• Childhood Kidney Diseases
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• v.9 no.1
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• pp.1-7
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• 2005

The production of concentrated urine is achieved by countercurrent multiplication in the renal medulla. The single effect of the outer medulla is the active NaCl reabsorption in the thick ascending limb, while the single effect of the inner medulla is the passive efflux of NaCl through the thin ascending limb. The passive mechanism in the inner medulla requires a high interstitial urea concentration which is maintained by intrarenal recycling of urea. During the past decade, many transport proteins involved in the urine concentrating mechanism have been cloned, which has enabled us to understand the countercurrent multiplication mechanism on a molecular basis. This review will summarize the locations and functions of the renal medullary transport proteins, and the recent insights that have been acquired into the long term regulation of urea transporters.

• Asian-Australasian Journal of Animal Sciences
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• v.2 no.3
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• pp.462-464
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• 1989

• The Journal of the Korea institute of electronic communication sciences
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• v.8 no.7
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• pp.1075-1081
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• 2013

Twitter, Facebook, and KakaoStory are the major SNS in Korea. Social knowledge production is being produced by those services from numerous collaboration and co-participation in those SNS. Wikipedia or Naver JishikIN service was regarded as the representative product of collective knowledge production during the wired internet era. However now at the wireless internet era centered with smart phones, various forms of collective knowledge production would be achieved by connecting to SNS in real-time. In this thesis, the survey data of collective knowledge production for users of three SNS have been compared and analyzed. The difference of the collective knowledge production mechanism among Twitter, Facebook and KakaoStory has been studied and compared through three variables: the motivation of collective knowledge production, the preference of collective knowledge production model, and collective knowledge production cultural perception. As a result of the analysis of the discriminant factors for three SNS user groups, it turns out that the diversity-toward usage motivation, personal contribution motivation, and collective knowledge production tendency perception are the most influential variables. This thesis is of significance in that it unites the value of social science such as social capital and collective knowledge production from the viewpoint of computer science and opens the new chapter of collective knowledge production with the real-time SNS of wireless internet from the wired internet.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.30A no.12
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• pp.88-97
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• 1993

Electrostatic Discharge(ESD) is one of the major reliability, issues for today's VLSI production. Since the gate oxide with a thickness of 100~300$\AA$ is vulnerable to several thousand volt of ESD surge, it is necessary to control the ESD events and design an efficient protection circuit. In this paper, physical mechanism of the catastrophic ESD damage is investigated by transient analysis based upon Human Body Model(HBM). Using two-dimensional electrothermal simulator, we study the failure mechanism of the output protection devices by ESD and discuss the design issues for the optimun protection network.

• Microbiology and Biotechnology Letters
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• v.23 no.5
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• pp.593-598
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• 1995

The cultural conditions of Bullera singularis were optimized for the efficient production of galactooligosaccharide (GOS), Optimum temperature was 25$\circ$C, pH was 6.0, inoculum size was over 5% (v/v), initial lactose concentration was over 5% (w/v). The GOS production increased with microbial growth. Maximum amount of 72% (w/w) GOS was obtained from the optimized medium (5% lactose and 0.75% yeast extract) in 70 hours. Seven types of GOS (3 of dimer, 2 of trimer, 1 of tetramer, and 1 of pentamer) were identified by two-dimensional TLC. A new mechanism of GOS production is proposed based on the metabolism of carbon source.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.154-158
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• 1997

This paper proposes a new resource allocation system where overall performance can be improved using production smoothing method. In economic point of view, market price is determined by the market mechanism that is subject to the law of demand and supply. Similarly, agents determine whether to allocate tasks to machines by profit and loss or not. In existing resource allocation system, tasks are exclusively allocated to agents with better manufacturing conditions, because they are evaluated by the only currency. But in the proposed resource allocation system, agents are evaluated by not only a currency but also machine specifications. Hereby, the production smoothing is achieved and we expect to improve system performance In this study, we propose a resource allocation system with consideration of Production Smoothing.

