• Molecules and Cells
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• v.20 no.2
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• pp.157-166
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• 2005

The c-myc proto-oncogene encodes a nuclear protein that is deregulated and/or mutated in most human cancers. Acting primarily as an activator and sometimes as a repressor, MYC protein controls the synthesis of up to 10-15% of genes. The key MYC targets contributing to oncogenesis are incompletely enumerated and it is not known whether pathology arises from the expression of physiologic targets at abnormal levels or from the pathologic response of new target genes that are not normally regulated by MYC. Regardless of which, available evidence indicates that the level of MYC expression is an important determinant of MYC biology. The c-myc promoter has architectural and functional features that contribute to uniform expression and help to prevent or mitigate conditions that might otherwise create noisy expression. Those features include the use of an expanded proximal promoter, the averaging of input from dozens of transcription factors, and real-time feedback using the supercoil-deformable Far UpStream Element (FUSE) as physical sensor of ongoing transcriptional activity, and the FUSE binding protein (FBP) as well as the FBP interacting repressor (FIR) as effectors to enforce normal transcription from the c-myc promoter.

• The Journal of Korean Medicine
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• v.37 no.2
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• pp.76-84
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• 2016

Objectives: We evaluated the anti-fatigue effects of Rh2-enriched Korean ginseng (Ginseng Rh2+) using a forced exercise-induced chronic fatigue mouse model. Methods: ICR male mice were subjected to running wheel for 1 h, 5 days/week during 4 weeks, and running velocity was gradually increased. Each running session was followed by oral administration of distilled water, Ginseng Rh2+ (150 or 300 mg/kg), or N-acetyl-L-cysteine (NAC, 100 mg/kg) 1 h later. The exercise tolerance and forced swimming test were performed to evaluate the fatigue condition. Results: Chronic forced exercise reduced the physical activity, as evidenced by the behavioral tests, which were notably ameliorated by Ginseng Rh2+ treatment. Ginseng Rh2+ treatment also attenuated the alterations of energy metabolism and oxidative stress in skeletal muscle tissues and/or sera, including malondialdehyde (MDA), lactate concentration and its related factors (lactate dehydrogenase, blood urea nitrogen, and glucose levels). Conclusion: These findings strongly suggest that Ginseng Rh2+ exerts a potent anti-fatigue effect through modulation of energy metabolism and oxidative response.

• The Journal of Information Systems
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• v.29 no.1
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• pp.201-224
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• 2020

Purpose The study focuses on the physical activity behavior change effect of smart wristband, which is the most popular type of fitness tracker nowadays. The purpose of the research is to investigate how people's workout behavior may change after wearing a smart band and examine what kind of role persuasive design plays in behavior change. Design/Methodology/Approach This research employed an experimental study to examine whether the user's workout behaviors changed after using wristband from the "Behavior Wizard" perspective. A representative smart wristband from a major vendor was selected as the objects of experimental study. In the experiment, by comparing users' workout behavior before and after using the wristband, behavior changes of all the experiment participants were classified into one of the 15 behavior change types. Users perceived persuasive design characteristics were measured and group differences were tested among different behavior change groups. Findings This research found that nearly half of the participants changed their workout behavior while half retained their workout status or no exercise status. Half of the participants who did not do exercise in their spare time started walking in the experiment. Results also showed that participants who started working out perceived higher levels of persuasive design devised into the smart band than participants who preserved no exercise status, except for facilitation and reward strategies. Participants who retained workout and those who increased workout frequency perceived no difference in smart band persuasive design.

• Journal of Korean Academy of Rural Health Nursing
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• v.13 no.1
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• pp.21-33
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• 2018

Purpose: The purpose of this study was to identify health problems in the community by providing healthy village projects centered and based on the actual living site and to enhance the empowerment of the community related to health. Methods: The participants were 600 people who lived in one of the 5 villages under the jurisdiction of one Primary Health Care Post (PHCP) in D city. The Community Health Practitioner (CHP) carried out the projects to increase geographical and temporal accessibility by building infrastructures through connecting human and physical resources in the community. The health leaders who were trained through the project consistently managed, and periodically checked the residents' health status. Results: The participants in the projects had significantly lower levels of depression, routine stress, and activity of daily living (ADL) disorders, and higher interpersonal relationships, and health-related quality of life (HRQoL) compared to the control group. Conclusions: The healthy village projects centered on the living site led to voluntary participation from the residents, improve HRQoL and enhanced empowerment of community.

• Journal of the Korean Society of Food Culture
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• v.31 no.6
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• pp.587-596
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• 2016

The purpose of this study was to determine health consciousness and eating habits of workers at Deluxe hotels in Seoul and Gyonggi-do. To determine health levels, this study focused on quality of sleep, current state of health, smoking, drinking, regular exercise, dietary behavior patterns, dietary habits, and food intake patterns. Out of 228 subjects, 145 (63.6%) were males and 83 (36.4%) were females. Majority of workers (86.9%) graduated from university. A majority (57.0%) worked more than 10 years. Average health condition was 'little tired', whereas 18.4% of subjects were 'always tired'. Male percentages for smoking and drinking were higher than those for females. A total of 44.3% of workers ate twice a day. Regular physical activity was high, but regular exercise rate was slightly low. Male average eating speed was faster than that of females and had lower scores for desirable eating habits. Shift workers ate night meals more than non- shift workers. This study shows that workers at Deluxe hotels need to take better care of their health.

