• The Korean Journal of Physiology and Pharmacology
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• v.27 no.5
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• pp.457-470
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• 2023

The aim of this study was to investigate the role of kinesin superfamily member 15 (KIF15) in nasopharyngeal carcinogenesis (NPC) and explore its underlying mechanisms. We employed various assays, including the CCK-8 assay, flow cytometry, the Transwell and scratch assay, Western blotting, and nude mice transplantation tumor, to investigate the impact of KIF15 on NPC. Our findings demonstrate that KIF15 plays a critical role in the proliferation, apoptosis, migration, and invasion of NPC cells. Furthermore, we discovered that silencing KIF15 inhibits cell proliferation, migration, and invasion while promoting apoptosis, and that KIF15's effect on NPC cell growth is mediated through the PI3K/AKT and P53 signaling pathways. Additionally, we showed that KIF15 promotes nasopharyngeal cancer cell growth in vivo. Our study sheds light on the significance of KIF15 in NPC by revealing that KIF15 knockdown inhibits NPC cell growth through the regulation of AKT-related signaling pathways. These findings suggest that KIF15 represents a promising therapeutic target for the prevention and treatment of NPC.

• 한국체육학회지인문사회과학편
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• v.51 no.4
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• pp.407-417
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• 2012

The purpose of the study was to determine the effects of pilates mat exercise on cardiovascular disease risk factors and inflammation markers in sarcopenic obesity elderly. All subjects were sarcopenic obesity(height for each of the arms, legs, appendicular muscle mass ratio of 1.16kg/m², 4.31kg/m², 5.21kg/m² under and % body fat is more than 30%) elderly performed the pilates mat exercise during 12-week for 60 minutes 3 times a weeks. All subjects of this study were examined the changes in cardiovascular disease risk factors(TC, TG, HDL-C, LDL-C, Glucose, Insulin) and inflammation markers(fibrinogen, adiponectin, leptin, CRP). The results of the study in the exercise group were as follows; The weight, % body fat, TC, TG, LDL-C, fibrinogen, CRP had significantly decreased and muscle mass, HDL-C, adiponectin had significantly increased. And also, pilates mat exercise can effective to improve sarcopenic obesity, and pilates mat exercises performed coy shrink obesity to cardiovascular disease and inflammatory response indicators of older women as old man's physical features of the deterioration of the prevention of obesity and muscle strength loss, causing the effective exercise method is meant to be.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.685-690
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• 2023

It was analyzed that the volume of deep excavation works adjacent to existing underground structures is increasing according to the population growth and density of cities. Currently, many underground structures and tracks are damaged by external factors, and the cause is analyzed based on the measurement results in the tunnel, and measurements are being made for post-processing, not for prevention. The purpose of this study is to analyze the effect on the deformation of the structure due to the excavation work adjacent to the urban railway track in use. In addition, the safety of structures is evaluated through machine learning techniques for displacement of structures before damage and destruction of underground structures and tracks due to external factors. As a result of the analysis, it was analyzed that the model suitable for predicting the structure management standard value time in the analyzed dataset was a polynomial regression machine. Since it may be limited to the data applied in this study, future research is needed to increase the diversity of structural conditions and the amount of data.

• Journal of Navigation and Port Research
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• v.47 no.1
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• pp.1-9
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• 2023

Many studies have analyzed marine accidents, and since marine accident information is updated every year, it is necessary to periodically analyze and identify the causes. The purpose of this study was to prevent accidents by identifying and analyzing the causes of marine accidents using previous and new data. In marine accident data, 1,921 decisions by the Korea Maritime Safety Tribunal on marine accidents on fishing ships over 16 years were collected in consideration of the specificity of fishing ships, and 1,917 cases of accident notification text history by the Ministry of Maritime Affairs and Fisheries over 3 years were collected. The decision data and text data were classified according to variables and quantified. Prior probability was calculated using a Bayesian network using the quantified data, and fishing ship marine accidents were predicted using backward propagation. Among the two collected datasets, the decision data did not provide the types of fishing ships and fishing areas, and because not all fishing ship accidents were included in the decision data, the text data were selected. The probability of a fishing ship marine accident in which engine damage would occur in the West Sea was 0.0000031%, as calculated by backward propagation. The expected effect of this study is that it is possible to analyze marine accidents suitable for the characteristics of actual fishing ships using new accident notification text data to analyze fishing ship marine accidents. In the future, we plan to conduct research on the causal relationship between variables that affect fishing ship marine accidents.

