• 대한기계학회논문집A
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• 제20권3호
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• pp.910-932
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• 1996

A problem of determining the effective conductivity of a useful model of sphere-matrix type, disordered three-phase composite media is considered. Specifically, a three-phase media in which two-phase composite spheres, consisting of spheres of conductivity $k_2$((phase 2) and concentric shells of conductivity $k_3$(phase 3), are randomly distributed in a matrix of conductivity $k_1$( (phase 1) is considered. As for the structure models configuring three-phase composite media, three different structure models of PCS, PS-1 and PS-2 models are defined, which are analogous to well-established PCS, PS structure models of two-phase composite media. Futhermore, a generalized PS-PCS structure model is proposed to incorporate thesee three different models in one. Effective condectivity $k^{\ast}$of multiphaes composite media is greatly influenced by the phase connectivity of each disspersed phase material, as well as phase conductivities and phase volume fractions. Phase connectivity of three-phase PCS, PS-1, PS-2 composite media is quantified by the impentrability parameter $\lambda$. Mathematically rigorous first-order cluster bounds on $k^{\ast}$ are derived for these models of three-phase composite media, and as computation examples, first-order cluster bounds on $k^{\ast}$ for three-phase composites consisting of largely different phase conductivities are computed and compared as function of concnectivity parpmeter $\lambda$. Results and discussions are given.

• The Korean Journal of Physiology and Pharmacology
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• 제24권1호
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• pp.101-110
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• 2020

Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With its inward-rectifying current-voltage relationship and high calcium permeability, TRPC4 channels permit calcium influx once the channel is opened by muscarinic receptor stimulation. Polyamines are known to inhibit nonselective cation channels that mediate the generation of mIcat. Moreover, it is reported that TRPC4 channels are blocked by the intracellular spermine through electrostatic interaction with glutamate residues (E728, E729). Here, we investigated the correlation between the magnitude of channel inactivation by spermine and the magnitude of channel conductance. We also found additional spermine binding sites in TRPC4. We evaluated channel activity with electrophysiological recordings and revalidated structural significance based on Cryo-EM structure, which was resolved recently. We found that there is no correlation between magnitude of inhibitory action of spermine and magnitude of maximum current of the channel. In intracellular region, TRPC4 attracts spermine at channel periphery by reducing access resistance, and acidic residues contribute to blocking action of intracellular spermine; channel periphery, E649; cytosolic space, D629, D649, and E687.

• 한국물환경학회지
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• 제34권1호
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• pp.57-66
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• 2018

Water disasters such as flash floods and inundation caused by localized heavy rainfall in urban areas have a large impact on climate change but are also closely related to the increase in impervious areas as pointed out in domestic and international studies. It is difficult to secure natural green areas in urban areas that have already been developed. So, urban regeneration can be expected using water management optimized with technologies to secure infiltration and storage capacity such as Low-Impact Development technology. In this study, the water cycle improvement ability was confirmed by applying the LID technology within the district unit plan of the environmentally friendly village, and the economic feasibility of LID application was analyzed by estimating the costs and benefits of installing the facilities. The site was planned to conserve sufficient green and plans for securing the watershed infiltration and storage capacity were formulated with the application of additional LID technology, such as infiltration trenches, rain barrels and permeable pavements. The LID design method applicable to the site was established, and the water balance of the watershed was analyzed through simulations of the SWMM model. The water circulation improvement effect was confirmed through the water balance analysis, and the cost-benefits were determined according to the estimation method, and the economic analysis was conducted. This study confirms that the investment of LID technology is economically feasible for the hydrological improvement effect of the housing complex.

• Biomaterials and Biomechanics in Bioengineering
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• 제1권1호
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• pp.27-39
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• 2014

We have previously described a new multilayer alginate microcapsule system, and the goals of the present study were to assess the in vitro function of islets encapsulated in its inner layer, and the angiogenic ability of FGF-1 delivered from the external layer in an omentum pouch. Following isolation and culture, islets were encapsulated in the inner core of microspheres ($500-600{\mu}m$ in diameter) with a semi-permeable poly-L-ornithine (PLO) membrane separating two alginate layers, and both unencapsulated and encapsulated islet function was assessed by a dynamic glucose perifusion. For angiogenesis experiments, one group of microcapsules without FGF-1 (control) and another (test) containing FGF-1 with heparin encapsulated in the external layer were made. One hundred microcapsules of each group were transplanted in Lewis rats (n = 5/group) and were retrieved after 14 days for assessment of angiogenesis. Glucose perifusion of unencapsulated and encapsulated islets resulted in similar stimulation indices. The release of FGF-1 resulted in increased vascular density compared to controls. In conclusion, islets encapsulated in the core of multilayer alginate microcapsules maintain functionality and the microcapsule's external layer is effective in delivery of FGF-1 to enhance graft neovascularization in a retrievable omentum pouch.

