• Clinical and Experimental Reproductive Medicine
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• v.46 no.4
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• pp.197-201
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• 2019

Objective: The aim of this study was to establish whether differences in ovarian size exist between the right and the left ovary of the same individual in women with polycystic ovary syndrome. Methods: In total, 206 Korean women with polycystic ovary syndrome were included in this study. In all participants, a transvaginal or transrectal ultrasound examination was conducted in the early follicular phase of the menstrual cycle. Results: A significant linear correlation was found between the two ovaries with regard to antral follicle count and ovarian volume. The mean antral follicle count in the right ovary (26.75 ± 11.72) was significantly higher than that in the left ovary (23.98 ± 10.85), and the mean volume of the right ovary (11.06 ± 5.17 cm³) was significantly different from that of the left ovary (9.12 ± 4.89 cm³). Conclusion: Ovarian size is different between the right and the left ovary in women with polycystic ovary syndrome.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7011-7014
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• 2014

The polycystic ovary syndrome is the most common endocrinological disorder of reproductive age women with a prevalence of 5 to 8 %. The most common diagnostic criteria used for polycystic ovary syndrome are oligo- or an-ovulation, clinical and/ or biochemical signs of hyperandrogenism and polycystic ovaries. Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone due to anovulation and persistent stimulation of the endometrium may lead to endometrial hyperplasia or adenocarcinoma development. In this mini review, we aimed to evaluate the possible relationship between polycystic ovary syndrome and endometrial cancer.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.1
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• pp.122-137
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• 2018

Objectives: This study is to review the effect of Korean medicinal herbs on treatment of polycystic ovary induced rat models reported in domestic & foreign journals. Methods: 7 electronic databases (Pubmed, CNKI, EMBASE, Oasis, RISS, CENTRAL, Koreankt) were searched with term as polycystic ovary, and study reports on polycystic ovary impairment with Korean medicinal herbs. After selecting several studies, the analysis was focused on items reflected in the Rotterdam criteria for diagnosis of polycystic ovary syndrome such as hyperandrogenism (HA), ovarian weight, the number of follicle cysts, estrous cycles, and etc. Results: 15 studies were reviewed. As a polycystic ovary induction material, estradiol valerate (EV) was used in 9 studies, testosterone propionate (TP) in 2 studies and dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), Poretsky's method and letrozole (LE) was used in rest 4 studies, respectively. Tribulus terrestris (TT), Nardostachys jatamansi (NJ), Lycii cortex (LC), Cinnamomum cassia kees (CCK) and Atractylodis macrocephalae koidz (AMK) produced statistically significant results related to hyperandrogenism. In ovarian weight, Silybum marianum (SM), AMK and Alllium sativum (AS) were statistically significant. In the the number of follicle cysts, SM and TT were statistically significant. In estrous cycles, AMK, NJ, TT and Coix lacryma-jobi (CL) were statistically significant. Conclusions: Based on the diagnosis criteria of Rotterdam, TT, NJ, AMK, SM, AS, and CL produced statistically significant results in rat model.

• Women's Health Nursing
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• v.20 no.4
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• pp.255-265
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• 2014

Purpose: Polycystic Ovary Syndrome Questionnaire (PCOSQ) was developed to measure health-related quality of life of women who had polycystic ovary syndrome. The purpose of this study was to exam reliability and validity of the Korean version of PCOSQ. Methods: A sample of 101 women who had polycystic ovarian syndrome was recruited from outpatient gynecology clinics. Factor analysis was carried out to verify the composition of dimensions of the Korean version of PCOSQ. Concurrent validity was examined by assessing the correlation between the PCOSQ and health related quality of life, and convergent validity was evaluated by testing correlation between PCOSQ and depression. Reliability was assessed using Cronbach's ${\alpha}$. Results: The content validitywas satisfactory (CVI=0.85). Factor analysis identified 5 factors, and factor loadings of the PCOSQ ranged from .48 to .90. Correlation was found between the PCOSQ and health related quality of life (Physical component score: r=.33, p=.001; Mental component score: r=.44, p<.001) and between the PCOSQand depression (r=-.36, p<.001). The Cronbach's ${\alpha}$ of the PCOSQ was .93, indicating reliable reliability. Conclusion: These results demonstrate that the Korean version of PCOSQ is a reliable and valid instrument for evaluating Korean-speaking women with polycystic ovarian syndrome.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.3
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• pp.175-186
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• 2020

