• Genomics & Informatics
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• v.16 no.4
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• pp.19.1-19.11
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• 2018

MicroRNAs (miRNAs), small non-coding RNAs, have been implicated in various diseases and cellular functions as microregulators of gene expression. Although the history of miRNA investigation in autoimmune $Sj{\ddot{o}}gren^{\prime}s$ syndrome (SjS) is fairly short, a substantial amount of data has already been accumulated. These findings clearly indicate potential clinical implications of miRNAs, such as autoantigen expression and autoantibody production, viral miRNAs regulating the calcium signaling pathway, and aberrant immune cell regulation and cytokine production. Research endeavors in the field are currently underway to select disease-specific diagnostic and prognostic biomarkers by utilizing different types of tissues or biological specimens of SjS patients. Various techniques for miRNA analysis with different stringencies have been applied, with the most recent one being next-generation sequencing. This review compiles and highlights differentially-expressed miRNAs in various samples collected from SjS patients and their potential implications in the pathogenesis of SjS. To facilitate the development of miRNA-targeted personalized therapy in the future, we urge more follow-up studies that confirm these findings and elucidate the immunopathological roles of differentially-expressed miRNAs. Furthermore, improved diagnostic criteria for the disease itself will minimize sampling errors in patient recruitment, preventing the generation of inconsistent data.

• Journal of Korea Water Resources Association
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• v.47 no.6
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• pp.523-536
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• 2014

A water supply reliability is mainly influenced by water demand, reservoir storage, and inflow change caused from drought. The water supply reliability can vary depending on the method of dam operation. In Korea, the deficit-supply method which complements water deficit as water shortage occurs in downstream areas has been used for the national water resources master plan using K-WEAP, but the prime flow method, an alternative approach, would show different results of water supply reliability in comparison to the deficit-supply method. The objective of this research is to compare and analyze differences in water supply reliability according to dam operation methods. These results can be used to re-evaluate water supply reliability of dam in a circumstance considering steady dam release for instreamflow in downstream and hydroelectric power generation.

• Journal of Power System Engineering
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• v.21 no.6
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• pp.13-20
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• 2017

Ni-base superalloy Haynes 282 was developed as a gas turbine material for use in the ultra-super-critical stage (USC) of next-generation coal-fired power plants. Temperatures in the USC stage exceed $700^{\circ}C$ during operation. In spite of its important role Haynes 282 in increasing the performance of high-pressure turbines, as a result of its high-temperature capability, there is little information on the microstructure, deformation mechanism, or mechanical properties of the cast condition of this alloy. The aim of present study is to examine the creep properties of cast alloy and compare with wrought alloy. The ${\gamma}^{\prime}-precipitates$ were coarsen with the increase of aging time ranging from 8 to 48 hrs. A creep test performed at $750^{\circ}C$ showed faster minimum creep rate and shorter rupture lifetime with the aging time. A creep test performed showed only a slight difference in the rupture life between cast and wrought products. Based on the creep test results, the deformation mechanism is discussed using fractographs.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.1
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• pp.199-206
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• 2005

Mask manufacturing is a high COC and COO process in developing of semiconductor devices because of mask production tool with high resolution. Direct writing has been thought to be the one of the patterning method to cope with development or small-lot production of the device. This study consists two categories. One is the additional process of the direct and maskless patterning generation using SLA for easy and convenient application and the other is a removal process using wet-etching process. In this study, cured status of epoxy pattern is most important parameter because of the beer-lambert law according to the diffusion of UV light. In order to improve the contact force between patterns and substrate, prime process was performed and to remove the semi-cured resin which makes a bad effects to the pattern, spin cleaning process using TPM was also performed. At a removal process, contact force between photo-curable resin as an etching mask and Si wafer is important parameter.

• Journal of Power System Engineering
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• v.15 no.5
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• pp.16-21
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• 2011

The large scale decisive battle will be gradually reduced on the sea in the future and surface combatant ship installed advanced weapon units as well as propulsion system will be continuously increased. The high level of military technology leads to appear state-of-the-art weapon system using high power energy. As a results, fossil fuel powered main prime mover as diesel engine and gas turbine which are composed of mechanical propulsion system should be decreased from combatant ship in the near future. The new building naval combatant ship with the latest technology has electric based propulsion method of the hybrid type combined with mechanical and electrical drive. U.S. and Royal Navy, especially, select the integrated fully electric based propulsion system for the next generation combat ship and play an important roll for developing them. In this context, this paper was focused on the deduction of implications through analyzing the combatant ship propulsion system using diesel and gas turbine engine which are promoted on the worldwide.

