• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.148-159
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• 2007

Purpose: Vasomotor symptoms including hot flash are very common to postmenopausal women. Estrogen therapy was regarded as the best option for relieving menopausal symptoms until 2002, when the Women#s Health Initiative(WHI) reported the side effect of the therapy. Consequently, studies on the complementary and alternative medical herbs and therapy for the management of menopausal symptoms have followed. And so we have reviewed some international clinical studies about the management of postmenopausal symptoms with acupuncture therapy. Methods: "Menopause and acupuncture" was designated as a key word in the search site. Pub Med, and nine papers dealing with hot flash among the relevant RCTs were selected, and then, the effect of acupuncture on hot flash and the way the researches had been done was examined. Results : The intensity of hot flash reduced significantly and the frequency of hot flash was inclined to reduce, but not significantly, compared to the controlled group. Conclusion: Each clinical test has its limitations in point of the number of the required samples. However, it still shows the possibility that acupuncture itself will be effective enough to reduce the intensity of hot flash to a certain degree. It is believed that extensive clinical tests on the effect of acupuncture on hot flash will need to be done hereafter. And when the tests are carried out, it is required to exclude placebo effect, do blind test, and carefully select and control the methods.

• Korean Journal of Biological Psychiatry
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• v.2 no.1
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• pp.91-99
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• 1995

A on-off study was designed to evaluate the effects of addition of transdermal esrtradiol to tricyclic antidepressants on depression level, vasomotor symptom(hot flush), sexual functions and hormonal status, plasma 5-hydroxyindoleascetic acid(5-HIAA) level in postmenopausal women with depression. Plasma level of estradiol, progesterone, LH, FSH, prolactin and 5-HIAA was measured by Time-resolved fluoroimmunoassay and HPLC(High Performance Liquid Chromatography). To asses their symptoms, the BDI(Beck Depression Inventory) and modified symptom scale, extracted from women's health questionnaire were used. Depression score, sexual function score were decreased by the last 4-weeks of addition of transdermal estradiol to antidepressant treatment, not Significant, but vasomotor symptom (hot flushes) score was decreased significantly(p<0.05) by the last 4-weeks of the given treatment. Thus, during addition of transdermal estradiol to antidepressants treatment, only vasomotor symptom(hot flushes) was improved significantly, but depression level was not changed in postmenopausal women with depression. Plasma FSH, estradiol and prolactin level was not changed in postmenopausal women with depression. Plasma FSH, estradiol and prolactin levels were increased by the last 4-weeks of the treatment. There were not significant correlations between clinical symptoms and plasma hormonal status and 5-HIAA level in baseline. After the last 4-weeks of transdermal estradiol treatment, the change of depression score was correlated significantly with change of serum prolactin and 5-HIAA level and the change of vasomotor symptom score was correlated significantly with the change of plasma prolactin level.

• The Journal of Korean Obstetrics and Gynecology
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• v.15 no.4
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• pp.238-246
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• 2002

Recently we observed and treated a 49-year-old postmenopausal female with enlarged uterine myoma who taking through the hormone replacement therapy(H.R.T). We regard the cause of this case as insufficiency of kidney-yin(腎陰虛), stagnation or the phlegm and pathologic blood(痰瘀阻滯) and H.R.T. ln general cases, myomas grow in size if estrogen and progesterone is present and do not increase in size if estrogen and progesterone levels are low. So if a woman can get to menopause without having symptoms from the myomas, then it is likely that she will never have problems from the growths that require treatment. But Taking postmenopausal estrogen and progestin replacement therapy can cause myomas to grow. So we recommended her to stop the H.R.T. gave herbal-medicine and acupuncture therapy. Thus we could get a good result as follows. The uterine myomas were significantly declined but no change on it's characters. Hot flush and general conditions were also significantly improved And body weight was lessened for about 4.7kg. But vaginal dryness was appeared, So we planed another therapy for that symptom.

