• 산경연구논집
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• 제10권9호
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• pp.19-24
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• 2019

Purpose - In the digital era, technology advancement enables goods and services to be produced more efficiently but also create economy risk in the global economy including Indonesia. Previous studies stated that the risk can be mitigated through export diversification. This study investigates strategy to expand the markets for existing products and explore the potential market. Research design, data, and methodology - The criteria was followed using a review and considerations combination through the Focus Group Discussion (FGD) to determine the priority product in trading house of Indonesia. This study implemented market share to explore those products' markets and compare it to other ASEAN countries. Results - The Indonesian potential products are T-shirts, singlets and other vests of textile materials, knitted or crocheted (excluding cotton); food preparations; medicaments consisting of mixed or unmixed products for therapeutic or prophylactic purposes; soap in the form of flakes, granules, powder, paste or in aqueous solution; and cocoa powder, not containing added sugar or other sweetening matter. The market analysis also showed that Indonesia still had not optimally accessed yet the largest market in the world for each product. Conclusions - The government should focus more on increasing the competitiveness of those products, particularly in those global marketplaces.

• 약학회지
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• 제60권3호
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• pp.135-140
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• 2016

Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone, which is associated with stabilization of many oncogenic proteins for cancer cell survival. Hsp90 is overexpressed 2-10 fold higher in cancer cells than normal cells. Due to its potential to simultaneously disable multiple signaling pathway, Hsp90 has been identified as a validated target for cancer therapy. Accordingly, we designed and synthesized 2',4'-dimethoxychalcone derivatives to inhibit Hsp90 chaperone function. Among 2',4'-dimethoxychalcone derivatives, we found that compound 1g disrupted Hsp90 chaperoning function and impaired the growth of cancer cells. These findings indicated that 1g could serve a potential lead compound to target Hsp90 in cancer chemotherapy.

• 한국항공운항학회지
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• 제29권1호
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• pp.38-46
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• 2021

The Organization's ability to respond to social disasters has begun to be treated as important through social shock situations that have never been experienced, such as COVID-19. Among them, the ability to respond to unexpected risks and resilience is emerging. Since social disasters such as infectious diseases are periodically repeated, compounded, and enlarged, they develop into a global crisis situation, so this crisis response capability is treated as national competitiveness. Therefore, this study aims to improve the organization's response capability in terms of risk response and resilience under rapid social disasters such as COVID-19. The aviation safety field was taken as an example. From the Safety-II perspective, safety management focuses on the ability to resilience in response to system vulnerabilities in various situations. In this study, I intend to apply RAG(Resilience Assessment Grid) of Respond, Monitor, Learn and Anticipate, the four major potential of resilience engineering. Based on Hollnagel's research, potential elements were classified into four, and items were organized through an expert panel using Delphi techniques. The final configured RAG items are 15 Respond, 15 Monitor, 15 Learn and 11 Anticipate. The RAG was evaluated by 42 experts in the field of aviation safety.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2009년도 추계학술대회 논문집
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• pp.315-318
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• 2009

Electric shock is the accident caused by the current through a person or animal's body. That is characterized by the physiological effects. In this paper, we evaluate performance of protection against electric shocks for TT and TN grounding systems which are used by a low voltage consumer nowadays. The performance of protection against electric shocks for TT grounding system is very excellent in equipotential area of the third class grounding, but the performance is poor outside the equipotential area. The performance of protection against electric shocks for TN grounding system is excellent because the potential difference is less than 50V. Accordingly, the performance of protection for TN grounding system is good as compared with that for TT grounding System.

• 한국전산유체공학회지
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• 제12권3호
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• pp.20-28
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• 2007

A fast and robust method of grid generation to multiple functions has been developed for flow analysis in three dimensional space. It is based on the Non-Uniform Rational B-Spline(NURBS) of an approximation method. Many of NURBS intrinsic properties are introduced and much more easily understood. The grid generation method, details of numerical implementation. examples of application, and potential extensions of the current method are illustrated in this paper. The object of this study is to develop the surface grid generation and the grid cluster techniques capable of resolving complex flows with shock waves, expansion waves, shear layers. The knot insert method of Non-Uniform Rational B-Spline seems well worked. In addition, NURBS has been widely utilized to generate grids in the computational fluid dynamics community. Computational examples associated with practical configurations have shown the utilization of the algorithm.

