• 한국철도학회논문집
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• 제9권4호
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• pp.335-342
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• 2006

Disaster management system should be built for minimizing damage factor that affects to construction facility from natural disaster. It could be classified by three categories such as disaster prevention, damage survey and recovery phases. For an integrated disaster management system, a disaster information classification system(DICS) is necessary for the reasonable disaster information management. This study suggests an integrated DICS that includes disaster type classification, facility type classification and information type classification for disaster management service. The applicability of suggested DICS is verified by railway facility and the research result could be used as a basic information system for national disaster management system.

• 지질공학
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• 제24권4호
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• pp.575-581
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• 2014

The reliable measurement of geotechnical properties in cold regions should account for their fluctuations with temperature. The objective of this paper is to introduce a chemical model based on the Arrhenius equation that can predict the properties of materials as their temperature changes. The model can monitor phases and reaction rates as they change with temperature. It has been already applied in the fields of geology, construction, chemistry, materials engineering, and food science. The application of the Arrhenius equation requires a reliable estimate of the activation energy. Therefore, this study also demonstrates several methods for evaluating activation energy in different contexts through summaries and reviews of previous research related to the Arrhenius equation. This paper may be of wide use in obtaining temperature-dependent parameters in geotechnical engineering.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 춘계 학술논문 발표대회 1부
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• pp.137-140
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• 2011

A systemic building maintenance management is necessary to supply an convenience and safety environment by maintain the origin features for a building's life. However, the exist maintenance management system has some problems such as interoperability of information or standardization of data. In those reasons, a critical information for maintenance a building may be lost and changed. In addition, the data could be crashed or lost on a process of re-input or re-produce. This paper purpose the interoperability in exchanging data between design/construction and operation phases. In addition, this model will enhance the efficiency of building maintenance tasks through information quality improvement and data reproduction prevention.

• 한국한의학연구원논문집
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• 제8권1호
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• pp.27-43
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• 2002

The aim of this study is to find out the relationships between the vocal sounds and physiologie and pathologic mechanisms based on the Eum-yang and five phases theory[陰陽五行論]. Firstly, concrete characters of vital rhythm of five-viscera were analyzed and patterns of the five-note in oriental music were converted into that of western music, then it was investigated, the possibility of oriental music therapy using sounds as stimulation methods like herbs, acupuncture, and moxibustion. In conclusion, it was found that controlling the Five-visceral vital rhythm by sounds could be used as one of methods for prevention and treatment of disceases, growing on and balancing a body, etc.

• 대한이식학회지
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• 제28권3호
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• pp.113-120
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• 2014

Two-signal models are useful in explaining various types of immune responses. In particular, secondary, so-called costimulatory, signals are critically required for the process of T-cell activation, survival, differentiation, and memory formation. Early studies in rodent models showed that targeting T-cell costimulatory pathways elicits immunological tolerance, providing a basis for development of costimulatory therapeutics in allograft rejection. However, as the classic definition of T-cell costimulation continues to evolve, simple blockade of costimulatory pathways has limitations in prevention of allograft rejection. Furthermore, functions of costimulatory molecules are much more diverse than initially anticipated and beyond T cells. In this mini-review, we will discuss CD137-CD137L bidirectional signals as examples showing that two-signals can be applicable to multiple phases of immune responses.

• 한국방재학회 논문집
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• 제7권1호통권24호
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• pp.21-28
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• 2007

최근 기후변화로 빈번히 발생하고 있는 자연재해의 피해를 정확히 예상할 수는 없으나, 중대한 현상이 예상될 때 그에 맞는 적절한 예방활동을 통하여 피해를 최소화할 수 있다. 하지만 우리나라는 2000년 들어 기상재해에 의한 피해가 수조원에 달하는 만큼 자연재해에 의한 피해를 많이 입고 있는 실정이다. 따라서 본 논문에서는 2005년 9월 $5{\sim}7$일 동안 한반도에 영향을 끼친 태풍 Nabi와 1998년 일본 4개 현(懸)에 큰 피해를 입힌 호우에 관하여, 기상청과 방송, 신문의 기상정보 발표 현황과 보도내용, 기상정보 전달체계, 사후 평가에 대하여 분석함으로써 방재기상정보의 활용 효과를 높이기 위한 기초 자료를 제시하고자 하였다. 중대한 현상이 예상될 때는, 기상정보에 대한 국민들의 이해도를 높이고 사태의 심각성을 알리기 위해 기상청에서 보다 많은 보도자료를 발표해야 하며, 좀 더 정확한 피해 규모를 제시하기 위해서 국내 현황에 맞는 재해피해 예측 모델 개발이 필요하다. 방송사와 신문사는 공공기관의 재해대응, 현상의 자세한 정보와 예측, 방재상 주의점, 피해내역 및 복구 등 시민들이 알고자 하는 내용을 재해대응 단계에 맞게 적극적으로 보도할 필요가 있다. 또한 재해종료 후에 기상청과 소방방재청, 방송사 등은 방재관련 유관기관과 주민들을 상대로 반드시 사후검토를 실시하여 제공하고 있는 방재기상정보의 문제점을 파악하고 효과적으로 개선하여야 한다.

