• The Korean Journal of Physiology
• /
• 제24권2호
• /
• pp.389-402
• /
• 1990

The physiological characteristics of the neurons receiving the ventral root afferent inputs were investigated in the cat. A total of 70 cells were identified in the lumbosacral spinal cord. All these cells responded only to the C-strength stimulation of the distal stump of cut ventral root and the estimated conduction velocities of the VRA fibers were not faster than 4 m/sec. The majority of them were silent in resting state. For 49 cells, their peripheral receptive fields were characterized. Among them, 25 cells were exclusively excited by VRA inputs, 8 were inhibited and the remaining cells recevied both excitatory and inhibitory VRA inputs. According to the response pattern to the mechanical stimuli applied to their receptive fields, only a fourth of them were typical high threshold cell, a sixth, wide dynamic range cells, while remainings were a rather complex cells. Most of the cells receiving VRA inputs, received only the A ${\delta}-peripheral$ nerve inputs. Intravenous injection of morphine decreased the response of spinal cells to the VRA activation. The responses were abolished completely by counter irritation to the common peroneal nerve with C-strength-low frequency stimuli. These physiological properties of the spinal neurons receiving the VRA inputs are differ in some aspect from the spinal neurons receiving nociceptive inputs from the periphery, but still were consistent with the contention that VRA system might carry nociceptive informations arising from the spinal cord and/or neraby surrounding tissues.

• The Korean Journal of Physiology
• /
• 제7권1호
• /
• pp.49-51
• /
• 1973

Denuded nerve fibers containing the node of Ranvier were prepared from the nerve innervating the gastrocnemius muscle of the frog. The effects of temperature rise of the medium surrounding the naked nerve fibers were studied upon the muscle response. A rise in temperature of the order of $50^{\circ}{\sim}90^{\circ}C$ was proved ineffective in the production of contractions in the muscle. It is thus concluded that the widespread concept that heating is one of the nerve stimuli is inadequate, and that thermal pain is the indirect effect of thermal stimuli. The authors' standpoint about thermal stimulus is that thermal stimulus or heating is one thing, cooling is another.

• 한국보건간호학회지
• /
• 제8권2호
• /
• pp.35-56
• /
• 1994

This article was intended to survey whether Roy' Adapation model ('Roy Model') can be applied to family health assessment and to study whether application of the Roy Model to a Korean family is feasible. under the Roy Model, a family is viewed as an adaptation system having a series of process of input. process, feedback, and output. Further, the Roy Model indicates that a family contains Physiolosical, self-concept. role function and interdependent mode in respect of internal or external stimuli. In the event where the family health assessed, the adaptation mode of that family must be assess at the first stage. Then, the focal, contextual, residual stimuli affecting the family must be assessed. In 1984 Hanson suggested four types of family adaptation mode based upon the Roy Model and thereby enhanced the possibility for family health assessment. In order survey whether the Roy Model can be applied to the Korean family, the author of this article contracted adults of 169 who live in 'A' city to make open questions regarding family and then analyzed responses from them by utilizing Roy model. This study categorized family Adaptation mode based upon the' four types of family adaptation mode developed by Hanson. As a result of this study, family adaptation mode was categorized into 117 concepts. Those 117 concepts are consisted or Physiolosical mode of 47. self­concept mode of 56, role function mode of 9 and interdependent mode of 5. Further. stimuli affecting family were classified based upon Roy's definition as to three types of stimuli. Stimuli on a family are comprised focal stimuli concept of 19, contextual stimuli concepts of 19, one residual stimuli concept. this result implies that the Roy's Model can be applied to Korean family. Physiological mode shows meaning of survival. while self-concept mode reflects meaning of growth and emphasizes harmony among the family based on the familism. The role function mode shows continuity rather control of family member. By contrast, interdependent mode shows interaction with community to which the family belongs. but the degree of interaction does not appear too high. The analysis of family stimuli led this study to conclude that troubles within a family. changes in family structure and diease of family member generate stimuli. However, an application of the Roy Model contains the following problems: First, Roy argued that the family adaptation mode should be assessed at the first level family health assessment and then stimuli affecting family adaptation should be adaptation assessed at the second stage. To the belief of the author of this article. however, for checking family adaptation level. focal, contextual, residual stimuli should be confirmed by assessing stimuli at first stage. Then, the family adaptation mode in respect of such stimuli should be assessed. The rationale for this is that the family adaptation level is determined depending on degree of strength of focal. contextual. residual stimuli. Second. Whall (1991) raised a question 'Does one assess family adaptation mode and intervene in the stimuli?' 'Likewise, assessment of the family adaptation should be made in the following manner in order for family health to be enhanced. Third. Roy believes that additional stimuli (such as contextual and residual) are same as internal process (including nurturance. support, and socialization). However, the basis for this Roy's belief is not too clear. In spite of these problems which the author indicated above, it can be concluded that the Roy Model can serve as a good device for an assessment of family health and that the Roy Model can be applied to a Korean family. Finally, further research of family adaptation theory and family nursing theory is required for a development of these theories.

