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Surgical Treatment for Acute, Severe Brain Infarction

  • Park, Je-On;Park, Dong-Hyuk;Kim, Sang-Dae;Lim, Dong-Jun;Park, Jung-Yul
    • Journal of Korean Neurosurgical Society
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    • v.42 no.4
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    • pp.326-330
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    • 2007
  • Objective : Stroke is the most prevalent disease involving the central nervous system. Since medical modalities are sometimes ineffective for the acute edema following massive infarction, surgical decompression may be an effective option when medical treatments fail. The present study was undertaken to assess the outcome and prognostic factors of decompressive surgery in life threatening acute, severe, brain infarction. Methods : We retrospectively analyzed twenty-six patients (17 males and 9 females; average age, 49.7yrs) who underwent decompressive surgery for severe cerebral or cerebellar infarction from January 2003 to December 2006. Surgical indication was based on the clinical signs such as neurological deterioration, pupillary reflex, and radiological findings. Clinical outcome was assessed by Glasgow Outcome Scale (GOS). Results : Of the 26 patients, 5 (19.2%) showed good recovery, 5 (19.2%) showed moderate disability, 2 (7.7%) severe disability, 6 (23.1%) persistent experienced vegetative state, and 8 (30.8%) death. In this study, the surgical decompression improved outcome for cerebellar infarction, but decompressive surgery did not show a good result for MCA infarction (30.8% overall mortality vs 100% mortality). The dominant-hemisphere infarcts showed worse prognosis, compared with nondominant-hemisphere infarcts (54.5% vs 70%). Poor prognostic factors were diabetes mellitus, dominant-hemisphere infarcts and low preoperative Glasgow Coma Scale (GCS) score. Conclusion : The patients who exhibit clinical deterioration despite aggressive medical management following severe cerebral infarction should be considered for decompressive surgery. For better outcome, prompt surgical treatment is mandatory. We recommend that patients with severe cerebral infarction should be referred to neurosurgical department primarily in emergency setting or as early as possible for such prompt surgical treatment.

Development Plan for the GMT Fast-steering Secondary Mirror

  • Lee, Sugnho;Han, Jeong-Yeol;Park, Chan;Jeong, Ueejeong;Yoon, Yang-noh;Song, Je Heon;Moon, Bongkon;Park, Byeong-Gon;Cho, Myung K.;Dribusch, Christoph;Park, Won Hyun;Jun, Youra;Yang, Ho-Soon;Moon, Il-Kwon;Oh, Chang Jin;Kim, Ho-Sang;Lee, Kyoung-Don;Bernier, Robert;Gardner, Paul;Alongi, Chris;Rakich, Andrew;Dettmann, Lee;Rosenthal, Wylie
    • The Bulletin of The Korean Astronomical Society
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    • v.41 no.2
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    • pp.66.3-67
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    • 2016
  • The Giant Magellan Telescope (GMT) will feature two interchangeable Gregorian secondary mirrors, an adaptive secondary mirror (ASM) and a fast-steering secondary mirror (FSM). The FSM has an effective diameter of 3.2 m and built as seven 1.1 m diameter circular segments, which are conjugated 1:1 to the seven 8.4m segments of the primary. Each FSM segment contains a tip-tilt capability for fine co-alignment of the telescope subapertures and fast guiding to attenuate telescope wind shake and mount control jitter. This tip-tilt capability thus enhances performance of the telescope in the seeing limited observation mode. As the first stage of the FSM development, KASI conducted a Phase 0 study to develop a program plan detailing the design and manufacturing process for the seven FSM segments. The GMTO-KASI team matured this plan via an internal review in May 2016 and the revised plan was further assessed by an external review in June 2016. In this poster, we present the technical aspects of the FSM development plan.

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Effect of the Urease Accessory Genes on Activation of the Helicobacter pylori Urease Apoprotein

  • Park, Jeong-Uck;Song, Jae-Young;Kwon, Young-Cheol;Chung, Mi-Ja;Jun, Jin-Su;Park, Jeong-Won;Park, Seung-Gyu;Hwang, Hyang-Ran;Choi, Sang-Haeng;Baik, Seung-Chul;Kang, Hyung-Lyun;Youn, Hee-Shang;Lee, Woo-Kon;Cho, Myung-Je;Rhee, Kwang-Ho
    • Molecules and Cells
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    • v.20 no.3
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    • pp.371-377
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    • 2005
  • The roles that accessory gene products play in activating the Helicobacter pylori urease apoprotein were examined. The activity of the urease apoprotein increased in the following order when it was expressed with the accessory genes: ureG < ureGH < ureFGH < ureEFGH < ureIEFGH. Moreover, stepwise additions of ureE and ureI to ureFGH significantly increased urease activity. Urease apoproteins coexpressed with ureFGH, ureEFGH, and ureIEFGH had similar low chymotrypsin susceptibilities. In vivo and in vitro activation studies showed that the cooperative effect of the accessory proteins involved processes in which the UreFGH complex, UreE, and UreI were implicated. Thus, the UreFGH complex may serve to alter the conformation of the apoprotein into one that is more competent to assemble a stable metallocenter, and that facilitates cooperative effects.