• 한국지하수토양환경학회지:지하수토양환경
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• 제20권7호
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• pp.23-33
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• 2015

This study was conducted to provide the preliminary data on preparation for policy decisions regarding the groundwater supply scheme for N. Korea vulnerable to drought. Agricultural activities oriented to upland field due to the mountainous terrain more than 79% as well as the diversity of rainfall distribution over the country make more vulnerable to structural problems in the drought in N. Korea. Therefore, in anticipation of the expansion of exchange policies in agricultural sector, the available amount of groundwater needed for sustainable water resources supply was estimated for each administrative district after analyzing alluvium and hydrogeology distribution in N. Korea. Overall, the available amount of groundwater was estimated to 22.3 billion m³ (0.18 million m³/km²). The available amount of groundwater per unit area in Ryanggangdo and Gaesungsi was appeared very high in each of 0.56 and 0.39 million m³/km², respectively, and it would be interpreted that two districts have relatively wide area of volcanic rocks and alluvium with highly permeable characteristics, respectively. Finally, to maximize the utilization of this study result, the available amount of groundwater distribution map was developed on the basis of the 1 × 1 km grid network over the entire N. Korea.

• 한국조경학회지
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• 제34권4호
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• pp.84-95
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• 2006

This study begins by examining the reason for the lack of urban planning that takes the water cycle into consideration. While there are institutions that support environmentally friendly development or smooth water circulation, these designs are not reflected in planning nor in the real world. After reviewing foreign case studies, policy suggestions and possible policy implications for Korea are derived. In Korea, there is not a sufficient level of relevant laws or institutions systematically established to make it possible to deal with rainwater in a decentralized way. Instead, facility standards or guidelines are considered separately for the control of water and for preventing natural disasters. And even though an environmentally friendly approach is stipulated in relevant laws in terms of spatial planning, there are no planning systems or implementation tools to actualize this kind of approach. The factors that make decentralized rainwater management possible in urban planning are analyzed based on the case study of Germany. Germany requires developers to plan in order to achieve ecological urban development. In addition, as a detailed implementation tool to promote conservation of the water cycle, the law provides for various kinds of measures such as restrictions on the proportion of impervious surface area according to the use of the land, required compensation measures for environmental degradation following development, introduction of a fee for rainwater runoff and the establishment of ecological landscape planning. The actual reason these measures can be implemented however is the provision of planning guidelines and design criteria for rainwater utilization, absorption and containment, and the construction of a database for various environmental information.

• 한국조경학회지
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• 제34권4호
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• pp.18-36
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• 2006

The purpose of this research was to establish a green-networks from the perfective of landscape ecology in order to improve the function of urban green spaces. The study site was Dalsu-Gu in Daegu City. This research consisted of three phases. In the first phase, field surveys were carried out in order to understand existing distribution pattern of green spaces in the study site. 533 green spaces surveyed in the first phase were classified into 7 patterns and 24 types. The total area of the green spaces in Dalsu-gu was 3,329ha. Specifically the area of the 'urban nature parks' type was 57.49% of the total area of green spaces in Dalsu-gu, and it was expected that 'urban nature parks' type can play important roles in the green-networks in Dalsu-gu. Two analysis with green spaces in 9 types including 'urban nature parks', 'rivers' and 'neighborhood parks' were performed to establish a basic network frame of the green-networks. In the second phase, 'mutual connectivity analysis' and 'mutual matrix analysis' were performed to select core green spaces of a green-networks using 'areas of each green space and a distance between each space' and 'a rate of green spaces and a rate of water permeable pavement'. The results of the second phase indicated that, in mutual connectivity analysis, large green spaces apart from each other were evaluated as having higher mutual connectivity than small green spaces near to each other. In mutual matrix analysis, the green spaces with higher mutual connectivity and the small green spaces near to each other were evaluated as having better mutual matrix. In the last phase, we structured a basic frame of the green-networks in Dalsu-Gu. The results suggested that the basic frame of the green-networks in Dalsu-Gu was composed on four green-network axes and its shape mirrored a cruciform(+) of northwest${\longleftrightarrow}$southeast directions and southwest${\longleftrightarrow}$northeast directions, The Duryu neighborhood park is at the central point of this green-networks.