• 대한인간공학회지
• /
• 제31권2호
• /
• pp.271-279
• /
• 2012

Objective: This study classified three different emotional states(boredom, pain, and surprise) using physiological signals. Background: Emotion recognition studies have tried to recognize human emotion by using physiological signals. It is important for emotion recognition to apply on human-computer interaction system for emotion detection. Method: 122 college students participated in this experiment. Three different emotional stimuli were presented to participants and physiological signals, i.e., EDA(Electrodermal Activity), SKT(Skin Temperature), PPG(Photoplethysmogram), and ECG (Electrocardiogram) were measured for 1 minute as baseline and for 1~1.5 minutes during emotional state. The obtained signals were analyzed for 30 seconds from the baseline and the emotional state and 27 features were extracted from these signals. Statistical analysis for emotion classification were done by DFA(discriminant function analysis) (SPSS 15.0) by using the difference values subtracting baseline values from the emotional state. Results: The result showed that physiological responses during emotional states were significantly differed as compared to during baseline. Also, an accuracy rate of emotion classification was 84.7%. Conclusion: Our study have identified that emotions were classified by various physiological signals. However, future study is needed to obtain additional signals from other modalities such as facial expression, face temperature, or voice to improve classification rate and to examine the stability and reliability of this result compare with accuracy of emotion classification using other algorithms. Application: This could help emotion recognition studies lead to better chance to recognize various human emotions by using physiological signals as well as is able to be applied on human-computer interaction system for emotion recognition. Also, it can be useful in developing an emotion theory, or profiling emotion-specific physiological responses as well as establishing the basis for emotion recognition system in human-computer interaction.

• 한국감성과학회:학술대회논문집
• /
• 한국감성과학회 1998년도 춘계학술발표 논문집
• /
• pp.44-56
• /
• 1998

Effects of the music and white noise on recovery of the autonomic and cortical responses evoked by aversive visual stimulation were analyzed in 20 subjects. It was suggested that the music is able to exert modulatory influence on the physiological activity resulted from exposure to unpleasant IAPS based stimuli. Spectral power of DDG, heart rate(HR)respiration rate (RSR) and electrodermal activity(EDA)were recorded and analyzed for each experimental condition. It was observed HR and RSR deceleration, increased EDA and electrocortical activation expressed in decreased alpha power and increase of delta activity ao occipital and frontal areas. Obtained results suggest that audutory stimulation both with pleasant and sad music lead to restoration of pre-stimulation activation levels of most physiological parameters during listenning to music and in post-stimulation period. White noise evoked short-term physiological responses typical for orienting reaction and quite distinct from changes produced by music. Available data to differentiate effeces among pleasant and sad music, due toqualitative similarities of physilolgical patterns, but suppert an assumption that music is capable to facilitate the process of recovery of physilolgical responses elicited by visual stimulation of negative valence, thus positively modulate post-stress state.