Effect of Temperature, Deep Sea Water and Seed Quality on Growth of Buckwheat Sprouts

  • Xoxiong, Briatia;Chang, Kwang-Jin;Ahn, Chul-Hyun;Lim, Yong-Sub;Kim, Yeon-Bok;Park, Sang-Un;Park, Byoung-Jae;Sung, In-Je;Park, Cheol-Ho
    • Korean Journal of Plant Resources
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    • v.24 no.6
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    • pp.724-728
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    • 2011
  • With both common and Tartary buckwheat species, this study was aimed at producing new commercially useful bio-materials with higher nutritional and medicinal value due to higher components for health promotion and diseases care. In common buckwheat sprouts, it was found that root length at $20^{\circ}C$ was longer (5.93 cm) than at 25 and $30^{\circ}C$, whereas the hypocotyls length, fresh weight of each sprout, and whole fresh weight showed the highest value at $30^{\circ}C$. For Tartary buckwheat, the root length, hypocotyl length and fresh weight of each sprout and whole fresh weight were also the highest at $30^{\circ}C$. Common buckwheat (Suwon No.1) and Tartary buckwheat (KW45) sprouts cultured at $20^{\circ}C$ showed that hypocotyl length, fresh weight of each sprout, and whole fresh weight in the control were higher than those sprouts treated with 5% and 10% deep sea water (DSW), while the sprouts cultured at $30^{\circ}C$ showed were significantly longer hypocotyls than the control or 5% DSW treatment.

Idiopathic Fibrosing Mediastinitis Causing Extensive Fibrotic Veno-occlusion with Minimal Mediastinal Involvement (광범위한 섬유성 정맥 폐쇄를 동반한 특발성 섬유화성 종격동염 1예)

  • Kim, Je-Hyeong;Hur, Gyu-Young;Lee, Seung-Heon;Lee, Sang-Yeub;Park, Sang-Myun;Shin, Chol;Shim, Jae-Jeong;In, Kwang-Ho;Kim, Han-Kyeom;Kang, Kyung-Ho;Yoo, Se-Hwa
    • Tuberculosis and Respiratory Diseases
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    • v.52 no.3
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    • pp.278-282
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    • 2002
  • A 68-year-old woman was admitted after suffering facial edema with neck vein engorgement for approximately 2 months. A chest X-ray showed a mild widening of the superior mediastinum and a luminal obliteration of the superior vena cava(SVC) was noted on a computed tomograph. Venography showed that both subclavian veins were obstructed at the level of the proximal clavicle with a nonvisualization of the SVC. The SVC, both the innominate and the left internal jugular veins were completely obstructed with extensive cord-like fibrotic changes despite the absence of mediastinal involvement. The microscopic features showed a chronic granulomatous inflammation with a fibrosis minimally invading the mediastinal fat, which is consistent with fibrosing mediastinitis.

Inhibitory effect of Mori Folium ethanol extract on pro-inflammatory mediator in lipopolysaccharide - activated RAW 264.7 cells (상엽(桑葉) 추출물의 LPS로 유도된 RAW 264.7 세포에서의 항염증 효과)

  • Park, Sang-Mi;Byun, Sung-Hui;Kim, Young-Woo;Cho, Il-Je;Kim, Sang-Chan
    • The Korea Journal of Herbology
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    • v.27 no.3
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    • pp.31-38
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    • 2012
  • Objectives : Mori Folium is one of the traditional medicinal herb. It was commonly used for sericulture in the world and has been traditionally administered as natural therapeutic agent for the treatment of filariasis, diabetes and dropsy in East Asia. This study investigated an anti-inflammatory potential of Mori Folium ethanol extract (MFE). Methods : We examined the effects of MFE on the lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) in a murine macrophage cell line, RAW 264.7. Results : MFE inhibited production of NO and $PGE_2$ in a dose dependent manner and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, interleukin (IL)-1, IL-6 and tumor necrosis factor-${\alpha}$. As a plausible molecular mechanism, increased degradation of I-${\kappa}B{\alpha}$ and phosphorylation of I-${\kappa}B{\alpha}$, NF-${\kappa}B$ and MAP kinases by LPS were partly blocked by MFE treatment. Conclusions : These results suggest that MFE has an anti-inflammatory therapeutic potential, which may result from inhibition of NF-${\kappa}B$ activation and MAPK phosphorylation, thereby decreasing the expression of pro-inflammatory genes.

