• 대한화학회지
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• 제63권2호
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• pp.94-101
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• 2019

Nb, Mo-doped and Nb/Mo-codoped $VO_2(M)$ nanocrystallites with various doping levels were synthesized for the first time by a hydrothermal and post thermal transformation method. The reversible phase transition characteristics of those doped $VO_2(M)$ was comparatively investigated. Nb-doping of $VO_2(M)$ by this method resulted in a very efficient lowering of the transition temperature ($T_c$) with a rate of $-16.7^{\circ}C/at.%$ that is comparable to W-doping, while Mo-doping did not give a serious reduction of $T_c$ with only a rate of $-5.1^{\circ}C/at.%$. Nb/Mo-codoping gave a similar result to Nb-doping without a noticeable difference. The thin films of Nb-doped and Nb/Mo-codoped $VO_2(M)$ with a thickness of ca. 120 nm were prepared by a wet-coating of the nanoparticle-dispersed solutions. Those films showed a good thermochromic modulation of near infrared radiation with 30-35% for Nb-doped $VO_2(M)$ and 37-40% for Nb/Mo-codoped ones. Nb/Mo-codoped $VO_2(M)$ film showed slightly enhanced thermochromic performance compared with Nb-doped $VO_2(M)$ film.

• 이베로아메리카
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• 제12권2호
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• pp.383-428
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• 2010

To make a critical revision on the inherited social problems throughout the time in Mexico, not always turns out to be easy task, especially when the subject is lent to approach it from diverse perspective, one of them, the educative one. To analyze the low quality of the educative supply is complex subject. One of the maximum profits of institutional revolutionary Mexico was the creation of the Public Education Ministry in 1921. In the post-revolutionary and modern period, the seventies were characterized to be applied to the growth the infrastructure and the fortification of the educative system following the policy of "modernization and development". From the eighties, to lift the quality of the education was considered like one of the specific rules in the strategy of the call "educative revolution". In the nineties, through political programs and agreements, structural changes within the educative system were carried out with the intention to lift the quality of the services. In synthesis, the perspective in the educative policy of Mexico during the last thirty years of century xx, or post-revolutionary period, can be understood, from at least five specific conditions: educative profits in cover, modifications in the educational programs and contents, profits in the political agreements between the agents who take part within the educative system, changes and modifications to the laws applicable to the education, and; the search of the fairness through the compensatory programs. This paper tries to give answer to questions such as: The educative system reflects the ideals of the revolution? The present educative system is the product of a truncated revolution or the fruit of an untimely democracy?

• 한국정보통신학회논문지
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• 제16권4호
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• pp.643-653
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• 2012

본 논문에서는 버퍼 삽입 방법에 기반한 다중 클록 영역에서의 클록 트리 합성(clock tree synthesis, CTS) 기법에 대해서 논의한다. CTS를 수행하는데 있어서 준비해야하는 사항들과 실제적인 CTS 수행 방법들에 대해서 세부적인 기술들을 제안한다. 또한 CTS 수행 이후의 후처리 과정에 대해서도 제안한다. 버퍼 삽입 기반의 CTS는 기존에도 사용되는 방법인데 본 논문은 ASIC 및 SoC 상용 작업 현장에서 사용될 수 있는 실전적인 기법들에 대해서 논의하고자 한다. CTS는 사용되는 툴에 매우 의존적인데 본 논문은 Synopsys의 Astro를 대상으로 하였고, 이 툴을 이용하여 CTS를 수행하기 위한 세부적인 기술들에 대해서 이론을 바탕으로 경험적이고 고급적인 기법들을 제안한다. 본 논문을 통해 제안된 기법들은 많은 백앤드(backend) 설계자들에게 좋은 가이드가 될 것으로 기대한다.

• 대한의생명과학회지
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• 제23권4호
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• pp.372-379
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• 2017

This study was investigated to test whether paternal DNA that was destined for degradation was properly licensed by testing for the presence of mini-chromosome maintenance protein (MCM) 7 and origin recognition complex (ORC) 2 in the paternal pronuclei. ORC2 is one of the first licensing protein to come on and MCM7 is one of the last licensing protein to come on. Zygotes were prepared by injection of control and treated sperm injection (ICSI). To control for DNA breakage, epididymal spermatozoa were treated with DNase I to fragment the DNA, then injected into oocytes. The presence of MCM7 and ORC2 in the pronuclei of mouse zygotes was tested by immunohistochemistry, just before the onset of DNA synthesis, at 5 h after fertilization, and after DNA synthesis began, at 9 h post fertilization. We found that in all cases, both MCM7 and ORC2 were present in both pronuclei at 5 h after sperm injection, just before DNA synthesis began. This indicates that no matter how extensive the DNA damage, recruitment of licensing proteins to the origins of replication was not inhibited. Sperm DNA fragmentation does not prevent licensing of DNA replication origins. Furthermore, the embryo recognizes DNA that is damaged by nucleases. Our data indicate that the one-cell embryo does harbor a mechanism to prevent the replication of severely damaged DNA from spermatozoa, even though the embryos do not undergo classical apoptosis.