• Journal of Oriental Medical Thermology
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• v.6 no.1
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• pp.1-7
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• 2008

Purpose: This study was performed to find differerces between postmenopausal and premenopausal women on HRV and DITI. Methods: 26 postmenopausal women(mean age${\pm}$SD, $50.96{\pm}2.75$) and 26 premenopausal women (mean age${\pm}$SD, $49.46{\pm}3.33$) were compared with HRV which was conducted in the sitting position for 5 minutes. Temperature of specific acupoints-Indang, Chonjung(CV17), Kwanwon(CV4) was checked using DITI image and obtained ${\Delta}T1$(Chonjung-Kwanwon), ${\Delta}T2$(Indang-Kwanwon), T0(Kwanwon) value in each group. Results: HRV measurements generally decreased in postmenopausal group than premenopausal group but there was no significance. ${\Delta}T1$ increased significantly in postmenopausal group compared with premenopausal group. ${\Delta}T2$ also increased in postmenopausal group but there was no significance. Conclusion: It can be suggested that Chonjung(CV17) can be the useful point to evaluate postmenopausal women by using DITI.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.4
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• pp.136-143
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• 2005

Purpose : This study was performed to find differerces between postmenopausal and premenopausal women on HRV and DITI. Methods : 26 postmenopausal women(mean age${\pm}$SD, 50.96${\pm}$2.75) and 26 premenopausal women (mean age${\pm}$SD, 49.46${\pm}$3.33) were compared with HRV which was conducted in the sitting position for 5 minutes. Temperature of specific acupoints-Indang, Chonjung(CV17), Kwanwon(CV4) was checked using DITI image and obtained ${\Delta}T1$(Chonjung-Kwanwon), ${\Delta}T2$(Indang-Kwanwon), T0(Kwanwon) value in each group. Results : HRV measurements generally decreased in postmenopausal group than premenopausal group but there was no significance. ${\Delta}T1$ increased significantly in postmenopausal group compared with premenopausal group. ${\Delta}T2$ also increased in postmenopausal group but there was no significance. Conclusion : It can be suggested that Chonjung(CV17) can be the useful point to evaluate postmenopausal women by using DITI.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.4
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• pp.135-148
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• 2017

Objectives: This study was aimed to develop a Korean medicine clinical practice guidelines (CPG) of Climacteric and Postmenopausal Syndrome Methods: We conducted a questionnaire survey targeting Korean medicine doctors belonging to the Association of Korean Obstetrics and gynecology by e-mail and analyzed the answers. On October 18, 2016, we sent questionnaires to 583 people, and on October 31, 2016, we sent questionnaires to 581 people again. A survey ended on November 15, 2016. A total of 56 responded. Results: 1. 91.07% of respondents knew the concepts and contents of CPG, and all respondents agreed about the necessity of CPG. 2. Most common symptom of climacteric and postmenopausal syndrome that 65.75% of the respondents answered was the hot flush 3. To diagnosis a climacteric and postmenopausal syndrome, 69.64% of the respondents used pattern identification diagnosis mainly. 4. 36.84% of the respondents answered that herbal medicine and acupuncture are the most effective treatments for climacteric and postmenopausal syndrome. The most commonly used herb medicine was Kamisoyo-san. Conclusions: We figured out Korean Medicine doctors' recognition of Korean medicine clinical practice guideline, clinical diagnosis, treatment on climacteric and postmenopausal syndrome to make the contents of the CPG reflecting the clinical situation. Further research will be needed in the future.

• Korean Journal of Clinical Pharmacy
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• v.10 no.1
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• pp.7-12
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• 2000

This study is intended to provide information to menopausal women so they can control their symptoms. The basic data was gathered by interviewed 200 postmenopausal women on a HRT program. The women were questioned about their perception of menopause and compliance to the therapy with the fellowing result $71.7\%$ of the women experianced hot flushes, and $64.1\%$ experienced short term memory loss and some psychological symptoms. The women reported that these symptoms reduced their quality of life. $53\%$ of the women responded that menopause is a natural state and $59.1\%$ agreed to HRT based on their doctor's recommendation. $76.2\%$ of the women reported that HRT was effective, with $74.7\%$ reporting reduced hot flush symptoms $67.3\%$ of the women reported compliance with the medication schedule. and $43.9\%$ reported periodic non-compliance. Although HRT has been shown to be an effective treatment, the study found that less than $10\%$ of postmenopausal women are currently being treated and these treated women are generally negligent in continuing with HRT, The study recommends that a program be developed that explains the benefits and risks of HRT to be distributed to patients being treated by doctors and pharmacists. In conclusions, It is very important for hormone replacement therapy on menopausal women to take more intensive medication consultation to increase medication compliance and effectiveness of pharmacotherapy.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.168-178
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• 2008

