• Title/Summary/Keyword: Partial response

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The Effect of External Radiation Therapy in Management of Malignant Obstructive Jaundice due to Porta Hepatis Metastasis from Stomach Cancer (위암의 간문맥 전이로 발생한 악성 폐쇄성 황달에 대한 외부 방사선치료 효과)

  • Yang, Kwang-Mo;Kim, Joon-Hee;Kim, Chul-Soo;Suh, Hyun-Suk;Kim, Re-Hwe
    • Radiation Oncology Journal
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    • v.13 no.4
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    • pp.339-348
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    • 1995
  • Purpose : Since 1983, authors have conducted a study to evaluate the effect of external radiation therapy and to determine affected factors in management of the patients with malignant obstructive jaundice due to porta hepatis metastasis from stomach cancer. Materials and Methods : Thirty two patients with malignant obstructive jaundice due to porta hepatis metastasis from gastric cancer were presented. We have analysed 23 patients who were treated with external radiation therapy of more than 3000cGy. The radiation dose, disease extent at developement of jaundice, total bilirubin levels before radiation therapy, differentiation of histology, combind treatment, intent of primary surgery, initial stage of gastric cancer were analyzed to determine affected factors in radiation therapy. External radiation therapy was delivered with a daily dose of 180-300cGy, 5 times a week fractionation using 4 MeV linear accelerator. The radiation field included the porta hepatis with tumor mass by the abdominal ultrasonography or CT scan. In twenty three patients received more than 3000cGy, total irradiation dose was ranged from 3000cGy to 5480cGy, median 3770cGy. Among 23 patients, 13 patients were delivered more than equivalant dose of TDF 65(4140cGy/23fx). Results : Among 23 patients, complete, partial and no response were observed in 13, 5, 5 patients, respectively. The median survival for all patients was 5 momths. The significant prolongation of median survival was observed in complete responders(11 months) as compared to partial and no responders(5 months, 5 months respectively) Out of 13 patients with complete response, 6 patients lived more than a year Among 13 patients receiving more than 4140cGy equivalent dose, complete, partial and no response were observed in 10, 2 and 1 patients, respectively. The median survival for all these patients was 9.5 months. The median survival for complete responders(10/13) was 11.5 months. Among 10 patients receiving less than 4140cGy equivalent dose, complete, partial and no response were observed in 3, 3, 4 patients, respetively. The median survival for all these patients was 4.3 months Therefore, the radiation dose affected the results of treatment. For the complete response with prolongation of survival duration, at least 4140cGy equivalant dose should be delivered to porta hepatis. In evaluation of the disease extent, 7 patients of 13 complete responders showed localized disease in porta hepatis or peripancreatic area, but all patients with partial and no response showed wide extensive disease or persistant disease of primary gastric cancer. Therefore. the patients with the localized disease were the higher probability of complete response and long term survival. This study suggested that the radiation dose and the disease extent at developement of jaundice affected in radiation therapy for malignant obstructive jaundice. There were no serious complications related to external radiation therapy. Conclusion : External radiation therapy only could achieve the palliative effect in the patients with malignant obstructive jaundice due to porta hepatis metastasis from stomach cancer. This study suggested that the prolongation of survival duration could be achived in complete responders and radiation dose, extent of disease affected the results of treatment of malignant obstructive jaundice.