• The Korean Journal of Physiology and Pharmacology
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• 제1권6호
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• pp.673-679
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• 1997

It has been generally accepted that glutamate mediates the ischemic brain damage, excitotoxicity, and induces release of neurotransmitters, including norepinephrine(NE), in ischemic milieu. In the present study, the role of nitric oxide(NO) in the ischemia-induced $[^3H]norepinephrine([^3H]NE)$ release from cortex slices of the rat was examined. Ischemia, deprivation of oxygen and glucose from $Mg^{2+}-free$ artificial cerebrospinal fluid, induced significant release of $[^3H]NE$ from cortex slices. This ischemia-induced $[^3H]NE$ release was significantly attenuated by glutamatergic neurotransmission modifiers. $N^G-nitro-L-arginine$ methyl ester(L-NAME), $N^G-monomethyl-L-arginine$ (L-NMMA) or 7-nitroindazole, nitric oxide synthase inhibitors attenuated the ischemia-evoked $[^3H]NE$ release. Hemoglobin, a NO chelator, and 5, 5- dimethyl-L-pyrroline-N-oxide(DMPO), an electron spin trap, inhibited $[^3H]NE$ release dose-dependently. Ischemia-evoked $[^3H]NE$ release was inhibited by methylene blue, a soluble guanylate cyclase inhibitor, and potentiated by 8-bromo-cGMP, a cell permeable cGMP analog, zaprinast, a cGMP phosphodiesterase inhibitor, and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide generator. These results suggest that the ischemia-evoked $[^3H]NE$ release is mediated by NMDA receptors, and activation of NO system is involved.

• 자원환경지질
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• 제37권1호
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• pp.99-106
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• 2004

환경오염저감 및 제어기술은 환경/방재 기술분야로 포스트 반도체 주력산업의 고도화분야에 해당되며, 그 중 오염토양 및 지하수 복원기술은 앞으로 많은 수요가 예상되는 핵심기술이라 할 것이다. 국내의 경우 폐금속광산이 다수 존재하며 이로 인한 중금속 및 비소오염문제가 심각해지고 있는 시점에서 이를 복원하기 위한 최신기술의 동향을 알아보는 것이 필요할 것이다. 현재 이 분야의 선진국인 미국 및 유럽각국에서의 기술개발은 2차적인 오염을 유발하지 않을 청정기술의 개발과 개발기술의 현장적용에 초점이 맞추어 지고 있는 추세이다. 여기에 최근에 개발되어진 신기술중에 이러한 장점으로 인해 주목받고 있는 기술인 전기동력학 기술, 투수성 반응벽체기술, 고형화/안정화기술, 박테리아를 이용한 생체흡착기술, 박테리아를 이용한 용출기술, 식물정화기술을 소개하고자 한다.

• 한국지반환경공학회 논문집
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• 제5권3호
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• pp.41-50
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• 2004

침투거동에 대한 연구는 우기시 도로성토사면의 안정성 여부에 매우 중요하다. 본 연구는 도로성토사면의 몇가지 사례들에 대한 침투거동과 사면안정성의 분석을 근거로 하여 좀더 안정적인 도로성토사면의 유지 방안을 제안한 것이다. 본 연구 사례에서 선택한 도로붕괴단면은 가장 일반적인 평지부 도로성토사면의 경우와 산지부에 대한 도로성토사면인 경우이다. 본 연구의 결과를 요약하면 다음과 같다. 평지부 성토사면은 강우시 표면으로부터 침투가 시작되어 점차 성토 제체 내로 확대되었으며, 이때 도로성토사면의 침투거동은 불포화 흐름이론을 근거로 해석하였다. 특히 평지부 성토사면은 호우기간동안 사면표면에서의 강우침투로 인해 좀더 불안정하게 되었다. 산지부 성토사면의 경우 사면표면부로부터의 침투거동을 고려하여 해석하였으며, 사면표면부로부터의 강우침투로 인해 사면불안정이 증가되었음을 알 수 있었다. 산지부 성토사면의 경우 투수성이 큰 재료를 이용하여 원지반에 설치한 배수층은 도로 성토사면의 안정성 증대에 유용한 영항을 줄 것으로 판단된다.