• 한국학교수학회논문집
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• 제12권4호
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• pp.389-409
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• 2009

최근 이주민 100만인 시대의 도래라는 사회변화로 인해 우리 주위에 다문화, 다언어, 저소득층에서 오는 환경적 다양성을 지닌 학생들이 급증해가는 추세이다. 본 연구는 이들 대상으로 그 동안 이뤄진 국내외 연구들을 분석하여 그 기초(framework)를 마련하는 문헌고찰이다. 이들에 대한 관심은 아직 시작단계에 불과하여 다양성의 배경을 지닌 학생을 위한 수학교육 연구로써 국내의 선행연구는 찾아보기 어려울지라도 이와 관련성 있는 소수의 국내연구와 이민자 사회로써 오랜 역사를 지닌 외국에서 이루어진 선행 연구들을 살펴보는 것은 앞으로 이들을 위한 학습자료 개발과 연구 등에 기초를 제공한다. 따라서 이들 학생들의 수학 학습현장에서 시대적 흐름은 무엇인지, 이들을 위해 그간 어떤 지원이 이루어졌는지, 그리고 이들에게 필요한 구체적인 수학교수학습의 실제는 무엇인지를 파악하여 수학 교사를 포함한 수학교육자와 학교 행정가들에게 주는 시사점을 얻고자하였다.

• Journal of Microbiology and Biotechnology
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• 제25권10호
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• pp.1761-1767
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• 2015

Sevenband grouper, Epinephelus septemfasciatus, is becoming an important aquaculture species in Korea. However, viral nervous necrosis disease is a large problem causing mass mortality in sevenband grouper aquaculture. Recombinant protein vaccines are one of the best methods to reduce these economic losses. However, the cell-based expression method mainly produces inclusion bodies and requires additional procedures. In this study, we expressed a recombinant viral coat protein of sevenband grouper nervous necrosis virus (NNV) using a cell-free protein synthesis system. The purified recombinant NNV coat protein (rNNV-CP) was injected into sevenband grouper at different doses followed by a NNV challenge. Nonimmunized fish in the first trial (20 μg/fish) began to die 5 days post-challenge and reached 70% cumulative mortality. In contrast, immunized fish also starting dying 5 days postchallenge but lower cumulative mortality (10%) was observed. Cumulative morality in the second trial with different doses (20, 4, and 0.8 μg/fish) was 10%, 40%, and 50%, respectively. These results suggest that rNNV-CP can effectively immunize sevenband grouper depending on the dose administered. This study provides a new approach to develop a recombinant vaccine against NNV infection for sevenband grouper.

• Asian-Australasian Journal of Animal Sciences
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• 제15권7호
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• pp.992-997
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• 2002

Two in vivo experiments were conducted to evaluate the effect of novel urease inhibitor hydroquinone (HQ) on ammonia release rate from urea hydrolysis, nitrogen balance, nutrient digestibility and efficiency of microbial protein synthesis. In Exp. 1, twelve crossbred cannulated lambs were randomly assigned within initial body weight block to one of four HQ treatments, which included 0 (control), 30, 60 or 80 mg HQ/kg DM intake. Ammonia concentration and pH of ruminal fluid were immediately measured at 0, 2, 4, 6 and 8 h after feeding. Increasing the dose of HQ tended (p<0.15) to linearly decrease NH3 formation. The ammonia peak concentration (2 h post-feeding) in animals receiving HQ was approximately one-half of that in animals not receiving HQ (p<0.01), and a relatively sustained ammonia release could be obtained at the dose of 30 or 60 mg HQ/kg DM. In Exp. 2, sixteen intact crossbred lambs (weight $40{\pm}0.8kg$) were used in a $2{\times}2$ factorial design experiment. The four rations consisting of soybean meal-based (SBM) or urea-based (Urea) nitrogen source with or without HQ (S1, S0, U1 and U0) were fed in digestion and N balance trials. Apparent digestibility of major nutrients except that of ADF was not affected by either nitrogen source or addition of HQ. Regardless of nitrogen source, supplementation of HQ significantly improved ADF digestibility (p<0.05). The various ration had no effects on N metabolism in the presence of HQ. There was significant difference between total purine derivatives (PD), estimated efficiency of microbial N synthesis (p<0.05) and urea-N excretion (p<0.01) in the urine for the SBM ration and for the Urea ration. However, HQ had little influence on efficiency of microbial N synthesis as proportion of daily intake of total tract digestible OM (p>0.05). No interactions between main nitrogen source and HQ were measured throughout the trial. Results of this study suggest that addition of HQ to ration may improve ADF digestion with having no negative effect on N metabolism and microbial protein production.