• Korean Journal of Microbiology
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• v.26 no.4
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• pp.362-367
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• 1988

The strain YL 38-3, which was capable of producing extracellular cytosine deaminase, was isolated and taxonomically examined. The isolated strain was identified to be Bacillus polymyxa YL 38-3. The optimal conditions for the enzyme production from Bacillus polymyxa YL 38-3 were investigated. The enzyme production was reached maximum level in the medium containing 0.5% glucose, 0.2% beef extract, 0.5% NaCl and 0.1% $KH_{2}PO_{4}$ (pH 6.0). And the enzyme showed the highest activity when the strain YL 38-3 was cultivated at $35^{\circ}C$ for 24 gours under the initial pH 6.0. By the additions of peptone the extracellular enzyme production was inhibited, meanwhile the intracellular enzyme production was highly stimulated. It was, therefore, deduced that peptone was related to the secretion mechanism of the enzyme from this bacterial cell.

• YAKHAK HOEJI
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• v.57 no.1
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• pp.24-31
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• 2013

Although statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, have been shown to increase melanin synthesis, the exact mechanism of this action is not fully understood. In this study we investigated the possible involvement of intracellular $Ca^{2+}$ signal in the mechanism of stimulation of melanin synthesis induced by lovastatin in B16 cells. Lovastatin stimulated the production of melanin in a dose-dependent manner in the cells. Treatment with mevalonate, FPP and GGPP, precursors of cholesterol, did not significantly suppress the lovastatin-induced melanin production, suggesting that inhibition of cholesterol synthesis may not be involved in the mechanism of the action of lovastatin. In addition, lovastatin did not significantly alter the cAMP concentration and the stimulated production of melanin by lovastatin was not significantly changed by treatment with H89, a potent inhibitor of protein kinase A, which demonstrates that cAMP pathway may not be involved. However, lovastatin increased intracellular $Ca^{2+}$ concentration in a dose-related fashion. Treatment with EGTA, an extracellular $Ca^{2+}$ chelator did not significantly alter the lovastatin-induced intracellular $Ca^{2+}$ increase and melanin synthesis, whereas intracellular $Ca^{2+}$ reduction with BAPTA/AM and intracellular $Ca^{2+}$ release blockers (dantrolene and TMB-8) completely blunted these actions of lovastatin. Taken together, these results suggest that the intracellular $Ca^{2+}$ release may play an important role in the lovastatin-induced stimulation of melanin synthesis in B16 cells. These results further suggest that lovastatin may be useful for the treatment of hypopigmentation disorders, such as vitiligo.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.962-966
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• 2004

Suction transfer system with air suctioning is widely used and continuously developed in production automation. Air suctioning has some drawbacks in use. To generate vacuum in the suction cup with air suctioning, complex of mechanical component like as air compressor, air tube, air value is need, and it needs continuous air supply. And if the failure of the suction in a cup in the multi-suction cup system which is generally used occurs then the suctions of all of the cup will be fail. To overcome these drawbacks, new suction mechanism which uses permanent magnet for the movement of the suction cup is proposed. The proposed mechanism activates each suction cup separately, so the air leakage of a cup is not critical. The proposed suction system wasdesigned and fabricated in real world. With some experiments, the usability and performance of the suction mechanism was proved. The strong points of the proposed suction mechanism are simple structure, high energy efficiency, and discrete energy supply.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.9
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• pp.982-989
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• 2009

Parallel Kinematic Mechanism (PKM) is a device to perform the various motion in three-dimensional space and it calls for six degree of freedom. For example, Parallel Kinematic Mechanism is applied to machine tools, medical equipments, MEMS, virtual reality devices and flight motion simulators. Recently, many companies have tried to develop new Parallel Kinematic Mechanism in order to improve the cycle time and the precisional tolerance. Parallel Kinematic Mechanism uses general universal joint and spherical joint, but such joints have accumulated tolerance problems. Therefore, it causes position control problem and dramatically life time reduction. This paper focused on the rolling element to improve sliding precision in new sliding ball joint development. Before the final design and production, it was confirmed that new sliding ball joint held a higher load and a good geometrical structure. FEM analysis showed a favorable agreement with tensile and compressive testing results by universal testing machine. In conclusions, a new sliding ball joint has been developed to solve a problem of accumulated tolerance and verified using tensile and compressive testing as well as FEM analysis.