• Title/Summary/Keyword: Permeability of skin

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Effect of Propionic Acid Additive on Preparation of Phase Inversion Polysulfone Membrane (폴리설폰 상전환막의 제조에 있어 프로피오닉산 첨가제의 영향)

  • Han, Myeong-Jin;Choi, Seung-Rag;Park, So-Jin;Seo, Bum-Kyoung;Lee, Kune-Woo;Nam, Suk-Tae
    • Membrane Journal
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    • v.18 no.4
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    • pp.317-324
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    • 2008
  • Polysulfone membranes were prepared via the phase inversion process. With propionic acid as a nonsolvent additive, polysulfone casting solutions were solidified in an isopropanol bath. Propionic acid (PA) worked as a thermodynamic enhancer for phase separation and as a rheological suppressor for kinetic hindrance. Morphology of the prepared membranes significantly varied with propionic acid content in the casting solution. The dense skin layer, which was identified in the membrane prepared without PA, almost disappeared in the membrane prepared trom PA 10wt%. With 30wt% PA, the membrane revealed the morphological gradient from a nodular skin structure to a sponge-like substructure, including the finger-like cavity. Water permeability increased with PA content, and polyethylene glycol rejection decreased with the nonsolvent content.

Pharmacological and Biochemical studies on Telescopium telescopium - a marine mollusk from the Mangrove regions

  • Samanta, SK;Adhikari, D;Karmakar, S;Dutta, A;Roy, A;Manisenthil, KT;Roy, D;Vedasiromoni, JR;Sen, T
    • Advances in Traditional Medicine
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    • v.8 no.4
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    • pp.386-394
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    • 2008
  • The tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal, India, was extensively screened for pharmacological and biochemical properties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes (both direct and indirect), produced haemorrhagic lesions in the skin and also released haemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to produce pro-inflammatory effects when injected into the rat hind paw and also increased peritoneal vascular permeability. Furthermore, intravenous administration of TTE produced a decrease in blood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esterase activity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro). TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and protease activities.

Preparation and Evaluation of $PGE_1$ Urethral Suppositories ($PGE_1$ 요도좌제의 제조 및 평가)

  • Park Somin;Choi Myeongsin;Han Kyuwon;Kim Kil-Soo
    • YAKHAK HOEJI
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    • v.49 no.4
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    • pp.260-267
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    • 2005
  • [ $PGE_1$ ] is an endogenous substance of potent vasodialator as well as inhibitor of platelet aggregation. It has been used therapeutically in peripheral arterial occlusive disease and impotence. Intracavernous injection of $PGE_1$ for erectile dysfunction has been established for several years as a treatment option for erectile dysfunction of diverse etiologies, but this mode of administration is limited by penile discomfort, pain at the injection site, inconvenience and noncompliance. As the matter of worse, the $\beta-hydroxy$ moiety of $PGE_1$ is extremely susceptible to dehydration in solution to give inactive $PGA_1$ and $PGB_1$. For the improvement of stability, rapid absorption at action site and the convenience of application, $PGE_1$ was formulated as urethral suppositories of three types of formulations, such as PEG, witepsol, and the mixture of PEG and witepsol. The stability test of $PGE_1$ and the release test in urinary suppositories were performed. Futhermore, the effect of enhancers and vehicle composition on the penetration of $PGE_1$ through excised rat skin was evaluated by permeability coefficient and enhancement ratio.

Anaphylactic Shock Care during General Anesthesia -A Case Report- (전신마취 도중 유발된 아나필락시스 -증례보고-)

  • Choi, Byung-Ho;Sul, Sung-Han;Yoo, Jae-Ha
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.6 no.2 s.11
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    • pp.121-126
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    • 2006
  • Generalized anaphylaxis is a most dramatic and acutely life-threatening allergic reaction. Most fatalities from anaphylaxis occur within the first 30 minutes postantigenic exposure. The mechanism of generalized anaphylaxis is the reaction of IgE antibodies to an allergen that causes the release of histamine, bradykinin, and others. These chemical mediators cause the contraction of smooth muscles of the respiratory and intestinal tracts, as well as increased vascular permeability. Four major clinical symptoms are recognized: skin reactions, smooth muscle spasm (gastrointestinal and genitourinary tracts and respiratory smooth muscle), respiratory distress, and cardiovascular collapse. Epinephrine is the drug of choice for the management. Its syrnpathomimetic effects directly counteract most aspects of the attack. Respiration must be immediately supported by the establishment of a patent airway along with artificial ventilation. The circulation should be supported and the existing hypotension overcome by placing the victim in a position to allow gravity to aid venous return and by administering intravenous fluids, vasopressors, and corticosteroids. When an imperceptible pulse is evident, external cardiac compression must also be instituted. This is a case report of anaphylactic shock care during general anesthesia, possibly due to penicillin, pancuronium and others.