• Animal Bioscience
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• 제34권6호
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• pp.993-1005
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• 2021

Objective: Zearalenone (ZEA) has estrogen-like effects. Our previous study has shown that ZEA (0.5 to 1.5 mg/kg) could induce abnormal uterine proliferation through transforming growth factor signaling pathway. To further study the other regulatory networks of uterine hypertrophy caused by ZEA, the potential mechanism of ZEA on porcine endometrial epithelial cells (PECs) was explored by the Illumina Hiseq 2000 sequencing system. Methods: The PECs were treated with ZEA at 0 (ZEA0), 5 (ZEA5), 20 (ZEA20), and 80 (ZEA80) µmol/L for 24 h. The collected cells were subjected to cell cycle, RNA-seq, real-time quantitative polymerase chain reaction, immunofluorescence, and western blot analysis. Results: The proportion of cells in the S and G2 phases decreased (p<0.05), but the proportion of cells in the G1 phase increased (p<0.05) in the ZEA80 treatment. Data analysis revealed that the expression of Wnt pathway-related genes, estrogen-related genes, and mitogen-activated protein kinase pathway-related genes increased (p<0.05), but the expression of genetic stability genes decreased (p<0.05) with increasing ZEA concentrations. The relative mRNA and protein expression of WNT1, β-catenin, glycogen synthase kinase 3β (GSK-3β) were increased (p<0.05) with ZEA increasing, while the relative mRNA and protein expression of cyclin D1 (CCND1) was decreased (p<0.05). Moreover, our immunofluorescence results indicate that β-catenin accumulated around the nucleus from the cell membrane and cytoplasm with increasing ZEA concentrations. Conclusion: In summary, ZEA can activate the Wnt/β-catenin signaling pathway by up-regulating WNT1 and β-catenin expression, to promote the proliferation and development of PECs. At the same time, the up-regulation of GSK-3β and down-regulation of CCND1, as well as the mRNA expression of other pathway related genes indicated that other potential effects of ZEA on the uterine development need further study.

• 터널과지하공간
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• 제23권4호
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• pp.319-325
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• 2013

본 연구의 목적은 지하공동 내에 고압 압축공기를 저장하는 경우 발생할 수 있는 리스크를 평가하는 것이다. 문헌 조사와 CAES의 특성에 대한 연구를 통해 CAES 지하 저장 공동 개발과 관련된 리스크 요인을 선정하였다. 대분류 리스크 요인으로 기획 설계단계, 시공단계, 운영 유지관리단계의 3개를 고려하였으며, 중분류 리스크 요인으로 8개를, 소분류 리스크 요인으로 총 24개의 리스크 인자들을 선정하였다. 전문가 설문을 통해 얻어진 자료를 분석하기 위하여 AHP 기법을 적용하였으며 리스크 상호 간 상대적 중요도를 평가하였다. 해석 결과 대분류에서는 운영 유지관리단계 리스크, 중분류에서는 품질 안전 관련 리스크, 소분류에서는 압축공기 저장용 내조시스템의 기밀성 확보 실패가 가장 큰 리스크로 평가되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7143-7147
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• 2013

Background: The survival outcomes for women presenting with early breast cancer are influenced by treatment decisions. In Malaysia, survival outcome is generally poor due to late presentation. Of those who present early, many refuse treatment for complementary therapy. Objective: This study aimed to explore the decision making experiences of women with early breast cancer. Materials and Methods: A qualitative study using individual in-depth interviews was conducted to capture the decision making process of women with early breast cancer in Malaysia. We used purposive sampling to recruit women yet to undergo surgical treatment. A total of eight participants consented and were interviewed using a semi-structured interview guide. These women were recruited from a period of one week after they were informed of their diagnoses. A topic guide, based on the Ottawa decision support framework (ODSF), was used to facilitate the interviews, which were audio recorded, transcribed and analysed using a thematic approach. Results: We identified four phases in the decision-making process of women with early breast cancer: discovery (pre-diagnosis); confirmatory ('receiving bad news'); deliberation; and decision (making a decision). These phases ranged from when women first discovered abnormalities in their breasts to them making final surgical treatment decisions. Information was vital in guiding these women. Support from family members, friends, healthcare professionals as well as survivors also has an influencing role. However, the final say on treatment decision was from themselves. Conclusions: The treatment decision for women with early breast cancer in Malaysia is a result of information they gather on their decision making journey. This journey starts with diagnosis. The women's spouses, friends, family members and healthcare professionals play different roles as information providers and supporters at different stages of treatment decisions. However, the final treatment decision is influenced mainly by women's own experiences, knowledge and understanding.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.167-174
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• 2016

One of the major causes of morbidity and mortality in breast cancer patients is delay in seeking help. Leventhal's self-regulation model provides an appropriate framework to assess delay in seeking help. The aim of this study was to investigate the relationship between "illness perception" and "help seeking delay" in breast cancer patients based on Leventhal's self-regulation model. In this correlational descriptive study with convenience sampling conducted in 2013, participants were 120 women with breast cancer who were diagnosed in the last year and referred to chemotherapy and radiotherapy centers in Rasht, Iran. Data collection scales included demographic data, Revised Illness Perception Questionnaire (IPQ-R)and a researcher made questionnaire to measure the delay in seeking help. Pre-hospital delay (help seeking delay) was evaluated in 3 phases (assessment, disease, behavior). The data were analyzed using SPSS-19. The mean (SD) age calculated for the patients was $47.3{\pm}10.2$. Some 43% of the patients had a high school or higher education level and 82% were married. The "pre-hospital delay" was reported ${\geq}3months$. Logistic regression analysis showed that none of the illness perception components were correlated with appraisal and behavioral delay phases. In the illness delay phase, "time line" (p-value =0.04) and "risk factors"(p-value=0.03) had significant effects on reducing and "psychological attributions" had significant effects on increasing the delay (p-value =0.01). "Illness coherence" was correlated with decreased pre-hospital patient delay (p-value<0.01). Women's perceptions of breast cancer influences delay in seeking help. In addition to verifying the validity of Leventhal's self-regulation model in explaining delay in seeking help, the results signify the importance of the "illness delay phase" (decision to seek help) and educational interventions-counseling for women in the community.