• Journal of the Korean Geotechnical Society
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• v.26 no.3
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• pp.35-45
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• 2010

The mechanism of load transfer by punching shear in pile-supported embankments is investigated. Based on the geometric configuration of the punching shear observed in sand fills on soft ground, a theoretical analysis is carried out to predict the embankment loads transferred on a cap beam according to punching shear developed in pile-supported embankments. The equation presented by the theoretical analysis was able to consider the effect of various factors affecting the vertical loads transferred on the cap beam. The reliability of the presented theoretical equation is investigated by comparing it with the results of a series of model tests. The model tests were performed on cap beams, which had two types of width; one is narrow width and the other is wide width. Sand filling was performed through seven steps. Two types of loading pattern were applied at each filling step; one is the long-term loading, in which sand fills at each filling step were kept for 24 hours, the other is the short-term loading, in which sand fills at each filling step were kept for 2 hours. The vertical loads measured in all model tests show good agreement with the ones predicted by the theoretical equation. Finally, the predicted vertical loads also show good agreement with the vertical loads measured in a well-instrumented pile-supported embankment in field, where cap beams were placed on too wide space.

• Journal of the Korean Geotechnical Society
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• v.23 no.5
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• pp.77-88
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• 2007

Lateral earth pressure and horizontal displacement of the diaphragm walls constructed in multi-soil layers were analyzed by the field instrumentation from six building construction sites in urban area. The distribution of the developed earth pressure of the anchored diaphragm walls during excavation shows approximately a trapezoid diagram. The maximum earth pressure of anchored diaphragm walls corresponds to $0.45{\gamma}H$ and the earth pressure acts at the upper part of the walls. The maximum earth pressure is two times larger than the empirical earth pressure of flexible walls in sands suggested by Terzaghi and Peck(1967), Tschebotarioff(1973), and Hong and Yun(1995a). The horizontal displacement of diaphragm walls is closely related with supporting systems such as struts, anchors, and so on. The horizontal displacement of anchored walls shows less than 0.1 percent of the excavated depth, and the horizontal displacement of strutted walls shows less than 0.25 percent of the excavated depth. Therefore, the restraining effect of horizontal displacement to the anchored diaphragm walls is larger than the strutted diaphragm walls. In addition, since the horizontal displacement of the diaphragm walls is lower than the criterion, $\delta=0.25%H$, used for control the anchored retention wall using soilder piles, the safety of excavation sites applied with the diaphragm walls is pretty excellent.

• Therapeutic Science for Rehabilitation
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• v.12 no.2
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• pp.69-83
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• 2023

Objective : This study, as a preliminary study, applied an Information & Communication Technology (ICT) home-based program to elderly people aged 65 years or older to confirm the effect of the cognitive enhancement program and to find the possibility of remote rehabilitation. Methods : This study from August to October 2022, three subjects were selected and the intervention was conducted for about 2 months. This intervention was conducted using Korean version of Mini-Mental State Examination, Korean version of Montreal Cognitive Assessment (MoCA-K), Computer Cognitive Senior Assessment System, and the Center for Epidemiologic Studies Depression scale to evaluate cognitive improvement before and after the program. The therapist remotely set the level of cognitive training according to the subject's level through weekly feedback. Results : After the intervention, all subjects showed improved scores in most items of the MoCA-K conducted before and after the intervention. In addition, among the items of Cotras-pro, upper cognition, language ability, attention, visual perception, and memory were improved. Conclusion : Cognitive rehabilitation training using an ICT home-based program not only prevented dementia but also made it habitual. Through this study, it was confirmed that remote rehabilitation for the elderly could be possible.