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The Analysis on the Work Environment and Working Clothes Wearing Conditions of Shipyard Painters (조선소 도장작업자의 작업환경 및 작업복 착의실태 분석)

  • Bae, Hyun-Sook;Park, Hye-Won;Park, Gin-Ah
    • Journal of the Korean Society of Clothing and Textiles
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    • v.34 no.3
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    • pp.518-528
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    • 2010
  • This study analyzes the work environment and the work clothes wearing conditions of shipyard painters. In addition to this, three types of experimental painting work clothes were evaluated by painters in terms of the material performance and wearing functions. The findings on the harmful painting work environmental factors were organic solvents, noise, heavy dust, high temperatures, and noxious fumes. The body parts damaged during painting operations were the skin, arms, whole body, and face. In general, the satisfaction with the wearing performance of work clothes for painting was low especially in regards to sweat absorbency, sweat permeability, body protection, covering, and the work motion suitability. The satisfaction with the wearing sense of painting working clothes (regardless of the type of material) was high in the order of movement comfort> sensual comfort> physiological comfort. The satisfaction in overall comfort according to the types of material was high in the order of nylon> SMS nonwoven fabric> SF nonwoven fabric.

Multilamellar Liquid Crystals for the Stabilization of Retinoids (레티노이드 안정화를 위한 다중층 액정제제)

  • Yoon, Moung-Seok;Chung, Youn-Bok;Han, Kun
    • Journal of Pharmaceutical Investigation
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    • v.29 no.4
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    • pp.279-285
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    • 1999
  • Retinoids in anti-wrinkle cosmetics are widely used for the treatment of the photoaging skin these days, but very unstable in the presence of water. Multilamellar liquid crystal vesicles consisted of $poly(oxyethylene)_{15}oleyl$ ether $(POE_{15}OE)$ or $poly(oxyethylene)_{15}stearyl$ ether $(POE_{15}SE)$, cetostearyl alcohol (CSA) and cholesterol or oils were prepared to increase the stability of retinyl acetate or retinyl palmitate. $POE_{15}SE-CSA-Water$ systems were more unstable than $POE_{15}SE-CSA-Water$ systems due to the bended structure of oleyl groups. For the modification of vesicles, cholesterol was added. The enthalpy values were decreased reaching to zero and the water permeability of systems was decreased, but the stabilizaton of retinyl acetate was not greatly improved. The stability of retinyl acetate may depend on its location in the structure. Various oils were added for further stabilization and isopropyl myristate was most effective. In practice, retinyl palmitate showed better stability in the same vesicle than retinyl acetate, and the improved vesicles could be used for the anti-wrinkle cosmetics

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Thermal Insulation of Protective Clothing Materials in Extreme Cold Conditions

  • Mohamed Zemzem;Stephane Halle;Ludwig Vinches
    • Safety and Health at Work
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    • v.14 no.1
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    • pp.107-117
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    • 2023
  • Background: Thermophysiological comfort in a cold environment is mainly ensured by clothing. However, the thermal performance and protective abilities of textile fabrics may be sensitive to extreme environmental conditions. This article evaluated the thermal insulation properties of three technical textile assemblies and determined the influence of environmental parameters (temperature, humidity, and wind speed) on their insulation capacity. Methods: Thermal insulation capacity and air permeability of the assemblies were determined experimentally. A sweating-guarded hotplate apparatus, commonly called the "skin model," based on International Organization for Standardization (ISO) 11092 standard and simulating the heat transfer from the body surface to the environment through clothing material, was adopted for the thermal resistance measurements. Results: It was found that the assemblies lost about 85% of their thermal insulation with increasing wind speed from 0 to 16 km/h. Under certain conditions, values approaching 1 clo have been measured. On the other hand, the results showed that temperature variation in the range (-40℃, 30℃), as well as humidity ratio changes (5 g/kg, 20 g/kg), had a limited influence on the thermal insulation of the studied assemblies. Conclusion: The present study showed that the most important variable impacting the thermal performance and protective abilities of textile fabrics is the wind speed, a parameter not taken into account by ISO 11092.