• 한국통신학회논문지
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• 제37A권9호
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• pp.786-791
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• 2012

본 논문에서는 3차원 합성영상의 화질 개선을 위하여 깊이영상의 경계를 개선하는 방법을 제안한다. 깊이영상을 부호화할 때 객체의 경계부근에서 왜곡이 발생하게 되는데, 이러한 왜곡은 합성영상의 화질을 떨어뜨리는 원인이 된다. 본 논문에서 제안하는 방법은 경계 주변만을 필터링하기 위해 에지 맵을 추출하고, 이를 이용하여 객체의 경계를 포함하는 매크로블록에만 제안하는 방법을 적용한다. 여기서 경계주변의 참조 화소의 빈도, 유사성, 거리 등 세 가지 요소를 고려하는 윈도우-기반의 경계 선명화 필터를 적용하여 중앙의 대상 화소를 최적의 화소값으로 대체한다. 제안한 방법은 다시점 비디오 부호화의 참조 소프트웨어인 JMVC 8.3에 디블록킹 필터의 후처리로 구현했다. 기존 방법들과 비교하여 평균 0.49 dB의 화질 개선과 16.58%의 비트율 감소가 있었고, 주관적으로도 개선된 부분을 확인하였다.

• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.447-452
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• 2013

In this study we report a new method for the synthesis of a silica monolithic column bed with bimodal pores (throughpores and mesopores). The template induced synthesis method was used to direct bimodal pores simultaneously instead of the usual post base-treating method. Block polymer Pluronic F127 was chosen as a dual-function template to form hierarchically porous silica monolith with both macropores and mesopores. This is a simplification of the method of monolithic column preparation. Poly(ethylene glycol) was used as a partial substitute for F127 can effectively prevent shrinkage during the monolith aging process without losing much surface area (944 $m^2/g$ to 807 $m^2/g$). More importantly, the resultant material showed a much narrower mesopore size (centered at 6 nm) distribution than that made using only F127 as the template reagent, which helps the mass transfer process. The solvent washing method was used to remove the remaining organic template, and it was proved to be effective enough. The new synthesis method makes the fabrication of the silica monolithic column (especially capillary column) much easier. All the structure parameters indicate that monolith PFA05 prepared by the above method is a good material for separation, with the merits of much higher surface area than usual commercial HPLC silica particles, suitable mesopore volume, narrow mesopore size distribution, low shrinkage and it is easily prepared.

• Journal of Ginseng Research
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• 제45권1호
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• pp.58-65
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• 2021

Background: Panax ginseng, as one of the most widely used herbal medicines worldwide, has been studied comprehensively in terms of the chemical components and pharmacology. The proteins from ginseng are also of great importance for both nutrition value and the mechanism of secondary metabolites. However, the proteomic studies are less reported in the absence of the genome information. With the completion of ginseng genome sequencing, the proteome profiling has become available for the functional study of ginseng protein components. Methods: We optimized the protein extraction process systematically by using SDS-PAGE and one-dimensional liquid chromatography mass spectrometry. The extracted proteins were then analyzed by two-dimensional chromatography separation and cutting-edge mass spectrometry technique. Results: A total of 2,732 and 3,608 proteins were identified from ginseng root and cauline leaf, respectively, which was the largest data set reported so far. Only around 50% protein overlapped between the cauline leaf and root tissue parts because of the function assignment for plant growing. Further gene ontology and KEGG pathway revealed the distinguish difference between ginseng root and leaf, which accounts for the photosynthesis and metabolic process. With in-deep analysis of functional proteins related to ginsenoside synthesis, we interestingly found the cytochrome P450 and UDP-glycosyltransferase expression extensively in cauline leaf but not in the root, indicating that the post glucoside synthesis of ginsenosides might be carried out when growing and then transported to the root at withering. Conclusion: The systematically proteome analysis of Panax ginseng will provide us comprehensive understanding of ginsenoside synthesis and guidance for artificial cultivation.