• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 추계 학술발표회 논문집
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• pp.213-216
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• 2006

The designer has difficulty due to inadequacy of provisions in the domestic design code and lack of understanding for behavior of D-region. The reinforced concrete pi(${\pi}$)-shaped RC rahmen bridge consists of various failure mechanisms as the crushing or splitting from compression concrete, and shearing failure under the loading plate. However, predicting those failure mechanisms is very difficult. In this study, the pi(${\pi}$)-shaped RC rahmen bridge is analyzed and designed by using strut-tie model. Adequacy for the application of strut-tie model is verified by comparison with the way used in current design practice. As a result that designing the structures should be maked a comparison between strut-tie model and current conventional design method.

• 한국광학회:학술대회논문집
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• 한국광학회 2000년도 하계학술발표회
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• pp.164-165
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• 2000

There has recently been a considerable amount of interest in two-photon(TP) processes because of their applications to 3-D optical data storage and imaging, up-conversion lasing, and optical power limiting. Recently, the role of Dithienothlophene(DTT) as $\pi$-center of two-photon absorption(TPA) molecules was reported to give a large enhancement of TPA, compared with the benzeniods counterparts.$^{[1]}$ In this report, we carried out two experiments to investigate nonlinear optical absorption of the molecules in which central DTT is attached through conjugation to either a D/D or a D/A pair at the ends, forming a D-$\pi$-D(1 and 3) or D-$\pi$-A(2 and 4) sequence(Fig.1). All the samples were prepared in solutions with the same molar concentration. (omitted)

• 한국식품영양과학회지
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• 제42권9호
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• pp.1446-1451
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• 2013

Chitosan 함유 보존제를 각각 1%, 3%, 5% 첨가하여 제조한 patty의 관능검사 결과, 맛과 종합적 기호도의 경우 PI-1 처리구, PII-1 처리구가 대조구보다 유의적으로 높은 값을 나타내었다. DPPH 라디칼 소거능은 대조구, 1% PI-1 처리구, 1% PII-1 처리구가 각각 13.54%, 21.78%, 14.07%로 PI-1 처리구가 대조구보다 유의적으로 높았다. 총균수는 저장 10일째 PI-1 처리구는 $10^4$ CFU/g으로 대조구보다 약 1 log cycle 낮았으며, 대장균군수는 저장 10일째 PI-1 처리구가 2.98 log CFU/g으로 가장 낮았으며, 다음은 PII-1 처리구 낮았다. 가열 감량은 PI-1 처리구와 PII-1 처리구가 대조구보다 낮았고, 저장기간이 경과할수록 유의적으로 감소하는 경향을 나타내었다. 보수력은 PI-1 처리구가 65.84%로 가장 높았으며, 저장기간 동안 대조구보다 높은 값을 유지하였다. 휘발성 염기태 질소는 대조구가 5일째까지, 보존제 처리구는 10일째까지 가식권의 한계치 이하로 나타났다. L 값은 저장기간 동안 뚜렷한 변화는 나타나지 않았고 a 값은 저장 5일째부터 급격히 낮아졌으며, b 값은 저장기간 동안 서서히 증가하는 경향을 나타내었다.

• 한국진공학회지
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• 제17권5호
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• pp.375-380
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• 2008

Dipyrromethene 유도체 분자 중 하나인 삼각형 모양의 Co-DPM 거대분자 (Co-DPM-trimer, Fig. 1)를 이용하여 흑연 표면에서 다양한 저차원 분자 나노구조를 형성할 수 있었으며, 이를 주사 터널링 현미경(scanning tunneling microscope)으로 관찰하였다. Co-DPM-trimer 분자를 $CH_2Cl_2$ 용매에 녹여 흑연 표면에 뿌리면, 용매가 증발되며 그 동안 표면에 분자 나노구조가 형성된다. 본 연구에서는 다양한 두께의 긴 1차원 분자선과 2차원 구조인 육각형 패턴을 관찰하였다. 1차원 분자선과 2차원 육각형 패턴의 높낮이 및 구조를 분석한 결과, 1차원 분자선의 경우 흑연 표면에 'edge-on'정렬로 연속된 $\pi-\pi$ stacking 상호작용에 의해서, 그리고 육각형 패턴 구조는 'face-on'정렬을 통해서 형성된 것으로 보인다.

