• BMB Reports
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• v.53 no.11
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• pp.565-575
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• 2020

Gene therapy is emerging as a treatment option for inherited genetic diseases. The success of this treatment approach greatly depends upon gene delivery vectors. Researchers have attempted to harness the potential of viral vectors for gene therapy applications over many decades. Among the viral vectors available, gutless adenovirus (GLAd) has been recognized as one of the most promising vectors for in vivo gene delivery. GLAd is constructed by deleting all the viral genes from an adenovirus. Owing to this structural feature, the production of GLAd requires a helper that supplies viral proteins in trans. Conventionally, the helper is an adenovirus. Although the helper adenovirus efficiently provides helper functions, it remains as an unavoidable contaminant and also generates replication-competent adenovirus (RCA) during the production of GLAd. These two undesirable contaminants have raised safety concerns and hindered the clinical applications of GLAd. Recently, we developed helper virus-free gutless adenovirus (HF-GLAd), a new version of GLAd, which is produced by a helper plasmid instead of a helper adenovirus. Utilization of this helper plasmid eliminated the helper adenovirus and RCA contamination in the production of GLAd. HF-GLAd, devoid of helper adenovirus and RCA contaminants, will facilitate its clinical applications. In this review, we discuss the characteristics of adenoviruses, the evolution and production of adenoviral vectors, and the unique features of HF-GLAd as a new platform for gene therapy. Furthermore, we highlight the potential applications of HF-GLAd as a gene delivery vector for the treatment of various inherited genetic diseases.

• IE interfaces
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• v.13 no.3
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• pp.396-404
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• 2000

For most order-based production, it is important to meet urgent orders from important customers while maintaining high on-time delivery rate for successful supply chain management. In this paper, we propose an approach and a structure of planning system to implement Capable-To-Promise which promises the delivery time to the received order. We suggest and compare a few alternative order receiving policies for CTP.

• IE interfaces
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• v.12 no.3
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• pp.424-436
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• 1999

Due to environmental change in market, delivery satisfaction to customers and reduction of lead time are critical in the make-to-order manufacturing system. A case of production scheduling process restructuring is studied for one company which employed ERP system. Based on the standard module ERP package provided, they modified and added several functions for their specific processes, and implemented it in production scheduling. The ratio of delivery satisfaction has been improved from 51.1% to 60.8%, and manufacturing lead time has been reduced from 43 days to 30 days in average during 10 months. Moreover, they achieved several side effects such as real time production scheduling and workload analysis, information sharing over all departments, and improving flexibility in receiving orders.

• Korean Journal of Construction Engineering and Management
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• v.17 no.4
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• pp.49-56
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• 2016

Recent research has been ongoing for modular buildings in the country and interest increases. However, the activation of modular building projects is obstructed in the construction industry. There are many reasons to identity for this obstruction but one issue should be focussed. Modular buildings require to change the existing construction production system to a new construction production system, which is factory production - transportation - erection. However, the existing project delivery system in the public sector could not be adapted for this new construction production system due to the obligation of multi prime contract use, such as electrical, communication, fire fighting contracts by Law. Therefore, modular buildings in the existing project delivery system are separately contracted by multi prime contracts and modular units composed of the buildings are contracted by an architectural prime contractor as a commodity. As results, construction costs are increased, potential quality problems are raised and the existing project delivery system is finally an obstacle not to maximize benefits of the modular buildings. In this paper, we propose a new project delivery system for the modular buildings to adapt then ew construction production system.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1456-1461
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• 2004

Companies of Build-to-Order(BTO) strive to achieve customer responsiveness and cost efficiency simultaneously. The success of BTO depends upon the high volume production based on product plat form and delayed differentiation principle on the one hand, and upon the rapid estimation of delivery and cost for the customer orders on the other hand. Expeditious processing of a specific order requires the rearrangement of production resources and the schedule, which results in increased cost. This paper describes a cost estimation method using activity-based costing depending on the schedule change caused by urgent customer orders.