• 감성과학
• /
• 제12권3호
• /
• pp.317-324
• /
• 2009

본 연구에서는 정서 유발 프로토콜을 이용하여 유발된 다섯 가지 정서(기쁨, 슬픔, 분노, 스트레스와 무료함)에 따른 아동의 심혈관계 반응의 차이를 밝히고자 하였다. 아동에게 음악, 색채, 심상을 유발하는 이야기, 인형으로 구성된 복합자극을 제시하는 동안 이들의 심혈관계 반응을 측정하고, 자극에 대한 적합성(유발된 정서의 유형)과 효과성(유발된 정서의 강도)을 정서평가척도 상에 평정하도록 하였다. 분석에 사용된 심혈관계 생리반응 변수는 심박수, 호흡주기 관련 심박률 변화, 심박률 분산, 심박률 분산의 고주파수 성분, 저주파수 성분과 혈류량이었다. 연구 결과, 스트레스 유발하는 자극을 제외한 네 가지 정서 유발 자극은 아동에게 각 정서(기쁨, 슬픔, 분노와 무료함)를 적절하고 효과적으로 유발시킨 것으로 나타났다. 또한 호흡주기 관련 심박률 변화를 제외한 모든 심혈관계 지표에서 정서에 따른 유의한 차이가 나타났다. 정서에 따라 특징적인 심혈관계 반응이 나타났으며, 이는 심혈관계 반응을 이용하여 아동정서를 구분하는 것이 가능함을 의미한다.

• 한국미생물·생명공학회지
• /
• 제30권1호
• /
• pp.15-20
• /
• 2002

Diacylglycerol Kinase (DGK)는 E. coli 및 진핵세포에서의 신호전달에 관여하며, 또한 미생물에서 생리적 자극에 따라 다른 발현 양상을 보이는 것으로 밝혀져 있다. Bacillus subtilis에서 이 유전자에 대한 환경에서의 자극 신호들, 즉 pH 변화, 삼투압의 변화 및 온도의 변화에 따른 발현양상을 연구하였다. 이미 동정된 dgk locus의 KpnI-HindIII의 0.45 kb의 DNA fragment를 probe로 하여 Dot blot, Northern blot analysis를 통해 발현량을 조사해 본 결과 dgk 유전자는 pH변화, 삼투압의 변화 및 온도의 변화에 대응하여 발현되는 유전자임을 알 수 있었다. 특히 낮은 pH, 고 삼투압, 및 저온에서 dgk 유전자의 발현량이 많아짐을 확인 할 수 있었다. Northern hybridization에서 약 2.5kb의 mRNA가 관찰되었다. dgk gene의 ORF size는 약 0.4 kb로 관찰된 transcript size와는 일치하지 않았다. 따라서 Streptococcus mutans의 dgk gene과 마찬가지로 B. subtilis의 dgk 유전자도 polycistronic mRNA로 발현되는 것을 추정할 수 있었으며, 염색체상의 dgk gene에서 상류의 ORF2까지의 크기가 약 2.5 kb로 관찰된 mRNA size와 동일하였다. dgk gene 상류의 ORF2영역의 0.6 kb의 DNA fragment를 probe로 하여 northern blot hybridization을 수행한 결과, 2.5 kb의 mRNA가 관찰되었으며 발현되는 형태도 dgk probe를 이용한 결과와 동일하였다. 따라서 dgk gene은 상류부위의 ORF2 gene과 operon을 형성하여 polycistronic mRNA로 전사되는 것으로 판단된다.

