• Journal of Preventive Medicine and Public Health
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• v.45 no.5
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• pp.291-300
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• 2012

Objectives: We aimed to estimate the annual socioeconomic burden of coronary heart disease (CHD) in Korea in 2005, using the National Health Insurance (NHI) claims data. Methods: A prevalence-based, top-down, cost-of-treatment method was used to assess the direct and indirect costs of CHD (International Classification of Diseases, 10th revision codes of I20-I25), angina pectoris (I20), and myocardial infarction (MI, I21-I23) from a societal perspective. Results: Estimated national spending on CHD in 2005 was $2.52 billion. The majority of the spending was attributable to medical costs (53.3%), followed by productivity loss due to morbidity and premature death (33.6%), transportation (8.1%), and informal caregiver costs (4.9%). While medical cost was the predominant cost attribute in treating angina (74.3% of the total cost), premature death was the largest cost attribute for patients with MI (66.9%). Annual per-capita cost of treating MI, excluding premature death cost, was $3183, which is about 2 times higher than the cost for angina ($1556). Conclusions: The total insurance-covered medical cost ($1.13 billion) of CHD accounted for approximately 6.02% of the total annual NHI expenditure. These findings suggest that the current burden of CHD on society is tremendous and that more effective prevention strategies are required in Korea.

• Journal of the korean academy of Pediatric Dentistry
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• v.25 no.3
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• pp.555-561
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• 1998

Hypophosphatasia is a rare metabolic disorder which manifests characteristics such as abnormal mineralization of bone and dental tissues, diminished serum and tissue alkaline phosphatase, and increased urinary secretion of PEA. It inherited as an autosomal recessive or dominant trait and occurs in all races. In general, hypophosphatasia can be classified in 4 subtypes which are the perinatal, infantile, childhood, adult type depending upon the age at presentation and severity. In young children with Hypophosphatasia the long bones show irregular defects, and the skull showes poor calcification. In older children with premature closure of the skull sutures there may be multiple lucent area called gyral or convolutional markings, described as resembling beaten copper, presumably resulting from increased intracranial pressure. Examination of the jaws reveals a generalized lucency of the maxilla and mandible. the cortical bone and lamina dura are thin, and the alveolar bone may be deficient. Clinical features of Hypophosphatasia include premature loss of deciduous teeth, especially incisors, hypoplasia or aplasia of root cementum, enamel hypoplasia, irregular calcification of dentin, large pulp chamber, and resorption of marginal alveolar bone and roots. Our report involves a patient with a chief complaint of early loss of both Mx. and Mn. deciduous incisors. After conducting a through clinical and radiographic examination this patient was referred to pediatrics under the suspicion of hypophosphatasia, the diagnosis proved to be correct and successful results were accomplished through a denture made to improve esthetics and function.

• Clinical and Experimental Pediatrics
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• v.46 no.3
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• pp.308-311
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• 2003

Congenital chloride diarrhea is a serious autosomal recessive disease, and defect of intestinal electrolyte absorption that involves, specifically, $Cl^-/{HCO_3}^-$ exchange in the distal part of the ileum and colon. The clinical feature is dominated by profuse, watery diarrhea containing high concentrations of chloride(>90 mmol/L) and sodium. The chloride loss results in severe dehydration with a hypochloremic alkalosis. The molecular pathology involves an epithelial $Cl^-/{HCO_3}^-$ exchanger protein. Mucosal ion transport is affected to differing degrees and the severity of the disease may thus vary. Recently, a gene defect on chromosome 7 has been identified. However, there was a deficit in replacement of fluid and electrolyte, abdominal distension remained and the character of stools was watery. We report a case of congenital chloride diarrhea in a premature female who presented with watery diarrhea containing high concentrations of chloride and abdominal distension.

• Journal of the korean academy of Pediatric Dentistry
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• v.43 no.2
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• pp.187-191
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• 2016

Early loss of a primary second molar can cause mesial drift or tilting of the permanent first molar. We present a case of the early loss of the mandibular primary molars in a 5-year-old girl. The patient required extraction of the mandibular left primary first and second molars due to folliculitis on the successors. A flexible denture was used for eruption guidance of the permanent first molar and the recovery of masticatory function simultaneously.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.12 no.3
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• pp.42-48
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• 1990

This is a case report on an unusual - heavy buccal frenum in young lady which was treated by frenectomy, vestibuloplasty and total-palatal mucosal free graft. The authors noticed that this abnormal condition lead several chronic complications in young patient as like as premature loss of upper molar teeth, early and rapid loss of alveolar bone around insertion of frenum, over - extended eruption of lower molar teeth and abnormal mandibular movements, etc. After frenectomy and surgical extension of buccal vestiblue on both upper and lower posterior regions, we obtained a full - sized palatal mucosal graft and moved it on upper and lower extension area seperately as two pieces of free grafts to offer inherent function of denture - bearing mucogingiva and same color - matching with oral mucosa and to prevent post - operative relapse of vestibular height. We discussed here about unusual abnormality and their complications of unusual buccal frenum and its treatment.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.3 no.1
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• pp.26-30
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• 2007

