• 제목/요약/키워드: Phospholipids

검색결과 472건 처리시간 0.032초

Effects of Methyltestosterone and Flutanide on Phospholipid Hydroperoxide Glutathione Peroxidase Gene Expression in the Reproductive System of Male Mice

  • Kang, Min-Joung;Nam, Sang-Yoon;Kwon, Young-Bang;Kang, Jong-Koo
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.161-161
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    • 2001
  • Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is an antioxidant selenoenzyme which interacts directly with and diminishes peroxidized phospholipids, cholesterol and cholesteryl ester in tissues. PHGPx activity appears in most tissues, but is especially high in testis. In testis, PHGPx level decreases in hypophysectomized rats but is partially restored after gonadotropin treament.(omitted)

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Lysophosphatidic Acid and Lysophosphatidylserine, New Bioactive Lysophospholipids

  • Arai, Hiroyuki
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.109-110
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    • 2003
  • Phospholipids function as major components of biological membranes as well as precursors of biologically active lipid messengers. It is well known that arachidonic acid attached at the sn-2 position of phosphoglycerides serves as a precursor of prostaglandins and leukotrienes. Recently, it has been recognized that lysophospholipids such as lysophosphatidic acid, sphingosine 1-phosphate, lysophosphatidylserine and monoglyceride also function as lipid messengers with a variety of biological activities. (omitted)

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Biochemistry and structure of phosphoinositide phosphatases

  • Kim, Young Jun;Jahan, Nusrat;Bahk, Young Yil
    • BMB Reports
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    • 제46권1호
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    • pp.1-8
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    • 2013
  • Phosphoinositides are the phosphorylated derivatives of phosphatidylinositol, and play a very significant role in a diverse range of signaling processes in eukaryotic cells. A number of phosphoinositide-metabolizing enzymes, including phosphoinositide-kinases and phosphatases are involved in the synthesis and degradation of these phospholipids. Recently, the function of various phosphatases in the phosphatidylinositol signaling pathway has been of great interest. In the present review we summarize the structural insights and biochemistry of various phosphatases in regulating phosphoinositide metabolism.

Bacillus cereus에 의한 Phospholipase C (PLC) 생산

  • 서국화;이종일
    • 한국생물공학회:학술대회논문집
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    • 한국생물공학회 2002년도 생물공학의 동향 (X)
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    • pp.232-234
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    • 2002
  • 공업적으로 중요성이 날로 더해가는 phospholipase C (PLC) 를 Bacillus cereus를 이용하여 생산하였다. 또한, plc::gfp fusion protein 을 생산하는 재조합 E. coli 를 제조하고 배양하였으며 특히 형광센서를 이용하여 PLC 의 생산 특성을 모니터링하였다.

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Graphene Derivatives for Bioanalytical Chemistry

  • Min, Dal-Hee
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2011년도 제40회 동계학술대회 초록집
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    • pp.10-10
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    • 2011
  • Graphene and graphene derivatives have attracted enormous attention from various research fields for applications in electronic devices, transparent electrodes, biosensors, drug delivery system and surface coatings. In the viewpoint of chemist, the chemical structure of graphene derivatives seems intriguing but detailed structures are being revealed only recently while engineering approaches for various applications are being executed very actively. Recently, several reports are available on interactions of graphene with biomolecules including proteins and nucleic acids. In this talk, I'll introduce recent studies which harness graphene derivatives for developing bioanalytical platforms to quantitatively analyze various enzyme activities. The systems rely on attractive interaction between graphene oxide and nucleic acids or phospholipids.

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Phospholipase $A_2$에 의한 인지질의 가수분해반응에서 기질의 미셀화가 반응속도에 미치는 영향 (Effect of Substrate Micellization on the Hydrolysis Rate of Phospholipid by Phospholipase $A_2$)

  • 김형주;신우진;최태부
    • 한국미생물·생명공학회지
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    • 제21권2호
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    • pp.163-170
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    • 1993
  • The effect of substrate micellization on the hydrolysis rate in the production of lysopho-sphatidylcholine (LPC) from phosphatidylcholine (PC) using hog pancreas phospholipase A2(PLA2) was studied. The optimal temperature and pH for the reactions in aqueous phase was found 42C and 7.2, respectively. For a given PC concentration, initial reaction rate was progressively increased with the addition of sodium deoxycholate (DOC), which could transform the bilayer of phospholipids into micellar structure.

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Oxidation of Ferrocytochrome c by Membrane-Associated Ferricytochrome c

  • Kim, Yu-Shin;Sanghwa Han
    • 한국생물물리학회:학술대회논문집
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    • 한국생물물리학회 1999년도 학술발표회 진행표 및 논문초록
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    • pp.46-46
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    • 1999
  • Positively charged cytochrome c interacts with the negatively charged mitochondrial inner membrane. This interaction induces conformational changes in bound cytochrome c. In order to estimate the effect of cytochrome c-membrane interaction on the mitochondrial electron transfer, we have investigated oxidation of ferrocytochrom c in the presence of anionic phospholipids.(omitted)

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DIVERGENT ROLES OF A NOVEL PHOSPHOLIPASE $A_2$ IN CELL DEATH

  • Schnellmann, Rick G.
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.68-88
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    • 2002
  • Phospholipase A$_2$ (s) are esterases that hydrolyze the sn-2 ester bond in phospholipids, releasing a fatty acid and a lysophospholipid. We previously showed that most PLA$_2$ activity in rabbit renal proximal tubule cells (RPTC) was Ca$\^$2+/-independent, localized to the endoplasmic reticulum (ER-iPLA$_2$), and inhibited by the specific Ca$\^$2+/-independent PLA$_2$ inhibitor bromoenol lactone (BEL).(omitted)

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Chlorella ellipsoidea 엽록체의 인지질 생합성 및 지방산 조성에 미치는 탄소원의 효과 (Effect of Carbon Sources on the Synthesis of Phospholipid and Fatty Acid Composition in Chloroplast of Chlorella ellipsoidea)

  • 정효선
    • Journal of Plant Biology
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    • 제33권1호
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    • pp.49-54
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    • 1990
  • Chlorella cells were cultured with M4N media treated with glucose (5 mM) sucrose (10 mM) and raffinose (30 mM). Phospholipids and their fatty acid compositions were analyzed in the chloroplast isolated from cultured Chlorella cells. Growth rate was prominently raised in the treatment with raffinose. Glucose was the most excellent carbon source in the biosynthesis of total lipid, phosphatidylcholine(PC), phosphatidylethanolamine(PE), phosphatidylinositol(PI) of the chloroplast. Also, the major fatty acids were palmitic, linoleic and linolenic acid during the biosynthesis of phospholipid in the control and in the treatment with carbon sources.

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