• 감성과학
• /
• 제26권1호
• /
• pp.43-54
• /
• 2023

본 연구는 참가자 간 상관(Intersubject correlation: ISC)기법을 통해 정서 유발 자극에 대한 한 참가자의 반응과 그 참가자를 제외한 나머지 참가자들의 반응 간 일치성이 각 정서표상 범주(지배가, 각성가, 정서가)와 다양한 감각양상(청각, 시각, 촉각)에서 어떠한 차이가 있는지 밝히고자 하였다. 참가자 간 상관을 계산하기 위해 사용된 데이터는 참가자들의 청각, 시각, 촉각 자극에 대한 생리 측정치와 정서 평정치로 구성되었으며, 한 참가자의 데이터 세트와 나머지 참가자들의 데이터 세트의 평균으로 구분한 뒤 가능한 모든 자극 쌍에 대해 상관을 구하는 방식으로 참가자 간 상관을 계산하였다. 연구 결과, 지배가를 기준으로 재정렬한 데이터 세트에 대한 참가자들의 반응 일치성은 청각 감각양상 조건보다 시각 감각양상 조건에서 높은 ISC 값을 얻었다. 다음으로 각성가로 재정렬한 데이터 세트의 경우 시각 감각양상과 청각 감각양상에서 차이가 있음은 같았지만, 지배가 기준으로 재정렬한 데이터 세트와 결과가 상반되었다. 마지막으로, 정서가를 기준으로 재정렬된 데이터 세트는 모든 감각양상에서 부정적인 데이터 세트들이 긍정적인 데이터 세트보다 참가자들의 반응 일치성이 더 높았다. 모든 데이터 세트에서 정서표상 범주의 높고 낮음과 상관없이 촉각 감각양상에서 높은 ISC 값을 얻었다. 본 연구의 결과는 참가자 간 상관의 다양한 감각양상과 정서표상에 대한 반응의 일치성이 의미하는 바에 대한 해석을 제시하며, ISC 분석 방법이 참가자 반응의 차이에 대한 패턴을 측정하는 유용한 도구가 될 가능성을 제시하였다.

• BMB Reports
• /
• 제55권12호
• /
• pp.577-586
• /
• 2022

Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and pathological condition. During tumorigenesis, cancer cells are repeatedly exposed to diverse stress stimuli from the tumor microenvironment, and the dynamics of SGs is often modulated due to the alteration of gene expression patterns in cancer cells, leading to tumor progression as well as resistance to anticancer treatment. In this mini review, we provide a brief discussion about our current understanding of the fundamental roles of SGs during physiological stress and the effect of dysregulated SGs on cancer cell fitness and cancer therapy.

• 한국감성과학회:학술대회논문집
• /
• 한국감성과학회 2000년도 춘계 학술대회 및 국제 감성공학 심포지움 논문집 Proceeding of the 2000 Spring Conference of KOSES and International Sensibility Ergonomics Symposium
• /
• pp.370-379
• /
• 2000

Autonomic responses were analyzed in 323 college students exposed to visual stimulation with Korean Affective Picture System (KAPS). Cardiac, vascular and electrodermal variables were recorded during 30 sec of viewing affective pictures. The same slides intended to elicit basic emotions (fear, anger, surprise, disgust, sadness, happiness) were presented to subjects in 2 trials with different experimental context. The first time slides were shown without any instructions (passive viewing), while during the second with instruction to exert efforts to magnify experienced emotion induced by pictures (active viewing). The aim of the study was to differentiate autonomic manifestations of emotions elicited by KAPS stimulation and to identify the role of instructed emotional engagement on physiological response profiles. The obtained results demonstrated reproducibility of responses in both trials with different contexts. Pairwise comparison of physiological responses in emotion conditions revealed the most pronounced differentiation for "ear-anger" and "fear-sadness" pairs (in electrodermal and HR variability parameters). "Fear-surprise" pair was also well differentiable. The typical response profile for all emotions included HR acceleration (except happiness and surprise), an increase of electrodermal activity, and a decrease of pulse volume. Higher cardiovascular and electrodermal reactivity to fear observed in this study, e.g., as compared to data with IAPS as stimuli, can be explained by cultural relevance and higher effectiveness of KAPS as stimuli, can be explained by cultural relevance and higher effectiveness of KAPS in producing certain emotions such as fear in Koreans.