• Architectural research
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• v.15 no.4
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• pp.191-200
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• 2013

Since Modern Movement flexibility has been one of the most attractive words in architecture. However, "overprovision first, division later" has been the most prevailing design method for spatial flexibility, and many of buildings designed for flexible use are practically quite inflexible due to insufficient building systems or/and irresponsible planning. There have been two dominant strategies to achieve architectural flexibility: multi-functionality and polyvalence. These two approaches, which point contradictory directions, actually reflect the difficulty in providing a proper form of architectural flexibility. Multi-functionality can afford changeable environments with satisfying spatial conditions; however it lacks tolerance to accommodate other uses but intended functions by architects. Meanwhile, flexibility by a polyvalent form relies on the vague anticipation of user's various interpretations. In this study by looking up these two different standpoints and historical precedents flexibility in architecture is carefully scrutinized focused on the contradiction, and as an alternative for architectural flexibility contextual relations is proposed. Unlike both multi-functionality and polyvalence, which produce flexibility by changing its own properties, manipulating contextual relations infuses flexibility into space by changing the properties of a building, not of its individual room. By using this contextual relations method, a community-centered school in Manhattan, NY, which was in danger of being closed because of its academic failure, is represented as a flexible space.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3247-3252
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• 2013

The convergence of ICT and cloud computing is treated as a main issue all over the fields including education. This development leads to change from e-learning to u-learning and smart education. Therefore, we need to study in term of the systematic and a long-term viewpoint how smart education environment have an influence on the practical space. And we need a concrete study for smart education space based on property of space. Under these critical mind, this study understands the smart education space in terms of the convergence of computing space and physical space. As a Result, smart education space have major property such as flexibility, communication, polyvalence.

• Journal of Microbiology and Biotechnology
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• v.16 no.11
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• pp.1784-1790
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• 2006

Bacillus anthracis is a causative agent of anthrax. Anthrax toxins are composed of a protective antigen (PA), lethal factor (LF), and edema factor (EF), in which the PA is a central mediator for the delivery of the two enzymatic moieties LF and EF. Therefore, the PA has been an attractive target in the prevention and vaccinization for anthrax toxin. Recently, it has been reported that the molecule consisting of multiple copies of PA-binding peptide, covalently linked to a flexible polymer backbone, blocked intoxification of anthrax toxin in an animal model. In the present study, we have screened novel diverse peptides that bind to PA with a high affinity (picomolar range) from an M13 peptide display library and characterized the binding regions of the peptides. Our works provide a basis to develop novel potent inhibitors or diagnostic probes with a diverse polyvalence.