Weekly Variation of Ischemic Stroke Onset in 3 Regions (3개 지역에 따른 허혈성 뇌혈관 질환의 요일 별 발생 특징 비교)

  • Kim, So-Yeon;Lee, Sang-Kwan;Sung, Kang-Kyung;Kim, Hyun-Sik;Kwon, So-Yeon;Je, Jun-Tae;Park, Man-Yong;Lim, Jin-Young;Kim, Yun-Sik;Moon, Sang-Kwan;Kim, Min-Soo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.5
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    • pp.1167-1171
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    • 2009
  • Ischemic stroke has been the leading cause deaths and the critical disability. In addition, the clinical problem of ischemic stroke have the poor prognosis and high mortality rate. The study aim was to identify the incidence variation of ischemic stroke by days of the week and its relationship with residences in males. We analyzed 607 males patients with ischemic stroke diagnosed by magnetic resonance image or computerized tomography. They were admitted to the oriental hospital of Kyunghee, Daejeon, Wonkwang university. We analyzed the onset of ischemic stroke using a ${\chi}2$ test. The results showed significant weekly variation of ischemic stroke onset and the differences of weekly variation according to residences. A deeper knowlegde of the underlying weekly variation could be provide more effective insights for preventive approach.

Survey of Oriental Medical Care for Traffic Accident Patients with Automobile insurance; 544 Cases Report (교통사고 환자 544례를 통한 한방자동차보험의 실태에 관한 조사)

  • Park, Seo-Young;Lee, Yun-Kyu;Kim, Jae-Su;Lim, Seong-Chul;Lee, Bong-Hyo;Jung, Tae-Young;Ha, Il-Do;Han, Sang-Won;Lee, Kyung-Min
    • Journal of Acupuncture Research
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    • v.26 no.3
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    • pp.1-10
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    • 2009
  • Objectives : The main purpose of this Survey is to make a research on the actual condition of Automobile insurance system in oriental medical care. Methods : In this research, we surveyed 544 patients of traffic accident who were visited oriental medical clinic or hospital in Daegu, Korea from January, 1, 2008 to December, 31, 2008 according to medical chart. They made up Questionnaire about sex, age, pattern of accidents, days to visit oriental medical clinic, motivation to visiting clinic, damaged part of the body, chief complaint, treatment given to them, medication, tests, days of treatment and the effect. Results : The patients visited oriental medical clinic or hospital were fewer numbers from most of traffic accident patients. And most of their symptoms were light and the treatment and test of oriental medicine was limited for them because of automobile insurance limitation. Conclusions : For this study, we confirmed a possibility for the treatment of traffic accident patients in oriental medical treatment. Still, we needs to expend the boundary of treatment and to come into application of insurance.

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Experimental Demonstration of Enhanced Transmission Due to Impedance-matching Si3N4 Layer in Perforated Gold Film

  • Park, Myung-Soo;Yoon, Su-Jin;Hwang, Je-Hwan;Kang, Sang-Woo;Kim, Deok-kee;Ku, Zahyun;Urbas, Augustine;Lee, Sang Jun
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.359-359
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    • 2014
  • In this study, surface plasmon resonance structures for the selective and the enhanced transmission of infrared light were designed. In order to relieve the large discontinuity of refractive index between air and metal hole array, $Si_3N_4$ was used as the impedance matching layer. Experimental parameter were calculated and determined in advance by the rigorous coupled wave analysis (RCWA) simulation, and then the experiment was carried out. A 2-dimensional metal hole array structures were patterned on the size of $1{\times}1cm^2$ GaAs substrate using photolithography process, and 5 nm thick Ti, 50 nm thick Au were deposited by E-beam evaporator, respectively. Subsequently, $Si_3N_4$ films with various thicknesses (150, 350, 550, and 750 nm) were deposited by plasma enhanced chemical vapor deposition (PECVD). For the comparison, transmittance of specimens with and without $Si_3N_4$ was measured using Fourier transform infrared spectroscopy (FTIR) in the range of $2.5-15{\mu}m$. Furthermore, the surface and the cross-sectional images were collected from the specimens by scanning electron microscopy (SEM). From the results, it was demonstrated that the transmittance was enhanced up to 80% by the deposition of 750 nm $Si_3N_4$ at $6.23{\mu}m$. It has advantage of enhanced transmission despite the simple fabrication process.

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Fabrication and Performance Evaluation of Temperature Sensor Matrix Using a Flexible Printed Circuit Board for the Visualization of Temperature Field (온도장 가시화를 위한 연성회로기판을 이용한 온도센서 어레이 제작 및 성능평가)

  • Ahn, Cheol-Hee;Kim, Hyung-Hoon;Cha, Je-Myung;Kwon, Bong-Hyun;Ha, Man-Yeong;Park, Sang-Hu;Jeong, Ji-Hwan;Kim, Kui-Soon;Cho, Jong-Rae;Son, Chang-Min;Lee, Jung-Ho;Go, Jeung-Sang
    • Journal of the Korean Society of Visualization
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    • v.7 no.2
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    • pp.17-21
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    • 2010
  • This paper presents the fabrication and performance measurement of a temperature sensor array on a flexible substrate attachable to a curved surface using MEMS technology. Specifically, the fabrication uses the well-developed printed circuit board fabrication technology for complex electrode definition. The temperature sensor array are lifted off with a $10{\times}10$ matrix in a $50\;mm{\times}50\;mm$ to visualize temperature distribution. Copper is used as temperature sensing material to measure the change in resistances with temperature increase. In a thermal oven with temperature control, the temperature sensor array is Characterized. The constant slope of resistance change is obtained and temperature distribution is measured from the relationship between resistance and temperature.