• Journal of Veterinary Clinics
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• v.36 no.4
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• pp.219-224
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• 2019

The aim of this study was to evaluate the safety and effects of a soy lecithin-based supplement on the general health, skin condition, and blood lipid levels of dogs. Twenty-five, healthy, privately-owned dogs were enrolled in the study. Oral supplementation was administered for 8 weeks in the treatment group. Evaluation items included a thorough physical examination, owner responses to a questionnaire, blood analysis (CBC, CRP, serum chemistry, lipid profile). The results showed a significant improvement in amount of exercise, water intake, skin exfoliation in the treatment group (P < 0.05) but no significant changes in the other evaluation items, including no significant changes in blood component results following administration of the supplement. Most dogs well tolerated the treatment, and there were no serious adverse events. We suggest that soy lecithin has potential as a nutraceutical for the positive effect of general health condition such as activity and skin condition. Further studies are needed to establish the appropriate dose level and administration frequency of soy lecithin in dogs.

• Journal of Korean Biological Nursing Science
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• v.21 no.2
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• pp.152-159
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• 2019

Purpose: To understand awareness, attitude and knowledge levels of muscle health of adults over 18 years old. Methods: This study was a cross-sectional study using questionnaires. A total of 401 questionnaires were included for final analysis. Mean and standard deviation of the continuous variables were analyzed and frequency analysis of categorical variables was performed. To identify differences according to general characteristics, t-test was used. Results: Awareness scores about the importance of muscle health and exercises were 8.3 and 13.0, respectively. Attitude score and knowledge score were 12.4 and 15.0, respectively. There were differences in attitude toward muscle health according to gender, age, physical activity, and diet habits. However, there was no difference in attitude toward muscle health according to educational level, smoking, drinking, or sleeping. Conclusion: It is necessary to seek a strategy to improve awareness and attitude toward muscle health based on knowledge, not merely to raise knowledge level about muscle health. Since nurses play a central role in health promotion and disease prevention, they should also play an important role in strategic development and application of intervention.

• Health Policy and Management
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• v.31 no.3
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• pp.374-383
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• 2021

Background: The purpose of this study is to identify the factors affecting the depressive mood experience in university students by gender. Methods: This study is a descriptive survey that conducted a secondary analysis using data from the 2020 Community Health Survey, which is conducted annually in Korea. The study targets 8,928 college students, 4,682 male students and 4,246 female students. Data analysis was conducted after creating a composite sample plan file that reflected layering variables, colony variables, and weights. Results: Factors affecting the depressive mood experience of both males and females were household income, smoking, subjective stress levels, changes in drinking and smoking, and the number of encounters caused by coronavirus disease 2019 (COVID-19). Factors influencing the depressive mood experience of females were the presence of breakfast, changes in physical activity due to COVID-19, and the presence of helpers in self-quarantine due to COVID-19 (p<0.05). Conclusion: Psychological counseling programs should be promoted to actively utilize mental health in those in their 20s and 30s. Universities also need to detect depressed students early through screening and perform timely and appropriate interventions.

• Clinical and Experimental Pediatrics
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• v.64 no.5
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• pp.196-207
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• 2021

Over the last few decades, the rates of pediatric obesity have more than doubled regardless of sociodemographic categorization, and despite these rates plateauing in recent years there continues to be an increase in the severity of obesity in children and adolescents. This review will discuss the pediatric obesity mediated cardiovascular disease (CVD) risk factors such as attenuated levels of satiety and energy metabolism hormones, insulin resistance, vascular endothelial dysfunction, and arterial stiffness. Additionally, early intervention to combat pediatric obesity is critical as obesity has been suggested to track into adulthood, and these obese children and adolescents are at an increased risk of early mortality. Current suggested strategies to combat pediatric obesity are modifying diet, limiting sedentary behavior, and increasing physical activity. The effects of exercise intervention on metabolic hormones such as leptin and adiponectin, insulin sensitivity/resistance, and body fat in obese children and adolescents will be discussed along with the exercise modality, intensity, and duration. Specifically, this review will focus on the differential effects of aerobic exercise, resistance training, and combined exercise on the cardiovascular risks in pediatric obesity. This review outlines the evidence that exercise intervention is a beneficial therapeutic strategy to reduce the risk factors for CVD and the ideal exercise prescription to combat pediatric obesity should contain both muscle strengthening and aerobic components with an emphasis on fat mass reduction and long-term adherence.

• Journal of East-West Nursing Research
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• v.28 no.2
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• pp.122-131
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• 2022

Purpose: This study aimed to identify the factors related to fear of falling (FOF) in different age groups from community-dwelling mid to late-adults. Methods: To identify the factors related to FOF, data of 162,684 adults over 45 years of age from 2019 Community Health Survey was analyzed using logistic regression with complex samples. Results: Factors related to FOF found in all age groups were sex, previous experience of falls, physical activity levels over moderate intensity, subjective health status, number of chronic diseases, stress, depression, and cognitive decline. In the 45-64 age group, the FOF was significantly higher in the groups of low education level and low monthly household income. In the 65-74 and over 75 age groups, the FOF was significantly higher in the groups of not living with spouse and walking not practiced. Conclusion: We suggests that understanding of risk factors and early detection of fall risk patients in each age group are necessary to establish and apply tailored fall prevention programs for prevention and management of the FOF in community-dwelling mid to late-adults.