Leukocyte adhesion deficiency(LAD) is a rare autorecessive defect of phagocytic function resulting from a lack of leukocyte cell surface expression of ${\beta}_2$ integrin molecules(CD 18) that are essential for leukocyte adhesion to endothelial cells and chemotaxis. As a results, patients with LAD suffer from severe bacterial infections and impaired wound healing. A small number of patients with leukocyte adhesion deficiency-1 have a milder defect, with residual expression of CD18. These patients tend to survive beyond infancy; they manifest progressive severe periodontitis, alveolar bone loss, periodontal pocket formation, and partial or total premature loss of the primary and permanent dentitions. In this report, we report on a 7 year old girl with severe oral involvement. The most import focus should be to control infections to reduce the risk for future infection.

• Environmental Analysis Health and Toxicology
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• v.31
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• pp.23.1-23.6
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• 2016

Objectives A stable follow-up participation rate is a very important factor for validity in a cohort study. This study analyzed the factors that affect the participation rate at one hospital-based birth cohort in South Korean. Methods The participants were recruited from the Mothers' and Children's Environmental Health study between 2006 and 2010. The analysis targeted 1751 mothers who participated in a birth cohort. We conducted analyses of general characteristics during pregnancy and those of infants at birth that affect the participation rate of the 6-month follow-up survey. Results The participation rate for the 6-month follow-up survey was 60.4%. The participation rate in the follow-up of the subsequent period decreased within a 5% to 10% range compared to the number of subjects. The participation rate of premature infants was 16.9% lower than that of a full-term infant (52.6% vs. 69.5%). Analysis showed a 16.7% difference between the participation rate of low-birthweight infants in follow-ups (53.7%) and the participation rate of infants with normal weight (70.4%). The participation rate of mothers who were employed during pregnancy was significantly lower for the 6-month follow-up compared to the participation rate of mothers who were unemployed during pregnancy. Conclusions In this study, factors such as premature birth, low-birthweight, and the employment status of the mother during pregnancy affected the participation rate of the follow-up survey for the birth cohort at six months. A specific strategy is needed to encourage survey participation for the high risk groups in the follow-ups.

• Steel and Composite Structures
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• v.33 no.6
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• pp.849-864
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• 2019

One way to achieve sustainable construction is to reduce concrete consumption by use of more sustainable and higher strength concrete. Modern building codes do not cover the use of ultra-high strength concrete (UHSC) in the design of composite structures. Against such background, this paper investigates experimentally the mechanical properties of steel fibre-reinforced UHSC and then the structural behaviors of UHSC encased steel (CES) members under both concentric and eccentric compressions as well as pure bending. The effects of steel-fibre dosage and spacing of stirrups were studied, and the applicability of Eurocode 4 design approach was checked. The test results revealed that the strength of steel stirrups could not be fully utilized to provide confinement to the UHSC. The bond strength between UHSC and steel section was improved by adding the steel fibres into the UHSC. Reducing the spacing of stirrups or increasing the dosage of steel fibres was beneficial to prevent premature spalling of the concrete cover thus mobilize the steel section strength to achieve higher compressive capacity. Closer spacing of stirrups and adding 0.5% steel fibres in UHSC enhanced the post-peak ductility of CES columns. It is concluded that the code-specified reduction factors applied to the concrete strength and moment resistance can account for the loss of load capacity due to the premature spalling of concrete cover and partial yielding of the encased steel section.

• The korean journal of orthodontics
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• v.7 no.1
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• pp.31-39
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• 1977

The patient, 18-year-old girl, had a class III malocclusion with the lateral compression of the maxilla due to the premature loss of the canines, mild mandibular prognathism, and mouth breathing habit. The treatment plan consisted of 1) rapid maxillary expansion 2) a period of retention 3) extraction of the first mandibular premolars instead of surgical correction 4) completion of orthodontic treatment with multibanded system. The maxilla was separated in the midline by the application of orthopedic forces via a cemented rapid maxillary expansion device. After 18 months, She gained functional overbite-overjet relationship, good interdigitation of buccal segments, and facial harmony due to the retraction of lower anterior teeth.

• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.22-27
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• 2009

Retinopathy of prematurity (ROP) is a major cause of blindness that affects premature infants. With advances in neonatology, ROP is likely to emerge as the most serious problem of vision loss in children even in developed countries; such a situation could be called the third epidemic of ROP. However, controversy and uncertainty still surround favorable outcomes of ROP. For successfully controlling ROP, timely and accurate screening is crucial because early treatment leads to favorable outcomes. Standard guidelines, including ROP classification, have provided satisfactory instructions for the screening and treatment of ROP. To improve the structural and functional outcomes of ROP, optimizing the timing of surgical interventions including cryotherapy, laser-photocoagulation, encircling, and vitrectomy is essential; these interventions can prevent the sequelae of ROP. It is essential for the neonatologist and the ophthalmologist to cooperate extensively for the successful treatment of ROP.