• IE interfaces
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• v.9 no.2
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• pp.159-171
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• 1996

In recent, most'of automobile industries adopt the concept of JIT production. According to the concept, the paternal manufacturers require their suppliers to supply parts just in time, so it is very important for a subcontractor to produce the parts in the appointed time of delivery. This study develops a production information system for Woosin Industry, which is one of such subcontractors of Hyundai Motors Company(HMC). The system is developed for use in Client/Server environment. In this study, the following three modules are developed, i. e., the production scheduling module, the sales management module to deal with the information about orders of HMC, delivery of parts, and bill collecting, and the module for supporting material requirements planning and purchase of material.

• Journal of Industrial Convergence
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• v.5 no.2
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• pp.21-32
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• 2007

This paper deals with the sequencing problem in the operation of the manufacturing systems with the constraint of buffer capacity. Some of studies for this theme have been progressed for several years. And then most of them considered only one objective, such as maximum lateness, machine utilization, makespan, mean flowtime and so on. This study deal with two objectives of the delivery for customers and the idle time of machines for producers. For the decision of sequence, the utility function is used. The developed heuristic algorithm presents a good solution. Through a numerical example, the procedures of the job sequencing is explained.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.3
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• pp.61-67
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• 2020

The fourth industrial revolution encourages manufacturing industry to pursue a new paradigm shift to meet customers' diverse demands by managing the production process efficiently. However, it is not easy to manage efficiently a variety of tasks of all the processes including materials management, production management, process control, sales management, and inventory management. Especially, to set up an efficient production schedule and maintain appropriate inventory is crucial for tailored response to customers' needs. This paper deals with the optimized inventory policy in a steel company that produces granule products under supply contracts of three targeted on-time delivery rates. For efficient inventory management, products are classified into three groups A, B and C, and three differentiated production cycles and safety factors are assumed for the targeted on-time delivery rates of the groups. To derive the optimized inventory policy, we experimented eight cases of combined safety stock and data analysis methods in terms of key performance metrics such as mean inventory level and sold-out rate. Through simulation experiments based on real data we find that the proposed optimized inventory policy reduces inventory level by about 9%, and increases surplus production capacity rate, which is usually used for the production of products in Group C, from 43.4% to 46.3%, compared with the existing inventory policy.

• Advances in nano research
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• v.14 no.2
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• pp.165-177
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• 2023

Nanomotors are gaining popularity as novel drug delivery methods since they can move rapidly, penetrate deeply into tissues, and be regulated. The ability of manufactured nanomotors to swiftly transport therapeutic payloads to their intended location constitutes a revolutionary nanomedicine strategy. The nanomotors for the drug delivery purpose are released in the blood flow under the different physical conditions, so the stability investigation of these devices is essential before the production, especially in the sport and physical exercise conditions that the blood flow enhances. As a result, using dynamic analysis, this article investigates the stability of the nanomotor released in the blood flow when sport and physical activity circumstances increase blood flow. The considered nanodevice is made of a central motor, and nanotubes are used for the nanomotor blade, which is the drug capsule. Finally, the stability examination of nanomotor as the drug delivery equipment is discussed in detail, and the proposed results can present beneficial results in designing and producing small-scale intelligent devices.

• KSBB Journal
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• v.19 no.5
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• pp.341-347
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• 2004

Several gene delivery therapies are being developed for treatment of serum protein deficiency. EPO is one of the most promising therapeutic agent for this treatment which is currently being investigated in depth. This study has the ultimate purpose of improving the gene delivery system for an increase of red blood cell production. A plasmid DNA was constructed smaller than other plasmids for an increase in penetration into animal cells, and two genes were cloned into each vector as a co-delivery system to express erythropoietin, and interluekin-3 or thrombopoietin, which can act on erythroid cell, thus activating hematopoiesis synergically. This co-delivery system has an advantage of decreasing the labour required for industrial production of DNA vaccine. A new plasmid vector, pVAC, in size 2.9 kb, was constructed with the essential parts from PUC 19 and pSectagB, which is much smaller than other plasmid vector and is the size of 2.9 kb. Co-delivery system was constituted by cloning human erythropoietin with each of human interluekin-3 gene or human thrombopoietin gene into both pVAC and pSectagB. As a result, the transfection efficiency of pVAC was higer than that of pSectagB in vitro, and hematocrit level of the mice injected with pVAC is higher than that of other mice. And co-delivery system, made of several plasmid DNAs, was expressed in vitro.