• Journal of Industrial Convergence
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• v.21 no.3
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• pp.139-148
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• 2023

This study was conducted through Google online survey from November 24 to November 26, 2021 targeting 276 students from the department of dental hygiene at a university in Gangwon-do. The purpose of this study was to investigate the infection awareness of uniforms, recognition of washing rules, and the intention to prevent infectious diseases through individualism and collectivist self-esteem. Statistical methods were analyzed using SPSS Statistics 24.0 and AMOS 21.0 as follows. For analysis, frequency analysis, exploratory factor analysis, confirmatory factor analysis, reliability analysis, structural equation, and ANOVA analysis were performed. As a result, it was confirmed that the models of uniform infection awareness, uniform washing rule recognition(p<.001), self-esteem, individualism, and collectivist intention to prevent infectious diseases were suitable(p<.001). Collectivism was found to affect the perception of uniform infection, the recognition of uniform washing rules, and the intention to prevent infectious diseases, confirming that self-esteem and collectivism had an effect on the change of perception for infection prevention. In the future, it will be possible to use the uniform washing method considering collectivism in infection control education of the dental hygiene.

• Journal of Environmental Health Sciences
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• v.48 no.1
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• pp.1-8
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• 2022

Objectives: The purpose of this study is to reveal the circumstances under which the cases of harm to health caused by humidifier disinfectant were neglected and show the points where the number of victims and the degree of damage could have been reduced. In addition, it attempts to describe how damage management proceeded immediately after the incident and actually exacerbated the damage. Finally, it explores the unfortunate aspects of the recent trial. By doing so, it attempts to take this as an opportunity to consider whether a tragic event such as the humidifier disinfectant incident could occur in the future. Methods: This study collected and analyzed data on chemical material characteristics related to humidifier disinfectants, data on health effect characteristics, data on related laws and regulations from the Ministry of Environment, data related to the damage investigation by the Korea Environmental Industry and Technology Institute, and current contents. Results: The lack of related systems and laws is the area where the greatest responsibility for the cause of the humidifier disinfectant disaster falls, so it is difficult for the government to escape this responsibility. Establishing a dedicated department to identify the prevalence of certain diseases within the functions of the Health Insurance Review and Assessment Service to monitor health can greatly contribute to the prevention and management of diseases through early detection and management of group outbreaks caused by harmful factors. Humidifier disinfectant damage relief should have been expanded earlier beyond HDLI (humidifier disinfectant lung injury) to include non-specific diseases such as asthma, pneumonia, and interstitial pneumonia. The scope of relief benefits should have also been expanded earlier to include the payment of disability benefits. Fortunately, with the 2020 revision of the Special Act, the conditions for estimating causal relations were eased and individual screening systems such as health impact assessment were reorganized along with the introduction of a rapid screening system. Conclusions: The management system for chemical substances in a country is clearly of paramount importance, and the ministry in charge must have a response system in case of damage to health effects. Administration that looks at the victims' situation from their point of view is needed, and technical countermeasures are required to quickly recognize the prevalence of certain diseases.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.20-37
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• 2023

Although traffic signal installations are continuously expanding, the effect of preventing traffic accidents remains unverified. Totally, 7,045 traffic accident data (such as signal violations) registered with TCS were manually searched for a 7-year period from 2013 to 2019 for 1,602 traffic signals in Daejeon Metropolitan City. The top 20 traffic accident intersections were identified, the traffic accident investigation records and field maps were viewed to compare the driving direction and signal phase of the violated vehicle, and the cause of the traffic accident was divided into insufficient signal operation design (operation) and driver negligence (intentional). Results of the analysis revealed that 75% of traffic accidents occurred in thru-left-turn traffic signals and overlap; moreover, extending the yellow time or operating all red signals due to countermeasures against traffic accidents occurring in yellow signals resulted in reduced traffic accidents. Data indicated that Permissive Left Turn requires improvement with the signal operation. In addition, since The Korean National Police Agency is not computerized for traffic accident sites and signal-related data, the lack of manpower necessitates improvement and utilization of TCS when establishing traffic accident prevention measures. It is believed that it will contribute to signal operation by analyzing vast amounts of data collected in the field and presenting improvement measures.