Antimicrobial Effect of Supercritical Robinia pseudo-acacia Leaf Extracts and Its Transdermal Delivery System with Cell Penetrating Peptide

  • Heo, Soo Hyeon;Park, Su In;Lee, Jinseo;Kim, Miok;Shin, Moon Sam
    • International Journal of Advanced Culture Technology
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    • v.8 no.1
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    • pp.226-235
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    • 2020
  • In this paper, we present to evaluate physiological activity of Robinia pseudo-acacia leaf and its skin penetration using liposome and cell penetrating peptide. After extraction with Robinia pseudo-acacia leaf using the distilled water and supercritical, various physiological activities were examined. In antioxidants experiments, the total concentration of polyphenol compounds was determined to be 56.88 mg/g in hydrothermal extract, 45.07 mg/g in supercritical extract. The DPPH radical scavenging ability at 1,000 ㎍/mL was 33.97% in supercritical extract. The scavenging effect on SOD experiment at 500 ㎍/mL was 76.41% in supercritical extract. In the antimicrobial experiments, the hydrothermal extract had no effect, but supercritical extract represented maximum clear zone of 14.00 mm in Staphylococcus aureus strain. Liposome containing the RSE (Robinia pseudo-acacia leaf supercritical extract) reduced particle size and stabilized zeta potential. In the epidermal permeability experiment, it was confirmed that the permeation of liposome containing the RSE and cell penetrating peptides was remarkable.

Characterization of Edible Film Fabricated with Channel Catfish Ictalurus punctatus Gelatin by Cross-Linking with Transglutaminase

  • Oh, Jun-Hyun
    • Fisheries and Aquatic Sciences
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    • v.15 no.1
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    • pp.9-14
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    • 2012
  • The objectives of this research were to improve the film-forming properties of Channel Catfish Ictalurus punctatus skin gelatin (CSG) by cross-linking with transglutaminase (TG), determine and optimize the TG reaction time, and characterize the mechanical and barrier properties of CSG edible film. Cross-linking of CSG was performed by TG for 0, 10, 20, 30, and 40 min at $50^{\circ}C$, and the reaction was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The color and mechanical and barrier properties of edible films fabricated with CSG cross-linked with TG were characterized. Gelatin yields from the extraction ranged from 18.2% to 23.3%. SDS-PAGE exhibited dark bands at 120 and 250 kDa, indicating successful TG-mediated cross-linking. The color of CSG film was not affected by TG cross-linking. The tensile strength of CSG films cross-linked with TG decreased from 42.59 to 21.73 MPa and the percent elongation increased from 42.92% to 76.96% as reaction times increased from 0 to 40 min. There was no significant difference in water vapor permeability of CSG films.

Application of Amorphous wire to ECT(Eddy Current Testing) Probe (아몰퍼스 와이어의 ECT probe 적용에 대한 검토)

  • Kim, Y.H.;Shin, K.H.;SaGong, Gun
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.08a
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    • pp.47-51
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    • 2002
  • ECT(eddy currentign testing) is very effective technique to detect a flaw within a conductor. Co-based amorphous wire was used as a sensor head. The wire has almost 0 magneto-striction and high permeability. An uniform magnetic field was applied to 1mm thick copper plate and $25{\mu}m$ thick aluminum sheet conductor using spiral typed coil The size of the coil has $40mm{\times}40mm$ outer width and $8mm{\times}8mm$ inner width. The copper plate and aluminum sheet has 0.5mm and 0.1mm wide gap, respectively. The frequency range of applied field was 100kHz-600kHz. The induced voltage difference of 2.5mV was obtained in the maximum voltage and minimum one measured across the gap of the 1mm thick conductor. In the case of aluminum sheet, 0.4mV was obtained. From this results, the effectiveness of Co-based amorphous wire was confirmed in the ECT technique.

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