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Induction Chemotherapy Followed by Radiotherapy for Stage IV Hypopharyngeal Cancer (4기 병기 하인두암에서 선행 항암화학요법후 방사선치료)

  • Kang Ki Mun;Chai Gyu Young;Kim Jin Pyeong;Lee Won Seop
    • Radiation Oncology Journal
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    • v.22 no.4
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    • pp.247-253
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    • 2004
  • Purpose: Hypopharyngeal cancer is diagnosed at the advanced stage in most cases, which the prognosis known to be poor. Thus, the efficacy of induction chemotherapy followed by radiotherapy, with regards to the response and survival rate for stage IV hypopharyngeal cancer patients, was examined. Materials and Methods: From July 1998 to February 2000, 18 cases were diagnosedas AJCC stage IV hypopharyngeal cancer without distant metastasis. These patients were treated with induction chemotherapy followed by radiotherapy, and the results retrospectively analyzed. The regimen of the induction chemotherapy was the 5-FU and cisplatincombination, at 3-week intervals for, 2 cycles. The total radiation dose for the primary lesion and metastatic lymph nodes was $68.4\~72.0$Gy (median: 70.2 Gy). Results: The: The median follow up period was 28 months, ranging from 7 to 99 months. The 3-year overall survival and disease-free survival rate were 41.7 and $31.1\%$, respectively. In 6 cases ($33.3\%$), conservation of the larynx for over 3 years was possible. After the induction chemotherapy there were 16 partial responses ($88.8\%$), 1 complete response and 1 with no response ($5.6\%$ each), therefore, 17 of the 18 cases ($94.6\%$) showed responses. After the completion of the induction chemotherapy and radiotherapy, a complete response was noted in 13 cases ($72.2\%$), a partial response in 5 ($27.8\%$), with an overall response rate of $100\%$. In the analysis of the prognostic factors influencing the survival rate, the 3-year and disease-free survival rates for the complete and partial response groups were 43.1, and $20.0\%$, and 39.6, and $20.0\%$, respectively (p=0.0003, p=0.002). Only the final response after treatment completion was statistically significant. Conclusion: For stage IV hypopharyngeal cancer, induction chemotherapy followed by radiotherapy was an effective treatment, with no severe side effects.

An Analytical Solution of Dynamic Responses for Seabed under Coexisting Fields of Flow and Partial Standing Wave with Arbitrary Reflection Ratio (흐름과 임의반사율을 갖는 부분중복파와의 공존장하에서 해저지반내 동적응답의 해석해)

  • Lee, Kwang-Ho;Kim, Dong-Wook;Kang, Gi-Chun;Kim, Do-Sam;Kim, Tae-Hyung;Na, Seung-Min
    • Journal of the Korean Geotechnical Society
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    • v.31 no.6
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    • pp.27-44
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    • 2015
  • An analytical solution of dynamic responses for seabed in finite and infinite thicknesses including shallow has been developed under flow and partial standing wave with arbitrary reflection ration coexisting field at a constant water depth condition. In the analytical solution, a field was simply transited to a coexisting field of progressive wave and flow when reflection ratio was 0 and to a coexisting field of fully standing wave and flow when reflection ratio was 1. Based on the Biot's consolidation theory, the seabed was assumed as a porous elastic media with the assumptions that pore fluid is compressible and Darcy law governs the flow. The developed analytical solution was compared with the existing results and was verified. Using the analytical solution the deformation, pore pressure, effective and shear stresses were examined under various given values of reflection ratio, flow velocity, incident wave's period and seabed thickness. From this study, it was confirmed that the dynamic response of seabed was quite different depending on consideration of flow, which causes changing period and length of incident and reflection waves. It was also confirmed that dynamic response significantly depends on the magnitude of reflection ratio.

Blind Adaptive Equalization of Partial Response Channels (부분 응답 채널에서의 블라인드 적응 등화 기술에 관한 연구)