Purpose: To verify the relationship of SA2000E results and acupuncture treatment efficacy on postmenopausal women. Methods: Longitudinal analyze relationship of the SA2000E results and hot flush VAS score changes of a clinical trial participants in 2006. Results: Someone who has high Vaso-aging degree by SA2000E represented better hot flash VAS decreasing efficacy. And the diminution rate of hot flash VAS, after 1week from the 1st treatment day was 0.311(p=0.0001), and finally 0.672(p = 0.0396). There are no statistical differences between study group and control group. Conclusion: Clinical trial participant who has better Vaso-physiological function present more hot flash reduce efficacy by acupuncture therapy. Vaso-aging degree by SA2000E could be use as a predictor of acupuncture hot flash treatment result.

• Journal of the East Asian Society of Dietary Life
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• v.14 no.3
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• pp.233-242
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• 2004

The purpose of this study was to investigated the possibility of Meles meles as an edible functional resource. To assess the effects of Meles meles fermented liquid(ML) with medicinal plants in postmenopausal women, the menopause symptoms, hematological and serum chemical variables and bone health indices were examined. Twenty five postmenopausal women participated in the study. As a result, in postmenopausal women, ML supplements were effective in reducing the incidence of menopause symptoms, such as insomnia(44.0%), sensitivity(40.0%), headache(34.0%), hot flush and decreased vaginal lubrication(20.0%) after 12 weeks. Also serum estradiol and calcitonin and calcium levels were 23.27 pg/mL, 14.88 pg/mL and 8.86 mg/dL before the ML intake. Levels were significantly increased of estradiol and calcitonin and calcium after ML intake during 12 weeks to 30.36 pg/mL, 21.61 pg/mL and 10.01 mg/dL. Osteocalcin and bone alkaline phosphatase activity were 14.36 ng/mL, 21.55 U/L before the ML intake, but according to ML intake, the levels were significantly decreased. In conclusion, ML play benefical roles in the prevention of bone loss and menopause symptoms. Howere current data are not sufficient to determine the effective doses for benefical effect as well as harmful effect and support dietary recommendation level for ML. Therefore, our results should be viewed with caution. But Meles meles fermented liquid with medicinal plants can be used as possible food resources and functional food materials, more studies are needed to identify the proper mechanism of ML.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.213-228
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• 2007

Purpose: This master‘s thesis to evaluate the grade of life after medication a Dangguijakyak-san(pasabu) and Gyejibongnyeong-hwan(cheongwal) with in postmenopausal women get lowering quality of life caused by vasomotor symptoms with hot flush. Methods: A subject who signing on the clinical trial written consent by self-will is registered this clinical trial after decided suitable by selection and exception standard, after take a medical experiment and checkup according to clinical trial plan. Registered subject should valuated by settled schedule after take the testing medicine 1,2 during thirty-day. In this period, a subject allocated at relatively better suited experimental group by oriental doctor after consideration of general efficacy and nature of a medicine at second visiting. Results: The result of comparison in the remedial value with sixteen patients who ended the experiment is like next list. 1. There's no regarded difference of comparison in general conditions between two patient groups. 2. There's no regarded difference during observation period before take medicine. 3. By period of measurement, there's something regarded differences most of patients of two parts after taking medicine. 4. There's no regarded difference at alteration phase of each standard according to kind of medicine. 5. There's no abnormal views reflected at allergy, Laboratory and Physical Examination during experiment. Conclusion: This experiment evidence a Dangguijakyak-san and Gyejibongnyeong-hwan can help for improvement generally life quality of postmenopausal women and certify safety of herbs.