Objectives: The purpose of this study is to report the effect of Jokyeongjongok-tang-gami in case of oligomenorrhea patients classified with gan-ulgiche and eumheo due to polycystic ovary syndrome. Methods: Three patients suffering from oligomenorrhea due to polycystic ovary syndrome were treated with korean medical treatment (herbal medicine, moxibustion, acupuncture) more than 3 months. The patients classified with gan-ulgiche and eumheo were treated with Jokyeongjongok-tang-gami. Results: Three oligomenorrhea patients recovered normal menstrual cycle more than 3 times after taking Korean medical treatment for 3~6 months. Conclusions: This 3 cases classified with gan-ulgiche and eumheo show Jokyeongjongok-tang-gami is effective on patients with rare menstruation due to polycystic ovary syndrome.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.1
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• pp.84-98
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• 2007

Purpose : Polycystic ovarian syndrome(PCOS) is a endocrine disorder and still remains as one of the common causes of anovulation in women of reproductive age. There are some evidences that nerve growth factor(NGF) is involved in the pathogenesis of PCOS. In this research, the effects of ShingihwanhapChangbudodam- Tang(SCT) on the estradiol valerate(EV)-induced polycystic ovary(PCO) were investigated in rats. Methods : PCO was induced by single intramuscular injection with EV(4mg) in female rats. Rats in PCO control group(n = 8) were EV injected and orally administrated distilled water for sixty days. Rats in SCT-treated group(n = 8) were EV injected and orally administrated SCT for same duration. The weights of body, ovary and adrenal gland were measured. And also, ovarian histopathology and NGF immunohistochemistry were performed. Results : The weights of ovaries in SCT-treated group were significantly increased compared with control group. The numbers of secondly and mature follicles, and corpora lutea in SCT-treated group were significantly increased compared with control group. The numbers of atretic follicles were significantly decreased compared with control group. The expression of NGF positive reaction in the ovarian granulosa cells of SCT-treated group were lesser observed than control group. Conclusion : From the these results, we concluded that ShingihwanhapChangbudodam-Tang(SCT) has inhibitory effect on the development of EV-induced polycystic ovary. And it's effect may be related with decreased NGF activities in the ovary.

• Journal of Korean Medicine for Obesity Research
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• v.8 no.1
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• pp.101-108
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• 2008

Objective The purpose of this study is to evaluate the effectiveness of obesity management program with herbal medication(Changbudodamtanggamibang) on an obese female patient with oligomenorrhea resulted from polycystic ovary syndrome. Methods I applied herbal medication(Changbudodamtanggamibang), acupuncture, auricular acupuncture, electrolipolysis, low calorie diet, aerobic exercise, behavioral modification therapy and fumigation therapy to her. Results Her weight decreased from 64.3kg to 54.0kg, BMI from $26.4kg/m^2$ to $22.2kg/m^2$, PBF from 38.9% to 29.6%, and WHR from 0.89 to 0.82. Menstrual period was normalized from 60days to 34days. ConclusionThese results provides an evidence that obesity management program with herbal medication(Changbudodamtanggamibang) is effective on oligomenorrhea of an obese female patient with polycystic ovary syndrome.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.81-85
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• 2011

Objective : This study was designed to investigate the effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. Methods : We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats. Results : Treatment with AGR did not affect body weights, amount of food and water uptake. Administration group of AGR restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated control group. Conclusion : These results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.4
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• pp.658-662
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• 2011

This study was designed to investigate the effects of Gleditsiae Spina (GS) on polycystic ovary (PCO) induced by estradiol valerate in female rats. We investigated the effects of GS on changes in body weights and food and water uptake for 5 weeks. In addition, we also examined the effects on ovary weights. Finally, we observed histopathological changes in PCO rats. Treatment with GS did not affect body weights, amount of food and water uptake compared with non-treated control group. Administration group of GS restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in GS group compared with non-treated control group. These results suggest that GS can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.

• Clinical and Experimental Reproductive Medicine
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• v.32 no.1
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• pp.9-16
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• 2005

Objective: This study was performed to evaluate the effect of isoflavone supplementation on hormone levels, lipid profiles and total antioxidant status in patients with polycystic ovary syndrome. Methods: Total 11 women with polycystic ovary syndrome were supplemented daily with 150mg of isoflavone for 6 months. Blood samples were collected 0, 3, and 6 months after supplement of isoflavone for analysis of LH, FSH, E2, testosterone, free testosterone, SHBG levels, serum lipid profiles, and total antioxidant status (TAS). Results: After 6 months isoflavone supplementation, the hormone levels did not change significantly. Serum lipid profiles did not show any significant change in total cholesterol, LDL-cholesterol, triglyceride, lipoprotein(a), and free fatty acid levels. However, there was significant increase in HDL-cholesterol (p<0.05) for 3 months. Total antioxidant status was increased significantly after isoflavone supplementation for 6 months (p<0.05). Conclusion: Isoflavone supplementation showed positive effects on the HDL-cholesterol and total antioxidant status. it is implicated that isoflavone supplementation will may have a effect on cardiovascular disease in patients with polycystic ovary syndrome.