• 제목/요약/키워드: Potential barrier

Search Result 645, Processing Time 0.033 seconds

Synthesis of 5-Azacytidine Nucleosides With Rigid Sugar Moiety As Potential Antitumor Agents

  • Kim, Myong-Jung;Lee, Ji-Young;Shin, Ji-Hye;Chun, Moon-Woo
    • Proceedings of the PSK Conference
    • /
    • 2002.10a
    • /
    • pp.363.3-364
    • /
    • 2002
  • Unmodified nucleosides exist in either S-type or N-type conformation, but due to the low energy barrier between this two dominating conformers a fast equilibrium between them exists in solution state. Therefore. many approaches to lock the puckering of the furanose ring in N-type or S-type have been made since HIV-1 reverse transciptase is able to discriminate between two conformationally locked carbocyclic AZT triphosphate analogues. (omitted)

  • PDF

Nuclide Release from Penetrations in Radioactive Waste Container (방사성 폐기물 저장용기 표면의 결함으로부터 핵종유출 연구)

  • Kim, Chang-Lak
    • Nuclear Engineering and Technology
    • /
    • v.21 no.4
    • /
    • pp.302-307
    • /
    • 1989
  • Nuclide release through penetrations in radioactive waste container is analyzed. Penetrations may result from corrosion or cracking and may be through the container material or through deposits of corrosion products. The analysis deals with the resultant nuclide release, but not with the way these penetrations occur. Numerical illustrations show that mass transport from multiple holes can be significant and may approach the mass transfer rate calculated from bare waste forms. Although partially-failed containers may present an important long-term barrier to release of radionuclides, numerous small holes on a container surface have the potential of bypassing the effectiveness of these barriers.

  • PDF

pH Effects at Doped Si Semiconductor Interfaces (Doping된 Si 반도체 세계에서 pH 효과)

  • 천장호;라극환
    • Journal of the Korean Institute of Telematics and Electronics
    • /
    • v.27 no.12
    • /
    • pp.1859-1864
    • /
    • 1990
  • The effect of H+ and OH- ion concentrations at doped Si semiconductor/pH buffer solution interfaces were investigated in terms of cyclic current-voltage characteristics. The effects of space charge on oppositely doped Si semiconductors, i.e., p-and n-Si semiconductors, can be effectively applied to study the pH effects and the slow surface states at the interfaces. The adsorptions of H+ and OH- inons on the doped Si semiconductor surfaces are physical adsorption rather than chemical adsorption. Adsorptive processes and charging effects of the slow surface states can be explained as the potential barrier variations and the related current-voltage characteristics at the interfaces. Under forward bias, the charged slow surface states on the p-and n-si semiconductor surface are donor and acceptor slow surface states, respectively. The effects of minority carriers on the slow surface states can be neglected at the doped Si semiconductor interfaces.

  • PDF

Potential Roles of Protease Inhibitors in Cancer Progression

  • Yang, Peng;Li, Zhuo-Yu;Li, Han-Qing
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.18
    • /
    • pp.8047-8052
    • /
    • 2016
  • Proteases are important molecules that are involved in many key physiological processes. Protease signaling pathways are strictly controlled, and disorders in protease activity can result in pathological changes such as cardiovascular and inflammatory diseases, cancer and neurological disorders. Many proteases have been associated with increasing tumor metastasis in various human cancers, suggesting important functional roles in the metastatic process because of their ability to degrade the extracellular matrix barrier. Proteases are also capable of cleaving non-extracellular matrix molecules. Inhibitors of proteases to some extent can reduce invasion and metastasis of cancer cells, and slow down cancer progression. In this review, we focus on the role of a few proteases and their inhibitors in tumors as a basis for cancer prognostication and therapy.

Magnetic Tunnel Junctions with Magnesium Oxide Barriers

  • Nagahama Taro;Moodera Jagadeesh S.
    • Journal of Magnetics
    • /
    • v.11 no.4
    • /
    • pp.170-181
    • /
    • 2006
  • Spin dependent tunneling has enormously activated the field of magnetism in general, and in particular spin transport studies, in the past ten years. Thousands of articles related to the subject have appeared with many fundamental results. Importantly, there is great interest in their potential for application. There was another surge of activity in this field since the past five years - created by the theoretical prediction of a large tunnel magnetoresistance that arises due to band symmetry matched coherent tunneling in epitaxial magnetic tunnel junctions with (001) MgO barrier and experimentally well demonstrated. This further development in the field has boosted the excitement in both fundamental science as well as the possibility of application in such as magnetic random access memory, ultra sensitive read heads, biosensors and spin torque diodes. This review is a brief coverage of the field highlighting the literature that deals with magnetic tunnel junctions having epitaxial MgO tunnel barriers.

