• Journal of Ecology and Environment
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• v.30 no.2
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• pp.201-207
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• 2007

Researchers have used a variety of methods to measure patterns of animal movement, including the use of spatial data (mapping the position of a moving animal at specified intervals) and direct estimation of travel path length by pacing under a moving animal or group. I collected movement data from five groups of siamangs (Symphalangus syndactylus) using two different methods concurrently to estimate the effects of the method of data collection on estimates of daily path length (DPL). Estimates of DPL produced from spatial data collected at 15-minute intervals were 12% lower than estimates of DPL produced by pacing under the traveling animal. The actual magnitude of the difference was correlated with the travel distance, but there was no correlation between the proportional difference and the travel distance. While the collection of spatial data is generally preferable, as spatial data permit additional analyses of patterns of movements in two or three dimensions, the relatively small difference between the DPL's produced using different methods suggests that pacing is an acceptable substitute where the collection of spatial data is impractical. I also subsampled the spatial data at increasing time intervals to assess the effect of sampling interval on the calculation of daily path lengths. Longer sampling intervals produced significantly shorter estimates of travel paths than shorter sampling intervals. These results suggest that spatial data should be collected at short time intervals wherever possible, and that sampling intervals should not exceed 30 minutes. Researchers should be cautious when comparing data generated using different methods.

• Journal of the Korean Institute of Landscape Architecture
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• v.23 no.1
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• pp.157-173
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• 1995

Seowons were first established during the Koryo Dynasty and contain primate shrines for the service of ancestors and ancient sages. Seowons were located in a scenic or rural place some distance from a residential area. The direct motive for building the Seowon came from the need for transcendental concealment and evasive retirement which developed as a result of oppression of scholars The indirect motivations were the development of loaming in an idyllic natural settings and the creation of a beautiful natural environment. he purpose of tai study is to investigate the characteristics and transformation process of the location of Seowon in the Chosen dynasty. The results of this research are summarized as fellows : 1. Seowons were in hilly areas with good geographical features including a nice view of the mountains and waters. Beowons were also built on the relation place of an ancient sage and of destroyed Buddist temples. 2. The location patterns of seowon in the Choson dynasty underwent three stages with the change of time Political and social phenomena influenced the transformation of the location patterns Research in this area is at an early stage. The present study was confined to an examination of 7he characteristics and transformation process of the location of seowons. However, it is hoped that this study will offer meaningful guide for further research.

• Journal of information and communication convergence engineering
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• v.2 no.2
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• pp.132-137
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• 2004

Most of the current computer vision theories are based on hypotheses that are difficult to apply to the real world, and they simply imitate a coarse form of the human visual system. As a result, they have not been showing satisfying results. In the human visual system, there is a mechanism that processes information due to memory degradation with time and limited storage space. Starting from research on the human visual system, this study analyzes a mechanism that processes input information when information is transferred from the retina to ganglion cells. In this study, a model for the characteristics of ganglion cells in the retina is proposed after considering the structure of the retina and the efficiency of storage space. The MNIST database of handwritten letters is used as data for this research, and ART2 and SOM as recognizers. The results of this study show that the proposed recognition model is not much different from the general recognition model in terms of recognition rate, but the efficiency of storage space can be improved by constructing a mechanism that processes input information.

• Clinical and Experimental Vaccine Research
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• v.12 no.4
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• pp.291-297
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• 2023

Enterovirus infections induce infectious diseases in young children, such as hand, foot, and mouth disease which is characterized by highly contagious rashes or blisters around the hands, feet, buttocks, and mouth. This predominantly arises from enterovirus A71 or coxsackievirus A16 infections and in severe cases, they can lead to encephalitis, paralysis, pulmonary edema, or even fatality, representing a global health threat. Due to the absence of effective therapeutic strategies for these infections, various experimental animal models are being investigated for the development of vaccines. During the early stages of research on enterovirus infections, non-human primate infections exhibited symptoms like those in humans, leading to their utilization as model animals. However, due to economic and ethical considerations, their current usage is limited. While enterovirus infections do not readily occur in mice, an infection model with mouse-adapted strain in neonatal mice has been employed. Cellular receptors have been identified in human cells, and genetically modified mice expressing these receptors have been used. Most recently, the utilization of Mongolian gerbil model is actively being considered and should be pursued for further animal model development. So, herein, we provide a summarized overview of the current portfolio of available enterovirus infection models, emphasizing their respective advantages and limitations.

• IMMUNE NETWORK
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• v.21 no.3
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• pp.24.1-24.13
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• 2021

Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.

• International Journal of Molecular Medicine
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• v.43 no.5
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• pp.2230-2240
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• 2019

Hair follicles (HFs) are a well-characterized niche for adult stem cells (SCs), and include epithelial and melanocytic SCs. HF cells are an accessible source of multipotent adult SCs for the generation of the interfollicular epidermis, HF structures and sebaceous glands in addition to the reconstitution of novel HFs in vivo. In the present study, it was demonstrated that HF cells are able to be induced to differentiate into cardiomyocyte-like cells in vitro under specific conditions. It was determined that HF cells cultured on OP9 feeder cells in KnockOut-Dulbecco's modified Eagle's medium/B27 in the presence of vascular endothelial growth factors differentiated into cardiomyocyte-like cells that express markers specific to cardiac lineage, but do not express non-cardiac lineage markers including neural stem/progenitor cell, HF bulge cells or undifferentiated spermatogonia markers. These cardiomyocyte-like cells exhibited a spindle- and filament-shaped morphology similar to that presented by cardiac muscles and exhibited spontaneous beating that persisted for over 3 months. These results demonstrate that SC reprogramming and differentiation may be induced without resulting in any genetic modification, which is important for the clinical applications of SCs including tissue and organ regeneration.