• 대한산업공학회지
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• 제33권4호
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• pp.410-418
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• 2007

This article suggests the methods to investigate adverse movement across global stock markets arising from insolvency of subprime mortgage in U.S. Our application deals with asymptotic tail dependence of daily stock index returns (KOSPI, DJIA, Shanghai Composite) of three countries; Korea, U.S., and China, over specific period via extreme value theory and copula functions. Daily stock index returns among three countries show higher extremal dependence during the period exposed to systematic shock. We confirm that extreme value theory and copula functions have potential to well describe the extreme dependence between three countries' daily stock index returns.

• Computers and Concrete
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• 제6권5호
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• pp.377-390
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• 2009

In this paper an improved one-dimensional frame element for modelling of reinforced concrete beams and columns subjected to impact is presented. The model is developed in the framework of a flexibility fibre element formulation that ignores the shear effect at material level. However, a simple shear cap is introduced at section level to take account of possible shear failure. The effect of strain rate at the fibre level is taken into account by using the dynamic increase factor (DIF) concept for steel and concrete. The capability of the formulation for estimating the element response history is demonstrated by some numerical examples and it is shown that the developed 1D element has the potential to be used for dynamic analysis of large framed structures subjected to impact of air blast and rigid objects.

• Journal of Microbiology and Biotechnology
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• 제22권11호
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• pp.1478-1481
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• 2012

Geldanamycin (GM) and its analogs are important anticancer agents that inhibit heat shock protein (Hsp) 90, which is a major chaperone protein in cancer cells. Accordingly, based on interest in obtaining novel natural GM derivatives, the potential of Streptomyces hygroscopicus JCM4427, a GM producer, was explored for novel natural GM derivative(s), resulting in the discovery of new GM analogs as a biosynthetic shunt product and intermediates from its fermentation broth. In this study, the fermentation, isolation, structure determination, and biological activity of the compounds, two new tetracyclic thiazinogeldanamycin (1) and 19-hydroxy-4,5-dihydrogeldanamycin (3), together with the three known 4,5-dihydrothiazinogeldanamycin (2), reblastatin (4), and 17-demethoxy-reblastatin (5), are described.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년도 제30회 춘계학술대회논문집
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• pp.9-13
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• 2008

충격파와 같은 moving load가 특별한 속도로 관 안을 전파한다. 이 관 안을 전파하는 moving load 속도는 flexural wave의 활성화의 정도와 큰 변형을 일으키는 공진이 발생할 가능성을 결정한다. 본 연구에서, 우리는 moving load가 관안을 통과하고 있을 때의 변위의 특별해와 공진현상이 일어날 조건을 보일 것이다. 또한 이 이론적 결과를 hydrocode를 이용하여 얻은 수치해석 결과와 비교하여 정당성을 보일 것이다. 이와 같은 결과를 바탕으로 본 연구는 원자력 발전소나 탄화수소 계열의 연료를 사용하는 산업분야에서 공진현상에 의한 대형 사고를 예방하는 목적을 가지고 있다.

• 한국정밀공학회지
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• 제8권4호
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• pp.118-125
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• 1991

Acoustic microscopy has attracted much interest recently as potential nondestructive evaluation technique for detecting and sizing defects of surface and sub-surface. Also acoustic emission testing method has been developed for detecting microcracks which is more than 30${\mu}m$ in length quantitatively on ceramics. In the present paper, acoustic emission during the four point bending test in hot-pressed sintered $Si_3N_4$ specimen which was stressed by thermal shock, has been measured by high sensitive sensing system. The surface and sub-surface cracks were detected by scanning acoustic micrscope of 800 MHz and conventional ultrasonic testing in C-scope image. The purpose was to investigate the location and size of cracks by SAM and AE technique, whose experimental data demonstrate good for detecting microcracks.