  • 이상경;이재천
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.11A
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    • pp.1827-1840
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    • 2001
  • In digital data transmission/storage systems, the compensation for channel distortion is conducted normally using a training sequence that is known a priori to both the sender and receiver. The use of the training sequences results in inefficient utilization of channel bandwidth. Sometimes, it is also impossible to send training sequences such as in the burst-mode communication. As such, a great deal of attention has been given to the approach requiring no training sequences, which has been called the blind equalization technique. On the other hand, to utilize the limited bandwidth effectively, the concept of partial response (PR) signaling has widely been adopted in both the high-speed transmission and high-density recording/playback systems such as digital microwave, digital subscriber loops, hard disk drives, digital VCRs and digital versatile recordable disks and so on. This paper is concerned with blind adaptive equalization of partial response channels whose transfer function zeros are located on the unit circle, thereby causing some problems in performance. Specifically we study how the problems of blind channel equalization associated with the PR channels can be improved. In doing so, we first discuss the existing methods and then propose new structures for blind PR channel equalization. Our structures have been extensively tested by computer simulation and found out to be encouraging in performance. The results seem very promising as well in terms of the implementation complexity compared to the previous approach reported in literature.

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Therapeutic Effects of Acupuncture and Herbal External Preparation on Healing of Deep Partial Thickness Burn Wound in Rats (심재성 2도 화상이 유발된 흰쥐의 조직 회복에 대한 침 및 한약외용제의 효과)

  • Jo, Hee-Guen;Park, Ae-Ryon;Choi, Jin-Bong
    • Journal of Korean Medicine Rehabilitation
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    • v.24 no.3
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    • pp.87-98
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    • 2014
  • Objectives The present study aimed to investigate the effects of acupuncture and herbal external preparation on wound healing procedure in a deep partial thickness burn model in rats. Methods A total of 40 male Sprague-Dawley rats were allocated into four groups with an equal number in each group: acupuncture treatment group, herbal external perparation group, Silver sulfadiazine dressing group and control group. We describe the effect of acupuncture and herbal external preparation on morphologic and histologic changes, epithelial growth factor (EGF), hematological value of the deep partial thickness burn wound in rats. Results At 21th day after wounding the wound size in acupuncture treat group and herbal external preparation group were decreased more significantly compared to control group. In addition, epidermal regeneration on acupuncture treatment was than other treatment and control group in histological finding. Hematological findings revealed that acupuncture treatment group and herbal external prepartion group was more effective than control group in reducing inflammation response induced by burn. In acupuncture treated group, neutrophil and leukocyte level were significantly decreased compared to other treatment group. Also, this study showed that EGF was obviously expressed in nascent tissue when wounds were treated with the acupuncture and herbal external preparation after injury. In particular, acupuncture treatment group had a significant increase of EGF expression in burn wound healing area when compared with the other treatment groups. Conclusions These findings suggest that acupuncture and herbal external prepration may improve burn wound healing through decreasing inflammatory reaction, increasing tissue regeneration and expression of EGF. Moreover, acupuncture treatment could be more effective in comparison with Silver sulfadiazine dressing.

Nonlinear analysis of composite beams with partial shear interaction by means of the direct stiffness method

  • Ranzi, G.;Bradford, M.A.
    • Steel and Composite Structures
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    • v.9 no.2
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    • pp.131-158
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    • 2009
  • This paper presents a modelling technique for the nonlinear analysis of composite steel-concrete beams with partial shear interaction. It extends the applicability of two stiffness elements previously derived by the authors using the direct stiffness method, i.e. the 6DOF and the 8DOF elements, to account for material nonlinearities. The freedoms are the vertical displacement, the rotation and the slip at both ends for the 6DOF stiffness element, as well as the axial displacement at the level of the reference axis for the 8DOF stiffness element. The solution iterative scheme is based on the secant method, with the convergence criteria relying on the ratios of the Euclidean norms of both forces and displacements. The advantage of the approach is that the displacement and force fields of the stiffness elements are extremely rich as they correspond to those required by the analytical solution of the elastic partial interaction problem, thereby producing a robust numerical technique. Experimental results available in the literature are used to validate the finite element proposed in the paper. For this purpose, those reported by Chapman and Balakrishnan (1964), Fabbrocino et al. (1998, 1999) and Ansourian (1981) are utilised; these consist of six simply supported beams with a point load applied at mid-span inducing positive bending moment in the beams, three simply supported beams with a point load applied at mid-span inducing negative bending moment in the beams, and six two-span continuous composite beams respectively. Based on these comparisons, a preferred degree of discretisation suitable for the proposed modelling technique expressed as a function of the ratio between the element length and depth is proposed, as is the number of Gauss stations needed. This allows for accurate prediction of the nonlinear response of composite beams.