• The korean journal of orthodontics
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• v.36 no.1 s.114
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• pp.84-90
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• 2006

The aims of this study were to investigate the prevalence of spaced, closed, and crowded primary dentitions by sex and arch in Korean children from Kanghwa, and to determine the frequency of the primate and developmental spaces. The differences in the mesiodistal crown diameters and the arch dimensions between the spaced, closed, and crowded primary dentitions were also evaluated. Dental casts of 102 preschool children (57 males and 45 females, aged $4{\sim}5$ years) were studied. The prevalence of spacing in the primary dentition was 63.2% In males and 57.8% in females. The frequency of spacing was greater in males than in females, and greater in the maxillary arch than in the mandibular arch. The crowns were significantly larger and the arches significantly narrower in closed and crowded dentitions than in those with spacing (p<0.05). The results showed that the prevalence of spacing was lower than that found in previous studies and the presence of spacing in the anterior region was related to the mesiodistal crown diameter and the intercanine width.

• Korean Journal of Veterinary Research
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• v.50 no.4
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• pp.273-277
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• 2010

The objective of this study was to investigate the infection rate of gastro-intestinal tract parasites on acquired laboratory nonhuman primates, Vervet monkey, Cynomolgus monkey, and Rhesus monkey acquired from Japan and China. These monkeys have been acclimating at an individual housing condition after our legal quarantine period. We examined 133 fecal samples to investigate parasitic infection using direct smear and formalin-ether-sedimentation technique. As a result, total parasitic infection rate was 33.8% (n = 45/133) for all monkeys. Two species of macaques, cynomolgus and rhesus, were infected with Trichuris trichiura (4), Giardia lamblia (4) and Balantidium coli (41). Vervet monkeys, which had been controlled by individual housing system for a long time, were clear for parasitic infection. The protozoan, Balantidium coli was one of the most frequently detected in these monkey colonies. Double infection was noted in only 4 monkeys and involved with Trichuris trichiura and Balantidium coli. Serious clinical symptoms were not observed in the most of the infected monkeys, but the monkeys infected by Giardia lamblia showed intermittent or chronic watery diarrhea. Consequently, the prophylactic anthelmintic treatment and periodic monitoring are essential to preserve the SPF colonies in the laboratory facility.

• Journal of Microbiology and Biotechnology
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• v.28 no.9
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• pp.1413-1425
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• 2018

Shiga toxins (Stxs) are the main virulence factors expressed by the pathogenic Stx-producing bacteria, namely, Shigella dysenteriae serotype 1 and certain Escherichia coli strains. These bacteria cause widespread outbreaks of bloody diarrhea (hemorrhagic colitis) that in severe cases can progress to life-threatening systemic complications, including hemolytic uremic syndrome (HUS) characterized by the acute onset of microangiopathic hemolytic anemia and kidney dysfunction. Shiga toxicosis has a distinct pathogenesis and animal models of Stx-associated HUS have allowed us to investigate this. Since these models will also be useful for developing effective countermeasures to Stx-associated HUS, it is important to have clinically relevant animal models of this disease. Multiple studies over the last few decades have shown that mice injected with purified Stxs develop some of the pathophysiological features seen in HUS patients infected with the Stx-producing bacteria. These features are also efficiently recapitulated in a non-human primate model (baboons). In addition, rats, calves, chicks, piglets, and rabbits have been used as models to study symptoms of HUS that are characteristic of each animal. These models have been very useful for testing hypotheses about how Stx induces HUS and its neurological sequelae. In this review, we describe in detail the current knowledge about the most well-studied in vivo models of Stx-induced HUS; namely, those in mice, piglets, non-human primates, and rabbits. The aim of this review is to show how each human clinical outcome-mimicking animal model can serve as an experimental tool to promote our understanding of Stx-induced pathogenesis.

• Journal of Veterinary Clinics
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• v.25 no.4
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• pp.314-316
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• 2008

Acute gastric dilatation (AGD), one of the common causes of emergency occurs in macaca monkeys that are accommodated as laboratory-housed nonhuman primates. This report introduces some cases of occurrence in raising primates. The primates revealed an acute gastric dilatation, including the histories that were trained by monkey chair, anesthetized for the study or intact case. The clinical signs were comatose condition with sever abdominal distension, dehydration, cyanosis and apnea. One case died by deterioration of systemic body condition and performed necropsy. The other cases recovered from the AGD by the emergency treatment using the gastric tube and fluid therapy. Necropsy revealed the huge stomach filled with water, gas and ingesta. This report suggests that etiologic factors of AGD may include non-specific factors like these cases, with special emphasis on the incidence and management of AGD in nonhuman primates.