Barriers to Employment Among Low-Income Mothers in Rural United States Communities

  • Son, Seo-Hee;Dyk, Patricia Hyjer;Bauer, Jean W.;Katras, Mary Jo
    • International Journal of Human Ecology
    • /
    • v.12 no.1
    • /
    • pp.37-49
    • /
    • 2011
  • This article addresses potential barriers to sustained employment for rural low-income mothers. Drawing from a two panel longitudinal sample of 240 families from the Rural Families Speak project, it examines the extent to which human capital and family factors were related to these mothers' ability to be employed. Comparisons are made between mothers, who over a three-year period, were continuously unemployed, intermittently employed, or stably employed. Many of these rural low-income mothers faced multiple individual and family barriers that impacted their labor force participation. Notably food insecurity, mental health, caring for a young child, housing, and a family history of welfare were associated with less stable employment. The implications for public policy and service delivery are discussed.

The effect of sintering temperature on the electrical properties of ZnO ceramics (ZnO세라믹스의 소결온도가 전기적 특성에 미치는 영향)

  • 김용혁;이덕출
    • Electrical & Electronic Materials
    • /
    • v.8 no.1
    • /
    • pp.40-47
    • /
    • 1995
  • Electrical properties of ZnO ceramics based on Bi oxide was investigated in relation to sintering temperature. In the temperature range >$1150^{\circ}C$ to >$1350^{\circ}C$ the grain size increased from 9.mu.m to 20.mu.m when the sintering temperature was raised. The leakage current in the low voltage range increased as the potential barrier decreases, which is caused by increasing the grain size at high temperature. The dielectric characteristics of the ZnO ceramics was also affected by sintering temperature. Large dielectric constant was attributed, to the grainboundary layer of polycrystalline ZnO ceramics and decreasing grainboundary width. The variation of breakdown voltage with sintering temperature was attributed to the change of the donor concentration in the ZnO grain and grain size. The results showed that breakdown voltage increased decreasing grain size and donor concentration. Nonohmic coefficient was associated with the lower breakdown voltage per grainboundary layer due to the grain growth and higher donor concentration.

  • PDF

Characteristics of Pd/polycrystalline 3C-SiC Schottky diodes for high temperature gas sensors (고온 가스센서용 Pd-다결정 3C-SiC 쇼트키 다이오드의 특성)

  • Ahn, Jeong-Hak;Chung, Gwiy-Sang
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • 2008.11a
    • /
    • pp.275-275
    • /
    • 2008
  • This paper describe the fabrication of a Pd/polycrystalline 3C-SiC schottky diode and its characteristics, in which the polycrystalline 3C-SiC layer and Pd Schottky contact were deposited by using APCVD and sputter, respectively. Crystalline quality, uniformity, and preferred orientations of the Pd thin film were evaluated by SEM and XRD, respectively. Pd/poly 3C-SiC Schottky diodes were fabricated and characterized by I-V and C-V measurements. Its electric current density Js and barrier height voltage were measured as $2\times10^{-3}$ A/$cm^2$ and 0.58 eV, respectively. These devices were operated until about $400^{\circ}C$. Therefore, from these results, Pd/poly 3C-SiC Schottky devices have very high potential for high temperature chemical sensor applications.

  • PDF

A New Scaling Theory for the Effective Conducting Path Effect of Dual Material Surrounding Gate Nanoscale MOSFETs

  • Balamurugan, N.B.;Sankaranarayanan, K.;Suguna, M.
    • JSTS:Journal of Semiconductor Technology and Science
    • /
    • v.8 no.1
    • /
    • pp.92-97
    • /
    • 2008
  • In this Paper, we present a scaling theory for dual material surrounding gate (DMSGTs) MOSFETs, which gives a guidance for the device design and maintaining a precise subthreshold factor for given device parameters. By studying the subthreshold conducting phenomenon of DMSGTs, the effective conductive path effect (ECPE) is employed to acquire the natural length to guide the design. With ECPE, the minimum channel potential is used to monitor the subthreshold behavior. The effect of ECPE on scaling factor significantly improves the subthreshold swing compared to conventional scaling rule. This proposed model offers the basic designing guidance for dual material surrounding gate MOSFETs.

A Study on the Design of Front Side Member for Applied Tailor Welded Blanks (Tailor Welded Blanks 적용을 위한 Front Side Member의 설계기법 연구)

  • 강대철;전병희;전한수
    • Transactions of the Korean Society of Machine Tool Engineers
    • /
    • v.10 no.1
    • /
    • pp.51-58
    • /
    • 2001
  • The use of tailor welded blanks (TWB) in automotive applications is increasing due to the potential of weight and cost saving. The object of this study is development of the front side member by static analysis and crash simulations. Accord-ing to the results , energy absorption and barrier force is very important parameter to control passenger safety and deforma-tion shape. A energy absorbability point of view, tailor welded blanks is most effective to absorb energy than non-twb. Non-TWB front side member and TWB applied front side member were simulated. It shows reduce stmping parts weight reduction and cost down.

  • PDF