• 전자공학회논문지A
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• 제30A권9호
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• pp.6-13
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• 1993

In is well-known that system performance in the high speed digital radio communication system is usually deteriorted due to the frequency selective fading distortion. In this paper, bit error rate(BER) performance by the reception phase error in cellular mobile communication systems is derived and analyzed. The system is modeled as a frequency selective fast Rayleigh fading channel corrupted by additive white gaussian noise(AWGN) and co-channel interference(CCI). Our numerical results show that for the 24KBaud(48Kb/s) $\pi$/4-DQPSK operated at carrier frequency 800 MHz and C/I<20 dB, the BER will be dominated by CCI if the vehicular speed is below 100 Km/h. The results show that performance, when reception phase error is below $\pi$/12, is deterioreted less than 3 dB, and that performance, when reception phase error is above $\pi$/12, is degraded over 3 dB.

• 분석과학
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• 제6권1호
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• pp.39-45
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• 1993

시스-펩티드 모델 화합물인 디케토페라진을 수용액과 $D_2O$에서 320~218nm 사이의 여기 파장을 이용하여 라만 스펙트럼을 측정하였다. 본 연구는 공명 증폭되는 아미드 밴드를 명명하고, 그 증폭 메카니즘을 규명하는 데 목적이 있다. 3개의 공명 증폭된 시스-펩티드 표본밴드가 수용액 상태에서 1676, 1533, $806cm^{-1}$에서 관찰되었고, 이것을 각각 아미드, I, II, S 밴드로 명명하였다. $1533cm^{-1}$ 아미드 II 밴드는 수용액 상태의 공명 라만 스펙트럼에서 가장 큰 밴드였으며, 순수한 C-N 신축운동이며, N-H를 N-D로 치환한 결과 $1520cm^{-1}$로 이동되었다. 이 밴드는 아마도 단백질내에 존재하는 시스형 펩티드를 관찰할 수 있는 표본 밴드가 될 것으로 예상된다. 여기 주파수를 바꾸어 가며 얻은 라만 밴드 크기 변화와, Albrecht A-항 모델로부터 시스 펩티드 라만 밴드가 188nm 근방의 펩티드 ${\pi}-{\pi}^*$ 전자 전이에 의하여 공명 증폭됨을 증명하였다. 이러한 자료를 바탕으로 시스 펩티드 ${\pi}^*$ 들뜬 상태의 기하구조는 전자 바닥 상태와 비교하여 C-N 결합이 늘어난 형태일 것으로 제안하였다.

• Macromolecular Research
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• 제17권9호
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• pp.672-681
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• 2009

A series of inert and photo-stable Er(III)-encapsulated complexes based on ${\pi}$-extended dendritic anthracene ligands bearing G3-aryl-ether dendron ([G3-AnX]-$CO_2H$), which retain different ${\pi}$-bridging systems, such as single (X= S), double (X= D) and triple (X= T) bonds was designed and synthesized to establish the structure-property relationship. The near infrared emission intensities of Er(III)-encapsulated complexes were enhanced dramatically by increasing the ${\pi}$-conjugated extension of anthracene ligands. The time-resolved luminescence spectra show monoexponential decays with a lifetime of $2.0{\sim}2.4ms$ for $Er^{3+}$ ions in thin films, and calculated intrinsic quantum yields of $Er^{3+}$ ions are in the range of $0.025{\sim}0.03%$. As a result, all Er(III)-encapsulated dendrimer complexes exhibit the near IR emission with the following order: $Er^{3+}-[G3-AnD]_3$(terpy) > $Er^{3+}-[G3-AnS]_3$(terpy) ${\approx}$ $Er^{3+}-[G3-AnT]_3$(terpy), because $Er^{3+}-[G3-AnD]_3$(terpy) has a higher relatively spectral overlap J value and energy transfer efficiency. In addition, the lack of detectable phosphorescence and no significant spectral dependence of the ${\pi}$-extended anthracene moieties on the solvent polarity support energy transfer from their singlet state to the central $Er^{3+}$ ion taking place in $Er^{3+}-[G3-AnX]_3$(terpy).

