and outdoor NO$_2$ level ($R^2$=0.50). The driver’s NO$_2$ exposure using LP-gas with 24.4$\pm$8.0 ppb were statistically different from those using diesel with 36.3$\pm$14.1 ppb(p<0.01). The effect of driver’s smoking for personal NO$_2$ exposure was not found. It was considered that the main NO$_2$in driver is transportation. Since drivers mostly spent their times in indoor and inside car, time-weighted average model could be used to estimated personal NO$_2$ exposure using time activity diary, Though we did not measure all microenvironments, the estimated personal NO$_2$ exposures with 26.9$\pm$10.2 ppb were statistically correlated with measured personal NO $_2$ exposures30.3$\pm$9.7 ppb ($R^2$=0.89). The mean and standard deviation of personal NO$_2$ exposure using Mote-Carlo simulation were 26.6$\pm$7.2 ppb.

• Human Ecology Research
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• v.58 no.1
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• pp.75-86
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• 2020

This study examined the mediating effect of intimate partner violence (IPV) between alcohol use and relational satisfaction by the Actor Partner Interdependence Model (APIM). For this study, data were drawn from the 13^th-wave Korea Welfare Panel data and a total of 2,263 married couples were included in the analysis. SPSS 25.0 and AMOS 24 were used to analyze data and the Actor Partner Interdependence Mediation Model (APIMeM) examined the mediating effect. The results of this study are summarized as follows. First, the actor effect and the partner effect on the relationship of alcohol use and partner violence were all verified to be positive effects. Second, the actor effect and the partner effect on the relationship of partner violence and relational satisfaction were all verified to be negative effects. Third, comparison of the actor effect and partner effect between the husband and wife showed that the partner effect in which alcohol use to partner violence was greater in the husband than in the wife. In addition, both the actor and partner effect of violent reducing their relational satisfaction were greater in wives than in husbands. The findings of this study suggest that IPV has a mediating role between couples' alcohol use and the relational satisfaction and husband's violent behavior has more negative effect on the quality of the relationship than the wife's violent behavior.