Synthesis of 5-Azacytidine Nucleosides With Rigid Sugar Moiety As Potential Antitumor Agents

  • Published : 2002.10.01

Abstract

Unmodified nucleosides exist in either S-type or N-type conformation, but due to the low energy barrier between this two dominating conformers a fast equilibrium between them exists in solution state. Therefore. many approaches to lock the puckering of the furanose ring in N-type or S-type have been made since HIV-1 reverse transciptase is able to discriminate between two conformationally locked carbocyclic AZT triphosphate analogues. (omitted)

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