• Bulletin of the Korean Chemical Society
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• 제29권3호
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• pp.656-662
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• 2008

Antagonists of the d -opioid receptor are effective in overcoming resistance against analgesic drugs such as morphine. To identify novel antagonists of the d -opioid receptor that display high potency and low resistance, we performed 3D-QSAR analysis using chemical feature-based pharmacophore models. Chemical features for d -opioid receptor antagonists were generated using quantitative (Catalyst/HypoGen) and qualitative (Catalyst/HipHop) approaches. For HypoGen analysis, we collected 16 peptide and 16 non-peptide antagonists as the training set. The best-fit pharmacophore hypotheses of the two antagonist models comprised identical features, including a hydrophobic aromatic (HAR), a hydrophobic (HY), and a positive ionizable (PI) function. The training set of the HipHop model was constructed with three launched opioid drugs. The best hypothesis from HipHop included four features: an HAR, an HY, a hydrogen bond donor (HBD), and a PI function. Based on these results, we confirm that HY, HAR and PI features are essential for effective antagonism of the d -opioid receptor, and determine the appropriate pharmacophore to design such antagonists.

• Molecules and Cells
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• 제41권6호
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• pp.532-544
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• 2018

Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR-374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1. Finally, cell viability, cell cycle and apoptosis were detected. According to the KFGG analysis of DEGs, PTEN was involved in a variety of signaling pathways and miRs were associated with cancer development. The results showed that MiR-374b was highly expressed, while PTEN was downregulated in the GIST tissues. The levels of miR-374b, PI3K, AKT and PTEN were related to tumor diameter and pathological stage. Additionally, miR-374b increased the mRNA and protein levels of PI3K, Akt, MMP2, MMP9, P53 and cyclinD1, suggesting that miR-374b activates PI3K/Akt signaling pathway in GIST-T1 cells. Moreover, MiR374b promoted cell viability, migration, invasion, and cell cycle entry, and inhibited apoptosis in GIST cells. Taken together, the results indicated that miR-374b promotes viability and inhibits apoptosis of human GIST cells by targeting PTEN gene through the PI3K/Akt signaling pathway. Thus, this study provides a new potential target for GIST treatment.

• 한국염색가공학회:학술대회논문집
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• 한국염색가공학회 2011년도 제44차 학술발표회
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• pp.63-63
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• 2011

The donor-${\pi}$-acceptor (D-${\pi}$-A) chromophoric dye system has received great attention in variety fields such as electroluminescent materials, sensors and optoelectronic devices. There are many research activities focused on the development for abovementioned application materials with the high-performance properties. In the previous work, we are reported that novel D-${\pi}$-A dye, 2-[4-(9H-carbazol-9-yl)benzylidene]-2,3-dihydroinden-1-one, is successfully attained and exhibited a positive fluorescence solvatochromism. In this work, the molecular structure and packing geometry of 2-[4-(9H-carbazol-9-yl)benzylidene]-2,3-dihydroinden-1-one was discussed by their conformational structure. Their single yellow prism crystal having approximate dimensions of $0.30{\times}0.10{\times}0.10$ mm was carried out with a Rigaku RAXIS RAPID imaging plate area detector with graphite monochromated $CuK_{\alpha}$ radiation. Their crystal structure were solved by using the CrystalStructure crystallographic software package.