Effects of Overall Shading and Partial Shading on the Response of Chlorophyll Fluorescence of Soybean (전면적차광과 부분차광이 콩 엽록소 형광 반응에 미치는 영향)

  • Cho, Yuna;Jo, Euni;Jeong, Jae-Hyeok;Yoon, Changyong;An, Kyunam;Cho, Jaeil
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.23 no.3
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    • pp.163-168
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    • 2021
  • The growth experiment under shading condition has been performed to understand the eco-physiological responses of crops to light in terms of photosynthesis. There are two types of shading: overall shading and partial shading. In this study, the chlorophyll fluorescence of soybean was observed under the overall shading of the box made by polyresin and the partial shading at agrivoltaic system. The overall shading condition during vegetative growth induced lower SPAD and Electron transport rate (ETR). These lower values recovered after removal of shading box. However, the Non-photochemical fluorescence quenching (NPQ) became lower under overall shading and higher under partial shading. Such increase in NPQ limited crop photosynthesis even though the ETR was almost same to the control without shading treatment. Under the condition of partial shading, the values of SP AD and ETR for soybean did not change. However, the NPQ was higher than control condition. This suggests that the crop photosynthesis under both types of shading would be decreased by different eco-physiological processes which are the lower ETR in overall shading and the higher NP Q in partial shading despite the reduced light under shading conditions.

The Partial Response Signals for Optical Recording System (광 기록 시스템을 위한 부분 응답 신호)

  • 이주현;이재진
    • Proceedings of the IEEK Conference
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    • 2000.09a
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    • pp.975-978
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    • 2000
  • 본 논문에서는 고밀도 광 기록 시스템에서 코드율이 2/3인 (1,7) 코드를 사용하여 부분 응답의 목표를 다양하게 변화시켜 여러 가지 목표 응답에 대해 잡음의 대부분을 차지하는 지터(jitter) 성분만을 고려했을 때와 이에 부가적인 백색잡음(AWGN)만을 고려하였을 경우의 성능을 각각 비교, 분석하였다. 또한, 이 실험 결과를 토대로 고밀도 광 기록 채널에 적용시킬 수 있는 가능한 부분 응답들을 조사하였고, 그 결과 PR(6,6,8,4,3) ML 코드가 고밀도 기록 시스템에서 좋은 데이터 검출 능력을 나타냄을 보였다.

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The selection to position visco-elastic material for reduction radiated sound power from a stiffened plate (보강판의 음향방사파워저감을 위한 제진재의 위치선정)

  • 안호일;김사수
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 1996.04a
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    • pp.257-262
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    • 1996
  • The first purpose of this study investigates the influence of stiffening on the acoustic response of stiffened plates, which are often employed in steel structures. And the radiation efficiency is measured by average mean square velocity and sound intensity of stiffened plates. The second, it determines influence of mass, damp and stiffeness due to the partial adhesive visco-elastic material to reduce radiated sound power.

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The Procedure of Finding Operating Conditions Minimizing Quality Loss and Case Study (공정 데이터를 이용한 조업 조건 결정 절차와 사례연구)

  • Jeong Il Gyo;Jeon Chi Hyeok
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2003.05a
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    • pp.76-80
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    • 2003
  • The procedure of finding operating conditions minimizing qualify loss is proposed with a real industry example. The procedure consists or major two parts - the selection or process variables critical to the response and He determination or operating conditions. The coefficients or ridge regression and the and stores or partial least squares are applied to select important process variables. Functional approach and Non-functional approach are used to find proper operating conditions of important process variables.

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