• Journal of IKEEE
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• v.23 no.2
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• pp.438-447
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• 2019

As the IoT-based hyper-connected society grows, public-key cryptosystem such as RSA is frequently used for encryption, authentication, and digital signature. Public-key cryptosystem use very large (safe) prime numbers to ensure security against malicious attacks. Even though the performance of the device has greatly improved, the generation of a large (safe)prime is time-consuming or memory-intensive. In this paper, we propose ET-MR and ET-MR-MR using Euler sieve so it runs faster while using less memory. We present a running time prediction model by probabilistic analysis and compare time and memory of our method with conventional methods. Experimental results show that the difference between the expected running time and the measured running time is less than 4%. In addition, the fastest running time of ET-MR is 36% faster than that of TD-MR, 8.5% faster than that of DT-MR and the fastest running time of ET-MR-MR is 65.3% faster than that of TD-MR-MR and similar to that of DT-MR-MR. When k=12,381, the memory usage of ET-MR is 2.7 times more than that of DT-MR but 98.5% less than that of TD-MR and when k=65,536, the memory usage of ET-MR-MR is 98.48% less than that of TD-MR-MR and 92.8% less than that of DT-MR-MR.

• Cross-Cultural Studies
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• v.21
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• pp.31-52
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• 2010

Even though Chilean writer Roberto $Bola{\tilde{n}}o^{\prime}s$ novel Amulet was inspired by a historical account, it significantly rewrites the story as well as redefines the people who witnessed the history. This novel focuses on the Uruguayan poet Auxilio Lacouture, the self-anointed "mother of Mexican Poetry". She is trapped in a bathroom at the UNAM in Mexico City for thirteen days while the army storms the campus for the repression of the student movement, which was decreed by the sinister Díaz Ordaz and culminated in the holocaust of Tlatelolco. In the space isolated from the outside world, Auxilio attempts to reconstruct the past and to describe the future through an illogical exercise of times. In the meantime, her temporal recollections finally approach the definition of a generation whose historical experience is crucially marked by the key year of 1968, when the novel is set. The only one who remained on the campus, she defends the university's autonomy only by reading and writing poetry. The novel ends in a scene densely imbued with allegorical imagination, by which the author endeavors to justify her generation, more concretely, "the peoples without history", as defined by bohemian poets. The protagonist represents, in some sense, an allegory of the innocence and truth of the history. Her existence per se manifestly demonstrates the power of literature because the literature within this novel in short becomes the most resilient amulet resisting the political violence in an era of increasing madness.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.48 no.2
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• pp.14-20
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• 2011

In mobile ad hoc networks where the communication nodes are moving around, one may perform dynamic routing that can increase the total communication throughput of the network, by determining the ranks of pairs of nodes according to their communication throughput. The balanced Howell rotation is a tournament design scheme for bridge games. This paper explains that the balanced Howell rotation can be applied to enhance the overall communication throughput of mobile ad hoc networks, and proposes and proves the condition under which the balanced Howell rotations may exist.

• Journal of applied mathematics & informatics
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• v.12 no.1_2
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• pp.143-154
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• 2003

A finite group G is called (l, m, n)-generated, if it is a quotient group of the triangle group T(l, m, n) = 〈$\chi$, y, z│$\chi$$\^$l/ = y$\^$m/ = z$^n$ = $\chi$yz = 1〉. In [19], the question of finding all triples (l, m, n) such that non-abelian finite simple group are (l, m, n)-generated was posed. In this paper we partially answer this question for the sporadic group Ru. In fact, we prove that if p, q and r are prime divisors of │Ru│, where p < q < r and$.$(p, q) $\neq$ (2, 3), then Ru is (p, q, r)-generated.

• Korean Journal of Mathematics
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• v.16 no.4
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• pp.481-494
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• 2008

Iteration functions $K_m(z)$ and $U_m(z)$, $m{\geq}2$are defined recursively using the determinant of a matrix. We show that the fixed-iterations of $K_m(z)$ and $U_m(z)$ converge to a simple zero with order of convergence m and give closed form expansions of $K_m(z)$ and $U_m(z)$: To show the convergence, we derive a recursion formula for $L_m$ and then apply the idea of Ford or Pomentale. We also find a Toeplitz matrix whose determinant is $L_m(z)/(f^{\prime})^m$, and then we adapt the well-known results of Gerlach and Kalantari et.al. to give closed form expansions.