Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.363.2-363.2
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- 2002
Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3′,4′- Tetrahydrofuran Ring
- Kim, Myong-Jung (College of Pharmacy, Seoul National University) ;
- Chung, Soon-Yong (College of Pharmacy, Seoul National University) ;
- Liang, Cheng-Wu (College of Pharmacy, Seoul National University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University)
- Published : 2002.10.01
Abstract
A number of 2',3'-deoxynucleosides have been discovered to possess significant antiviral activity against HIV-1 and other viruses. Since it has been suggested that proper conformation of the dideoxynucleosides in terms of ring puckering of the five-membered sugar moiety is required for them to exhibit antiviral activity a number of nucleoside analogues to fix sugar-ring puckering have been synthesize and evaluated for antiviral activity. (omitted)
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